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Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

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论职业教育政策的生态性价值取向

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中国职业技术教育 2024年第19期 31-38页

作者：陶军明刘萍江西科技师范大学职业教育研究院江西科技师范大学图书馆

职业教育作为一种类型教育,跨界属性决定了其利益场域的多元性、系统性和复杂性。因而,职业教育政策就调整的范围和对象而言,也完全突破了一般意义上教育政策“纯粹”的、“基于教育”的特点。通过对生态本体的认识以及职业教育政策本... 详细信息

职业教育作为一种类型教育,跨界属性决定了其利益场域的多元性、系统性和复杂性。因而,职业教育政策就调整的范围和对象而言,也完全突破了一般意义上教育政策“纯粹”的、“基于教育”的特点。通过对生态本体的认识以及职业教育政策本质的梳理,发现生态性是职业教育政策的固有属性之一。职业教育政策过程中利益冲突的存在,导致职业教育政策的决策空间会受到利益和价值判断的挤压与影响,客观上要求职业教育政策主体具备系统化思维,职业教育政策过程应该坚持和彰显共同体内涵的生态性价值取向。职业教育政策生态性价值取向意味着职业教育政策的运行应秉承动态平衡、多元共治、自我创新以及以人为本等原则。

关键词：职业教育政策生态性价值取向

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双机械臂协作最优装配位置及多目标轨迹优化

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机械传动 2024年第1期48卷 39-45页

作者：王天瑞陶平武汉科技大学冶金装备及其控制教育部重点实验室湖北武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室湖北武汉430081

为了解决以传统人工示教方式确定双机械臂协作装配位置的局限性和随机性,以双机械臂轴孔协调装配为工程背景,针对协作装配过程中机械臂的整体运动灵活性和轨迹规划,采用粒子群算法进行多次寻优,求解整体全局灵活性最优的装配位置,并基... 详细信息

为了解决以传统人工示教方式确定双机械臂协作装配位置的局限性和随机性,以双机械臂轴孔协调装配为工程背景,针对协作装配过程中机械臂的整体运动灵活性和轨迹规划,采用粒子群算法进行多次寻优,求解整体全局灵活性最优的装配位置,并基于最优位置进行了多目标轨迹优化。分析了双机械臂协调装配过程中的运动约束关系,以可操作度为灵活性评价指标,提出了双机械臂协作装配系统的可操作度评价方法,以此构建优化目标函数,采用粒子群算法,在双机械臂协作空间中求取系统全局可操作度最优的装配位置;基于灵活性最优位置,采用多目标粒子群算法,以时间、能耗、冲击为目标进行了轨迹优化,并在Matlab机器人仿真平台进行了仿真分析。结果表明,将灵活性指标运用到轨迹规划中,能提高机械臂作业效率,降低能耗与冲击损耗;且整个运动过程可维持较高可操作度,能有效规避传统人工示教方式的随机性,实现双机械臂协作装配的最优灵活性轨迹规划。

关键词：轴孔协作装配最优装配位置可操作度轨迹优化

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高温多组分混合气体热导率理论预测

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工程热物理学报 2024年第8期45卷 2460-2465页

作者：缐磊曹涛锋陈磊陶文铨西安交通大学能源与动力工程学院热流科学与工程教育部重点实验室西安710049 西安航天动力技术研究所固体推进全国重点实验室西安710100

准确获取高温燃气的热学性质是开展火箭发动机喷管数值仿真的基础。由于采用实验方法获取高温下气体热导率极其困难,基于理论计算手段预测高温下气体热导率成为更好的选择。本研究中,使用考虑高温电子激发态的Istomin修正计算了H_(2)、C... 详细信息

准确获取高温燃气的热学性质是开展火箭发动机喷管数值仿真的基础。由于采用实验方法获取高温下气体热导率极其困难,基于理论计算手段预测高温下气体热导率成为更好的选择。本研究中,使用考虑高温电子激发态的Istomin修正计算了H_(2)、CO以及N_(2)气体在300~4000 K温度范围内的热导率。结合Wassiljewa方程构建了高温下多组分混合气体导热性质理论预测模型,预测了两种燃烧气体在300~4000 K温度范围的混合气体热导率,为喷管精细化仿真提供燃气热学性质参考数据。

关键词：燃烧气体高温热导率火箭发动机

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Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(Life Sciences) 2024年第1期67卷 67-82页

作者： Chun-Kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao Jun-xiang Gu xian-Xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao Xiao-Die Liu Bao-Juan Li Ming-Hui Wang Hai-Long Dong Hao-Hong Li Peng-Cheng Huang Yun-Qing Li Wu-Gang Hou Jin-Lian Li tao Chen Department of Anatomy and K.K.Leung Brain Research Centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic Medical Sciences Beijing 100850China Key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China Department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health Centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier Research Center of Brain&Brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

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Selective separation of pyrene from mixed polycyclic aromatic hydrocarbons by a hexahedral metal-organic cage

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Chinese Chemical Letters 2024年第1期35卷 523-527页

作者： Ya-Liang Lai Juan Su Le-Xiong Wu Dong Luo Xue-Zhi Wang xian-Chao Zhou Chuang-Wei Zhou Xiao-ping Zhou Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China

Polycyclic aromatic hydrocarbons(PAHs)play an important role in the industry,and the development of new materials for the selective separation of PAHs is of great *** this work,we report a hexahedral metal-organic cage with low symmetry by subcomponent *** this cage,the eight ZnII centers adopt an interestin∧∧/△△△△△△or∧∧∧∧∧∧/△△*** cage with a cavity volume of 520˚A3 can bind anthracene,phenanthrene,and pyrene to form 1:1 host-guest complexes,while the bigger triphenylene,chrysene,perylene,and coronene cannot be *** binding constant Ka of pyrene is about 1.110×10^(3)(mol/L)^(−1),which is more than an order of magnitude larger than that of anthracene and phenanthrene(111(mol/L)^(−1),277(mol/L)^(−1),respectively).X-ray structure studies reveal that the pyrene is located in the cavity and stabilized by multiple C–H…π*** separation from a mixture of PAHs,pyrene with>96.1%purity can be *** work provides a useful method for the first time for the selective separation of pyrene from PAHs mixture by utilizing a metal-organic cage as the material,making it a useful tool for purifying and separating specific compounds from complex mixtures.

关键词： Polycyclic aromatic hydrocarbons Metal-organic cage Host-guest chemistry Selective separation

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Estimation of speed-related car body acceleration limits with quantile regression

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Railway Sciences 2024年第5期3卷 575-592页

作者： Jianli Cong Hang Zhang Zilong Wei Fei Yang Zaitian Ke tao Lu, Rong Chen ping Wang Zili Li China Academy of Railway Sciences Corporation Limited Infrastructure Inspection Research InstituteBeijingChina School of Civil Engineering Beijing Jiaotong UniversityBeijingChina and Planning and Standard Research InstituteNational Railway AdministrationBeijingChina MOE Key Laboratory of High-Speed Railway Engineering Southwest Jiaotong UniversityChengduChina Department of Engineering Structures Delft University of TechnologyDelftNetherlands

Purpose–This study aimed to facilitate a rapid evaluation of track service status and vehicle ride comfort based on car body ***,a low-cost,data-driven approach was proposed for analyzing speed-related acceleration limits in metro ***/methodology/approach–A portable sensing terminal was developed to realize easy and efficient detection of car body ***,field measurements were performed on a 51.95-km metro *** from 272 metro sections were tested as a case study,and a quantile regression method was proposed to fit the control limits of the car body acceleration at different speeds using the measured ***–First,the frequency statistics of the measured data in the speed-acceleration dimension indicated that the car body acceleration was primarily concentrated within the constant speed stage,particularly at speeds of 15.4,18.3,and 20.9 m/***,resampling was performed according to the probability density distribution of car body acceleration for different speed domains to achieve data ***,combined with the traditional linear relationship between speed and acceleration,the statistical relationships between the speed and car body acceleration under different quantiles were *** concluded the lateral/vertical quantiles of 0.8989/0.9895,0.9942/0.997,and 0.9998/0.993 as being excellent,good,and qualified control limits,respectively,for the lateral and vertical acceleration of the car *** addition,regression lines for the speedrelated acceleration limits at other quantiles(0.5,0.75,2s,and 3s)were ***/value–The proposed method is expected to serve as a reference for further studies on speedrelated acceleration limits in rail transit systems.

关键词： Car body acceleration Track status monitoring Speed-related acceleration limit Quantile regression Vehicle ride quality

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An Amphipathic Ionic Sieve Membrane for Durable and Dendrite-Free Zinc-Ion Batteries

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Renewables 2024年第1期2卷 52-60页

作者： xian-xiang Zeng Shu Zhang tao Long Qing-Yuan Zhao Hong-Rui Wang Wei Ling Xiong-Wei Wu Aiping Yu Zhongwei Chen School of Chemistry and Materials Science Hunan Agricultural UniversityChangsha 410128 Department of Chemical Engineering University ofWaterlooWaterlooOntario N2L 3G1 National Key Laboratory of Catalytic Energy Conversion Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023

Rechargeable aqueous zinc-ion batteries are expected to be widely deployed for grind-scale energy storage due to the merits of low expenditure,safety,and so ***,challenges on the Zn anode,including dendrite growth and parasitic reactions with aqueous electrolytes hinder its ***,an amphipathic ionic sieve(AIS)membrane was designed to screen Zn^(2+)from the bulk of aqueous electrolyte by ruling out water solvent and assisting Zn^(2+)to deposit with a smooth morphology under a confined *** benign characteristics enabled AIS to run Zn symmetric cells over 2300 h with a voltage of 1 mA h·cm^(−2) at each cycle and tolerated long-term standby for more than 3 months.A low self-discharge rate and outstanding cycling stability were realized in V_(2)O_(5)/Zn batteries at equal weight for cathode and anode(N/P ratio≈1.39).This asymmetrical wetting separator proved a facile strategy to solve interfacial dendrites and parasitic reactions in Zn metal-based batteries.

关键词： zinc anode dendrite amphipathicity desolvation separator

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磁性微球在循环肿瘤细胞和病毒以及核酸分离富集和检测分析中的应用进展

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分析化学 2024年第6期52卷 778-788页

作者：郭玲香周健平杨涛东南大学化学化工学院东南大学智能材料研究院

磁性微球是一种多用途复合材料，通常以纤维素、壳聚糖、二氧化硅以及聚苯乙烯等生物兼容性好的材料为包覆载体，通过表面的活性基团（—OH、—COOH、—NH2和—SH等）负载荧光分子、抗体和核酸等，可以特异性识别癌细胞、病毒和遗传物... 详细信息

磁性微球是一种多用途复合材料，通常以纤维素、壳聚糖、二氧化硅以及聚苯乙烯等生物兼容性好的材料为包覆载体，通过表面的活性基团（—OH、—COOH、—NH2和—SH等）负载荧光分子、抗体和核酸等，可以特异性识别癌细胞、病毒和遗传物质。借助其自身优异的磁响应特性，磁性微球可实现快速分离和富集，在免疫分析、细胞分离以及环境检测等领域具有广阔的应用前景；磁性微球还可与微流控芯片等结合，构建高通量检测平台。本文介绍了近5年来磁性微球在循环肿瘤细胞检测、病毒抗原抗体和核酸检测等前沿分析领域中的应用进展，并讨论了以磁性微球以及以其为载体开发的检测分析试剂盒的商业化前景。

关键词：磁性微球循环肿瘤细胞病毒抗原核酸检测评述

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基于ICP-MS研究转炉钢渣微粉吸附镍和铅的动力学机理

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光谱学与光谱分析 2024年第2期44卷 594-600页

作者：徐修平徐维成于先坤陈煜杨刚张浩金属矿山安全与健康国家重点实验室安徽马鞍山243000 冶金减排与资源综合利用教育部重点实验室(安徽工业大学) 安徽马鞍山243002 中钢集团马鞍山矿山研究院股份有限公司安徽马鞍山243000 南京农业大学草业学院江苏南京210095 中冶宝钢技术服务有限公司上海201999 安徽工业大学冶金工程学院安徽马鞍山243032

随着工业化的发展,水体和土壤中的重金属污染日益严重。其中,重金属镍是一种常见的致敏性金属,会引起人体过敏发炎,甚至会引发癌症;血液中铅浓度的超标会危害人的神经系统、心血管系统和生殖系统,造成终身性的危害。因此,治理镍和铅重... 详细信息

随着工业化的发展,水体和土壤中的重金属污染日益严重。其中,重金属镍是一种常见的致敏性金属,会引起人体过敏发炎,甚至会引发癌症;血液中铅浓度的超标会危害人的神经系统、心血管系统和生殖系统,造成终身性的危害。因此,治理镍和铅重金属污染具有十分重要的意义。钢渣是炼钢过程中产生的一种副产物,其存在难以利用与附加值低的问题。同时加之管理制度的不健全,导致大量钢渣露天堆放,对土地资源、地下水源,以及空气质量造成严重影响。钢渣微粉具有比表面积大、多孔、化学活性高等特性,被广泛利用,可以成为吸附材料。本文以转炉钢渣微粉为研究对象,利用激光粒度仪、电感耦合等离子体质谱仪、比表面积与孔隙度吸附仪、X射线荧光光谱仪等测试转炉钢渣微粉的基本性质,重点研究转炉钢渣微粉添加量、重金属初始浓度、溶液pH和吸附时间对转炉钢渣微粉吸附Ni^(2+)、Pb^(2+)的效果,结合吸附动力学与吸附等温线理论揭示转炉钢渣微粉对Ni^(2+)、Pb^(2+)的吸附作用机理,为处理镍、铅重金属污染和工业废水处理提供技术支持与理论依据。结果表明:当转炉钢渣微粉添加量大于12.5 g·L^(-1)、重金属初始浓度小于100 mg·L^(-1)、溶液pH大于3和吸附时间大于120 min时,转炉钢渣微粉对Ni^(2+)、Pb^(2+)的吸附效果良好,即基本达到90%。转炉钢渣微粉对Ni^(2+)、Pb^(2+)的吸附符合准二级动力学模型,吸附速率由边界扩散和颗粒内扩散共同控制,吸附过程以化学吸附为主。转炉钢渣微粉的结构具有多孔性为物理吸附Ni^(2+)、Pb^(2+)提供吸附空间,转炉钢渣微粉的化学成分不仅具有碱性与Ni^(2+)、Pb^(2+)形成络合产物,而且水化过程中CaO与SiO_(2)生成C—S—H凝胶,对Ni^(2+)、Pb^(2+)形成络合吸附与硅酸盐体系包裹。转炉钢渣微粉对Ni^(2+)、Pb^(2+)吸附可能存在多层吸附。吸附Ni^(2+)、Pb^(2+)的过程为优惠吸附,吸附容易进行,其理论最大吸附量分别为18.785和17.002 mg·g^(-1)。

关键词： ICP-MS 转炉钢渣微粉 Ni2+ Pb2+ 吸附动力学

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