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Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-Yun Zhang Xin Liu Shuo Zheng Wen-Qun Xi Xue-ping Wu Dan-Yao Nie Hui-Ling Hu Jian-tao Wang Xin-Hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P<0.001).Positive correlations were observed between hsa_circ_0007482 expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482 inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482 knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2 expression in ***,hsa_circ_0007482 knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482 effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

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复合菌种发酵黄浆水的风味品质分析

食品与发酵工业 2024年第11期50卷 308-316,I0012,I0013页

作者：陶祥婕胡萍贵州大学酿酒与食品工程学院贵州贵阳550025

为了探究不同菌种组合对发酵黄浆水风味品质的优化改善,该研究比较了复合乳酸菌发酵、乳酸菌酵母菌混合发酵、自然发酵3种方式制作的发酵黄浆水,测定发酵过程中理化指标,采用HPLC和GC-MS对酸浆中有机酸和挥发性风味物质组成及差异分别... 详细信息

为了探究不同菌种组合对发酵黄浆水风味品质的优化改善,该研究比较了复合乳酸菌发酵、乳酸菌酵母菌混合发酵、自然发酵3种方式制作的发酵黄浆水,测定发酵过程中理化指标,采用HPLC和GC-MS对酸浆中有机酸和挥发性风味物质组成及差异分别进行研究,结合相对气味活度值(relative odor activity value,ROAV)分析其中的关键香气成分,并与主要有机酸做相关性分析。结果表明,发酵期间,黄浆水pH值、蛋白质、还原糖含量显著降低;复合发酵组总酚和总黄酮含量均提高;相比自然发酵组多出5种游离氨基酸,其总量比自然发酵组提高了198.34%;丁二酸含量显著增加。采用GC-MS共检出74种挥发性风味成分,通过ROAV法筛选出25种关键风味物质。醇类和酮类为黄浆水主要香气物质,复合菌种发酵更有助于积累酯类物质。挥发性风味成分与特征有机酸关联性分析表明,乳酸与乙酸乙酯、苯乙酸乙酯、乙酸异戊酯、异戊醇、正辛醇、γ-壬内酯等酯类、醇类物质呈正相关(P<0.05);丁二酸、柠檬酸和苹果酸与丁香子酚、乙酸乙酯、乙酸异戊酯等呈正相关(P<0.05),这些挥发性物质相对含量在复合发酵组中均为最高。综上,黄浆水经复合菌种发酵可提高营养价值和风味品质。

关键词：复合菌种黄浆水发酵有机酸风味相关性

Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu ping Wei Shu-Cai Wan Hao-Qing Xie xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

基于虚拟现实的纪念馆展厅空间展陈一体化系统

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兵工自动化 2024年第8期43卷 10-13页

作者：陶萍江苏爱涛文化产业有限公司艺术工程一部南京210000

为优化纪念馆展陈布局,提升用户对纪念馆展厅空间展陈系统的体验感,设计基于虚拟现实的纪念馆展厅空间展陈一体化系统。纪念馆数据组织层利用摄像机与传感器等设备采集纪念馆展厅与展品图像数据,通过图像解析模块将采集的2维图像数据解... 详细信息

为优化纪念馆展陈布局,提升用户对纪念馆展厅空间展陈系统的体验感,设计基于虚拟现实的纪念馆展厅空间展陈一体化系统。纪念馆数据组织层利用摄像机与传感器等设备采集纪念馆展厅与展品图像数据,通过图像解析模块将采集的2维图像数据解析为DICOM3.0标准数据格式,并利用基于视觉感知的图像增强方法预处理图像,由此获取纪念馆场景数据;纪念馆展陈3维建模层基于场景数据,利用3D MAX软件,根据展厅空间布局陈列形状特征构建纪念馆展厅及展品的3维模型,实施模型渲染与烘焙处理;纪念馆虚拟展示层基于所构建的展厅与展品3维模型,利用3维展示与全景漫游等方式实现纪念馆可视化虚拟展示。实验结果表明:该系统模型构建精度较高,可为用户提供更优质的交互感与沉浸式体验感。

关键词：虚拟现实展厅空间展陈一体化图像数据处理 3维模型构建全景漫游

Megafossils of Betulaceae from the Oligocene of Qaidam Basin and their paleoenvironmental and phytogeographic implications

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Plant Diversity 2024年第1期46卷 101-115页

作者： tao Yang Jia-Hao Cai Yan-Zhi Dai Hong-Yu Chen Lei Han Li Zhang Wei-Yu Liang Xu-Jun Li Wen-Jia Li Jing-Yu Wu San-ping Xie De-Fei Yan School of Earth Sciences and Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou UniversityLanzhou 730000China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Center for Research and Education on Biological Evolution and Environments School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China

Understanding the paleoenvironment and phytogeographical history of the Tibetan Plateau,China relies on discovering new plant *** Qaidam Basin has long been regarded as an ideal‘field laboratory’to investigate the paleoclimate and paleobiological evolution of the northern Tibetan ***,fossil angiosperms from the Qaidam Basin are rare,and our knowledge of its paleovegetation is ***,we report fossil leaves and fruits of Betulaceae found from the Oligocene Shangganchaigou Formation of northwestern Qaidam Basin(Huatugou area).Comparative morphological analysis led us to assign the fruits to the Betula subgenus Betula and the leaves to Carpinus *** findings,together with other reported fossil plants from the same locality,reveal a close floristic linkage between the Qaidam Basin and Europe during the *** northern pathway of this floristic exchange may have crossed through the Qaidam Basin during the late *** floristic linkage may have been facilitated by the continuous narrowing of the Turgai Strait and stronger westerlies,which transported moisture and provided favorable climatic ***,fossil plants collected from the Qaidam Basin suggest that during the Oligocene this region had warm and humid deciduous broad-leaf forest,which differs from the region’s modern vegetation and indicates that the Qaidam Basin may have been a suitable region for these plants to flourish and spread during the Oligocene.

关键词： Paleoenvironment Biogeography Betulaceous fossil Qaidam basin Tibetan Plateau Oligocene

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong Weng Kang-ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang tao Liu Xing Huang Hang Zheng Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

Unconventional Organic Low-Dimensional Crystals:Diversity and Potential Applications

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CCS Chemistry 2024年第7期6卷 1628-1653页

作者： Jin Feng Mao Sun Ying-Xin Ma Zhen-Yu Geng Chuan-Zeng Wang Shu-ping Zhuo Shu-Hai Chen Hong-tao Lin Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000 School of Resources and Environmental Engineering Shandong University of TechnologyZibo 255000 Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123

Organic low-dimensional crystals have garnered escalating interests in the realms of miniaturized optoelectronics and integrated *** continual expansion of molecular systems and improvement in experimental conditions have given rise to unconventional organic low-dimensional crystals,which showcase a variety of appealing structure-dependent properties in the realm of organic semiconductors,owing to their adaptable physicochemical characteristics and exceptional optoelectronics ***,the development of unconventional low-dimensional crystals is filled with abundant possibilities due to their diverse application ***,we present a comprehensive overview of advancements in research on representative cases of unconventional low-dimensional organic crystals,using a systematic and rational structural ***,we have also discussed the existing challenges and future directions,aspiring to deepen understanding and encourage further research exploration in this field.

关键词： organic semiconductor crystal growth precise synthesis noncovalent interaction integrat-ed photonics

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2024年

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-tao Zheng Yi-Wei Dong Li-ping Huang Xiao-ping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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融合全局信息的多图神经网络会话推荐

小型微型计算机系统 2024年第4期45卷 769-776页

作者：黄涛徐贤华东理工大学计算机科学与工程系上海200237

基于会话的推荐旨在根据当前会话预测下一个最可能交互的物品.由于单个会话点击序列较短,仅使用会话本身的信息很难提供准确的推荐.因此,综合考虑其它会话之间的交互信息已成为一种趋势,为了提高推荐性能,本文提出一种融合全局信息的多... 详细信息

基于会话的推荐旨在根据当前会话预测下一个最可能交互的物品.由于单个会话点击序列较短,仅使用会话本身的信息很难提供准确的推荐.因此,综合考虑其它会话之间的交互信息已成为一种趋势,为了提高推荐性能,本文提出一种融合全局信息的多图神经网络会话推荐模型(GIMGNN)来增强会话推荐的效果.该模型首先通过超图卷积神经网络和门控图神经网络从全局会话超图和局部会话图中学习两个级别的物品表示,然后通过注意力机制将反向位置信息融合到两种表示中,最后利用融合后的表示完成预测.在两个真实数据集Yoochoose和Diginetica上进行了一系列实验,实验结果表明,对比性能最优的基准模型,GIMGNN模型在Yoochoose上P@20和MRR@20至少提升了2.42%和4.01%,在Diginetica上P@20和MRR@20至少提升了6.56%和9.11%,验证了模型的有效性.

关键词：会话推荐超图卷积神经网络门控图神经网络注意力机制位置信息