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Clinical efficacy of intradermal type Ⅰ collagen injections in treating skin photoaging in patients from high-altitude areas

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World Journal of Clinical Cases 2024年第16期12卷 2713-2721页

作者： Bin Yang Ao He Bin-Bin Bu Gong Zhuo Qing-Zhu Zhou Jia-Hang He liu liu Wen-Li Huang xian Zhao Department of Plastic and Cosmetic Surgery The Affiliated Calmette Hospital of Kunming Medical UniversityThe First People's Hospital of KunmingCalmette Hospital KunmingKunming 650224Yunnan ProvinceChina Department of Dermatology The People's Hospital of Chuxiong Yi Autonomous PrefectureChuxiong Yi Autonomous Prefecture 675099Yunnan ProvinceChina

BACKGROUND Photoaging,a result of chronic sun exposure,leads to skin damage and pigmentation changes.Traditional treatments may have limitations in high-altitude areas like Yunnan Province.Intradermal Col Ⅰ injections stimulate collagen production,potentially improving skin quality.This study aims to assess the efficacy and safety of this treatment for photoaging.AIM To evaluate the efficacy and safety of intradermal typeΙcollagen(ColΙ)injection for treating photoaging.METHODS This prospective,self-controlled study investigated the impact of intradermal injections of ColΙon skin photodamage in 20 patients from the Yunnan Province.Total six treatment sessions were conducted every 4 wk±3 d.Before and after each treatment,facial skin characteristics were quantified using a VISIA skin detector.Skin thickness data were assessed using the ultrasound probes of the Dermalab skin detector.The Face-Q scale was used for subjective evaluation of the treatment effect by the patients.RESULTS The skin thickness of the right cheek consistently increased after each treatment session compared with baseline.The skin thickness of the left cheek significantly increased after the third through sixth treatment sessions compared with baseline.The skin thickness of the right zygomatic region increased after the second to sixth treatment sessions,whereas that of the left zygomatic region showed a significant increase after the fourth through sixth treatment sessions.The skin thickness of both temporal regions significantly increased after the fifth and sixth treatment sessions compared with baseline(P<0.05).These findings were also supported by skin ultrasound images.The feature count for the red areas and wrinkle feature count decreased following the treatment(P<0.05).VISIA assessments also revealed a decrease in the red areas after treatment.The Face-QSatisfaction with Facial Appearance Overall and Face-Q-Satisfaction with Skin scores significantly increased after each treatment session.The overall appearance of the patients improved af

关键词： Photoaging TypeΙcollagen Face-Q High-altitude area Skin photodamage Patient satisfaction

Research on the Path of Integrating Ideological and Political Courses into College Physical Education Courses Under the Background of Cultivating Moral Character and Cultivating People

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Journal of Contemporary Educational Research 2023年第11期7卷 244-249页

作者： xian liu Hubei Polytechnic University Huangshi 435003Hubei ProvinceChina

The national education department clearly pointed out in the“Guidelines for the Construction of Ideological and Political Curriculum in Colleges and Universities”that colleges and universities need to take on the fundamental task of cultivating moral character and cultivating people in the process of education,and reasonably integrate ideological and political courses into the curriculum to promote the overall improvement of students’ideological and political quality.This article outlines the connotation of ideological and political courses in the context of cultivating moral character and cultivating people,analyzes and summarizes the significance of integrating ideological and political courses into college physical education courses,summarizes existing problems in the construction of ideological and political courses in college physical education,and explores the path of integrating ideological and political courses into college physical education courses under the background of cultivating moral character and cultivating people,with a view to providing guidelines for teachers.

关键词： Cultivating moral character Ideological and political courses Physical education courses Colleges and universities

Identification of multiple regulatory genes involved in TGase production in Streptomyces mobaraensis DSM 40587

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Engineering Microbiology 2023年第4期3卷 20-28页

作者： xian liu Dan Wang Yuru Zhang Xiaoxin Zhuang Linquan Bai State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Joint International Research Laboratory of Metabolic&Developmental Sciences Shanghai Jiao Tong UniversityShanghai 200240China Taixing Dongsheng Bio-Tech Co. Ltd.Taixing 225411China

Microbial transglutaminase(TGase)is a protein that is secreted in a mature form and finds wide applications in meat products,tissue scaffold crosslinking,and textile engineering.Streptomyces mobaraensis is the only licensed producer of TGase.However,increasing the production of TGase using metabolic engineering and heterologous expression approaches has encountered challenges in meeting industrial demands.Therefore,it is necessary to identify the regulatory networks involved in TGase biosynthesis to establish a stable and highly efficient TGase cell factory.In this study,we employed a DNA-affinity capture assay and mass spectrometry analysis to discover several transcription factors.Among the candidates,eight were selected and found to impact TGase biosyn-thesis.Notably,SMDS_4150,an AdpA-family regulator,exhibited a significant influence and was hence named AdpASm.Through electrophoretic mobility shift assays,we determined that AdpASm regulates TGase biosynthesis by directly repressing the transcription of tg and indirectly inhibiting the transcription of SMDS_3961.The latter gene encodes a LytR-family positive regulator of TGase biosynthesis.Additionally,AdpASm exhibited negative regulation of its own transcription.To further enhance TGase production,we combined the overexpression of SMDS_3961 with the repression of SMDS_4150,resulting in a remarkable improvement in TGase titer from 28.67 to 52.0 U/mL,representing an 81.37%increase.This study establishes AdpA as a versatile regulator involved in coordinating enzyme biosynthesis in Streptomyces species.Furthermore,we elucidated a cascaded regulatory network governing TGase production.

关键词： Transglutaminase Streptomyces mobaraensis AdpA Transcription Regulatory network

Emergency Treatment of Acute Decompensated Severe Aortic Stenosis with Transcatheter Aortic Valve implantation under the Coplane View Using J-Tipped Wires Fluoroscopy

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Cardiology Discovery 2023年第4期3卷 273-276页

作者： xian liu Yingdong Wang Yuhe Sheng Bin Wang Kai Xu Department of Cardiology Cardiovascular Research Institute of People's Liberation ArmyNorthern Theater General HospitalShenyangLiaoning 110016China

Patients experiencing severe aortic stenosis with acute decompensation often face elevated surgical aortic valve replacement risks,leading to high postoperative mortality rates.However,for some patients eligible for transcatheter aortic valve implantation(TAVI),computed tomography angiography for assessing the aortic root and coronary artery might be challenging before the TAVI procedure.This case highlights a patient who underwent emergency TAVI guided by coplane view generated using J-tipped wires fluoroscopy without computed tomography evaluation before the TAVl.This approach reduces contrast usage during the TAVI procedure,significantly mitigating the risks of renal injury and heart function deterioration.

关键词： Aortic valve stenosis Transcatheter aortic valve implantation Severe aortic stenosis

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妊娠期口腔急症的临床考量

华西口腔医学杂志 2024年第2期42卷 142-153页

作者：张雪峰刘显刘畅华成舸口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院成都610041

妊娠期是口腔疾病患病和治疗的特殊时期,妊娠期发生的口腔急症需得到恰当的处置。一方面,孕妇生理环境、个人习惯的改变增加了部分口腔疾病的易患性;另一方面,为了保证孕妇和胎儿安全,临床治疗策略局限。孕妇应掌握口腔健康知识、增强... 详细信息

妊娠期是口腔疾病患病和治疗的特殊时期,妊娠期发生的口腔急症需得到恰当的处置。一方面,孕妇生理环境、个人习惯的改变增加了部分口腔疾病的易患性;另一方面,为了保证孕妇和胎儿安全,临床治疗策略局限。孕妇应掌握口腔健康知识、增强口腔保健意识。口腔医生应在“孕前预防,孕期治标,孕后治本”的原则下,根据不同的妊娠时期制定合适的治疗方案,以最安全、简单、有效的手段控制急症、防止疾病进展,避免对孕妇和胎儿的不良影响。防治结合,让孕妇和口腔医生共同维护妊娠期口腔健康。本文围绕妊娠期治疗原则,对妊娠期口腔急症治疗的时机选择、临床管理和不同疾病的治疗策略等进行了总结。

关键词：妊娠期口腔疾病急症治疗时机临床管理治疗策略

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色味锁夸克物质与夸克星

物理学报 2024年第5期73卷 75-84页

作者：初鹏程刘鹤杜先斌青岛理工大学理学院青岛266033

讨论了零温、强磁场下基于准粒子模型的奇异夸克物质、色味锁夸克物质的热力学性质.结果表明色味锁夸克物质比奇异夸克物质更稳定,压强会随着色味锁态能隙常数的增大而增加.并且发现强磁场下磁星的最大质量会随着色味锁夸克物质的能隙... 详细信息

讨论了零温、强磁场下基于准粒子模型的奇异夸克物质、色味锁夸克物质的热力学性质.结果表明色味锁夸克物质比奇异夸克物质更稳定,压强会随着色味锁态能隙常数的增大而增加.并且发现强磁场下磁星的最大质量会随着色味锁夸克物质的能隙常数的增加而增加,磁星的潮汐形变率会随着能隙常数的增加而增加,磁星最大质量的中心密度会随着能隙常数的增加而降低.结果还说明考虑色味锁态得到的磁星质量半径关系可以满足最近实验观测PSR J0740+6620,PSR J0030+0451,和HESS J1731-347所给出的质量半径约束.

关键词：夸克物质夸克星磁星

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求解最小公倍数问题的量子安全多方计算协议

计算机学报 2024年第6期47卷 1393-1412页

作者：李子贤刘文杰南京信息工程大学软件学院南京210044 江苏省大气环境与装备技术协同创新中心南京210044 江苏省先进计算与智能服务工程研究中心南京210044

最小公倍数是解决很多数学问题的基础工具,在隐私保护的情况下如何对其进行多方协同计算具有一定的研究价值.部分经典安全多方计算协议虽然能够求解该问题,但计算复杂度为指数级.本文通过将最小公倍数问题转化为求多个周期函数的连接函... 详细信息

最小公倍数是解决很多数学问题的基础工具,在隐私保护的情况下如何对其进行多方协同计算具有一定的研究价值.部分经典安全多方计算协议虽然能够求解该问题,但计算复杂度为指数级.本文通过将最小公倍数问题转化为求多个周期函数的连接函数的周期,提出了一个基于量子周期查找算法的最小公倍数协议,将复杂度降为多项式级.在协议中,发起方对每个参与方发送一个粒子.每个参与方对粒子施加一个Oracle操作,其中Oracle函数的周期即各自的私有整数.然后,发起方通过运行量子周期查找算法来计算出连接函数的周期,即各自整数的最小公倍数.为了防御共谋和伪造攻击,采用星-环混合拓扑结构对粒子发送方进行诚实性检验.由于量子周期查找算法存在一定的失败概率,设计了一个量子匿名输出检验协议来检验最小公倍数结果的正确性.安全性分析表明了该协议在恶意模型下具有无条件安全性,且协议的计算复杂度和通信复杂度分别为O(n^(3)m^(2)log(nm))和O(n^(2)mlog(nm)),均为多项式级.此外,该协议具有较好的扩展性,可应用于安全多方最大公约数计算、有理数求和、最值计算等问题.

关键词：量子计算量子信息安全多方计算最小公倍数量子周期查找算法匿名输出检验隐私计算

Inhibition of thrombin by functionalized C_(60)nanoparticles revealed via in vitro assays and in silico studies

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Journal of Environmental Sciences 2018年第1期30卷 285-295页

作者： Yanyan liu Jianjie Fu Wenxiao Pan Qiao Xue xian liu Aiqian Zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China Institute of Environment and Health Jianghan UniversityWuhan 430056China

The studies on the human toxicity of nanoparticles（NPs） are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. However, different from other kinds of NPs, fullerene-based NPs（C_（60） NPs） have been found to have an anticoagulation effect, although the potential target is still unknown. In the study, both experimental and computational methods were adopted to gain mechanistic insight into the modulation of thrombin activity by nine kinds of C_（60） NPs with diverse surface chemistry properties. In vitro enzyme activity assays showed that all tested surface-modified C_（60） NPs exhibited thrombin inhibition ability. Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C_（60） NPs, of greater hydrophobicity and hydrogen bond（HB） donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin. A simple quantitative nanostructure-activity relationship model relating the surface substituent properties to the inhibition potential was then established for the six competitive inhibitors.Molecular docking analysis revealed that the intermolecular HB interactions were important for the specific binding of C_（60） NPs to the active site canyon, while the additional stability provided by the surface groups through van der Waals interaction also play a key role in the thrombin binding affinity of the NPs. Our results suggest that thrombin is a possible target of the surface-functionalized C_（60） NPs relevant to their anticoagulation effect.

关键词： Thrombin C_（60） nanoparticle（NP） Surface modification Activity inhibition Quantitative nanostructure-activity relationship Molecular docking

Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang xian Wang Bing-Qian liu Ling Jin Yi-Nuo Huang Yang-Fan Yang Zi-Dong Chen Da-Hui Ma Qing-Shan Chen Chao-Jun Qin Bing-Min Feng Zhu-Min Yang Xing Huang Cheng-Jie Yang Sheng-Hui liu Ming-Xing Wu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild cataracts.The participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for 12mo.The primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at 12mo.The overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two groups.In the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations