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Association of food intake with a risk of metabolic dysfunction-associated fatty liver disease:a cross-sectional study

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Gastroenterology Report 2023年第1期11卷 439-445页

作者： xian-hua huang He-Wei Peng Jing-Ru huang Rong Yu Zhi-Jian Hu xian-E Peng Department of Epidemiology and Health Statistics Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public HealthFujian Medical UniversityFuzhouFujianP.R.China College of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianP.R.China Key Laboratory of Gastrointestinal Cancer Ministry of EducationFujian Medical UniversityFuzhouFujianP.R.China

Background:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a common liver disease,the risk of which can be increased by poor *** objective of this study was to evaluate the associations between food items and MAFLD,and to propose reasonable dietary recommendations for the prevention of ***:Physical examination data were collected from April 2015 through August 2017 at Nanping First Hospital(n=3,563).Dietary intakes were assessed using a semi-quantitative food frequency *** association between food intake and the risk of MAFLD was assessed by using the inverse probability weighted propensity ***:Beverages(soft drinks and sugar-sweetened beverages)and instant noodles were positively associated with MAFLD risk,adjusting for smoking,drinking,tea intake,and weekly hours of physical activity[adjusted odds ratio(ORadjusted):1.568;P=0.044;ORadjusted:4.363;P=0.001].Milk,tubers,and vegetables were negatively associated with MAFLD risk(ORadjusted:0.912;P=0.002;ORadjusted:0.633;P=0.007;ORadjusted:0.962;P=0.028).In subgroup analysis,the results showed that women[odds ratio(OR):0.341,95%confidence interval(CI):0.172–0.676]had a significantly lower risk of MAFLD through consuming more tubers than men(OR:0.732,95%CI:0.564–0.951).Conclusions:These findings suggest that reducing consumption of beverages(soft drinks and sugar-sweetened beverages)and instant noodles,and consuming more milk,vegetables,and tubers may reduce the risk of MAFLD.

关键词： metabolic dysfunction-associated fatty liver disease food intake cross-sectional study inverse probability of treatment weighting

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Complex structure of human Hsp90~N and a novel small inhibitor FS5

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Nuclear Science and Techniques 2020年第3期31卷 74-84页

作者： Rui Liu Xiao-Lu Lu xian-hua huang Wei He Jing-Jing Duan Jin Zhang Jian Li School of Basic Medical Sciences Nanchang UniversityNanchang 330031China College of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000China Human Aging Research Institute(HARI) School of Life SciencesNanchang UniversityNanchang 330031China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of EducationGannan Medical UniversityGanzhou 341000China

Heat shock proteins(Hsps)are a family of abundantly expressed ATP-dependent chaperone ***90 is an eminent member of Hsp *** far,two primary functions have been described for Hsp90:first,as a regulator of conformational change of some protein kinases and nuclear hormone receptors,and the other as an indispensable factor in cellular stress ***90 has an essential number of interaction proteins since it participates in almost every biological process and its importance is ***90 has an inextricable relationship in the pathogenesis of cancer,especially in the proliferation and irradiation of cancer cells,thus being a notable cancer *** the discovery of geldanamycin,the first inhibitor of Hsp90,from the bacterial species Streptomyces hygroscopicus,even more attention has been focused toward *** structure-based inhibitors of Hsp90 have been designed to develop an innovative method to defeat ***,already designed inhibitors have various deficiencies,such as hepatotoxicity,poor aqueous solubility,instability,and non-ideal oral *** on the aforementioned reasons and to achieve an optimal performance and fewer side effects,we designed a novel inhibitor of Hsp90,called FS5,and resolved the crystal structure of the Hsp90^N-FS5 complex(1.65 A°,PDB code 5XRB).Furthermore,we compared the complexes Hsp90^N,Hsp90^N-GDM,and Hsp90^N-ATP and suggest that the inhibitor FS5 may compete with ATP for binding to Hsp90,which can be regarded as a potential strategy for the development of novel cancer drugs in the future.

关键词： Heat shock protein 90 Complex crystal structure Interactions Anti-tumor drugs X-ray diffraction

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Rapid detection of colored and colorless macroand micro-plastics in complex environment via near-infrared spectroscopy and machine learning

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Journal of Environmental Sciences 2025年第1期147卷 512-522页

作者： Hui-huang Zou Pin-Jing He Wei Peng Dong-Ying Lan Hao-Yang xian Fan Lü hua Zhang Institute of Waste Treatment&Reclamation College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

To better understand the migration behavior of plastic fragments in the environment,development of rapid non-destructive methods for in-situ identification and characterization of plastic fragments is ***,most of the studies had focused only on colored plastic fragments,ignoring colorless plastic fragments and the effects of different environmental media(backgrounds),thus underestimating their *** address this issue,the present study used near-infrared spectroscopy to compare the identification of colored and colorless plastic fragments based on partial least squares-discriminant analysis(PLS-DA),extreme gradient boost,support vector machine and random forest *** effects of polymer color,type,thickness,and background on the plastic fragments classification were ***-DA presented the best and most stable outcome,with higher robustness and lower misclassification *** models frequently misinterpreted colorless plastic fragments and its background when the fragment thickness was less than 0.1mm.A two-stage modeling method,which first distinguishes the plastic types and then identifies colorless plastic fragments that had been misclassified as background,was *** method presented an accuracy higher than 99%in different *** summary,this study developed a novel method for rapid and synchronous identification of colored and colorless plastic fragments under complex environmental backgrounds.

关键词： Colorless microplastics Near-infrared hyperspectral imaging Plastic identification Partial least squares discriminant analysis Machine learning

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Dissolved organic matter characteristics linked to bacterial community succession and nitrogen removal performance in woodchip bioreactors

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Journal of Environmental Sciences 2025年第2期148卷 625-636页

作者： Achen Wang xiang Li Xuesong Luo Guangwen He Daqing huang Qiaoyun huang Xue-xian Zhang Wenli Chen National Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Soil Environment and Pollution Remediation College of Resources and EnvironmentHuazhong Agricultural UniversityWuhan 430070China School of Natural Sciences Massey University at AlbanyAuckland 0745New Zealand

Woodchip bioreactors are an eco-friendly technology for removing nitrogen(N)***,there needs to be more clarity regarding the dissolved organicmatter(DOM)characteristics and bacterial community succession mechanisms and their association with the N removal performance of *** laboratory woodchip bioreactors were continuously operated for 360 days under three influent N level treatments,and the results showed that the average removal rate of TN was 45.80 g N/(m3·day)when the influent N level was 100 mg N/L,which was better than 10 mg N/L and 50 mg N/*** succession of bacterial communities in response to influent N levels and DOM characteristics was an important driver of TN removal *** to high N levels enriched a copiotroph bacterial module(Module 1)detected by network analysis,including Phenylobacterium,Xanthobacteraceae,Burkholderiaceae,Pseudomonas,and Magnetospirillaceae,carrying N-cycle related genes for denitrification and ammonia assimilation by the rapid consumption of *** a process can increase carbon limitation to stimulate local organic carbon decomposition to enrich oligotrophswith fewer N-cycle potentials(Module 2).Together,this study reveals that the compositional change ofDOMand bacterial community succession are closely related to N removal performance,providing an ecological basis for developing techniques for N-rich effluent treatment.

关键词： Bacterial community succession Dissolved organic matter N removal performance Woodchip bioreactors

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Evolution and generation mechanism of retained oil in lacustrine shales: A combined ReaxFF-MD and pyrolysis simulation perspective

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Petroleum Science 2025年第1期22卷 29-41页

作者： Biao Sun Xiao-Ping Liu Jie Liu Tian Liu Zu-xian hua Wen-Di Peng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) College of Geosciences China University of Petroleum (Beijing) International Petroleum Exploration and Production Corporation SINOPEC

To accurately investigate the evolution characteristics and generation mechanism of retained oil, the study analyzed organic-rich lacustrine shale samples from the Paleogene Kongdian Formation in Cangdong Sag, Bohai Bay Basin. This analysis involves Rock-Eval pyrolysis, pyrolysis simulation experiments,Gas Chromatograph Mass Spectrometer（GC-MS）, and reactive molecular dynamics simulations（Reax FF）. The results revealed the retained oil primarily consisted of n-alkanes with carbon numbers ranging from C14to C36. The generation of retained oil occurred through three stages. A slow growth stage of production rate was observed before reaching the peak of oil production in Stage I. Stage II involved a rapid increase in oil retention, with C12-C17and C24-C32serving as the primary components,increasing continuously during the pyrolysis process. The generation process involved the cleavage of weak bonds, including bridging bonds（hydroxyl, oxy, peroxy, imino, amino, and nitro）, ether bonds, and acid amides in the first stage（Ro= 0.50%-0.75%）. The carbon chains in aromatic ring structures with heteroatomic functional groups breaks in the second stage（Ro= 0.75%-1.20%）. In the third stage（Ro= 1.20%-2.50%）, the ring structures underwent ring-opening reactions to synthesize iso-short-chain olefins and radicals, while further breakdown of aliphatic chains occurred. By coupling pyrolysis simulation experiments and molecular simulation technology, the evolution characteristics and bond breaking mechanism of retained oil in three stages were revealed, providing a reference for the formation and evolution mechanism of retained oil.

关键词： Lacustrine shale Retained oiliness evolution Pyrolysis simulation experiments ReaxFF molecular dynamics Hydrocarbon generation evolution

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Protective effects of imperatorin against cerebral ischemia/reperfusion-induced oxidative stress through Nrf2 signaling pathway in rats

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中国药理学与毒理学杂志 2017年第10期31卷 988-988页

作者： Wei HE Wei-wei CHEN xian-hua huang Yu-mei ZHOU Fang LIAO Department of Pharmacology Gannan Medical UniversityKey Laboratory of Cerebrovascular Pharmacology of Jiangxi Province

OBJECTIVE To investigates the effects of imperatorin on the oxidative stress in the cerebral cortex and hippocampus after focal cerebral ischemia/reperfusion *** Transient focal cerebral ischemia/reperfusion model in male Sprague-Dawley rats was induced by 2 h middle cerebral artery occlusion followed by 24 h ***(1.25 and 2.5 mg·kg-1)or vehicle were administered intraperitoneally at 1,5 and 9 h after the onset of *** 24 h after reperfusion,the biomarkers of oxidative stress such as the levels of reactive oxygen species(ROS),lipid peroxidation products malondialdehyde(MDA),nitric oxide(NO)and total antioxidant capacity(T-AOC),the activities of inducible nitric oxide synthase(iN OS),superoxide dismutase(SOD)and catalase(CAT)in the cerebral cortex and hippocampus were *** also assessed the nuclear factor erythroid 2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the NAD(P)H-quinone oxidoreductase 1(NQO-1)protein expression by Western *** As compared to vehicle-treated animals,imperatorin treatment significantly reduced the ROS,MDA,NO levels and i NOS activity,increased T-AOC and the activities of SOD and ***,imperatorin treatment also significantly induced the nuclear translocation of Nrf2,enhanced the protein expression of HO-1 and NQO-1 in the cerebral cortex and *** Our findings indicate that imperatorin can protect the brain against the excessive oxidative stress induced by cerebral ischemia/reperfusion through activation of Nrf2 signaling pathway.

关键词： imperatorin cerebral ischemia/reperfusion reactive oxygen species nuclear factor erythroid 2-related factor 2

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Isothermal reduction kinetics and reduction prediction for iron ore pellets

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Journal of Iron and Steel Research International 2025年第1期32卷 64-72页

作者： Fei Meng Hao Liu Yue-lin Qin huang-jie hua Yin Deng Ze-zheng Sun Long-hai Liu School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing401331China CISDI Group Co. Ltd.Chongqing401122China College of Materials Science and Engineering Chongqing UniversityChongqing400044China Sichuan Desheng Group Vanadium&Titanium Co. Ltd.Leshan614000SichuanChina

Iron ore pellets,as one of the main charges of blast furnaces,have a greater impact on the CO_(2)emission reduction and stable operation of blast *** isothermal reduction behavior of the pellets obtained from a Chinese steel plant was studied in the gas mixtures of CO and N_(2).The results showed the reduction process is divided into two *** reduction in the initial stage(time t≤40 min)is cooperatively controlled by internal diffusion and interface chemical reactions with the activation energy of 30.19 and 16.67 kJ/mol,*** controlling step of the reduction in the final stage(t>40 min)is internal diffusion with the activation energy of 34.60 kJ/*** reduction process can be described by two equations obtained from kinetic *** reduction degree can be predicted under different temperatures and time,and the predicted results showed an excellent correlation with the experimental *** reduction mechanisms were confirmed by the analysis of the scanning electron microscope equipped with an energy dispersive spectrometer and optical microscope.

关键词： Pellet Reduction behavior Kinetics Mechanism Reduction prediction

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Effect of two-pass rolling of textured roll and polished roll on surface topography and mechanical properties of 316L stainless steel ultra-thin strip

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Journal of Iron and Steel Research International 2025年第1期32卷 186-197页

作者： Zeng-qiang Zhang Xi Liao Zhong-kai Ren Zhen-hua Wang Ya-xing Liu Tao Wang Qing-xue huang College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment of Ministry of Education Taiyuan University of TechnologyTaiyuan030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan030024ShanxiChina Shanxi TISCO Stainless Steel Precision Strip Co. Ltd.Taiyuan030032ShanxiChina

The textured roll and polished roll were applied instead of the ground roll in a 20-high mill to conduct two-pass rolling of 316L stainless steel strip with thickness of 0.027 *** the two-pass rolling with the textured roll and polished roll(TPR),the surface roughness of the strip is dramatically reduced,and the surface topographical anisotropy index is diminished to 30.9%of the initial *** with the strip rolled using the ground roll in both passes(GGR),the elongation of TPR rolled strip is obviously improved,and the mechanical property anisotropy is greatly *** anisotropy index of tensile strength and elongation are 42.58%and 52.59%of that of GGR rolled strip,which is mainly attributed to the significant decrease of the texture intensity of the strip by TPR *** results indicate that TPR process can obtain the stainless steel ultra-thin strip with smooth and uniform surface topography and good mechanical properties.

关键词： Textured roll Polished roll Surface topography Mechanical property Stainless steel ultra-thin strip

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B2-CuZr reinforced amorphous alloy matrix composites:A review

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China Foundry 2025年第1期22卷 1-11页

作者： Wei Guo Run-hua huang Zhen Zhang Mi Zhao Jin-cheng Wang Yan-qiang Qiao Shu-lin Lü Shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan 430074China Research Institute of huazhong University of Science and Technology in Shenzhen Shenzhen 518057GuangdongChina

B2-CuZr phase reinforced amorphous alloy matrix composites has become one of the research hotspots in the field of materials science due to the“transformation-induced plasticity”phenomenon,which makes the composites show better macroscopic plastic deformability and obvious work-hardening behavior compared to the conventional amorphous alloy matrix composites reinforced with ductile ***,the in-situ metastable B2-CuZr phase tends to undergo eutectoid decomposition during solidification,and the volume fraction,size,and distribution of B2-CuZr phase are difficult to control,which limits the development and application of these *** date,much efforts have been made to solve the above problems through composition optimization,casting parameter tailoring,and post-processing *** this study,a review was given based on relevant studies,focusing on the predictive approach,reinforcing mechanism,and microstructure tailoring methods of B2-CuZr phase reinforced amorphous alloy matrix *** research focus and future prospects were also given for the future development of the present composite system.

关键词： amorphous alloy matrix composite B2-CuZr phase plasticity microstructure tailoring

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