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Unsedation colonoscopy can be not that painful: Evaluation of the effect of “Lamaze method of colonoscopy”

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World Journal of Gastrointestinal Endoscopy 2015年第15期7卷 1191-1196页

作者： Shao-Ping Yu Xiao-Dong Lin guang-Yao Wu Song-Hu Li Zong-Quan Wen Xiao-Hong Cen xian-guang huang Mei-Ting huang Department of Gastroenterology Dongguan Kanghua Hospital

AIM: To evaluate the pain relieving effect of intervention with "Lamaze method of colonoscopy" in the process of ***: Five hundred and eighty-five patients underwent colonoscopy were randomly divided into three groups, Lamaze group, anesthetic group and control group. Two hundred and twenty-four patients of Lamaze group, the "Lamaze method of colonoscopy" were practiced in the process of colonoscopy. The Lamaze method of colonoscopy is modified from the Lamaze method of childbirth, which helped patients to relieve pain through effective breathing control. One hundred and seventy-eight patients in anesthetic group accepted sedation colonoscopy. For 183 patients in control group, colonoscopy was performed without any intervention. The satisfactory of colon cleaning, intestinal lesions, intubation time, success ratio, pain grading and complications were recorded. All data were statistically ***: There were no significant differences at base line of the three groups(P > 0.05). Anesthetic group shows advantage in intubation time than the other two groups(P 0.05). The anesthetic group showed an apparent advantage in relieving pain(P < 0.01). Therefore, the "Lamaze method of colonoscopy" performed in colonoscopy could relieve pain effectively comparing with control group(P < 0.05). The patients in anesthetic group had the highest incidence of complications(P < 0.05).CONCLUSION: The performance of the "Lamaze method of colonoscopy" in the process of colonoscopy could relieve patients' pain, minimize the incidence of complications, and is worthy promotion in clinical practice.

关键词： Colonoscopy No sedation Pain Lamaze technique

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Numerical simulation of bubble detachment at submerged orifice and analysis of interface stability

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Journal of Hydrodynamics 2019年第2期31卷 293-302页

作者： xian-xian Yu Yi-wei Wang Chen-guang huang Te-zhuan Du Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Sciences University of Chinese Academy of ScienceBeijing 100049China Beijing Institute of Mechanical and Electrical Engineering Beijing 100074China

This paper presents the experimental and numerical results of the bubble detachment from a submerged orifice at a constant gas flow *** compressible large eddy simulation combined with the volume of fluid method is adopted in the simulation and is validated by *** transition criterion from the elongation stage to the detachment is *** the detaching stage in the simulation,the distributions of the pressure and the surface tension on the cylindrical bubble neck are *** Rayleigh-Plesset equation in the cylindrical coordinate frame is used to describe this *** on the comparison between the numerical results and the equation analysis,a reference value of the uncertain integral parameter in the equation is determined.

关键词： Bubble interfacial dynamics large eddy simulation instability criterion Rayleigh-Plesset equation

Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction

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Chinese Journal of Polymer Science 2024年第2期42卷 256-266,I0010页

作者： Can-Can Zhang Jun-Long Yang Ya-Jiang huang guang-xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Polypropylene(PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystallinity. This structural feature causes chain slippage in PP under stress,significantly constraining its service lifetime. In this study, thermally reduced graphene oxide(TrGO) nanosheets were incorporated into the PP matrix, yielding a nanocomposite with exceptional creep resistance performance. Results demonstrated that at a stress of 25 MPa, a 2.0 wt% TrGO content could enhance the creep failure lifetime of PP by 21.5 times compared to neat PP. Rheology, transmission electron microscopy(TEM),and scanning electron microscopy(SEM) characterization techniques were employed to analyze the mechanism of TrGO's influence on PP's creep behavior. It was observed that when TrGO content exceeded 1.0 wt%, an effective particle network structure formed within the PP matrix. This homogeneously dispersed TrGO-formed particle network structure restricted the migration and rearrangement of PP molecular chains, enabling prolonged stress resistance without structural failure. By combining the time-strain superposition method with the critical failure strain as a criterion, generalized creep compliance curves for PP and its composites were established, facilitating the prediction of material creep failure lifetimes, with a strong agreement between experimental and predicted lifetime values. This research proposes a novel strategy aimed at developing polypropylene materials and products with enhanced long-term stability and durability, thus extending service life, reducing failure risk, and broadening their potential across various application domains.

关键词： Thermally reduced graphene oxide Polypropylene Creep failure and lifetime prediction

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铂修饰氮化铝纳米管对CO的吸附性能研究

原子与分子物理学报 2025年第1期42卷 88-94页

作者：任舒宁何建桥黄海深沈光先吴波贵州师范大学物理与电子科学学院贵阳550025 遵义师范学院物理与电子科学学院遵义563006

本文采用基于密度泛函理论的第一性原理研究了铂修饰的(5,5)氮化铝纳米管的几何结构、电子性质以及与一氧化碳(CO)之间的相互作用.结果表明:铂原子吸附于氮化铝纳米管表面氮原子的顶位时能量最低.铂原子附近可以吸附四个CO分子,平均吸... 详细信息

本文采用基于密度泛函理论的第一性原理研究了铂修饰的(5,5)氮化铝纳米管的几何结构、电子性质以及与一氧化碳(CO)之间的相互作用.结果表明:铂原子吸附于氮化铝纳米管表面氮原子的顶位时能量最低.铂原子附近可以吸附四个CO分子,平均吸附能在1.189-2.940 eV之间,铂原子的修饰有效提高了氮化铝纳米管对CO分子的吸附能力.本研究为实验上开发制备性能更加优良的CO气体传感器提供理论指导.

关键词：氮化铝纳米管第一性原理密度泛函理论

Genome-scale analysis of the cotton KCS gene family revealed a binary mode of action for gibberellin A regulated fiber growth

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Journal of Integrative Plant Biology 2016年第6期58卷 577-589页

作者： guang-Hui Xiao Kun Wang Gai huang Yu-xian Zhu The State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Beijing 100871 China Institute for Advanced Studies/College of Life Sciences Wuhan University Wuhan 430072 China College of Life Sciences Shaanxi Normal University Xi'an 710062 China

Production of b-ketoacyl-Co A, which is catalyzed by 3-ketoacyl-CoA synthase（KCS）, is the first step in very long chain fatty acid（VLCFA） biosynthesis. Here we identified 58 KCS genes from Gossypium hirsutum, 31 from G. arboreum and 33 from G. raimondii by searching the assembled cotton genomes. The gene family was divided into the plant-specific FAE1-type and the more general ELO-type. KCS transcripts were widely expressed and 32 of them showed distinct subgenome-specific expressions in one or more cotton tissues/organs studied. Six Gh KCS genes rescued the lethality of elo2Δelo3Δ yeast double mutant,indicating that this gene family possesses diversified *** KCS genes with GA-responsive elements（GAREs） in the promoters were significantly upregulated by gibberellin A_3（GA）.Exogenous GA_3 not only promoted fiber length, but also increased the thickness of cell walls significantly. GAREs present also in the promoters of several cellulose synthase（CesA） genes required for cell wall biosynthesis and they were all induced significantly by GA_3. Because GA treatment resulted in longer cotton fibers with thicker cell walls and higher dry weight per unit cell length, we suggest that it may regulate fiber elongation upstream of the VLCFA-ethylene pathway and also in the downstream steps towards cell wall synthesis.

关键词： 3-Ketoacyl-CoA synthase cotton expression patterns gibberellins very long chain fatty acids

A Novel Method for Heightening Sensitivity of Prism Coupler-Based SPR Sensor

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Chinese Physics Letters 2011年第5期28卷 143-146页

作者： ZHU Jia-Hu huang Xu-guang MEI xian Key Laboratory of Instrumentation Science and Dynamic Measurement(Ministry of Education) North University of ChinaTaiyuan 030051 National Key Laboratory for Electronic Measurement Technology Taiyuan 030051 No.33 Research Institute China Electronic Technology Group CorporationTaiyuan 030006

We present a novel method for heightening the sensitivity of a prism coupler-based surface plasmon resonance(SPR)*** method is based on the total reflection prism made of BK7 glass combined with the Kretschmann geometry of theattenuated total reflection(ATR)*** to the conventional methods of prism coupler-based SPR,the novel method provides higher sensitivity to the measurement *** simulations show that the detection sensitivity to the refractive index(RI)of the sensor based on the novel approach has a strong dependence on the thickness of the metal *** RI resolution of the sensor is predicted to be 8×10^(-7)refractive index units(RIU)under the condition of optimum metal film *** novel method can leave out a precision angle rotation device in the angle modulation and it is unnecessary to adjust the acceptance angle of the light *** principal advantage of this method over other methods of light intensity modulation based on prism coupler-based SPR is high sensitivity,expediency to measure and application of long distances.

关键词： refractive method angle

High-temperature Thermo-oxidative Aging of Vulcanized Natural Rubber Nanocomposites:Evolution of Microstructure and Mechanical Properties

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Chinese Journal of Polymer Science 2023年第8期41卷 1287-1297,I0010页

作者： Zhou-xian Li Yi-Ran Kong xiang-Fei Chen Ya-Jiang huang Ya-Dong Lv guang-xian Li College of polymer science and engineering State key laboratory of polymer materials engineering of ChinaSichuan UniversityChengdu 610065China

The aging of natural rubber(NR)at high temperatures will seriously affect its service lifetime in many key *** the present work,the changes in microstructure and mechanical properties of semi-efficient vulcanized NR/carbon black(CB)vulcanizates during thermooxidative aging at high temperatures(150-200℃)and a moderate temperature(95℃)were *** high temperatures,a two-stage aging behavior,which was characteristic of a first rapid decline and then a continuous rise in the crosslinking density(ve),was identified and was found to be closely related to the depletion behavior of *** surface cracking behavior observed in the second stage of high-temperature aging was discussed in terms of the grafting reaction of macromolecular radicals on CB particles and thermal *** contrast,the aging of NR at moderate temperatures was much mild,which featured a continuous increase in ve and an oxidation mechanism dominated by peroxy radicals attacking double *** general,the mechanical properties of NR vulcanizates during high-temperature aging depended on the competition effects of structural evolution in the crosslinked network and oxidation-induced chain scission.

关键词： Natural rubber nanocomposites High-temperature Thermo-oxidative aging

High-Resolution Plasmonic Refractive-Index Sensor Based on a Metal-Insulator-Metal Structure

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Chinese Physics Letters 2011年第5期28卷 120-123页

作者： ZHU Jia-Hu huang Xu-guang MEI xian Key Laboratory of Photonic Information Technology of guangdong Higher Education Institutes South China Normal UniversityGuangzhou 510006

A high-resolution plasmonic refractive-index sensor based on a metal-insulator-metal structure consisting of a straight bus waveguide and a resonator waveguide is proposed and numerically simulated by using the finite difference time domain method under a perfectly matched layer absorbing boundary *** analytic and simulated results show that the resonant wavelengths of the sensor have a linear relationship with the refractive index of material under *** on the relationship,the refractive index of the material can be obtained from the detection of one of the resonant *** resolution of refractive index of the nanometeric plasmonic sensor can reach as high as 10-6,giving the wavelength resolution of 0.01 *** could be applied to highly-resolution biological sensing.

关键词： waveguide resonator refractive