检索结果-南通市图书馆

Withdrawal of immunosuppression in liver transplantation and the mechanism of tolerance

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 470-476页

作者： chi-xian Zhang Pei-Hao Wen Yu-Ling Sun Institute of Hepatobiliary and Pancreatic Diseases Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhengzhou University School of Medicine

BACKGROUND： Immunosuppression reagents have side effects and cause considerable long-term morbidity and mortality in patients after liver transplantation. Sufficient evidences showed that minimization or withdrawal of immunosuppression reagents does not deteriorate the recipient＇s immune response and physiological function and therefore, is feasible in some recipients of liver transplantation. However, the mechanisms are not clear. The present review was to update the current status of immunosuppression in liver transplantation and the mechanism of minimization or withdrawal of immunosuppression in liver *** SOURCES： We searched articles in English on minimization or withdrawal of immunosuppression in liver transplantation in Pub Med. We focused on the basic mechanisms of immune tolerance in liver transplantation. Studies on immunosuppression minimization or withdrawal protocols and biomarker in tolerant recipients were also ***： Minimization or withdrawal of immunosuppression can be achieved by the induction of immune tolerance, which may not be permanent and can be affected by various factors. However, accurately evaluating immune status post-transplant is a prerequisite to achieve individualized immunosuppression. Numerous mechanisms for immune tolerance have been found, including immunophenotypic shift of memory CD8＋ T cells and CD4＋ T cell subsets. Activation of the inflammasome through apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain（ASC） in dendritic cells is associated with rejection after liver transplantation. CONCLUSIONS： Minimization or withdrawal of immunosuppression can be achieved by the induction of immune toler-ance via different mechanisms. This process could be affected by immunophenotypic shift of memory CD8＋ T cells and CD4＋ T cell subsets, which may be correlated with activation of the inflammasome through ASC in dendritic cells.

关键词： liver transplantation immunosuppression minimization withdrawal tolerance

Value of MR diffusion imaging in hepatic fibrosis and its correlations with serum indices

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第24期20卷 7964-7970页

作者： Xing-Rong Hu xian-nian Cui Qi-Tuo Hu Jun Chen Department of Imaging The Central Hospital of Enshi Autonomous Prefecture The Enshi Clinical College of Wuhan University Department of Laboratory The Central Hospital of Enshi Autonomous Prefecture Medical school of Hubei Institute for Nationalities Department of Radiology Renmin Hospital of Wuhan University

AIM: To compare apparent diffusion coefficient (ADC) values on diffusion-weighted imaging (DWI) of hepatic fibrosis patients with those of healthy controls and to identify their correlations with serum indices of live... 详细信息

关键词： Liver cirrhosis Diffusion-weighted imaging Hyaluronic acid Laminin Biological marker

Investigation of the possible source for the solar energetic particle event on 2017 September 10

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2018年第7期18卷 1-10页

作者： Ming-xian Zhao Gui-Ming Le Yu-Tian chi Key Laboratory of Space Weather National Center for Space WeatherChina Meteorological AdministrationBeijing 100081China School of Computer Science Anhui University of TechnologyMa'anshan 243032China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China

According to the solar proton data observed by Geostationary Operational Environmental Satellites （GOES）, ground-based neutron monitors on Earth and near-relativistic electron data measured by the ACE spacecraft, the onset times of protons with different energies and near-relativistic electrons have been estimated and compared with the time of solar soft and hard X-ray and radio burst data. The results show that first arriving relativistic and non-relativistic protons and electrons may have been accelerated by the concurrent flare. The results also suggest that release times of protons with different energies may be different, and the protons with lower energy may have been released earlier than those with higher energy. Some protons accelerated by concurrent flares may be further accelerated by the shock driven by the associated CME.

关键词： Sun coronal mass ejections (CMEs) - Sun flares - Sun particle emission

Short-term Load Forecasting of Regional Distribution Network Based on Generalized Regression Neural Network Optimized by Grey Wolf Optimization Algorithm

在线全文

学校读者我要写书评

暂无评论

CSEE Journal of Power and Energy Systems 2021年第5期7卷 1093-1101页

作者： Leijiao Ge Yiming xian Zhongguan Wang Bo Gao Fujian chi Kuo Sun Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjin 300132China china Electric Power Research Institute Co.Ltd Beijing 100192China. State Grid Tianjin Electric Power Company Tianjin 300010China.

Short-term load forecasting of regional distribution network is the key to the economic operation of smart distribution systems,which not only requires high accuracy and fast calculation speed,but also has a diversity of influential factors and strong *** paper proposes a short-term load forecasting model for regional distribution network combining the maximum information coefficient,factor analysis,gray wolf optimization,and generalized regression neural network(MIC-FA-GWO-GRNN).To screen and decrease the dimension of the multiple-input features of the short-term load forecasting model,MIC is first used to quantify the non-linear correlation between the load and input features,and to eliminate the ineffective features,and then FA is used to reduce the dimension of the screened input features on the premise of preserving the main information of input *** that the high-precision short-term丨oad forecasting based on GWO-GRNN model is *** is used to regressively analyze the input features after screening and dimension reduction,and the parameter of GRNN is optimized by using the GWO,which has strong global searching ability and fast *** a case study of a regional distribution network in Tianjin,china verifies the accuracy and applicability of the proposed forecasting model.

关键词： Factor analysis generalized regression neural network gray wolf optimization maximum information coefficient short-term load forecasting

Micro RNA transcriptome of skeletal muscle during yak development reveals that miR-652 regulates myoblasts differentiation and survival by targeting ISL1

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2023年第5期22卷 1502-1513页

作者： ZHOU Xue-lan GUO xian LIANG Chun-nian CHU Min WU Xiao-yun YAN Ping Key Laboratory of Yak Breeding Engineering of Gansu Province Lanzhou Institute of Husbandry and Pharmaceutical SciencesChinese Academy of Agricultural SciencesLanzhou 730050P.R.China Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau Ministry of Agriculture and Rural AffairsLanzhou 730050P.R.China

The growth and development of skeletal muscle also determine the meat production of yak, ultimately affecting the economic benefits. Hence, improving growth performance is a top priority in the yak industry. Skeletal muscle development is a complex process involving the regulation of several genes, including microRNAs(miRNAs). However,the transcription of miRNAs in yak skeletal muscle during prenatal to postnatal stages is unknown. We used small RNA sequencing(small RNA-Seq) to determine the global miRNAs of longissimus dorsi muscle from yak(the samples were collected from three fetuses and three adults). Totally 264 differently expressed miRNAs(|log2(fold change)|>1and P-value≤0.05) were detected between the two groups. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis showed that differently expressed miRNAs-targeted genes participated in pathways associated with muscle development, such as MAPK, PI3K-Akt, and Hippo signaling pathways, etc. MiR-652, which was up-regulated in the fetal group, was transfected into C2C12 myoblasts to examine its role. miR-652 promoted(P≤0.05)proliferation and differentiation, but inhibited(P≤0.001) apoptosis at early period. Furthermore, miR-652 reduced(P≤0.001) the proportion of C2C12 myoblasts in the G1 phase while increasing(P≤0.01) the proportion of cells in the S and G2 phases. Dual-luciferase reporter assays indicated that ISL1 served as a target of miR-652. In general, these findings expand our understanding of yak skeletal muscle miRNAs, and suggested that miR-652 probably regulated myogenesis by regulating ISL1.

关键词： skeletal muscle small RNA sequencing miR-652 C2C12 myoblast /SL1

Mechanism and threshold fluence of nanosecond pulsed laser paint removal

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第3期41卷 1022-1031页

作者： Qi Sun Jian-Zhong Zhou xian-Kai Meng Jia-nian Yang Zhao-Heng Guo Ming Zhu Shun Guo School of Mechanical Engineering Jiangsu UniversityZhenjiang 212013China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China

In this paper, the nanosecond pulse laser surface treatment of the waterborne anti-rust paint on HT250 gray cast iron was carried out. The area and depth of the per-pulse laser ablation paint layer were measured. The threshold of laser energy density was determined through the relations with ablation area and depth. The paint removal mechanism was discussed by analyzing the ablation features of the paint layer on laser cleaning. The features of the paint removal under various laser energy densities were characterized, and the process parameters in the experiments were *** results showed that there were four thresholds and three kinds of mechanisms in the paint removal process with nanosecond pulsed laser. The ablation threshold of substrate was deepened on the laser parameters. The ablation processes were included thermal ablation, thermal vibration and paint ionization concurrently, respectively. The surface cracks and paint debris were observed at the edge of the cleaning path, which were ascribed to the vibration effect by laser. In addition, the vibration effect could significantly increase the width of paint removal. Paint ionization has also a significant influence on the substrate morphology. Paint ionization would have an obvious impact on the formation of the substrate morphology. It is desirable to fabricate approach to remove the paint layer without damaging the substrate under optimized laser parameters by nanosecond pulse laser.

关键词： Laser paint removal Threshold of energy density Paint removal mechanism Surface morphology

Heat treatment effect on structural evolution and hydrogen sorption properties of Y_(0.5)La_(0.2)Mg_(0.3-x)Ni_(2) compound

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2023年第6期42卷 1813-1820页

作者： Hao Shen Li-Jun Jiang Ping Li Hui-Ping Yuan Zhi-nian Li Jun-xian Zhang National Engineering Research Center of Nonferrous Metals Materials and Products for New Energy GRINM Group Co.Ltd.Beijing100088China Institute for Advanced Materials and Technology University of Science and TechnologyBeijing100083China CNRS ICMPEUMR 7182Univ Paris Est CreteilThiais94320France GRIMAT Engineering Institute Co. Ltd.Beijing101407China

The effect of heat treatment on phase occurrence,crystal structures and hydrogen sorption properties of Y_(0.5)La_(0.2)Mg_(0.3-x)Ni_(2) compounds has been *** targeted compounds were synthesized through induction melting and processed heat treatment at 700 and 900℃,*** occurrence and structural properties were studied by X-ray powder diffraction(XRD).The global compositions and phase compositions have been determined by inductively coupled plasma-optical emission spectrometer(ICP-AES) and electron probe microanalysis(EPMA) respectively.

关键词： hydrogen treatment structural

Epstein-Barr virus negative primary hepatic leiomyoma: Case report and literature review

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第25期19卷 4094-4098页

作者： xian-Zhang Luo Chang-Sheng Ming Xiao-Ping Chen nian-Qiao Gong Institute of Organ Transplantation Department of Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of the Ministry of Health and Key Laboratory of the Ministry of Education

Primary hepatic leiomyoma is a neoplasm of mesen-chymal origin and occurs only rarely. Secondary to benign smooth muscle proliferation, it is usually found in adult women and is associated with Epstein-Barr virus (EBV) infection. Here, we report the 29 th case of primary hepatic leiomyoma with its unique features related to diagnosis, treatment and developmental biology. A 48-year-old man, with an immunocompromised status, complained of pain in the upper quadrant of the abdomen. Serological analysis indicated no presence of hepatitis virus, no human immunodeficiency virus, and no EBV infection. The levels of α-fetoproteinand carcinoembryonic antigen were normal. A mass was detected in segment Ⅲ of the hepatic lobe by ultrasonography and an abdominal computed tomography scan. Endoscopy had negative findings. Exploratory laparotomy found no existing extrahepatic tumor and left lateral lobectomy was performed. Pathological examination showed the mass to be a typical leiomyoma. The cells were positive for α-smooth muscle actin and desmin, and negative for the makers of gastrointestinal stromal tumor (GIST), including CD117, CD34 and DOG1 (discovered on GIST1). In situ hybridization revealed negative status for EBV-encoded small RNA. After left lateral lobectomy, the patient was not given chemotherapy or radiotherapy. During a 2-year follow- up, no sign of local recurrence or distant metastasis was observed. In conclusion, we report a rare case of primary hepatic leiomyoma in a male patient without EBV infection. Hepatic resection was curative. This case presents data to expand our knowledge concerning the complex and heterogeneous nature of primary liver leiomyoma, indicating that EBV infection is important but neither necessary nor sufficient for the development of primary liver leiomyoma.

关键词： Epstein-Barr virus Primary hepatic leiomyoma Cancer diagnosis Tumor resection Developmental biology

Reduced-order method for nuclear reactor primary circuit calculation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第11期35卷 28-45页

作者： Ze-Long Zhao Ya-Hui Wang Zhe-xian Liu Hong-Hang chi Yu Ma Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

Accurate real-time simulations of nuclear reactor circuit systems are particularly important for system safety analysis and *** effectively improve computational efficiency without reducing accuracy,this study establishes a thermal-hydraulics reduced-order model(ROM)for nuclear reactor circuit *** full-order circuit system calculation model is first established and verified and then used to calculate the thermal-hydraulic properties of the circuit system under different states as *** proper orthogonal decomposition method is used to extract the basis functions from snapshots,and the ROM is constructed using the least-squares method,effectively reducing the difficulty in constructing the ROM.A comparison between the full-order simulation and ROM prediction results of the AP1000 circuit system shows that the proposed ROM can improve computational efficiency by 1500 times while achieving a maximum relative error of 0.223%.This research develops a new direction and perspective for the digital twin modeling of nuclear reactor system circuits.

关键词： Reactor system model Primary circuit Reduced-order Proper orthogonal decomposition Least-squares method