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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-qing Xie xian-qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2.2. and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was2..To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

自然辩证法原理发展(2.18—2.2.):现状与展望

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自然辩证法研究 2024年第1期40卷 113-124页

作者：易显飞杨景钦湖南师范大学道德文化研究中心湖南师范大学马克思主义学院长沙410081 兰州大学马克思主义学院兰州730000

近年来国内对于自然辩证法原理研究的进展主要体现在三个方面:驳斥国外学者对自然辩证法的质疑,论证自然辩证法的正确性与科学性;对自然辩证法原理进行更深层次的理解和阐释,发掘自然辩证法新的维度,进而深化和拓展自然辩证法的深度和广... 详细信息

近年来国内对于自然辩证法原理研究的进展主要体现在三个方面:驳斥国外学者对自然辩证法的质疑,论证自然辩证法的正确性与科学性;对自然辩证法原理进行更深层次的理解和阐释,发掘自然辩证法新的维度,进而深化和拓展自然辩证法的深度和广度;进一步与中国的现实相结合,发展中国特色、中国风格的中国化自然辩证法。近年来西方学者对自然辩证法的研究和发展主要体现在:阐释蕴含在自然辩证法中的生态思想,并以此应对生态危机;阐释蕴含在自然辩证法中的政治社会学思想以及哲学思想,回应社会矛盾。通过上述,大致可推断未来自然辩证法原理的发展趋势:对自然辩证法的研究将继续深化和拓展;研究会更加注重问题导向、更加注重实践与理论的结合;研究将会渗透到各个学科之中,加速学科之间的交叉融合。

关键词：自然辩证法原理恩格斯西方马克思主义自然辩证法中国化

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui Lin Yi-Juan Liu Shao-Wei Lin Yan-Feng Shao Feng Qiu qing-Wu Qiu Zhang-Kun Xu Jin-xian Chen Liang-Huo Chen Zhen-Qun Lin Wen-Hua Dai Ming-qing Zhang Qi Jiang Zhong-qin Xiao xian-Xing Cheng xiang-Fei Zhang Wen-Bin You Wei Chen Long-qin Li Wei-Xing Lin Yong-Fu Wang Fu-Jin Lai Long-Qun Chen Zhong-Hua Huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 2. centers in Fujian,China(May 2.2.-April 2.2.).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 2. among 2. cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2.[95%confidence interval(95%CI):71.4%-86.8%],93.2.(86.6%-96.7%),92.2.(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2.),and 93.9%(87.4%-97.2.)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.02. and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(2..2.%and 13.73%vs 37.62.,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2.variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： xian Li Mengxin Xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha Wang Mei-qin Liu Zhixiang Huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2.is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2.for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2.IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2.infection.

关键词： vaccination vaccine sustained

长链非编码RNA(lncRNA)KCNQ1重叠转录物1靶向抑制miR-62.-5p在高糖诱导的视网膜色素上皮细胞损伤中的作用

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眼科新进展 2024年第8期44卷 613-618页

作者：秦朝军王鲜贵州医科大学临床医学院贵州省贵阳市550025

目的探究长链非编码RNA(lncRNA)KCNQ1重叠转录物1(KCNQ1OT1)靶向抑制miR-62.-5p在高糖诱导的视网膜色素上皮细胞损伤中的作用。方法采用实时荧光定量PCR(RT-qPCR)检测糖尿病视网膜病变(DR)、2.糖尿病(T2.M)、葡萄膜炎患者血清和房水KCN... 详细信息

目的探究长链非编码RNA(lncRNA)KCNQ1重叠转录物1(KCNQ1OT1)靶向抑制miR-62.-5p在高糖诱导的视网膜色素上皮细胞损伤中的作用。方法采用实时荧光定量PCR(RT-qPCR)检测糖尿病视网膜病变(DR)、2.糖尿病(T2.M)、葡萄膜炎患者血清和房水KCNQ1OT1表达水平。用不同浓度葡萄糖处理人视网膜色素上皮细胞(ARPE-19),并检测KCNQ1OT1表达情况,选择最佳作用浓度。将ARPE-19细胞分为对照组(CON组)、高糖组(HG组)、HG+抑制物对照(si-NC)组、HG+KCNQ1OT1抑制物(si-KCNQ1OT1)组、HG+模拟物对照(miR-NC)组、HG+miR-62.-5p组、HG+si-KCNQ1OT1+anti-miR-NC组、HG+si-KCNQ1OT1+anti-miR-62.-5p组。RT-qPCR检测各组细胞KCNQ1OT1、miR-62.-5p表达水平,流式细胞术检测细胞凋亡,ELISA检测各组细胞丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性,Western blot检测各组细胞活化的含半胱氨酸的天冬氨酸蛋白水解酶-3(cleaved Caspase-3)蛋白表达水平,双荧光素酶报告实验检测KCNQ1OT1、miR-62.-5p靶向关系。结果血清和房水中KCNQ1OT1表达水平:DR患者>T2.M患者>葡萄膜炎患者(均为P2.-5p显著降低(均为P2.-5P组细胞miR-62.-5p、SOD活性均显著升高,细胞凋亡率、cleaved Caspase-3蛋白表达、MDA含量均显著降低(均为P2.-5p组细胞miR-62.-5p、SOD活性均显著降低,细胞凋亡率、cleaved Caspase-3蛋白表达、MDA含量均显著升高(均为P2.-5p可以减轻高糖诱导的ARPE-19细胞凋亡和氧化损伤。

关键词： lncRNA KCNQ1OT1 miR-62.-5p 高糖视网膜色素上皮细胞凋亡氧化应激

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观察机制对囚徒困境博弈合作水平的影响

控制与决策 2024年第1期39卷 311-318页

作者：蒋贤惠蒋玉莲黄勤珍西南民族大学电气工程学院成都610041 西南民族大学国家民委电子信息重点实验室成都610041

在演化博弈论中,合作有利于增加群体收益.目前,大量的研究工作都在关注合作水平的提高,但忽视了理论与实际的相关性,同时策略更新时间仅限于一个点上的收益.为此,引入完全同步、相对同步、高斯异步、指数异步4种观察机制模型,考虑智能... 详细信息

在演化博弈论中,合作有利于增加群体收益.目前,大量的研究工作都在关注合作水平的提高,但忽视了理论与实际的相关性,同时策略更新时间仅限于一个点上的收益.为此,引入完全同步、相对同步、高斯异步、指数异步4种观察机制模型,考虑智能体观察期内所获得的平均收益.随后,采用蒙特卡洛方法进行实验仿真,并分析各观察机制对囚徒困境博弈合作水平的影响.结果表明:在4种模型中都存在观察时间阈值,此时合作水平将达到峰值;最高合作水平在指数异步模型中实现;高斯异步模型中,合作水平与方差成正相关;智能体间的异质性也对合作产生积极影响.这项研究有助于打破传统研究收益的局限,促进合作水平的提高.仿真实验结果为支持社会群体合作提供了一定的理论依据.

关键词：观察机制囚徒困境博弈异质性合作水平平均收益蒙特卡洛方法

微塑料和菲对土壤化学性质、酶活性及微生物群落的影响

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环境科学 2024年第1期45卷 496-507页

作者：刘沙沙秦建桥吴贤格肇庆学院环境与化学工程学院广东省环境健康与资源利用重点实验室肇庆526061

微塑料和多环芳烃(PAHs)因在土壤环境中广泛存在及其潜在生态风险而受到越来越多的关注.然而,关于微塑料-PAHs复合污染对土壤生态系统的影响鲜有报道.选用聚乙烯(PE)/聚丙烯(PP)和菲(PHE)作为微塑料和PAHs的代表,进行为期300d的微宇宙... 详细信息

微塑料和多环芳烃(PAHs)因在土壤环境中广泛存在及其潜在生态风险而受到越来越多的关注.然而,关于微塑料-PAHs复合污染对土壤生态系统的影响鲜有报道.选用聚乙烯(PE)/聚丙烯(PP)和菲(PHE)作为微塑料和PAHs的代表,进行为期300d的微宇宙培养实验,利用土壤农业化学分析方法和16S扩增子测序技术研究PE/PP和PHE的单一和复合污染对土壤化学特性、酶活性和微生物群落(数量、结构、功能)的影响,分析PE/PP和PHE存在下土壤性质、酶活性和菌群的互作关系.结果表明,PE/PP和PHE的单一和复合污染对土壤pH值、有效磷(AP)和微生物(细菌、放线菌、霉菌)数量没有产生明显影响,但显著提高了荧光素二乙酸酯酶(FDAse)活性;PE、PP、PHE-PE和PHE-PP的添加显著增加了土壤有机质(SOM)含量和脲酶活性,PHE、PHEPE和PHE-PP显著增强了脱氢酶和磷酸酶活性及速效氮(AN)含量;PHE的添加对微生物群落影响不大,PE、PP、PHE-PE和PHE-PP对群落产生了一定的影响.PE/PP和PHE能够促进微生物产生能量、生长和繁殖,加快污染物的代谢/降解和细胞膜转运等功能.PE/PP和PHE引起的AN和SOM变化是影响土壤酶活性的关键因子,AN、AP和pH的改变是微生物数量增加的主要原因;微生物群落结构的改变与土壤化学性质、酶活性具有一定的相关性,其中SOM对菌群的影响达到了显著水平,土壤中不同碳源(PE/PP和PHE)的存在及菌与菌之间的互作关系也会影响微生物群落的组成.综上,PE/PP和PHE通过改变土壤化学性质、酶活性和微生物群落及其互作过程来促进菌群适应污染物胁迫.

关键词：微塑料菲(PHE) 土壤性质酶活性微生物群落

Research Overview of Zhuang Medicine Fumigation Lotions

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Medicinal Plant 2024年第1期15卷 35-37页

作者： Bing qinG Jiangcun WEI Fangmei LI xianyi SHI Li LONG xian PENG Meiyan QIU Wen ZHONG Zujie qin Guangxi International Zhuang Medical Hospital Nanning 530201China

At present,there is little research on the application of Zhuang medicine fumigation lotions in skin diseases,and there is no research on related preparation processes and quality *** this paper,the characteristics of its formulation and the research progress in skin diseases are reviewed,in order to deepen the understanding of Zhuang medicine fumigation lotions and provide a more detailed theoretical basis for its clinical research,development and application.

关键词： Zhuang medicine fumigation lotions Ilicis Rotundae Cortex Eiliae Herba Polygoni Perfoliati Herba Rhei Radix Et Rhizoma

Midpoint transverse process to pleura block for postoperative analgesia following laparoscopic renal cyst decortication:Two case reports

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World Journal of Clinical Cases 2024年第18期12卷 3629-3635页

作者： Wei-Jie He Wen-Xing Xu Xu-Dong Zhang Yue Chen Shu-Ying He xian-qin Wei Xiao-Lan Huang Department of Anesthesiology Liuzhou People's Hospital affiliated to Guangxi Medical UniversityLiuzhou 545000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound Medicine Liuzhou People's Hospital affiliated to Guangxi Medical UniversityLiuzhou 545000Guangxi Zhuang Autonomous RegionChina

BACKGROUND The midpoint transverse process to pleura(MTP)block,a novel technique for thoracic paravertebral block(TPVB),was first employed in laparoscopic renal cyst *** SUMMARY Thoracic paravertebral nerve block is frequently employed for perioperative analgesia during laparoscopic cyst *** address safety concerns associated with TPVBs,we administered MTP blocks in two patients prior to administering general anesthesia for laparoscopic cyst *** MTP block was performed at the T9 level under ultrasound guidance,with 2. mL of 0.5%ropivacaine *** sensation to cold and pinprick was observed from the T8 to T11 dermatome *** postoperative Numeric Pain Rating Scale scores were 0/10 at rest and on movement,with none exceeding a mean 2. h numeric rating scale>*** MTP block was effective technique for providing postoperative analgesia for patients undergoing laparoscopic renal cyst decortication.

关键词： Midpoint transverse process to pleura block Laparoscopic renal cyst decortication Pain Analgesia Case report

液态CO2.高温蒸汽循环冲击煤体三维CT裂隙重构及劣化机理

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煤炭学报 2024年第S1期49卷 304-313页

作者：秦雷王平李树刚王伟凯张弦西安科技大学安全科学与工程学院东京大学新领域前沿科学研究院西安科技大学西部矿井开采及灾害防治教育部重点实验室

为解决液态CO2.结煤层孔隙冰融化时间冗长问题，提出液态CO2.高温蒸汽冷热循环冲击煤层增透技术。本文借助三维CT扫描测试技术，分析冷热循环冲击过程无烟煤三维孔隙结构参数及劣化机理。研究结果表明：（1）液态CO2.高温蒸汽冷热循环... 详细信息

为解决液态CO2.结煤层孔隙冰融化时间冗长问题，提出液态CO2.高温蒸汽冷热循环冲击煤层增透技术。本文借助三维CT扫描测试技术，分析冷热循环冲击过程无烟煤三维孔隙结构参数及劣化机理。研究结果表明：（1）液态CO2.高温蒸汽冷热循环冲击煤体三维孔隙不断延伸，逐渐形成贯通裂隙，三维孔隙数量、表面积、体积及切片最大面孔率均与冷热循环冲击次数指数相关；（2.根据霍多特孔隙分类法，结合等效直径计算公式，发现冷热循环冲击前期渗流孔体积比例增加，三维孔隙劣化表现为裂隙贯通，冷热循环冲击后期吸附孔体积比例增加，三维孔隙劣化表现为煤体内部产生大量新生孔隙。进一步分析得：（1）液态CO2.高温蒸汽冷热循环冲击煤体渗流孔半径分形维数增加，孔隙分形特征增强，表面粗糙度提高，热储集性能降低；（2.孔隙半径分型模型中lg r随冷热循环冲击次数增加而增加，表明孔径劣化扩张明显；（3）基于冷热循环冲击煤体孔隙力学损伤特征，归纳液态CO2.高温蒸汽冷热循环冲击煤体三维孔隙损伤模型；（4）利用投影法得到切片损伤率，定义液态CO2.高温蒸汽冷热循环冲击煤体三维孔隙损伤量。当冷热循环冲击12.时，三维孔隙损伤量为48.55。

关键词：冷热循环冲击三维CT扫描孔隙重构劣化机理损伤量