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国内外医疗服务定价机制研究现状及启示

卫生软科学 2017年第8期31卷 3-5,12页

作者：杨练王滢孙群王美先黄诗尧明星宇成都中医药大学管理学院四川成都611137 四川省疾病预防控制中心科研培训与质量管理处四川成都610041

梳理了国内外医疗服务定价研究的现状,提出借助博弈分析、成本定价理论以及计量经济学模型等其他公共产品成熟的定价理论,在充分考虑医疗服务行业特殊性的基础上,建立最优医疗服务定价理论模型并通过实证数据求解最优价格,以丰富和发展... 详细信息

梳理了国内外医疗服务定价研究的现状,提出借助博弈分析、成本定价理论以及计量经济学模型等其他公共产品成熟的定价理论,在充分考虑医疗服务行业特殊性的基础上,建立最优医疗服务定价理论模型并通过实证数据求解最优价格,以丰富和发展医疗服务领域定价理论和方法,为形成稳定的医疗服务定价机制提供参考。

关键词：医疗服务定价价格机制博弈分析

Double-Teeth-Shaped Plasmonic Waveguide Electro-Optical Switches

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Chinese Physics Letters 2011年第8期28卷 326-329页

作者： ZHU Jia-Hu huang Xu-Guang mei xian Key laboratory of Photonic Information Technology of Guangdong Higher Education Institutes South China Normal UniversityGuangzhou 510006

An electro-optical switch based on a plasmonic T-shaped waveguide structure with a double-teeth-shaped waveguide filled with 4-dimethylamino-N-methyl-4-stilbazolium tosylate is proposed and numerically *** Finite-difference time domain simulation results reveal that the structure can operate as a circuit switch by controlling the external voltages V1 and/or V_(2).The proposed structure can also operate as a variable optical attenuator,which can continuously attenuate the power of a light beam from 6 dB to 30 dB by an external electrical *** structure is of small size of a few hundred *** results may open a possibility to construct nanoscale high-density photonic integration circuits.

关键词： waveguide Waveguide structure

A Surface Plasmon Polariton Electro-Optic Switch Based on a Metal-Insulator-Metal Structure with a Strip Waveguide and Two Side-Coupled Cavities

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Chinese Physics Letters 2012年第6期29卷 175-177页

作者： ZHU Yun-Jin huang Xu-Guang mei xian School of Information and Optoelectronic Science and Engineering South China Normal UniversityGuangzhou 510006

We propose and numerically simulate a nanoscale electro-optic (EO) switch based on a metal-insulator-metal structure composed of a strip waveguide and two side-coupled cavities filled with an EO material of 4-dimethylamino-N-methyl-4-stilbazolium tosylate,using the finite difference time domain *** is found that the structure can be operated as an EO switch at a wavelength of 945nm,with a modulation depth of 27dB,a half-wave voltage of 5.3 V and a switching time of about 50 ps.

关键词： waveguide Waveguide structure

High-Resolution Plasmonic Refractive-Index Sensor Based on a Metal-Insulator-Metal Structure

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Chinese Physics Letters 2011年第5期28卷 120-123页

作者： ZHU Jia-Hu huang Xu-Guang mei xian Key Laboratory of Photonic Information Technology of Guangdong Higher Education Institutes South China Normal UniversityGuangzhou 510006

A high-resolution plasmonic refractive-index sensor based on a metal-insulator-metal structure consisting of a straight bus waveguide and a resonator waveguide is proposed and numerically simulated by using the finite difference time domain method under a perfectly matched layer absorbing boundary *** analytic and simulated results show that the resonant wavelengths of the sensor have a linear relationship with the refractive index of material under *** on the relationship,the refractive index of the material can be obtained from the detection of one of the resonant *** resolution of refractive index of the nanometeric plasmonic sensor can reach as high as 10-6,giving the wavelength resolution of 0.01 *** could be applied to highly-resolution biological sensing.

关键词： waveguide resonator refractive

Effect of Fuzheng Jiedu granule on immunological function and level of immune-related cytokines in immune-suppressed mice

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Journal of Integrative Agriculture 2016年第3期15卷 650-657页

作者： YU Zhan-mei huang xian-hui YAN Chao-qun GAO Jin LIANG Zi-sen Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation College of Veterinary Medicine South China Agricultural University

Fuzheng Jiedu granule exhibits a number of health benefits and it is thought that the mechanisms involved in these effects are due to the modulation of immunity. In this article, we studied the effect of Fuzheng Jiedu granule on immunological function and the expression of immune-related cytokines in immune-suppressed mice. 72 mice were randomly divided into six groups, with 12 in each group. The control groups included an untreated group, a negative control group（Cyclophosphamide） and a positive control group（Astragalus polysaccharide）. There were three treated groups, which were given different doses of Fuzheng Jiedu granule： a low dose（100 mg kg^（–1））, a medium dose（400 mg kg^（–1）） and a high dose（600 mg kg^（–1））. With the exception of the untreated control animals, each group received an intraperitoneal injection of Cyclophosphamide（100 mg kg^（–1）） for 3 days to establish the immune-suppressed model. Mice were then treated for 19 consecutive days and, 24 h after the last treatment, blood was taken for the eyeballs and serum separation was performed. Analysis was made of the levels of related cytokines（IgA, IgG, IgM, IL-6, IFN-γ, C3, C4 and TNF-α）, the transformation of lymphocytes and the immune organ indexes. The results showed that Fuzheng Jiedu granule can improve the levels of cytokines, the rate of proliferation of lymphocytes and the immune organ indexes of immune-suppressed mice.

关键词： Fuzheng Jiedu granule immune suppression cytokines lymphocytes immune organ index

Crystal Structures of (Z)-1-Phenyl-1-phenylseleno- 2-(p-tolylsulfonyl)ethene and (Z)-1,3-Diphenyl-3- phenyl-seleno-2-(p-tolylsulfonyl)-2-propen-1-ol

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Chinese Journal of Structural Chemistry 2004年第6期23卷 543-546页

作者： XIEmei-Hua huangxian DepartmentofChemistry ZhejiangUniversity（XixiCampus）Hangzhou310028China

The molecular structures of compounds (Z)-1-phenyl-1-phenylseleno-2-(p-tolyl- sulfonyl) ethene 1 (C21H18O2SSe, Mr = 413.37) and 1,3-diphenyl-3-phenylseleno-2-(p-tolylsulfonyl) -2-propen-1-ol 2 (C28H24O3SSe, Mr = 519.49) were determined by single-crystal X-ray diffraction analyses. Crystal 1 crystallizes in monoclinic, space group P21/n with a = 12.574(4), b = 12.087(3), c = 13.132(4) , b = 107.973(4), V = 1898.5(9) ?, Z = 4, Dc = 1.446 g/cm3, m = 2.098 mm-1, l = 0.71073 ? F(000) = 840, R = 0.0484 and wR = 0.1085. Crystal 2 crystallizes in monoclinic, space group P21/n with a = 7.0710(4), b = 14.6604(9), c = 24.3432(5) ? b = 94.76(1), V = 2514.8(3) 3, Z = 4, Dc = 1.372 g/cm3, m = 1.603 mm-1, l = 0.71073 ? F (000) = 1064, R = 0.0366 and wR = 0.0573. The X-ray diffraction analysis shows that both of the title compounds are in Z- configuration.

关键词： molecular structures z-configuration phenylseleno p-tolylsulfonyl

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Existence of Multiple Fixed Points for Nonlinear Operators and Applications

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Acta Mathematica Sinica,English Series 2008年第7期24卷 1079-1088页

作者： Jing xian SUN Ke mei ZHANG Department of Mathematics Xuzhou Normal University Xuzhou 221116 P. R. China Department of Mathematics Qufu Normal University Qufu 273165 P. R. China

In this paper, by the fixed point index theory, the number of fixed points for sublinear and asymptotically linear operators via two coupled parallel sub-super solutions is studied. Under suitable conditions, the existence of at least nine or seven distinct fixed points for sublinear and asymptotically linear operators is proved. Finally, the theoretical results are applied to a nonlinear system of Hammerstein integral equations.

关键词： cone fixed point index parallel sub-super solutions

Stereoselective Synthesis of δd-Selanyl Allylic Alcohols by Hydrozirconation of Propargyl Selenides

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Chinese Chemical Letters 2003年第3期14卷 255-256页

作者： mei Hua XIE xian huang 等 DepartmentofChemistry ZhejiangUniversityXi-xiCampushangzhou310028 StateKeyLaboratoryofOrganometallicChemistry ShanghaiInstituteofOrganicChemistryChineseAcademyofSciencesShanghai

Hydrozirconation of propargyl selenides afford (E)-3-selanyl vinylzirconocenes chlorides 2. Intermediates 2 reacted with aldehydes to obtain d-selanyl allylic alcohols.

关键词： Hydrozirconation propargyl selenides aldehydes allylic alcohols.