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Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells

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World Journal of Gastroenterology 2006年第9期12卷 1392-1396页

作者： Ya-ping Zhang Xi-xian Yao Xia Zhao Department of Gastroenterology the Second Hospital of Hebei Medical University Shijiazhuang 050000 Hebei Province China

AIM： To study the relationship between interleukin-lbeta （IL-1β） up-regulating tissue inhibitor of matrix metalloproteinase-1 （TIMMP-1） mRNA expression and phosphorylation of both c-jun N-terminal kinase （INK） and p38 in rat heffatic stellate cells （HSC）. METHODS： RT-PCR was performed to measure the expression of TIMMP-1 mRNA in rat HSC. Western blot was performed to measure IL-1β-induced JNK and p38 activities in rat HSC. RESULTS： TIMMP-1 mRNA expression （1.191± 0.079） was much higher after treatment with IL-1β （10 ng/mL） for 24 h than in control group （0.545±0.091）（P〈0.01）. IL-1β activated INK and p38 in a time-dependent manner. After stimulation with IL-1β for 0, 5, 15, 30, 60 and 120 min, the INK activity was 0.982±0.299, 1.501±0.720, 2.133±0.882, 3.360±0.452, 2.181±0.789, and 1.385 ± 0.368, respectively. There was a significant difference in JNK activity at 15 min （P〈 0.01）, 30 min （P〈 0.01） and 60 min （P〈0.01） in comparison to that at 0 min. The p38 activity was 1.061±0.310, 2.050±0.863, 2.380±0.573, 2.973±0.953, 2.421±0.793, and 1.755 ± 0.433 at the 6 time points （0, 5, 15, 30, 60 and 120 min） respectively. There was a significant difference in p38 activity at 5 min （P〈0.05）, 15 min （P〈0.01）, 30 min （P〈0.01） and 60 min （P〈0.01） compared to that at 0 min. TIMMP-1 mRNA expression trended to decrease in 3 groups pretreated with different concentrations of SP600125 （10 μmol/L, 1.022±0.113; 20 μmol/L, 0.869±0.070; 40 μmol/L, 0.666±0.123）. Their decreases were all significant （P〈0.05, P〈0.01, P〈0.01） in comparison to control group （without SP600125 treatment, 1.163±0.107）. In the other 3 groups pretreated with different concentrations of SB203580 （10 μmol/L, 1.507±0.099; 20 μmol/L, 1.698±0.107; 40 μmol/L, 1.857±0.054）, the expression of TIMMP-1 mRNA increased. Their levels were higher than those in the control group （without SB203580 treatment, 1.027 ± 0.061） with a significant statistical significance （P〈 0.01）. CONCLUSION： IL-1β has a direct action on hepati

关键词： Up-Regulation Animals Anthracenes Blotting, Western Cell Line Enzyme Inhibitors Imidazoles Interleukin-1 JNK Mitogen-Activated Protein Kinases Liver Liver Cirrhosis Phosphorylation Pyridines RNA, Messenger Rats Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Time Factors Tissue Inhibitor of Metalloproteinase-1 p38 Mitogen-Activated Protein Kinases

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The prevalence of azoospermia factor microdeletion on the Y chromosome of Chinese infertile men detected by multi-analyte suspension array technology

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Asian Journal of Andrology 2008年第6期10卷 873-881页

作者： Yi-Jian Zhu Si-Yao Liu Huan Wang ping Wei xian-ping Ding Institute of Medical Genetics Key Laboratory of Bio-resources and Eco-environment Ministry of Education College of Life Science Sichuan University Chengdu 610064 China

Aim： To develop a high-throughput multiplex, fast and simple assay to scan azoospermia factor （AZF） region microdeletions on the Y chromosome and establish the prevalence of Y chromosomal microdeletions in Chinese infertile males with azoospermia or oligozoospermia. Methods： In total, 178 infertile patients with azoospermia （nonobstructed）, 134 infertile patients with oligozoospermia as well as 40 fertile man controls were included in the present study. The samples were screened for AZF microdeletion using optimized multi-analyte suspension array （MASA） technology. Results： Of the 312 patients, 36 （11.5%） were found to have deletions in the AZF region. The rnicrodeletion frequency was 14% （25/178） in the azoospermia group and 8.2% （11/134） in the oligospermia group. Among 36 patients with microdeletions, 19 had deletions in the AZFc region, seven had deletions in AZFa and six had deletions in AZFb. In addition, four patients had both AZFb and AZFc deletions. No deletion in the AZF region was found in the 40 fertile controls. Conclusion： There is a high prevalence of Y chromosomal microdeletions in Chinese infertile males with azoospermia or oligozoospermia. The MASA technology, which has been established in the present study, provides a sensitive and high-throughput method for detecting the deletion of the Y chromosome. And the results suggest that genetic screening should be advised to infertile men before starting assisted reproductive treatments.

关键词： Y chromosome microdeletion azoospermia factor male infertility multi-analyte suspension array (MASA)

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Dynamics of Poly(methyl methacrylate)in Ionic Liquids with Different Concentration and Cationic Structures

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Chinese Journal of Polymer Science 2023年第2期41卷 315-324页

作者： Huan luo Xi He Gang Liu Yan-Hua Niu Guang-xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

The dynamic behavior of entangled poly(methyl methacrylate)(PMMA)chains in both the traditional monocationic ionic liquid(MIL)and synthetic dicationic ionic liquid(DIL)with the same anion bis[(trifluoromethyl)sulfonyl]imide([TFSI]−)has been examined over the wide composition range using differential scanning calorimetry and rheological ***/DIL and PMMA/MIL systems exhibit two glass transitions in the midrange of composition due to self-concentration *** in DIL shows slower relaxation behavior,however,after the iso-free-volume correction,the terminal relaxation timeτ_(0)of PMMA in both the DIL and MIL presents the power law behaviorτ_(0)∼ϕ^(v)with exponent v conforming to experimental results for conventional polymer solutions(v=2.0±0.2).At high ILs concentration(70%),the entanglement molecular weight M_(e)of PMMA/DIL system is lower than that of PMMA/MIL system owing to the formation of additional physical network in DIL,while the difference of M_(e)is reversed at low ILs *** composition dependence might be related to the fact that the probability of formation of physical cross-linking points in linked double imidazolium ring increases with the increase of DIL *** recovered creep strain of PMMA/DIL is almost 18 times of PMMA/MIL,exhibiting significantly better viscoelastic behavior.

关键词： Ionic liquids Terminal relaxation time Entanglement molecular weight Creep-recovery behavior

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A fluorescent probe based on a spiropyran for sensitive detection of Ce^3+ ion

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Journal of Rare Earths 2020年第4期38卷 445-450页

作者： Xin luo Dongling Chen Zhenxiang Xu Yanxi Song Hongqi Li Chunying xian Key Laboratory of Science&Technology of Eco-Textile Ministry of EducationCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Weifang Institute of Test and Measurement Weifang 261000China Penglai Xinguang Pigment Chemical Co. Ltd.Penglai 265600China School of Environmental Science and Engineering Donghua UniversityShanghai 201620China

A spiropyran-based probe was *** serves as a fluorescence turn-on probe for selective detection of Ce^3+in both ethanol and aqueous(water/ethanol,1:9 or 9:1,v/v)***3+can induce photochromism of the probe though the probe exhibits negligible photochromic property by *** probe is sensitive to Ce3+and the detection limit reaches 1.7μmol/*** exhibits a high selectivity for Ce^3+ion over other common metal cations including Li^+,Na^+,Ag^+,Sr^2+,Ni^2+,Co^2+,Hg^2+,Zn^2+,Cr^3+,Al^3+,Fe^3+and Bi^3+and lanthanide ions Nd^3+,Yb^3+and La^3+.The probe may be used for quantitative determination of the concentration of Ce3+ion in a range of 1-10μmol/L and for application to environmental water *** mechanism of the probe towards Ce3+ion is proposed.

关键词： Spiropyran Probe Cerium(Ⅲ)ion Fluorescent Rare earths

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A construction of inter-group complementary codes with flexible ZCZ length

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第10期12卷 846-854页

作者： Li-fang FENG xian-wei ZHOU ping-zhi FAN School of Information Engineering University of Science and Technology Beijing Beijing 100083 China Provincial Key Lab of Information Coding and Transmission Institute of Mobile Communications Southwest Jiaotong University Chengdu 610031 China

A general construction of inter-group complementary (IGC) codes is proposed based on perfect complementary (PC) codes,interleaving operation,and the orthogonal *** correlation properties of the newly constructed IGC codes can be described as follows:(1) the autocorrelation sidelobes of the codes are zeros in the zero correlation zone (ZCZ);(2) the cross-correlation functions (CCFs) between any two different codes of the same group are zeros in the ZCZ;(3) the CCFs between any two codes of different groups are zeros *** key point of this construction is that the ZCZ length of the generated IGC codes can be chosen *** is well known that there is a limitation between the ZCZ length and the number of mates;that is,the smaller is the length of ZCZ,the more are the IGC codes that can be ***,if we can choose the ZCZ length of the IGC codes flexibly according to the requirement of the system,more users can be accommodated in the system.

关键词： Z-complementary codes Perfect complementary codes Zero correlation zone

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Vehicle adaptive cruise control design with optimal switching between throttle and brake

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控制理论与应用（英文版） 2012年第4期10卷 426-434页

作者： Lihua luo ping LI Hui WANG College of Transport and Communication Shanghai Maritime University State Key Laboratory of Industrial Control Technology Zhejiang University

For vehicle adaptive cruise control （ACC） systems, the switching performance between throttle and brake determines the driving comfort, fuel consumption and service lives of vehicle mechanical components. In this paper, an ACC algorithm with the optimal switching control between throttle and brake is designed in model predictive control （MPC） framework. By introducing the binary integer variables, the dynamics of throttle and brake are integrated in one model expression for the controller design. Then the ACC algorithm is designed to satisfy not only safe car following, but also the optimal switching between throttle and brake, which leads to an online mixed integer quadratic programming solved by the nested two-loop method. The simulation results show that the proposed ACC algorithm meets the requirements of safe car following, outperforms the traditional algorithms by performing smoother responses, reducing the switching times between throttle and brake, and therefore improves driving comfort and fuel efficiency significantly.

关键词： Adaptive cruise control Model predictive control Optimal switching Throttle Brake

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A Two-Lane Cellular Automata Model with Influence of Next-Nearest Neighbor Vehicle

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Communications in Theoretical Physics 2006年第4期45卷 657-662页

作者： KONG xian-Juan GAO Zi-You LI Ke-ping School of Traffic and Transportation Beijing Jiaotong University Beijing 100044 China

In this paper, we propose a new two-lane cellular automata model in which the influence of the next-nearest neighbor vehicle is considered, The attributes of the traffic system composed of fast-lane and slow-lane are investigated by the new traffic model. The simulation results show that the proposed two-lane traffic model can reproduce some traffic phenomena observed in real traffic, and that maximum flux and critical density are close to the field measurements. Moreover, the initial density distribution of the fast-lane and slow-lane has much influence on the traffic flow states. With the ratio between the densities of slow lane and fast lane increasing the lane changing frequency increases, but maximum flux decreases. Finally, the influence of the sensitivity coefficients is discussed.

关键词： cellular automata car-following model double look-ahead model

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Strengthening absorption ability of Co-N-C as efficient bifunctional oxygen catalyst by modulating the d band center using MoC

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Green Energy & Environment 2023年第2期8卷 459-469页

作者： Jianwen Liu Ying Guo xian-Zhu Fu Jing-Li luo Chunyi Zhi Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen University518060China Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueKowloon TongHong KongChina Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada

Co-N-C is a promising oxygen electrochemical catalyst due to its high stability and good ***,due to the limited adsorption ability improvement for oxygen-containing intermediates,it usually exhibits inadequate catalytic activity with 2-electron pathway and high selectivity of hydrogen ***,the adsorption of Co-N-C to these intermediates is modulated by constructing heterostructures using transition metals and their derivatives based on d-band *** heterostructured nanobelts with MoC core and pomegranate-like carbon shell consisting of Co nanoparticles and N dopant(MoC/Co-N-C)are engineered to successfully modulate the d band center of active Co-N-C sites,resulting in a remarkably enhanced electrocatalysis *** optimally performing MoC/Co-N-C exhibits outstanding bi-catalytic activity and stability for the oxygen electrochemistry,featuring a high wave-half potential of 0.865 V for the oxygen reduction reaction(ORR)and low overpotential of 370 mV for the oxygen evolution reaction(OER)at 10 mA cm^(-2).The zinc air batteries with the MoC/Co-N-C catalyst demonstrate a large power density of 180 mW cm^(-2)and a long cycling lifespan(2000 cycles).The density functional theory calculations with Hubbard correction(DFT+U)reveal the electron transferring from Co to Mo atoms that effectively modulate the d band center of the active Co sites and achieve optimum adsorption ability with"single site double adsorption"mode.

关键词： Bifunctional oxygen catalysts Pomegranate-like shell D band theory Enhanced synergistic effect Rechargeable zinc air battery

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Corrosion behavior of a spark plasma sintered Fe-2OMn-11Al-1.8C- 5Cr alloy in molten aluminum

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Journal of Iron and Steel Research International 2018年第5期25卷 563-571页

作者： Jian Liu Wei-ping Chen xian-man Zhang Zhi-qiang Fu Guangdong Key Laboratory for Advanced Metallic Materials Processing South China University of TechnologyGuangzhou 510640 Guangdong China College of Engineering and Technology Normal College ofZunyi Zunyi 563006 Guizhou China Mechanical and Electrical Engineering College Hainan University Haikou 570228 Hainan China

The corrosion behavior of an Fe-20Mn-11Al-1.8C-5Cr alloy prepared by spark plasma sintering was investigated via immersion tests in molten aluminum at 750℃ for 1 and 4 h, respectively, and a hot work steel （AlSI H13） was included as a reference. The experimental results show that the corrosion rate of Fe-20Mn-11Al-1.8C-5Cr alloy is - 24% of that of H13 steel, suggesting that Fe-20Mn-11Al-1.8C-5Cr alloy in molten aluminum possesses better corrosion resistance than H13 steel. Detailed analysis show that k-carbide （（Fe, Mn）3AlCx） and Cr7C3 carbide precipitated in the matrix play a key role in enhancing the corrosion resistance of Fe-20Mn-11Al-1.8C-5Cr alloy in molten aluminum. Both of them show better corrosion resistance than 7-Fe matrix and H13 steel, and can also take on the role of roots in grasping the corrosion product and restrain them from spalling into the molten aluminum.

关键词： Fe-Mn-Al-C-Cr alloy · Molten aluminum. Immersion · Corrosion behavior

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Mesoporous CeO_(2)-C hybrid spheres as efficient support for platinum nanoparticles towards methanol electrocatalytic oxidation

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Journal of Rare Earths 2021年第6期39卷 674-681,I0003页

作者： Weili Li Qi Wang Lei Wang xian-Zhu Fu Jing-Li luo College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbenaT6G 2G6Canada

The development of direct methanol fuel cells(DMFCs) is partially limited by the poor kinetics of methanol oxidation reaction(MOR) at the anode *** was reported that the interaction between Pt and CeO_(2) enhances the electrocatalytic performance of Pt catalyst for *** this work,a hybrid material(CeO_(2)-C) composed of CeO_(2) and carbon was successfully prepared by a simple hydrothermal method followed by calcination in inert *** hierarchically porous nanostructure and especially good electronic conductivity of CeO_(2)-C make it an excellent support for Pt particles for application in electrocatalytic *** investigation reveals that triple-phase interface of Pt,carbon and CeO_(2) forms in Pt/CeO_(2)-C *** of the as-prepared catalyst for MOR was studied in alkaline *** Pt/CeO_(2)-C catalyst shows superior catalytic performance for MOR compared with Pt/CeO_(2) and the physical mixture of Pt/CeO_(2) and acetylene black(Pt/CeO_(2)+C).The significantly improved performance can be attributed to the synergetic effect between Pt particles and CeO_(2)-C support,and the better conductivity of CeO_(2)-*** study provides a possible method to expand the application potential of CeO_(2) materials in MOR,and may also be used in other electrocatalytic process.

关键词： Pt based catalyst Mesoporous CeO_(2)-C spheres Metal-support interaction Methanol oxidation Rare earths

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