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Antifungal efficacy of natamycin in experimental fusarium solani keratitis

International Journal of Ophthalmology(English edition) 2012年第2期5卷 143-146页

作者： xian-hui dong Wei-Juan Gao and Xiao-Ping He Laboratory of Spinal Cord Injury and Rehabilitation of Chengde Medical University Chengde 067000 Hebei Province China

AIM: To evaluate the efficacy of topical administration Natamycin, which is produced by China, in an experimental rabbit model of Fusarium solani keratitis, to provide experimental basis for the application of clinical safety. METHODS: Fusarium solani was induced in the right eye of 30 New Zealand rabbits. Forty-eight hours after inoculation, the animals were divided into 3 different treatment groups, 10 rabbit eyes of each group: Group 1 (Natamycin) treated with topical Natamycin, group 2 (Natacyn) treated with topical Natacyn, group 3 (control) treated with topical saline solution. The eyes of each group was examined clinically with slit lamp using ulcer scoring system on day 4, 10, 15, and 21 for status of healing, corneal vascularisation, iritis, hypopyon and macular nebula. The findings were recorded on day 10 and day 21. RESULTS: Ulcer score on day 10, day 15, day 21: The score of Natamycin group are 1.45 +/- 0.16, 1.08 +/- 0.11, 0.70 +/- 0.40. The score of Natacyn group are 1.35 +/- 0.12, 1.10 +/- 0.12, 0.65 +/- 0.35. the score of control group are 1.30 +/- 0.08, 3.63 +/- 0.28, 3.80 +/- 0.16. Natamycin group and Natacyn group were different from control group (P <0.01). There is no difference between Natamycin group and Natacyn group. Status of healing on day 10 and day 21: The cure rate of the Natamycin group is 90% on day 10, and 100% on day 21. The cure rate of the Natacyn group is 80% on day 10, and 100% on day *** group and Natacyn group were different from control group (P<0.01). There is no difference between Natamycin group and Natacyn group. Corneal vascularisation, iritis, hypopyon and macular nebula on day 10 and day 21: in Natamycin group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 2,0,0,2. In Natacyn group, the number of the eyes which have Corner vascularisation, iritis, hypopyon and macular nebula are 1,0,0,2. In control group, the number of the eyes which have Corner vascularisati

关键词： fusarium solan fungal keratitis natamycin natacyn

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Recent advances in ethanol gas sensors based on metal oxide semiconductor heterojunctions

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Rare Metals 2022年第6期41卷 1818-1842页

作者： Ling-Yun Gai Run-Ping Lai xian-hui dong Xing Wu Qiao-Tong Luan Jue Wang Hao-Feng Lin Wen-Hao Ding Guang-Lei Wu Wan-Feng Xie Big Data and Network Management Center Qingdao Agricultural UniversityQingdao 266109China School of Mechanical Electronic and Information Engineering China University of Mining and Technology-BeijingBeijing 10083China School of Material Science and Engineering State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071China School of Electronics and Information State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071China Shanghai Key Laboratory of Multidimensional Information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China

Metal oxide semiconductor heterojunctions(MOSHs)can enhance the performance of ethanol gas sen-sors *** gas sensors based on MOSHs are cost-effective and have excellent sensing response,good selectivity,fast response and recovery,long-term stability or repeatability,a low operating temperature,a facile fabrica-tion process,and versatile *** paper reviews the recent advances in gas sensors that are based on MOSHs and the advantages of using them to detect ethanol *** to the literature,compared with ethanol gas sen-sors that use single-component sensing materials,the MOSHs exhibit superior performance due to the synergy between the different components,which can amplify the reception and transduction components of the sensor *** the best of our knowledge,heterojunctions can be grouped into four main categories as metal oxide/metal oxide,metal oxide/metal sulfide,metal oxide/noble metal,and metal oxide/other materials,including rare-earth metals,g-C_(3)N_(4),and graphene,*** future trends and challenges that would be faced in the development of ethanol gas sensors based on MOSHs are discussed in ***,critical ideas and thinking regarding the future progress of MOSH-based gas sensors are presented.

关键词： Metal oxides Heterojunction Chemiresistori Ethanol sensor Synergistic behavior

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Exploring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies

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World Journal of Gastroenterology 2025年第2期31卷 147-156页

作者： Tong Qiao xian-hui Wen Department of Clinical Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Life Science and Technology Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Extensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental ***,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of *** paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and exploring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic *** fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut *** characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD ***,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary *** elucidating the complex interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关键词： Crohn’s disease Gut microbiome Dysbiosis Creeping fat Fecal microbiota transplantation

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Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload

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Neural Regeneration Research 2015年第5期10卷 778-785页

作者： xian-hui dong Jiang-tao Bai Wei-na Kong Xiao-ping He Peng Yan Tie-mei Shao Wen-guo Yu Xi-qing Chai Yan-hua Wu Cong Liu Chengde Medical University Hebei Chemical and Pharmaceutical Vocational and Technical College The 266 Hospital of Chinese PLA

Abnormally increased levels of iron in the brain trigger cascade amplification in Alzheimer＇s dis- ease patients, resulting in neuronal death. This study investigated whether components extracted from the Chinese herbs epimedium herb, milkvetch root and kudzuvine root could relieve the abnormal expression of iron metabolism-related protein in Alzheimer＇s disease patients. An APPs,~JPSI^E9 double transgenic mouse model of Alzheimer＇s disease was used. The intragas- tric administration of compounds from epimedium herb, milkvetch root and kudzuvine root improved pathological alterations such as neuronal edema, increased the number of neurons, downregulated divalent metal transporter 1 expression, upregulated ferroportin 1 expression, and inhibited iron overload in the cerebral cortex of mice with Alzheimer＇s disease. These com- pounds reduced iron overload-induced impairment of the central nervous system, indicating a new strategy for developing novel drugs for the treatment of Alzheimer＇s disease.

关键词： nerve regeneration neurodegenerative diseases Alzheimer's disease transgenic animalmodels mice epimedium herb milkvetch root kudzuvine root divalent metal transporter 1 ferroportin 1 neural regeneration

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Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-hui Jiang Wei-dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen Bo An Wen-Cheng An Gang Fu Wei Huang hui-xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu dong-Yi Yan Ke-hui Zhang Di Zhang Xi-Mao Cui Xiao-Hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

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中华民族现代文明:理论内涵、时代要求与世界意义

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海南大学学报（人文社会科学版） 2025年第1期43卷 1-7,F0002页

作者：董慧华中科技大学马克思主义学院湖北武汉430074 华中科技大学国家治理研究院湖北武汉430074

建设中华民族现代文明谱写了全面推进强国建设、民族复兴的新篇章,“新”就新在它既是一个新概念、一种新问题,也代表着一种新思维,彰显了习近平总书记对文化建设的深入思考。中华民族现代文明作为中国式现代化的文明成果,是党的百年文... 详细信息

建设中华民族现代文明谱写了全面推进强国建设、民族复兴的新篇章,“新”就新在它既是一个新概念、一种新问题,也代表着一种新思维,彰显了习近平总书记对文化建设的深入思考。中华民族现代文明作为中国式现代化的文明成果,是党的百年文化建设的宏阔升华,它厚植于中华文明与马克思主义融通结合的沃土,体现了对全人类共同价值的时代追寻。习近平文化思想为建设中华民族现代文明提供根本的理论指引、思想指引、精神指引和使命指引。建设中华民族现代文明,是对时代问题的积极回应,必须坚定文化自信、深化文明互鉴、推进文化传播,推动中华文明焕发时代荣光。

关键词：中华民族现代文明中华文明文化自信中国式现代化

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