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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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散体充填材料压实力学特性的宏细观研究

煤炭学报 2017年第2期42卷 413-420页

作者：闫浩张吉雄张升梅贤丞陈俊丽中国矿业大学矿业工程学院江苏徐州221116 中国矿业大学深部煤炭资源开采教育部重点实验室江苏徐州221116

为提高西部矿区散体充填材料的抗压性能,采用扫描电子显微镜技术、图像处理技术以及颗粒流数值模拟相结合的方法,研究散体充填材料的细观参数与宏观应变量之间的关系。通过选取颗粒等效粒径、颗粒形状系数、颗粒定向度、表观孔隙率、连... 详细信息

为提高西部矿区散体充填材料的抗压性能,采用扫描电子显微镜技术、图像处理技术以及颗粒流数值模拟相结合的方法,研究散体充填材料的细观参数与宏观应变量之间的关系。通过选取颗粒等效粒径、颗粒形状系数、颗粒定向度、表观孔隙率、连通率和颗粒接触关系等6个指标对散体充填材料的形态特征、孔隙特征、接触特征进行了细观量化分析;通过PFC数值模拟对散体充填材料细观参数与宏观压实力学特性的相关性进行了模拟研究,结果表明:颗粒摩擦因数和颗粒孔隙率是散体充填材料宏观应变量的主控参数。基于西部矿区散体充填材料的细观结构,从减少充填材料孔隙率和增大充填材料摩擦性两方面出发,对其进行优化,并将优化后的散体充填材料在陕北常兴煤矿3101工作面进行工业性试验,实测地表最大下沉量为15 mm,最大水平变形为0.8 mm/m,地表沉陷得到有效控制。

关键词：散体充填材料西部矿区细观参数宏观压实特性

从“赋权”到“赋能”的企业组织结构演进——基于韩都衣舍案例的研究

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中国工业经济 2017年第9期 174-192页

作者：罗仲伟李先军宋翔李亚光中国社会科学院工业经济研究所河南财经政法大学中国社会科学院研究生院

本文从演进的视角探索当前时代背景下企业内部组织结构的发展趋势,试图揭示信息时代企业组织结构新的基本原理。围绕时代转换背景,论文分析现代公司制度下的企业赋权组织原理,指出信息技术革命引致企业内部的组织性质发生重大改变,雇佣... 详细信息

本文从演进的视角探索当前时代背景下企业内部组织结构的发展趋势,试图揭示信息时代企业组织结构新的基本原理。围绕时代转换背景,论文分析现代公司制度下的企业赋权组织原理,指出信息技术革命引致企业内部的组织性质发生重大改变,雇佣关系被合作关系所取代,相应地"赋能"正在取代"赋权"成为实现组织激励约束功能的基本组织原理,由此提出一套企业组织结构赋能原理的基本假说。本文以韩都衣舍的组织结构创新实践为案例,分析该企业以信息技术运用为基础,运用互联网快速学习、整合资源、创新迭代、自我裂变、不断进化,通过持续的组织试验逐步形成"以产品小组为核心的单品全程运营体系"的过程。论述其重构企业组织结构,以组织平台化支撑和小组自组织方式实现组织激励约束,从而通过案例实证证实赋能组织原理并检验其逻辑合理性。本文在定义赋能组织原理内涵、揭示其作用机理的同时论证了运用这一组织原理的四个必要条件。

关键词：组织演进组织结构 “赋权”原理 “赋能”原理平台与小组单案例研究

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu xiandeng li Mi li xian Wu Xiaohui Huang Ajing Xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Targets capture by distributed active swarms via bio-inspired reinforcement learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu Yue li jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

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基于正交试验的生物柴油制取关键参数分析

武汉理工大学学报 2009年第6期31卷 146-149页

作者：侯献军袁守利颜伏伍彭辅明武汉理工大学汽车工程学院武汉430070

利用酯交换反应来制取生物柴油的方法和制取流程,基于正交试验设计方法分析了影响生物柴油制取的4个关键参数:醇油摩尔比、催化剂用量、反应温度和反应时间,确定了一个最佳的反应条件使反应酯化率最高,在实验室条件下酯化率可达94.2%。... 详细信息

利用酯交换反应来制取生物柴油的方法和制取流程,基于正交试验设计方法分析了影响生物柴油制取的4个关键参数:醇油摩尔比、催化剂用量、反应温度和反应时间,确定了一个最佳的反应条件使反应酯化率最高,在实验室条件下酯化率可达94.2%。在0#柴油中以不同比例添加生物柴油作为燃料在发动机上进行排放特性和经济特性对比试验,表明生物柴油比0#柴油具有更好的排放特性,而燃油消耗率变化不大。

关键词：正交试验生物柴油酯交换酯化率

Adhesion of probiotic strains to endometrial epithelial cell and interaction with endometritis-associated pathogens

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Adhesion of probiotic strains to endometrial epithelial cell...