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An Analysis of the Fragmentation of Observing Time At the Muztagh-Ata Site

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Research in Astronomy and Astrophysics 2024年第3期24卷 29-33页

作者： Wen-Bo Gu Jing Xu Guo-Jie Feng Xuan Zhang Le-Tian Wang Xin-Liang Wang Ali Esamdin Li-xian shen Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 83001lChina School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Cloud cover plays a pivotal role in assessing observational conditions for astronomical *** for the fraction of observing time,its fragmentation also wields a significant influence on the quality of nighttime sky *** this article,we introduce the functionΓ∈[0,1],designed to comprehensively capture both the fraction of available observing time and its *** in situ measurement data gathered at the Muztagh-Ata site between 2017 and 2021,we showcase the effectiveness of our *** statistical result illustrates that the Muztagh-Ata site affords approximately 122 nights that were absolutely clear and 205 very good nights annually,corresponding toΓ≥0.9 andΓ≥0.36 respectively.

关键词： site testing-atmospheric effects-methods statistical

Network Pharmacology of xian-Lian-Jie-Du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： Ming-Xia Zhao Cheng-Lin Song Qin-Chang Zhang Hao-Jie Du Shu-Qiong Zhang Yu-xian shen Yang Sun Hai-Bo Cheng Wen Lv Department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina Department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina Department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the xian-Lian-Jie-Du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology xian-Lian-Jie-Du decoction

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中医药治疗糖尿病胃轻瘫作用机制的研究现状

中国临床药理学杂志 2024年第3期40卷 459-463页

作者：陈琼沈贤敏王斐许恒南京中医药大学附属苏州市中医医院中心实验室江苏苏州215009 苏州市吴门医派研究院中药临床药学实验室江苏苏州215009

中医药在糖尿病胃轻瘫(DGP)的临床防治实践中具有一定的特色和优势。本文通过对近年来关于中医药治疗DGP的国内外研究进行整理和综述,发现中医药可以通过调节Cajal间质细胞、肠神经系统、胃肠激素、肠道菌群等方面发挥作用。本文从上述... 详细信息

中医药在糖尿病胃轻瘫(DGP)的临床防治实践中具有一定的特色和优势。本文通过对近年来关于中医药治疗DGP的国内外研究进行整理和综述,发现中医药可以通过调节Cajal间质细胞、肠神经系统、胃肠激素、肠道菌群等方面发挥作用。本文从上述几个方面对中医药治疗DGP的作用机制研究进展进行论述,为DGP的防治提供思路和科学依据。

关键词：中医药糖尿病胃轻瘫机制 Cajal间质细胞胃肠激素

Machine learning identifies the risk of complications after laparoscopic radical gastrectomy for gastric cancer

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World Journal of Gastroenterology 2024年第1期30卷 79-90页

作者： Qing-Qi Hong Su Yan Yong-Liang Zhao Lin Fan Li Yang Wen-Bin Zhang Hao Liu He-Xin Lin Jian Zhang Zhi-Jian Ye xian shen Li-sheng Cai Guo-Wei Zhang Jia-Ming Zhu Gang Ji Jin-Ping Chen Wei Wang Zheng-Rong Li Jing-Tao Zhu Guo-Xin Li Jun You Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen 361001Fujian ProvinceChina Department of Gastrointestinal Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery The First Hospital Affiliated to Army Medical UniversityChongqing 400038China Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrmuqi 830054Xinjiang Uygur Autonomous RegionChina Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Gastrointestinal Surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004Fujian ProvinceChina Department of Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of General Surgery Unit 4 Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361021Fujian ProvinceChina Department of Gastrointestinal Nutrition and Hernia Surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Gastrointestinal Surgery Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362002Fujian Provin

BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned *** To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery,guide perioperative treatment strategies for gastric cancer patients,and prevent serious *** In total,998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model,and 398 patients were included in the validation *** clinicopathological data and 30-d postoperative complications of gastric cancer patients were *** machine learning methods,lasso regression,random forest,and artificial neural networks,were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy,and their prediction efficacy and accuracy were *** The constructed complication model,particularly the random forest model,could better predict serious complications in gastric cancer patients undergoing laparoscopic radical *** exhibited stable performance in external validation and is worthy of further promotion in more *** Using the risk factors identified in multicenter datasets,highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were *** hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models.

关键词： Gastric cancer Laparoscopic radical gastrectomy Postoperative complications Laparoscopic total gastrectomy

维普期刊数据库评论

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竖向地震动对斜交连续梁桥的影响研究

工程抗震与加固改造 2024年第5期46卷 141-150页

作者：沈贤胡玉娟王军文石岩河北大墺城市规划设计有限公司河北邯郸056002 石家庄铁道大学四方学院土木工程系河北石家庄051132 石家庄铁道大学土木工程学院河北石家庄050043 兰州理工大学土木工程学院甘肃兰州730050

为充分了解竖向地震动对斜交连续梁桥的影响,以某3×30m斜交连续梁桥为背景,利用OpenSees软件建立考虑碰撞效应的计算模型,采用时程分析法对比研究了在两种地震动(水平双向地震动和三向地震动)输入工况下对桥梁支座、碰撞效应,以及桥面... 详细信息

为充分了解竖向地震动对斜交连续梁桥的影响,以某3×30m斜交连续梁桥为背景,利用OpenSees软件建立考虑碰撞效应的计算模型,采用时程分析法对比研究了在两种地震动(水平双向地震动和三向地震动)输入工况下对桥梁支座、碰撞效应,以及桥面位移、桥面转角的影响。分析结果显示:考虑竖向地震动后,全桥支座的纵、横向剪切力均有增长,各支座竖向力的变化幅度均很明显,尤其以桥台处支座最为显著;桥台处支座更容易出现剪切、挤压破坏或脱空;由于竖向地震动作用,支座的临界剪切力增大,使其约束作用增强,导致桥面纵、横向位移减小,主梁与桥台、挡块之间的碰撞效应明显减弱,桥面的旋转程度呈现较大降低。

关键词：斜交连续梁桥竖向地震动碰撞效应橡胶支座地震反应

翼型厚度及风速对垂直轴风力机气动性能影响研究

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机械设计与制造 2024年第10期 272-276页

作者：徐贤申宋磊杨宗霄吴延峰河南科技大学机电工程学院河南洛阳471003 河南省低风速风电技术工程试验室河南洛阳471003 河南科技大学车辆与交通工程学院河南洛阳471003

为研究翼型厚度及风速对垂直轴风力机气动性能的影响,选择NACA2412、NACA2415、NACA2418三种不同厚度翼型的垂直轴风力机在不同风速条件下,基于滑移网格法和剪切应力输运(SST)k-ω湍流模型对其进行性能仿真研究。通过对比功率系数C_(P)... 详细信息

为研究翼型厚度及风速对垂直轴风力机气动性能的影响,选择NACA2412、NACA2415、NACA2418三种不同厚度翼型的垂直轴风力机在不同风速条件下,基于滑移网格法和剪切应力输运(SST)k-ω湍流模型对其进行性能仿真研究。通过对比功率系数C_(P)、力矩系数C_(M)及平均功率P,分析了翼型厚度及风速对垂直轴风力机气动性能的影响。结果表明:在低叶尖速比时,增大翼型厚度不仅提高了风力机的功率系数及力矩系数,还增大了风力机高效运行的叶尖速比范围,提高风力机最大功率系数的同时降低了最佳转速。而风速对风力机的输出功率有着较大影响。研究结果可为风力机的结构设计与优化提供参考。

关键词：垂直轴风力机气动性能翼型厚度风速

患者报告结局在前列腺癌病人中应用的研究进展

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护理研究 2024年第15期38卷 2690-2695页

作者：李雪莲沈仙唐燕贾磊苏莉青常健上海市第一人民医院上海201620

对国内外开发的前列腺癌患者报告结局评估工具及其临床应用情况进行综述,以期为前列腺癌患者报告结局评估工具的应用、开发及临床实践提供借鉴和参考。

关键词：前列腺癌患者报告结局症状评估护理综述

半地半轨双层立式停车装置框架多目标结构优化

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机械设计与制造 2024年第4期398卷 248-253页

作者：沈仙法郁锦涛张月陈晓颖三江学院机械与电气工程学院江苏南京210012 南京工业大学机械与动力工程学院江苏南京211816

为实现半地半轨双层立式停车装置框架结构的轻量化,利用UG建立停车装置框架三维模型,并导入到ANSYS Workbench中进行静力学和模态分析,获得框架等效应力、总体变形、安全系数云图以及前6阶固有振型与频率,找到框架结构的冗余和薄弱部位... 详细信息

为实现半地半轨双层立式停车装置框架结构的轻量化,利用UG建立停车装置框架三维模型,并导入到ANSYS Workbench中进行静力学和模态分析,获得框架等效应力、总体变形、安全系数云图以及前6阶固有振型与频率,找到框架结构的冗余和薄弱部位,再分别以框架横梁和立柱截面的宽度、长度和厚度为优化变量,质量、应力、变形和安全系数为优化目标,以截面尺寸范围、许用应力和最小安全系数为约束条件,建立优化数学模型。然后在ANSYS Workbench响应面优化模块中进行试验设计,并采用多目标遗传算法对框架横梁和立柱的截面尺寸进行多目标优化,得到其截面尺寸的Pareto最优解集和候选设计点。在此基础上,提出框架整体优化设计方案并完成静力学验证。结果表明,优化后的框架整体总质量由优化前的988.731kg降低到664.645kg,降幅达32.78%,优化效果显著,并且其强度、变形和安全系数均满足安全要求。

关键词：停车装置框架结构优化 ANSYS Workbench 多目标遗传算法

褪黑素复合保鲜液对康乃馨切花保鲜效果的影响

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保鲜与加工 2024年第10期24卷 52-57,66页

作者：李爱英朱志玉沈娴臧运祥李鹏吴建国浙江农林大学园艺科学学院浙江省山区农业高效绿色生产协同创新中心浙江杭州311300 浙江农林大学现代农学院浙江杭州311300 嘉兴市农渔技术推广站浙江嘉兴314000 绍兴文理学院元培学院浙江绍兴312000

为了筛选褪黑素(Melatonin,MT)在康乃馨切花复合保鲜液中的最佳浓度。以康乃馨鲜切花为试材,采用常规保鲜剂与不同浓度褪黑素的保鲜液组合对康乃馨切花进行瓶插保鲜试验,考察各组鲜切花的花蕾花径变化、水分平衡值、过氧化物酶活性、丙... 详细信息

为了筛选褪黑素(Melatonin,MT)在康乃馨切花复合保鲜液中的最佳浓度。以康乃馨鲜切花为试材,采用常规保鲜剂与不同浓度褪黑素的保鲜液组合对康乃馨切花进行瓶插保鲜试验,考察各组鲜切花的花蕾花径变化、水分平衡值、过氧化物酶活性、丙二醛含量、可溶性蛋白含量及可溶性糖含量。结果表明:最佳组合为40μmol/L褪黑素+常规保鲜液(T3),该处理显著延迟了最大花径的出现时间,与CK(蒸馏水处理)相比延迟了6 d;相较于CK,T3组切花的水分平衡值下降趋势较缓,瓶插9 d才开始失水,而CK组为5 d,过氧化物酶活性比CK组高57.2%,丙二醛含量比CK组降低了39.98%,可溶性蛋白以及可溶性糖含量分别为CK组的250%和176.9%。综上,40μmol/L褪黑素+常规保鲜液处理对康乃馨鲜切花具有良好的瓶插保鲜效果。试验结果可为MT在康乃馨鲜切花保鲜中的应用提供理论参考。

关键词：褪黑素康乃馨保鲜剂花蕾花径理化指标