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Magnifying chromoendoscopy combined with immunohistochemical staining for early diagnosis of gastric cancer

World Journal of Gastroenterology 2013年第3期19卷 404-410页

作者： xian-mei meng Yi Zhou Tong Dang Xu-Yang Tian Jie Kong Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical College Institute of Digestive Diseases of Inner Mongolia Autonomous Region Department of Pathology The Second Affiliated Hospital of Baotou Medical College

AIM:To assess the diagnostic value of using magnifying chromoendoscopy combined with immunohisto-chemical staining of proliferating cell nuclear antigen (PCNA)and p53 in the detection of gastric precancerous lesions. METHODS:Ninety-five patients who were treated for abdominal discomfort,abdominal pain,bloating,and acid reflux at our hospital from January 2010 to December 2011 were included in the *** ordinary gastroscopic procedure was initially performed to select the *** subjects underwent magnifying chromo-endoscopy to observe morphological changes of gastric *** were then taken from each area of interest and sent for pathological examination and detection of PCNA and p53 expression by immunohistochemistry. An immunoreactivity score for each lesion was *** on immunoreactivity scores,immunohisto-chemical staining was then considered. RESULTS:Compared to intestinal metaplasia,gastric pits were more diverse in size,more irregular in shape, and more disorderly in arrangement in moderate and severe *** and p53 expression was sig-nificantly higher in precancerous lesions(intestinal metaplasia and dysplasia)than in chronic gastritis. PCNA expression showed an upward trend in types A-F *** number of cases that showed strong PCNA positivity increased significantly with an increase in the severity of *** sum test for independent samples showed that p53 expression was significantly higher in types E and F pits than in types A-D pits(H =33.068,P=0.000).Rank sum test for independent samples showed that PCNA expression was significantly higher in types E and F pits than in types A-D pits(H =31.791,P=0.001). CONCLUSION:The presence of types E and F pits,in which p53 and PCNA are highly expressed,is highly sug- gestive of the occurrence of early cancer,and patients developing these changes should be closely followed.

关键词： Magnifying chromoendoscopy Gastric precancerous lesions p53 Proliferating cell nuclear antigen Early gastric cancer

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Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett’s esophagus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第7期21卷 581-589页

作者： Yuan-yuan NIAN xian-mei meng Jing WU Fu-chu JING Xue-qin WANG Tong DANG Jun ZHANG Department of Gastroenterology the Second Affiliated Hospital of Baotou Medical CollegeBaotou 014040China Department of Gastroenterology the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China

Objective:To determine the characteristics of postprandial proximal gastric acid pockets(PPGAPs)and their association with gastroesophageal acid reflux in patients with Barrett’s esophagus(BE).Methods:Fifteen patients with BE(defined by columnar lined esophagus of≥1 cm)and 15 healthy individuals that were matched for age,gender,and body mass index,were *** fasting intragastric p H and the appearance time,length,lowest p H,and mean p H of the PPGAP were determined using a single p H electrode pull-through *** BE patients,a gastroesophageal reflux disease questionnaire(Gerd Q)was completed and esophageal 24-h p H monitoring was carried ***:The PPGAP was significantly longer(5(3,5)cm vs.2(1,2)cm)and the lowest p H(1.1(0.8,1.5)vs.1.6(1.4,1.9))was significantly lower in patients with short-segment BE than in healthy *** PPGAP started to appear proximally from the gastroesophageal p H step-up point to the esophageal *** acidity of the PPGAP was higher in the distal segment than in the proximal *** short-segment BE patients,there were significant correlations between the acidity and the appearance time and length of the *** length and acidity of the PPGAP were positively associated with gastroesophageal acid reflux *** acidity of the PPGAP was associated with the De Meester scores,the Gerd Q scores,and the fasting intragastric p ***:In patients with short-segment BE,a PPGAP is commonly *** length and acidity of PPGAP are associated with gastroesophageal acid reflux,the De Meester score,and the Gerd Q score in patients with short-segment BE.

关键词： Short-segment Barrett’s esophagus Postprandial proximal gastric acid pocket(PPGAP) Gastroesophageal acid reflux

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安尔碘、碘伏、洁芙柔3种消毒液洗手消毒效果分析

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天津护理 2004年第2期12卷 92-93页

作者：陈政昂梅鲜孟立松解放军第254医院天津300142

目的 :选择一种高效、快速、持续杀菌并对皮肤刺激小的洗手方法。方法 :手术人员 96名 ,随机分成 3组 ,每组 32人。碘伏组 ,采用 0 .5 %碘伏消毒液 5 0mL刷手 3min ;安尔碘组 ,取安尔碘Ⅰ型皮肤消毒剂 2 0mL ,纱布涂擦 1遍 ;洁芙柔组 ,... 详细信息

目的 :选择一种高效、快速、持续杀菌并对皮肤刺激小的洗手方法。方法 :手术人员 96名 ,随机分成 3组 ,每组 32人。碘伏组 ,采用 0 .5 %碘伏消毒液 5 0mL刷手 3min ;安尔碘组 ,取安尔碘Ⅰ型皮肤消毒剂 2 0mL ,纱布涂擦 1遍 ;洁芙柔组 ,取洁芙柔原液 2 0mL充分揉搓 3min。结果 :碘伏组与安尔碘组除菌率分别为 97.84 %和 10 0 % ,洗手前后的消毒效果差异显著 (P 0 .0 5 )。结论 :用安尔碘洗手是手术人员手部消毒的高效。

关键词：碘伏安尔碘洁芙柔洗手效果

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Synthesis of nano-TiO2 assisted by diethylene glycol for use in high efficiency dye-sensitized solar cells

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Chinese Chemical Letters 2017年第4期28卷 765-770页

作者： Lin Liu xiang-mei Yu Bao Zhang Shu-xian meng Ya-Qing Feng School of Chemical Engineer and Technology Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072 China

The performance of dye-sensitized solar cells（DSSCs） consisting of anatase TiO_2 nanoparticles that were synthesized via a hydrothermal method was *** synthesized TiO_2 nanoparticles were characterized by X-ray diffraction（XRD）,nitrogen sorption analysis,scanning electron microscopy（SEM）,high resolution transmission electron microscopy（HRTEM）,and UV-vis *** the J-Vcurve,electrochemical impedance spectroscopy（EIS）,and open-circuit voltage decay（OCVD） measurement were applied to evaluate the photovoltaic performance of *** with the commercial TiO_2nanoparticles（P25）,the synthesized-TiO_2 nanoparticles showed better *** adding diethylene glycol（DEG） before the hydrothermal process,the synthesized TiO_2 nanoparticles（hereafter referred to as TiO_2-DEG particles） shows narrower size distribution,larger specific surface area,higher crystallinity,and less surface defects than TiO_2（DEG free） *** analysis of photovoltaic properties of DSSCs based on TiO_2-DEG particles showed that the recombination of electron-hole pairs was decreased and the trapping of carries in grain boundaries *** was believed that the photoelectrode fabricated with the as-prepared TiO_2 nanoparticles improved the loading amount of dye sensitizers（N719）.and enhanced the photocurrent of the *** a result,the TiO_2-DEG particle based cells achieved a photo-to-electricity conversion efficiency（η） of 7.90%,which is higher than 7.53%for the cell based on TiO2（DEG free） and 6.59%for the one fabricated with P25.

关键词： Hydrothermal TiO2 Diethylene glycol Photoelectrode Dye-sensitized solar cells

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A new triterpenoid saponin from the leaves and stems of Panax quinquefolium L.

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Chinese Chemical Letters 2009年第10期20卷 1207-1210页

作者： Guo Yu Li Yi mei Zeng He meng xian Li Jin Hui Wang School of Pharmacy Shihezi University Shihezi 832002 China School of Traditional Chinese Materia Medica. Shenyang Pharmaceutical University Shenyang 110016 China

One new triterpcnoid saponin, quinquenoside L17 （1）, was isolated from the leaves and stems of Panax quinquefolium L., and its structure was elucidated as 20-O-[（β-D-xylopyranosyl-（1-6）-O-β-D-glucopyranosy）]-6-O-β-D-glucopyranosy1-dammar-24-ene- 3,6,12,20-tetraol, by the combination analysis of one-dimensional NMR and two-dimensional NMR, mass spectrometry, CD spectrum and chemical evidences.

关键词： Panax quinquefolium L. Quinquenoside L17 Triterpenoid saponin

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联合FOD-sCARS的土壤有机质高光谱机器学习估测模型

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光谱学与光谱分析 2025年第1期45卷 204-212页

作者：吴梦红窦森林楠姜然哲陈思李佳璇付佳伟梅显军吉林农业大学资源与环境学院吉林长春130118 吉林建筑大学测绘与勘查工程学院吉林长春130118 吉林大学生物与农业工程学院吉林长春130115

土壤有机质(SOM)含量是表征土壤质量的关键指标,在全球碳循环系统中发挥重大作用。快速准确的SOM估算和空间制图对土壤碳库估算、作物生长监测和耕地规划管理具有重要意义。利用传统方法监测区域性SOM含量耗时费力,基于高光谱遥感影像建... 详细信息

土壤有机质(SOM)含量是表征土壤质量的关键指标,在全球碳循环系统中发挥重大作用。快速准确的SOM估算和空间制图对土壤碳库估算、作物生长监测和耕地规划管理具有重要意义。利用传统方法监测区域性SOM含量耗时费力,基于高光谱遥感影像建立SOM估测模型是现在较为合理有效的方法。为探索解决目前高光谱遥感影像建立SOM含量估测模型存在光谱数据冗余、光谱数据特征提取精度低、小样本模型泛化能力不强的问题,选择位于青海省湟中县的研究区,共采集67个土壤样本。获取资源1号02D(ZY1-02D)高光谱遥感影像并进行预处理得到样点像元光谱数据,采用分数阶微分变换(FOD)方法挖掘与SOM含量具有响应关系的敏感波段,以0.2为一个步长,利用相关性阈值法对比分析不同阶次微分处理数据挖掘能力;运用稳定性竞争性自适应重加权采样算法(sCARS)去除高光谱冗余数据获取建模特征波段,选择随机森林(RF)、极端梯度提升树、极限学习机和岭回归机器学习作为建模算法,以全波段和特征波段光谱数据分别作为模型输入变量构建SOM估测模型进行高光谱反演研究工作;最后根据最优特征变量和建模算法,基于ZY1-02D遥感影像进行了SOM空间分布制图。结果表明:采用FOD变换相比整数阶可以大大提高波段与SOM含量间的相关性,挖掘出更多细微的与SOM含量产生响应关系的光谱波段,其中0.8阶微分变换效果最优,较原始波段相比相关系数最大值提高了0.546;相较于全波段光谱数据,采用sCARS特征提取方法获取特征波段构建模型的估测精度得到较大提升,说明sCARS可以有效提升建模数据的质量,提升模型预测精度。建模算法中RF表现最优,R_(p)^(2)(模型决定系数)达到0.766,RPD达到1.86,较全波段建模结果R_(p)^(2)提升约7.58%;基于FOD-sCARS和RF实现了区域SOM含量估测制图。研究进一步验证利用星载高光谱遥感影像是实现区域SOM估测制图的可靠途径,研究结果可为估测区域SOM含量提供新思路,为利用星载高光谱遥感影像绘制SOM含量空间分布图提供了数据支持。

关键词：高光谱遥感影像分数阶微分变换稳定性竞争性自适应重加权采样算法土壤有机质随机森林

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Existence of Multiple Fixed Points for Nonlinear Operators and Applications

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1079-1088页

作者： Jing xian SUN Ke mei ZHANG Department of Mathematics Xuzhou Normal University Xuzhou 221116 P. R. China Department of Mathematics Qufu Normal University Qufu 273165 P. R. China

In this paper, by the fixed point index theory, the number of fixed points for sublinear and asymptotically linear operators via two coupled parallel sub-super solutions is studied. Under suitable conditions, the existence of at least nine or seven distinct fixed points for sublinear and asymptotically linear operators is proved. Finally, the theoretical results are applied to a nonlinear system of Hammerstein integral equations.

关键词： cone fixed point index parallel sub-super solutions

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Telomerase reverse transcriptase promoter mutations in hepatocellular carcinogenesis

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Hepatoma Research 2019年第3期5卷 8-19页

作者： Zi-xian Ma Chun-mei Yang meng-Ge Li Hong Tu State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200032China

Through several studies exploiting next-generation sequencing,we are obtaining a clearer picture of the complex genetic and molecular landscape of hepatocellular carcinoma(HCC).Consistent with the findings of other cancer types,telomerase reverse transcriptase(TERT)promoter mutations have been frequently reported in HCC.C228T and C250T are two major types of hot spot mutations in the TERT promoter ***,in hepatitis B virus(HBV)-related HCC cases,the TERT promoter is recurrently interrupted by integration of HBV *** promoter mutations are thought to be an early event in HCC carcinogenesis,and they are significantly associated with disease *** this review,we provide an updated overview of the somatic mutations in the TERT promoter region and discuss their possible roles in the development of HCC.

关键词： Hepatocellular carcinoma telomerase reverse transcriptase mutation hepatitis B virus

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An experimental study on erodibility of intertidal sediments in the Yellow River delta

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International Journal of Sediment Research 2012年第2期27卷 240-249页

作者： xiang-mei meng Yong-gang JIA Hong-xian SHAN Zhong-nian YANG Jie-wen ZHENG First Institute of Oceanography State Oceanic Administration Key Laboratory of Marine Environment & Ecology Ministry of Education(Ocean University of China) Ph.D. Key Laboratory of Marine Environment & EcologyMinistry of Education(Ocean University of China)

The erodibility of intertidal sediments is an important factor affecting coastal *** July and October 2008,in situ measurement of erodibility of the surficial sediment were conducted using a recirculating flume at 20 tidal flat experiment sites along the seashore of the Yellow River *** the same time,the characteristics of sand ripples and biogenic features on the tidal flat were observed and the physical-mechanical sediment properties such as bulk density,water content,grain size distribution,plasticity,penetration resistance,shear strength and compressibility,were *** field measurement,it is obtained that the critical erosion shear stress of the surficial sediment on the tidal flat varies between 0.088 Pa and 0.254 *** factors influencing sediment erodibility are complicated because of physical and biological reworking after the sediment ***’s a positive correlation between shear strength and critical erosion shear *** burrowing crabs’ activities changed the sediment microtopography and made the sediment have greater roughness,and that is one possible reason for the higher *** formation of scour pits on the tidal flat correlates with the heterogeneous erodibility of the surficial sediment.

关键词： Erodibility Intertidal sediments Flume experiment Yellow River delta

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Limit Theorems for Critical Galton-Watson Processes with Immigration Stopped at Zero

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Acta Mathematica Sinica,English Series 2024年第2期40卷 435-450页

作者： Dou Dou LI mei ZHANG xian Yu ZHANG College of Statistics and Data Science Faculty of ScienceBeijing University of TechnologyBeijing 100124P.R.China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

In this paper,we consider a critical Galton-Watson branching process with immigration stopped at zero *** precise estimation on the probability generating function of the n-th population are obtained,and the tail prob... 详细信息

关键词： Branching immigration critical life period limit theorems

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