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Chinese Journal of Polymer Science 2007年第2期25卷 181-186页

作者： jing Luo xian-hong Wang ji Li Xiao-jiang Zhao Fo-song Wang State Key Laboratory of Polymer Physicsand Chemistry Changchun Institute of Applied Chermstry Graduate School of Chinese Academy of Sciences Changchun 130022 China

Electrostatic interaction conductive hybrids were prepared in water/ethanol solution by the sol-gel process from inorganic sol containing carboxyl group and water-borne conductive polyaniline （cPANI）. The electrostatic interaction hybrids film displayed 1-2 orders of magnitude higher electrical conductivity in comparison with common hybrids film, showing remarkable conductivity stability against water soaking. Most strikingly, it displayed ideal electrochemical activity even in a solution with pH = 14, which enlarged the conducting polyaniline application window to strong alkaline media.

关键词： Water-borne conductive polyaniline Sol-gel Electrostatic interaction.

Receptor variability-driven evolution of snake toxins

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Zoological Research 2018年第6期39卷 431-436页

作者： xian-hong ji Shang-Fei Zhang Bin Gao Shun-Yi Zhu Group of Peptide Biology and Evolution State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Three-finger toxins （TFTs） are well-recognized non- enzymatic venom proteins found in snakes. However, although TFTs exhibit accelerated evolution, the drivers of this evolution remain poorly understood. The structural complexes between long-chain α-neurotoxins, a subfamily of TFTs, and their nicotinic acetylcholine receptor targets have been determined in previous research, providing an opportunity to address such questions. In the current study, we observed several previously identified positively selected sites （PSSs） and the highly variable C-terminal loop of these toxins at the toxin/receptor interface. Of interest, analysis of the molecular adaptation of the toxin-recognition regions in the corresponding receptors provided no statistical evidence for positive selection. However, these regions accumulated abundant amino acid variations in the receptors from the prey of snakes, suggesting that accelerated substitution of TFTs could be a consequence of adaptation to these variations. To the best of our knowledge, this atypical evolution, initially discovered in scorpions, is reported in snake toxins for the first time and may be applicable for the evolution of toxins from other venomous animals.

关键词： Three-finger toxins Nicotinic acetylcholine receptor Driver

Struts与Hibernate在教学管理中的应用

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辽宁工程技术大学学报（自然科学版） 2008年第A1期27卷 216-218页

作者：贤继红黄培泉辽宁工程技术大学实验实训中心辽宁阜新123000

为解决教学过程中学生作业提交困难的问题,基于Struts框架技术和Hibernate持久化技术,以Tomcat为Web服务器、以SQLServer2000为数据库实现MVC模式,构建学生作业提交系统。利用该系统,学生在实验完成后,可以通过互联网提交所完成的实验... 详细信息

为解决教学过程中学生作业提交困难的问题,基于Struts框架技术和Hibernate持久化技术,以Tomcat为Web服务器、以SQLServer2000为数据库实现MVC模式,构建学生作业提交系统。利用该系统,学生在实验完成后,可以通过互联网提交所完成的实验项目。教师则可以通过互联网发布实验内容及实验要求,并批阅学生所完成的实验。Struts框架技术为Web设计提供安全、高效的MVC框架;所有数据请求及数据转发均由Struts的核心ActionServlet承担,简化业务流程;Hibernate数据持久化技术为Java对象访问、操纵数据库提供了可靠、高效的方式。该方法在教学管理及Web设计中具有一定的参考价值。

关键词： Struts Hibernate MVC 框架持久化

Evapotranspiration and its components partitioning based on an improved hydrological model: historical attributions and future projections

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Journal of Earth Science 2025年

作者： hong Du Sidong Zeng Yongyue ji Jun Xia College of Resources and Environmental Science， South-Central Minzu University Chongqing Institute of Green and Intelligent Technology， Chinese Academy of Sciences Chongqing School， University of Chinese Academy of Sciences State Key Laboratory of Water Resources and Hydropower Engineering Science， Wuhan University

Estimation and attribution of evapotranspiration （ET） and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer subsequently regional water resources management. In this study， an improved hydrological model is developed to estimate evapotranspiration and its components i.e.， evaporation （E） and transpiration （T） by integrated the advantages of hydrological modeling constrained by water balance and the water-carbon close relationships. Results show that the improved hydrological model could captures ET and its components well in the study region. During the past years， annual ET and E increase obviously about 2.40mm/a and 1.42mm/a， particularly in spring and summer accounting for 90%. T shows less increasement and mainly increases in spring while it decreases in summer. Precipitation is the dominant factor and contributes 74.1% and 90.0% increases of annual ET and E， while the attribution of T changes is more complex by coupling of the positive effects of precipitation， rising temperature and interactive influences， the negative effects of solar diming and elevated CO2. In the future， ET and its components tend to increase under most of the Shared Socioeconomic Pathways （SSP） scenarios except for T decreases under the very high emissions scenario （SSP5-8.5） based on the projections. From seasonal perspective， the changes of ET and the components are mainly in spring and summer accounting for 75%， while more slightly changes are found in autumn and winter. This study highlights the effectiveness of estimating ET and its components by improving hydrological model within water-carbon coupling relationships， and more complex mechanisms of transpiration changes than evapotranspiration and evaporation changes under the interactive effects of climate variability and vegetation dynamics. Besides， decision makers should pay attention to the more increases in the undesirable E than desirab

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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法治是中国式现代化的重要保障

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 7-16,F0002页

作者：莫纪宏中国社会科学院法学研究所北京100720

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保... 详细信息

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保障中国式现代化中的能力,推动法治与现代化同频共振、并肩前行发挥了政策引领作用。从法理层面准确认识法治对中国式现代化的保障机制和制度功能,要从历史维度、政治维度、理论维度、比较维度和实践维度“五个维度”有机统一的角度认识中国式现代化的具体特征和制度形态,针对不同层面的中国式现代化目标采取不同性质的法治应对和保障措施。法治在中国式现代化进程中,通过保障制度现代化推进中国式现代化。其中,法治自身也需要现代化。没有法治现代化就没有社会主义现代化。法治在推进中国式现代化过程中,通过不断提升自身效能和保障能力,逐步实现自身的现代化,成为中国式现代化事业的重要组成部分。

关键词：法治中国式现代化历史维度政治维度理论维度比较维度实践维度

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气动凿岩机凿岩与破碎转换结构的设计

凿岩机械气动工具 2013年第3期39卷 43-44页

作者：鲜继红张国栋洛阳风动工具有限公司技术中心河南洛阳471009

设计了一种能够实现气动凿岩机凿岩和破碎的转换结构,增加了破碎功能,转换操作简便,而气动凿岩机的主要功能不受影响。用户可选购此转换结构,增加的购买成本与新增功能相比,合算。

关键词：气动凿岩机凿岩破碎转换结构

Substrate specificity in the biomimetic catalytic aerobic oxidation of styrene and cyclohexanone by metalloporphyrins: kinetics and mechanistic study

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Green Chemical Engineering 2021年第2期2卷 217-223页

作者： xian-Tai Zhou hong-Bing ji Fine Chemical Industry Research Institute Sun Yat-sen UniversityGuangzhou510275China School of Chemical Engineering Guangdong University of Petrochemical TechnologyMaoming525000China

Substrate specificity is a hallmark of enzymatic *** this work,the biomimetic catalytic oxidation of styrene and cyclohexanone by iron(III)porphyrins and molecular oxygen was carried out,and remarkable differences in efficiency were *** specificity of the substrates for biomimetic catalytic oxidation was investigated by kinetics and mechanistic *** studies revealed that the oxidation of styrene followed Michaelis-Menten kinetics with KM=8.99 mol L^(-1),but the oxidation of cyclohexanone followed first-order kinetics with kobs=1.46×10^(-4) s^(-1),indicating that the styrene epoxidation by metalloporphyrins exhibited characteristics of enzyme-like catalysis,while the oxidation of cyclohexanone was in agreement with the general rules of chemical *** catalytic mechanisms for the two substrates were discussed by operando electron paramagnetic resonance spectroscopy,operando UV-vis spectroscopy,and KI/starch *** specificity was concluded to be attributed to the stability of high-valence species and oxygen transfer rate.

关键词： Substrate specificity Kinetics Oxidation Metalloporphyrins Mechanism

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自激式电感耦合等离子体光源设计及光谱分析

光谱学与光谱分析 2025年第1期45卷 66-71页

作者：卢思贤龙开红詹陈锐李明北方工业大学电气与控制工程学院北京100144 益阳职业技术学院电子与信息工程学院湖南益阳413055

电感耦合等离子体(ICP)光谱仪是一种应用范围很广的元素分析仪,主要用于元素定性与定量的分析。ICP光源是光谱仪的核心部件,它在光谱仪中扮演着至关重要的角色。目前主流的ICP光源有两种:自激式和他激式,各自具有优缺点。他激式光源电... 详细信息

电感耦合等离子体(ICP)光谱仪是一种应用范围很广的元素分析仪,主要用于元素定性与定量的分析。ICP光源是光谱仪的核心部件,它在光谱仪中扮演着至关重要的角色。目前主流的ICP光源有两种:自激式和他激式,各自具有优缺点。他激式光源电路复杂、体积庞大、阻抗匹配速度较慢、最大输出功率有限。设计了一种基于镀金工艺的高功率MOSFET和变频实现阻抗匹配的自激式ICP光源,该光源采用射频放大和阻抗匹配一体化的设计,把从负载线圈采样的频率信号f_(1)以及功率放大电路放大后的频率相位f_(0)进行相位比较,再根据两者相位差的变化,进而控制频率的变化,实现阻抗匹配;设计上采用了镀金工艺的金属化硅N通道型高功率的MOSFET实现功率放大,具有更大的功率密度、更小的体积,最大输出功率超过2400 W。对研制的ICP光源进行了电学静态测试,给出了鉴相器、压控振荡器以及功率的输出特性,验证了各电路在相应工作状态下的性能表现;同时结合光谱仪进行了包含Ba、Na和Li元素标准溶液的测试,获得了目标元素的光谱信号;另外,对获得的光谱信号进行了处理,使用了基于EEMD特征增强的方法对目标元素光谱信号进行有效增强,信号的线性决定系数(R^(2))从0.97降至0.99,相对标准偏差(RSD)从6.47%降至1.07%,增强了信号的准确性和可用性。本文所研制的自激式ICP光源,通过射频放大和阻抗匹配一体化设计缩小了体积,变频技术使阻抗匹配速度从毫秒级提升到纳秒级,镀金工艺的MOSFET技术使最大输出功率从原来的1800 W增加到2400 W,为ICP光源的进一步优化和应用奠定了基础,具有重要的科学研究和工程实践意义。

关键词：自激式ICP光源阻抗匹配光谱信号 EEMD算法

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang Yong-hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism