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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1351-1355页

作者： Lian-Yong Xie Chao Chen Wen-Jun Kong Kui-fang Du Chun-Gang Guo hong-Wei Dong Wen-Bin Wei Beijing YouAn Hospital Capital Medical UniversityBeijing100069China Beijing Tongren Eye Center Beijing Key Laboratoryof Intraocular Tumor Diagnosis and TreatmentBeijingOphthalmology&Visual Sciences Key LabBeijing Tong RenHospitalCapital Medical UniversityBeijing100730China

The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome(AIDS) patients with cytomegalovirus retinitis(CMVR) was investigated. A total of 32 eyes in 23 AIDS patients diagnosed as CMVR from 2017 to 2018 were included in the retrospective study. All patients underwent induction therapy by using intravenous drip of the anticytomegalovirus(CMV) agent ganciclovir(5 mg/kg q12 h) combined with intravitreal ganciclovir injection(3 mg/time, 2 times/wk). The visual acuity, fundus photographs, lesion location, and number of intravitreal injections were observed preoperatively and postoperatively. Totally 14 eyes were cured during induction therapy. The number of injections [4.13(2 to 6)] in CMVR patients with peripherally fundus lesions were significantly lower than those with central lesions (4.89(2 to 6))The individualized therapy of intravitreal ganciclovir injections for AIDS patients with CMVR can effectively reduce the numbers of intravitreal injections.

关键词： cytomegalovirus retinitis acquired immune deficiency syndrome ganciclovir intravitreal injection monotherapy

强弱刺激量针刺对肝郁化火型原发性失眠伴随抑郁焦虑情绪及生活质量影响的随机对照研究

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中华中医药杂志 2022年第2期37卷 1193-1197页

作者：田鸿芳赵吉平浙江中医药大学附属第三医院杭州310000 北京中医药大学东直门医院北京100700

目的:观察强弱刺激量针刺对肝郁化火型原发性失眠伴随的抑郁焦虑情绪及生活质量的影响。方法:将66例原发性失眠患者随机分为强刺激组和弱刺激组,每组33例。评价两组治疗前、治疗期第1、2、3、4周及随访期第8、12周的抑郁自评量表(SDS)... 详细信息

目的:观察强弱刺激量针刺对肝郁化火型原发性失眠伴随的抑郁焦虑情绪及生活质量的影响。方法:将66例原发性失眠患者随机分为强刺激组和弱刺激组,每组33例。评价两组治疗前、治疗期第1、2、3、4周及随访期第8、12周的抑郁自评量表(SDS)、焦虑自评量表(SAS)、中医证候量表及治疗前后的生活质量量表(SF-36)评分的变化情况。结果:治疗后两组SDS评分、SAS评分、中医证候总分各时点较治疗前显著下降(P<0.05),两组间比较,强刺激组SDS评分、中医证候总分均低于弱刺激组(P<0.05),强刺激组SAS评分均低于弱刺激组,第1、2、3周比较,差异有统计学意义(P<0.05)。SF-36评分,除弱刺激组躯体疼痛较治疗前无明显差异,两组其他症状均较治疗前显著改善(P<0.05),且强刺激组治疗后躯体疼痛维度较弱刺激组显著改善(P<0.05)。结论:针刺强弱刺激均可有效改善肝郁化火型原发性失眠患者的抑郁焦虑情绪、中医证候及提高生活质量,且具有一定的远期疗效,强刺激组上述各方面疗效均优于弱刺激组。

关键词：原发性失眠肝郁化火针刺刺激量抑郁焦虑生活质量随机对照研究

Morphology, photoluminescence and gas sensing of Ce-doped ZnO microspheres

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Transactions of Nonferrous Metals Society of China 2015年第11期25卷 3657-3663页

作者：李酽刘金城连晓雪吕谭赵方贤中国民航大学理学院天津300300

Ce-doped ZnO microspheres were solvothermally prepared, and their microstructure, morphology, photoluminescence, and gas sensing were investigated by X-ray diffractometer, field emission scanning electron microscopy, transmission electron microscopy, fluorescence spectrometer and gas sensing analysis system. The results showed that the Ce-doped ZnO microspheres were composed of numerous nanorods with a diameter of 70 nm and a wurtzite structure. Ce-doping could cause a morphological transition from loose nanorods assembly to a tightly assembly in the microspheres. Compared with pure ZnO, the photoluminescence of the Ce-doped microspheres showed red-shifted UV emission and an enhanced blue emission. Particularly, the Ce-doped ZnO sensors exhibited much higher sensitivity and selectivity to ethanol than that of pure ZnO sensor at 320 °C. The ZnO microspheres doped with 6% Ce (mole fraction) exhibited the highest sensitivity (about 30) with rapid response (2 s) and recovery time (16 s) to 50×10?6 ethanol gas.

关键词： Ce-doping ZnO morphology microspheres gas sensing photoluminescence

Effects of Different Bagging Treatments on Fruit Quality of Jinlan Pomelo

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Agricultural Science & Technology 2022年第1期23卷 1-5页

作者： TANG Yu-qin YAN Cheng-pu WANG Yu-ting HU Zhong-dong ZHU fang-hong Horticultural Research Institute Jiangxi Academy of Agricultural SciencesNanchang 330200PRC

In order to improve the exterior and interior quality of Jinlan pomelo,the suitable paper bag for Jinlan pomelo were screened through different bagging treatments involving single layer yellow paper bag,double layer yellow paper bag,three layer yellow paper bag,single layer red paper bag,double layer red paper bag,three layer red paper bag and no *** results showed that bagging could increase fruit weight and fruit brightness,promote the coloring of fruit and improve fruit appearance *** titratable acid content of fruit decreased and the sugaracid ratio and soluble solid-acid ratio of fruit increased after the treatment of yellow paper *** layer yellow paper bag could significantly increase the VC content,which had better effect on improving the exterior quality and interior quality than other *** study provided reference for selecting the paper bag type for Jinlan pomelo.

关键词： Jinlan Pomelo Bagging Exterior quality Interior quality

Predictive Models of Adjuvant Chemotherapy for Patients with Stage II Colorectal Cancer： A Retrospective Study

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Chinese Medical Journal 2017年第17期130卷 2069-2075页

作者： Bo Wei Xiao-Ming Zheng Pu-Run Lei Yong Huang Zong-Heng Zheng Tu-Feng Chen Jiang-Long Huang Jia-Feng fang Cheng-Hua Liang hong-Bo Wei Department of Gastrointestinal Surgery The Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background：It remains controversial whether patients with Stage II colorectal cancer would benefit from adjuvant chemotherapy after radical *** aim of this study was to establish two mathematical models to identify the suitable patients for adjuvant ***：The current study comprised of two *** the first step,353 patients with Stage Ⅱ colorectal cancer who underwent surgical procedures at the Third Affiliated Hospital of Sun Yat-sen University between June 2006 and December 2015 were entered and followed up for 6-120 *** clinical data were collected and enrolled into the *** established two mathematical models by univariate and multivariate Cox regression analysis to identify the target patients;in the second step,230 patients under the same standard between January 2012 and December 2016 were entered and followed up for 3-62 months to verify the two models＆#39; ***：In the first step,totally 340 surgical patients with Stage Ⅱ colorectal cancer were finally enrolled in this *** analysis showed that tumor differentiation （TD）（P 〈 0.001）,lymphovascular invasion （LVI）（P 〈 0.001）,uncertain or positive margins （UPM）（P 〈 0.001）,and fewer lymph nodes （LNs）（〈12） retrieved （P 〈 0.001） were correlated with the overall survival （OS） and disease free survival （DFS）.We obtained two models：（1） OS risk score =1.116 ＆#215; TD ＆#177; 2.202 ＆#215; LVI ＋ 3.676 ＆#215; UPM ＋ 1.438 ＆#215; LN-0.493;（2） DFS risk score =0.789 ＆#215; TD ＋ 2.074 ＆#215; LVI ＋ 3.183 ＆#215; UPM ＋ 1.329 ＆#215; *** to the models and cutoff points [（0.07,1.33） and （-0.04,1.30）,respectively],patients can be divided into three groups：low-risk,moderate-risk,and ***,the high-risk group patients could benefit from adjuvant *** the second step,totally 221 patients were finally used to verify the models＆#39; *** results proved that the models were accurate and feasible （P 〈 0.05）.Conclusions：A

关键词： Adjuvant Chemotherapy Risk Factors Mathematical Models Colorectal Cancer

适于不等双周期的干道双向绿波协调控制数解法

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交通运输系统工程与信息 2023年第1期23卷 86-96页

作者：卢凯赵一鸣叶志宏首艳芳华南理工大学土木与交通学院广州510640 华南理工大学亚热带建筑科学国家重点实验室广州510640 琶洲实验室广州510330 华南理工大学广州现代产业技术研究院广州511458

针对现有数解法研究主要适用于单周期控制方式的不足,本文提出一种适于不等双周期的干道双向绿波协调控制数解法,通过重新定义双周期控制方式,打破了双周期交叉口信号周期时长固定为公共信号周期时长1/2的局限,并归纳了双周期交叉口的2... 详细信息

针对现有数解法研究主要适用于单周期控制方式的不足,本文提出一种适于不等双周期的干道双向绿波协调控制数解法,通过重新定义双周期控制方式,打破了双周期交叉口信号周期时长固定为公共信号周期时长1/2的局限,并归纳了双周期交叉口的2种协调类型。本文算法首先通过计算干道的公共信号周期允许变化范围,为各交叉口选择合适的信号周期控制方式;其次,通过分析双周期交叉口的协调特点,推导出适用于双周期交叉口的理想交叉口间距计算公式;然后,通过设定双周期交叉口各相位绿信比的分配比,实现协调方向相位绿信比的分配;最后,以最大调整偏移绿信比之和最小为优化目标确定绿波协调控制方案。算例结果分析表明,与双周期模型法和单周期数解法相比,本文数解法求解方案的干道双向延误时间分别减少16.0%与19.6%,停车次数分别减少15.1%与15.5%,特别是本文数解法的求解方案能使支路车流和行人过街的平均延误时间较单周期数解法分别减少46.0%与50.7%。可见,本文数解法能够获得理想的绿波协调效果,扩大数解法的适用范围,在减少交叉口延误时间方面表现出明显优势。

关键词：交通工程不等双周期数解法绿波协调绿信比

Effects of metoclopramide on gastrointestinal myoelectric activity in rats

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World Journal of Gastroenterology 1997年第3期3卷 41-42页

作者： QIN Xiao Min 1, LI hong fang 1 and WANG Long De 2

AIM To investigate the differences of metoclopramide (MCP) action on myoelectric activity of antrum and small intestine. METHODS Ten healthy male Wistar rats, weighing 250g～350g, were anesthetized with ketamine hydrochloride (100mg/kg, intramuscularly). Four pairs of bipolar stainless steel electrodes 3mm apart were implanted on serosal surface of antrum and 1, 10 and 20cm distal to pylorus respectively. Five to 10 days after operation, the gastrointestinal myoelectric activity of fasted rats after intramuscular injection of 2 5, 6 and 12mg/kg MCP respectively ws recorded with a 8 channel EEG machine, and was quantitatively compared with the myoelectric activity after saline injection. RESULTS In fasted rats, 2 5mg/kg MCP increased the amplitude of spike activity (402 0μV±138 4μV, vs 345 0μV±163 4μV, P <0 05) and the percentage of the slow wave containing spike bursts (60 4%±22 0% vs 47 4%±22 5%, P <0 01) of small intestine (1cm distal to pylorus), but did not affect the myoelectric activity of antrum. Six and 12mg/kg MCP increased the amplitude of both the slow wave (332 8μV±200 1μV vs 191 2μV±143 9μV, P <0 01; 330 0μV±197 1μV vs 191 2μV±143 9μV, P <0 05) and the spike activity (180 5μV±69 7μV vs 121 8μV±63 3μV, P <0 05; 174 5μV±71 7μV vs 123 8μV±63 3μV, P <0 05) of antrum, while in small intestine (1cm distal to pylorus) only that of the amplitude of spike activity (407 3μV±179 0μV vs 345 0μV±163 4μV, P <0 05; 456 0μV±145 4μV vs 345 0μV±163 4μV, P <0 05) and the percentage of the slow wave containing spike bursts (61 7%±26 5% vs 47 4%±22 5%, P <0 01; 59 1%±17 3% vs 47 4%±22 5%, P <0 01) was increased and with latent period significantly prolonged (2 5min±0 35min vs 0 77min±0 18min, P <0 01). CONCLUSION Different mechanisms may be involved in increasing the myoelectric activity of antrum and small intestine after MCP administ

关键词： metoclopramide \ stomach \ intestine myoelectric activity

Gallbladder motility in patients with hepatic cirrhosis before and after portal azygous disconnection

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World Journal of Gastroenterology 2004年第21期10卷 3230-3233页

作者： hong-XuJin Shuo-DongWu Xue-FengZhang xian-YingChen Guo-XuZhang TheSecondDepartmentofGeneralSurgery SecondHospitalChinaMedicalUniversityShenyang110004LiaoningProvinceChina GeneralHospitalofShenyangMilitaryCommand Shenyang110016LiaoningProvinceChina DepartmentofNuclearMedicine GeneralHospitalofShenyangMilitaryCommandShenyang110016LiaoningProvinceChina

AIM:To determine and compare the effect of vagus nerve on gallbladder motility in patients with hepatic cirrhosis before and after portal azygous disconnection (PAD).METHODS: PAD operation (or Hassab's operation) was performed on 18 patients with portal hypertension, and anterior and posterior vagal trunks were cut. On d 3 before operation and d 10 after operation, ^99mTc-EHIDA 185 MBq was administered intravenously to the patients, and scintigraphy was performed at 0.25 rain/frame. A standard fat meal was administered 30 rain after scintigraphy, and dynamic imaging was performed 60 rain after the fat meal. Following appearance of the region of interest (ROI) in gallbladder, the time-activity curve of ROI was established. The following seven parameters were used: radioactivity at 30 min after injection of ^99mTc-EHIDA (RC 30min), bile emptying fraction (EF), bile emptying period (EP), emptying rate (ER), latent period (LP), latent period radiocounting increment (LI), and latent period radiocounting increment rate (LR).RESULTS: The RC 30 min decreased significantly after operation, compared with that before operation (2 693.6+ 2 406.9 vs 5 606.8±2 625.4, P<0.05). The radiocounting Of gallbladder increased gradually during LP. LP after operation was significantly longer than that before operation (13.36±5.92 vs 2.24±1.48, P<0.01). LI and LR after operation were significantly higher than those before operation (2 861.62±028.3 vs 331.21±421.02, and 113.42±49.52 vs 7.57±10.75, respectively, both P<0.01). EP after operation was significantly shorter than that before operation (18.5+6.3 vs 24.1+6.4, P<0.05). EF and ER after operation were significantly lower than those before operation (13.1+5.4 vs 32.3±16.3, and 0.7±0.3 vs 1.4±0.8, respectively, both P<0.01).CONCLUSION: PAD operation is a good clinical model in studying the effect of vagus on gallbladder motility. The gallbladder tension after PAD operation decreases significantly during the interdigestive phase. The late

关键词：胆囊运动性肝硬化单断路 EF

磁性Mn_(0.6)Zn_(0.4)Fe_(2)O_(4)@SiO_(2)催化H_(2)O_(2)降解亚甲基蓝效能及机制

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环境科学 2022年第5期43卷 2650-2661页

作者：徐冬莹余静郝旗杨迎春方淑红成都信息工程大学资源环境学院成都610225

为制备易固液分离和稳定性好的高效非均相类Fenton催化剂,利用正硅酸乙酯水解对Mn_(0.6)Zn_(0.4)Fe_(2)O_(4)磁性纳米颗粒(SF-MNPs)进行功能化修饰,制备得到Mn_(0.6)Zn_(0.4)Fe_(2)O_(4)@SiO_(2)(MZF@SiO_(2))磁性纳米复合物催化剂,采用透射电镜、X射线光电子能谱和振动样品磁强计等对MZF@SiO_(2)进行了表征,以难生物降解偶氮染料亚甲基蓝(MB)为目标污染物,考察了不同初始pH对MZF@SiO_(2)催化效能的影响,在近中性条件下(pH=6.5)研究了H_(2)O_(2)用量、MZF@SiO_(2)投加量和温度等对MB去除率的影响,及MZF@SiO_(2)的稳定性和循环使用性能,推测了催化反应机制.结果表明,无定形SiO_(2)将SF-MNPs完全包裹,MZF@SiO_(2)具有"核-壳"结构;磁核SF-MNPs的结晶度好,具有尖晶石结构;MZF@SiO_(2)的饱和磁化强度为18.6 emu·g^(-1),剩磁和矫顽力均较低,在水中的分散性和固液分离性能均较好.当反应时间为120 min,温度为303 K,MZF@SiO_(2)投加量为1.0 g·L^(-1),H_(2)O_(2)的利用率为74.50%,MB的去除率可达94.76%,一级反应速率常数为0.0466 min^(-1),MZF@SiO_(2)具有较好的稳定性和循环使用性能.该降解过程的速率控制步骤为固液界面反应,MZF@SiO_(2)+H_(2)O_(2)体系中的活化氧化物主要为·OH;包覆层SiO_(2)能加速电子传递,与SF-MNPs存在正协同作用;SF-MNPs中存在氧空位,有利于反应过程中的电子转移.所制备的MZF@SiO_(2)可磁分离,催化效率高,稳定性好,可重复使用,在实际印染废水处理中具有很好的应用前景.

关键词：磁性催化剂非均相类Fenton 亚甲基蓝(MB) 降解

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软件学报 2023年第1期34卷 404-420页

作者：马传旺张宇方滨兴张宏莉哈尔滨工业大学网络空间安全学院黑龙江哈尔滨150001 鹏城实验室广东深圳518055

匿名网络旨在公开网络环境中保护用户通信隐私.自Chaum提出Mix网以来,相关研究在几十年中不断取得进展.如今,匿名网络已发展成以Mix网、DC网或PIR(private information retrieval)为基础,并结合多种设计要素,使之适用于各种应用场景和... 详细信息

匿名网络旨在公开网络环境中保护用户通信隐私.自Chaum提出Mix网以来,相关研究在几十年中不断取得进展.如今,匿名网络已发展成以Mix网、DC网或PIR(private information retrieval)为基础,并结合多种设计要素,使之适用于各种应用场景和威胁模型.从匿名概念出发,介绍匿名网络领域的发展情况,分类阐述代表性研究工作及其设计选择,并系统地从匿名性、延迟和带宽开销等角度进行分析.

关键词：匿名网络 Mix网 DC网 PIR 匿名性