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一种新型无柄股骨假体的设计研究

工程设计学报 2005年第5期12卷 288-293页

作者：龚宪生王超重庆大学机械传动国家重点实验室重庆400044

通过对比传统有柄股骨假体的应力分布来研究新型无柄股骨假体的生物力学性能.利用真实人体股骨上端的CT扫描图像,建立完整股骨、2个或3个固定螺钉的无柄假体、传统有柄假体的三维有限元模型.模拟人单腿直立的载荷情况,分析和比较每种模... 详细信息

通过对比传统有柄股骨假体的应力分布来研究新型无柄股骨假体的生物力学性能.利用真实人体股骨上端的CT扫描图像,建立完整股骨、2个或3个固定螺钉的无柄假体、传统有柄假体的三维有限元模型.模拟人单腿直立的载荷情况,分析和比较每种模型的V on M ises应力分布.研究表明,无柄假体股骨上的V on M ises应力比传统有柄假体和完整股骨上的都要高;与传统有柄假体相比,防止了应力遮挡效应的产生;2个或3个固定螺钉的无柄假体在股骨的V on M ises应力分布上没有明显差别.新型无柄假体可以防止应力遮挡效应,和传统有柄假体相比能够使股骨上的应力分布更加符合实际的生理情况.

关键词：无柄股骨假体有限元分析应力遮挡效应人工股骨

Coronary spasm, a pathogenic trigger of vulnerable plaque rupture

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Chinese Medical Journal 2011年第23期124卷 4071-4078页

作者： wang Li-xin LU Shu-zheng ZHANG Wei-jun SONG xian-tao CHEN Hui ZHANG Li-jie Department of Cardiology Beijing Anzhen Hospital Capital University of Medical Sciences Beijing 100029 China

Objective This coronary artery spasm review aimed to explore the most possible pathogenic trigger mechanism of vulnerable plaque rupture. Data sources Data used in this coronary artery spasm review were mainly from Medline and Pubmed in English. Study selection These reports from major review on coronary artery spasm .and these research included coronary artery conception, pathogenesis of spasm, mechanisms of plaque rupture, epidemiological evidence, clinical manifestation and the relationship between coronary artery spasm and vulnerable plaque rupture. Results Coronary artery spasm is somehow related to the presence of atherosclerotic intima disease in the coronary artery. However, chronic low-grade inflammation causes coronary vessel smooth muscle cell hypersensitivity, which can directely cause coronary artery spasm. Myocardial infarction and sudden cardiac death may be initiated by a sudden intense localized contraction of coronary artery smooth muscle. Conclusion Coronary artery spasm may be one trigger that can initiate and exacerbate vulnerable plaque rupture.

关键词： coronary spasm vulnerable plaque rupture pathogenic trigger

Application of HYDRUS-1D in understanding soil water movement at two typical sites in the North China Plain

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Journal of Groundwater Science and Engineering 2016年第1期4卷 1-11页

作者： wang Shi-qin SONG xian-fang WEI Shou-cai SHAO Jing-li Key Laboratory of Agricultural Water Resources Center for Agricultural Resources ResearchInstitute of Genetics and Developmental BiologyChinese Academy of Sciences Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of Sciences Academy of Water Resources and Environment China University of Geosciences

Recharge and discharge, such as rainfall infiltration and evapotranspiration in vertical direction, are major processes of water cycle in the shallow groundwater area of the North China Plain. During these processes, soil water movement in the unsaturated zone plays an important role in the transformation from rainfall infiltration to groundwater. The soil water movement models were developed by using HYDRUS-1D software at two typical experimental sites in Cangzhou(CZ) and Hengshui(HS) with different soil, vegetation and similar climate conditions. As shown in the results, the comparison in precipitation infiltration features between the two sites is distinct. The soil water experiences strong evaporation after precipitation infiltration, which accounts for 63% of the total infiltration at the HS site where the soil is homogenous. It is this strong evaporation effect that leads to slight increase of soil water storage. At the CZ site, where the soil is heterogeneous, the evaporation effect exists from July to October of the simulation period. The total evaporation accounts for 33% of the total infiltration, and the evaporation rate is slow. At the end of the simulation period, the soil water storage increases and the water table decreases, indicating a strong storage capacity at this site.

关键词： HYDRUS-1D software Soil water movement Precipitation infiltration Evapotranspiration Groundwater recharge

Biallelic mutations in spermatogenesis and centriole-associated 1 like(SPATC1L)cause acephalic spermatozoa syndrome and male infertility

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Asian Journal of Andrology 2022年第1期24卷 67-72页

作者： You-Zhu Li Na Li Wen-Sheng Liu Yan-Wei Sha Rong-Feng Wu Ya-Ling Tang Xing-Shen Zhu Xiao-Li Wei Xiao-Ya Zhang Yi-Feng wang Zhong-xian Lu Fu-Xing Zhang Reproductive Medicine Center The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Intensive Care Unit Fujian Medical University Xiamen Humanity HospitalXiamen 361009China Obstetrics and Gynecology Center Department of Obstetrics and GynecologyZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Pharmaceutical Sciences State Key Laboratory of Cellular Stress BiologyXiamen UniversityXiamen 361102China Department of Andrology United Diagnostic and Research Center for Clinical GeneticsWomen and Children’s Hospital and School of MedicineXiamen UniversityXiamen 361005China Department of Obstetrics and Gynecology First Affiliated Hospital of Xiamen UniversityXiamen 361003China Department of General Surgery First Affiliated Hospital of Xiamen UniversityXiamen 361003China

Acephalic spermatozoa syndrome is a rare type of teratozoospermia that severely impairs the reproductive ability of male patients,and genetic defects have been recognized as the main cause of acephalic spermatozoa *** and centrioleassociated 1 like(SPATC1L)is indispensable for maintaining the integrity of sperm head-to-tail connections in mice,but its roles in human sperm and early embryonic development remain largely ***,we conducted whole-exome sequencing(WES)of 22 infertile men with acephalic spermatozoa *** in silico analysis of the candidate variants was conducted,and WES data analysis was performed using another cohort consisting of 34 patients with acephalic spermatozoa syndrome and 25 control subjects with proven *** identified biallelic mutations in SPATC1L(c.910C>T:***304Cys and c.994G>T:***332X)from a patient whose sperm displayed complete *** SPATC1L variants are rare and ***1L is mainly expressed at the head–tail junction of elongating *** containing pathogenic variants decreased the level of SPATC1L in ***,none of the patient’s four attempts at intracytoplasmic sperm injection(ICSI)resulted in a transplantable embryo,which suggests that SPATC1L defects might affect early embryonic *** conclusion,this study provides the first identification of SPATC1L as a novel gene for human acephalic spermatozoa ***,WES might be applied for patients with acephalic spermatozoa syndrome who exhibit reiterative ICSI failures.

关键词： acephalic spermatozoa syndrome biallelic mutations spermatogenesis and centriole-associated 1 like whole-exome sequencing

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“化经为史”:吕思勉经学观新论

史林 2022年第2期 169-178,222页

作者：王应宪华东师范大学历史学系 200241

吕思勉早年习染常州今文学风,思想中存留今文经学印记,然而经学仅是构成其学术体系的元素而非底色。吕思勉以历史学的眼光审视经书的价值,遵从求真治史的原则,抛却了今古和汉宋的家法和门户之见,重新分类、诠释儒家经典,化经书为史料,... 详细信息

吕思勉早年习染常州今文学风,思想中存留今文经学印记,然而经学仅是构成其学术体系的元素而非底色。吕思勉以历史学的眼光审视经书的价值,遵从求真治史的原则,抛却了今古和汉宋的家法和门户之见,重新分类、诠释儒家经典,化经书为史料,以为古史研究凭借;化经义为史意,讲求通经致用,信奉大同学说,向往世界大同,搭建了恢宏厚重的新史学体系。吕氏经学摆脱了传统经师的旧染而合乎现代史学真谛,也反映出近代学术转型中经学发展的新趋向。

关键词：吕思勉今文经学史学化经为史

冻干重组人脑利钠肽联合福辛普利钠治疗顽固性心力衰竭的临床研究

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现代药物与临床 2021年第6期36卷 1260-1263页

作者：王娴君天津市第四中心医院心内科天津300140

目的探讨冻干重组人脑利钠肽联合福辛普利钠片治疗顽固性心力衰竭的临床疗效。方法选择2018年10月—2019年11月在天津市第四中心医院治疗的74例顽固性心力衰竭患者,采用随机数字表法分为对照组和治疗组,每组各37例。对照组口服福辛普利... 详细信息

目的探讨冻干重组人脑利钠肽联合福辛普利钠片治疗顽固性心力衰竭的临床疗效。方法选择2018年10月—2019年11月在天津市第四中心医院治疗的74例顽固性心力衰竭患者,采用随机数字表法分为对照组和治疗组,每组各37例。对照组口服福辛普利钠片,初次给予10 mg,1次/d,若耐受,可逐渐增至40 mg,1次/d。治疗组在对照组基础上静脉给予冻干重组人脑利钠肽,初始剂量1.5μg/kg静脉推注3~5 min,然后以0.007 5μg/(kg·min)静脉滴注。两组患者经7 d治疗。观察两组患者临床疗效,比较治疗前后两组患者心功能指标每搏输出量(SV)、心脏指数(CI)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD),及血清心肌型肌酸激酶同工酶(CK-MB)、氨基末端脑钠肽前体(NT-pro BNP)、内皮素-1(ET-1)、半乳糖凝集素-3(Gal-3)、肌钙蛋白T(c Tn T)和Ⅲ型前胶原端肽(PⅢNP)水平。结果治疗后,对照组总有效率为70.27%,显著低于治疗组的89.19%(P<0.05)。治疗后,两组患者SV、CI和LVEF显著升高,而LVEDD显著降低(P<0.05),且治疗组心功能指标明显好于对照组(P<0.05)。治疗后,两组血清NT-pro BNP、Gal-3、cTnT、PⅢNP、ET-1和CK-MB水平均显著降低(P<0.05),且治疗组降低最明显(P<0.05)。结论冻干重组人脑利钠肽联合福辛普利钠片治疗顽固性心力衰竭可有效改善患者心功能,促进心肌酶学指标和心肌损伤指标的下降,具有一定的临床推广应用价值。

关键词：冻干重组人脑利钠肽福辛普利钠片顽固性心力衰竭每搏输出量左室射血分数氨基末端脑钠肽前体

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基于多波位杂波的通道相位误差估计方法

系统工程与电子技术 2012年第9期34卷 1788-1795页

作者：胡瑞贤王彤保铮西安电子科技大学雷达信号处理国家重点实验室陕西西安710071

雷达的通道误差会影响杂波抑制效果和参数估计性能。为解决此问题,提出了一种针对机载扫描模式雷达的通道相位误差估计方法。首先对不同接收通道的杂波数据进行干涉处理,然后结合扫描角来求解通道相位误差。为了减小系统噪声影响,提高... 详细信息

雷达的通道误差会影响杂波抑制效果和参数估计性能。为解决此问题,提出了一种针对机载扫描模式雷达的通道相位误差估计方法。首先对不同接收通道的杂波数据进行干涉处理,然后结合扫描角来求解通道相位误差。为了减小系统噪声影响,提高估计精度,选取主杂波内独立同分布的距离单元作为估计样本。另外,对多个波位的杂波求平均进一步降低了估计误差。机载雷达实测数据处理结果表明,该方法可以较好地补偿通道相位误差,并且可以显著提高系统的目标定位能力。

关键词：相控阵雷达扫描模式通道相位误差多波位杂波

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长江中游航道流速区划分及影响因素研究

水运工程 2014年第9期 115-120,125页

作者：王先登长江武汉航道局湖北武汉430014

为满足长江电子航道图系统功能需要,使长江电子航道图流速相关信息的显示更加符合实际航段的情况,基于声学多普勒流速剖面仪(ADCP)的测流数据,提出了基于船舶航行需求的主、缓流流速区划分方法。同时利用该方法,研究影响流速区划分的因... 详细信息

为满足长江电子航道图系统功能需要,使长江电子航道图流速相关信息的显示更加符合实际航段的情况,基于声学多普勒流速剖面仪(ADCP)的测流数据,提出了基于船舶航行需求的主、缓流流速区划分方法。同时利用该方法,研究影响流速区划分的因素,对研究河段进行科学分段。

关键词：主流缓流阈值分段

Effect of nicardipine combined with esmolol on systemic and tissue oxygenation during off-pump coronary artery bypass grafting surgery

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Chinese Medical Journal 2005年第2期118卷 130-135页

作者： wangTian-long JIANGYan YANGBa-xian Departmentofanesthesia PekingUniversityPeople＇sHospitalBeijing100044China

Background The hemodynamics and oxygenation severely fluctuated during the offpump coronary artery bypass grafting (OPCABG) This study aimed at investigating whether or not nicardipine combined with esmolol (1∶10) can maintain systemic and tissue oxygenation during OPCABGMethods Twenty patients scheduled for OPCABG were divided ramdomly into Group nicardipine (N) and Group nitroglycerine (X) respectively combined with esmolol (E) (Dosage ratio: 1 to 10) (Group N+E and Group X+E) with 10 patients in each group The mixed solution of N+E or X+E were titrated to maintain mean arterial blood pressure between 70 and 80 mmHg following anesthesia induction The variables of hemodynamics, arterial blood lactate content (Lac) and gastric intramucosal partial pressure of carbon dioxide were measured at the following time points: after induction of anesthesia (T1), prerevascularization (T2), grafting of left anterior descending (T3), right coronary descending (T4) and left coronary circumflexus branches (T5), postrevascularization (T6), the end of operation (T7) The delivery of oxygen (DO2), consumption of oxygen (VO2) and gastric intramucosal pH (pHi) were calculatedResults The cardiac index (CI) in Group N+E was significantly increased (P<005) as compared with T1 during OPCABG, while it was mildly decreased in Group X+E The stroke volumes at T4, T5 in Group N+E and at T3T6 in Group X+E were significantly decreased (P<005) The systemic vascular resistance indices in Group N+E were significantly decreased as compared with T1 (P<005) The heart rates in these two Groups were significantly elevated intraoperatively (P<005) The DO2 after the infus

关键词： off pump · coronary artery · revascularization · oxygenation · nicardipine · esmolol