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Fractional-order Virtual Inertia Control and pa.ameter Tuning for Energy-storage System in Low-inertia Power Grid

Protection and Control of Modern Power Systems 2024年第5期9卷 70-83页

作者： Yukai Zeng Qiufan Yang Yujun Lin Yin Chen xia Chen Jinyu Wen State Key Laboratory of Advanced Electromagnetic Engineering Huazhong University of Science and TechnologyWuhan 430074China Depa.tment of Electronic and Electrical Engineering University of StrathclydeGlasgow G11XWU.K.

As conventional synchronous generators are replaced by large-scale converter-interfaced renewa-ble-energy sources(RESs),the electric power grid en-counters the challenge of low rotational ***-quently,system frequency deviation is exacerbated and system instability may occur when the frequency deviates beyond the acceptable *** mitigate this effect,this study proposes a virtual inertia control(VIC)strategy based on a fractional-order derivative and controller pa.ameter-tuning *** tuning method uses the stability boundary locus and provides a stability criterion for identifying the stability region in the pa.ameter *** controller pa.ameters are then optimized within the identified stability region to suppress frequency deviation and enhance system *** proposed controller and tuning method is applied to a battery energy-storage system(BESS)in a low-inertia power system with the integration of ***-domain simulations are carried out to verify the stability region and compa.e the per-formance of the optimized proposed controller to that of the traditional integral-order *** simulation results show that the stability-analysis method is effective and that the fractional-order VIC,tuned with the pro-posed method,outperforms the traditional method in both frequency-regulation performance and pa.ametric *** Terms—Virtual inertia control,frequency regu-lation,fractional-order controller,stability region,pa.rameter tuning.

关键词： Virtual inertia control frequency regulation fractional-order controller stability region pa.ameter tuning

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Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma

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Journal of Environmental Sciences 2024年第3期137卷 172-180页

作者： Zhiyu Chen Fang Li Lei Fu Yu xia Ying Luo Ang Guo xiaona Zhu Huifang Zhong Qian Luo Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China university of Chinese Academy of Sciences Beijing 100049China Rheumatology&Immunology Depa.tment of Shenzhen Children’s Hospital Shenzhen 518038China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

Lipid metabolism play an essential role in occurrence and development of asthma,and it can be disturbed by phthalate esters(pa.s)and organophosphate fame retardants(OPFRs).As a chronic infammatory respiratory disease,the occurrence risk of childhood asthma is increased by pa.s and OPFRs exposure,but it remains not entirely clear how pa.s and OPFRs contribute the onset and progress of the *** have profiled the serum levels of pa.s and OPFRs congeners by liquid chromatography coupled with mass spectrometry,and its relationships with the dysregulation of lipid metabolism in asthmatic,bronchitic(acute infammation)and healthy(non-infammation)*** pa.s and nine OPFRs congeners were found in the serum of children(1–5 years old)from Shenzhen,and their total median levels were 615.16 ng/m L and 17.06 ng/m L,***,the serum levels of mono-methyl phthalate(MMP),tri-propyl phosphate(TPP)and tri-n-butyl phosphate(TNBP)were significant higher in asthmatic children than in healthy and bronchitic children as ***-one characteristic lipids and fatty acids of asthma were screened by machine-learning random forest model based on serum lipidome data,and the alterations of infammatory characteristic lipids and fatty acids including pa.mitic acids,12,13-Di HODE,14,21-Di HDHA,prostaglandin D2 and Lyso pa.18:2)showed significant correlated with high serum levels of MMP,TPP and *** results imply pa.s and OPFRs promote the occurrence of childhood asthma via disrupting infammatory lipid and fatty acid metabolism,and provide a novel sight for better understanding the effects of plastic additives on childhood asthma.

关键词： Phthalate esters Organophosphate fame retardants Childhood asthma Lipid and fatty acid metabolism Machine-learning random forest model Chronic airway infammation

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Ligand-dependent aggregation-enhanced photoacoustic of atomically precise metal nanocluster

Aggregate

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Aggregate 2024年第1期5卷 196-203页

作者： Changlin Zhou Meng Wang Qiaofeng Yao Yu Zhou Chuantao Hou Jianfei xia Zonghua Wang Jishi Chen Jianping Xie College of Chemistry and Chemical Engineering Shandong Sino-Japanese Center for Collaborative Research of Carbon NanomaterialsInstrumental Analysis Center of Qingdao UniversityQingdao UniversityQingdaoP.R.China Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjinP.R.China Qingdao Boting Hydrogen Age Ocean Technol R&D Ctr. Qingdao Boting Technol Co.Ltd.Shandong Hydrogen Times Marine Technology Co.Ltd.QingdaoP.R.China Depa.tment of Chemical and Biomolecular Engineering National University of SingaporeSingapore Joint School of National university of Singapore and Tianjin university International Campus of Tianjin UniversityBinhai New CityFuzhouP.R.China

Atomically precise metal nanoclusters(MNCs),as a potential type of photoacoustic(pa.contrast agent,are limited in application due to their low pa.conversion efficiency(pa.E).Here,with hydrophilic Au25SR18(SR=thiolate)as model NCs,we present a result that weakly polar solvent induces aggregation,which effectively enhances pa.intensity and *** pa.intensity and pa.E are highly dependent on the degree of aggregation,while the aggregation-enhanced pa.intensity(AEpa.positively correlates to the protected *** an AEpa.phenomenon indicates that aggregation actually accelerates the intramolecular motion of Au NCs,and enlarges the proportion of excited state energy dissipa.ed through vibrational *** result conflicts with the restriction of intramolecular motion mechanism of aggregation-induced *** experiments show that the increased energy of AEpa.originates from the aggregation inhibiting the intermolecular energy transfer from excited Au NCs to their surrounding medium molecules,including solvent molecule and dissolved oxygen,rather than restricting radiative *** study develops a new strategy for enhancing the pa.intensity of Au NCs,and contributes to a deeper understanding of the origin of the pa.signal and the excited state energy dissipa.ion processes for MNCs.

关键词： aggregation-enhanced photoacoustic gold nanocluster intermolecular excited state energy transfer intramolecular motion ligand effect

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Bioinspired coacervate-based bioinks for construction of multiscale tissue engineering scaffolds

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Nano Research 2024年第9期17卷 8209-8219页

作者： Zhongwei Guo Shiqiang Zhang Yilin Guo Jingjing xia xiao Wu Hao Hu Rongcheng Hu Fangli Huang Qiulei Gao Chun Liu Jingjiang Qiu Wei Sun School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Depa.tment of Mechanical Engineering and Mechanics Tsinghua UniversityBeijing 100084China Precision Medicine Institute Guangdong Provincial Key Laboratory of Orthopedics and TraumatologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Depa.tment of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA

Engineering hydrogels that resemble biological tissues of various lengths via conventional fabrication techniques remains ***-dimensional(3D)bioprinting has emerged as an advanced approach for constructing complex biomimetic 3D architectures,which are currently restricted by the limited number of available bioinks with high printability,biomimicry,biocompa.ibility,and proper mechanical *** by ubiquitous coacervation phenomena in biology,we present a unique mineral-biopolymer coacervation strategy that enables the hierarchical assembly of nanoclay and recombinant human collagen(RHC).This system was observed to undergo a coacervation transition(liquid‒liquid phase sepa.ation)*** formed dense phase sepa.ated from its supernatant is the coacervate of clay-RHC-rich complexes,where polymer chains are sandwiched between silicate *** dynamics simulation was first used to verify and explore the coacervation ***,the coacervates were demonstrated to be potential bioinks that exhibited excellent self-supporting and shear-thinning viscoelastic *** extrusion-based printing,the versatility of the bioink was demonstrated by reconstructing the key features of several biological tissues,including multilayered lattice,vascular,nose,and ear-like structures,without the need for precrosslinking operations or support ***,the printed scaffolds were cytocompa.ible,elicited minimal inflammatory responses,and promoted bone regeneration in calvarial defects.

关键词： bioinks coacervation mineral-biopolymer nanoclay tissue engineering scaffold

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Correlation between postoperative chemotherapy regimen and survival in pa.ients with resectable gastric adenocarcinoma accompa.ied with vascular cancer thrombus

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1618-1628页

作者： Ze-Feng Yang Zhuan-xia Dong Chen-Jie Dai Li-Zheng Fu Hong-Mei Yu Yu-Sheng Wang Depa.tment of Health Statistics School of Public HealthShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Medical university Taiyuan 030001Shanxi ProvinceChina Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment Taiyuan 030001Shanxi ProvinceChina MOE Key Laboratory of Coal Environmental pa.hogenicity and Prevention Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Depa.tment of Oncology Digestive The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Depa.tment of Digestive Oncology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROunD pa.ients with resectable gastric adenocarcinoma accompa.ied by vascular cancer thrombus(RGAVCT)have a poor prognosis,with a 5-year survival rate ranging from 18.42%-53.57%.These pa.ients need a reasonable postoperative treatment plan to improve their *** To determine the most effective postoperative chemotherapy regimen for pa.ients with *** We retrospectively collected the clinicopa.hological data of 530 pa.ients who un-derwent radical resection for gastric cancer between January 2017 and January 2022 and who were pa.hologically diagnosed with gastric adenocarcinoma with a choroidal cancer ***-thermore,we identified the high-risk variables that can influence the prognosis of pa.ients with RGAVCT by asse-ssing the clinical and pa.hological features of the pa.ients who met the inclusion *** also assessed the significance of survival outcomes using Mantel-Cox univariate and multivariate *** subgroups of pa.tients with stages Ⅰ,Ⅱ,and Ⅲ disease who received single-,dual-,or triple-drug regimens following surgery were analyzed using SPSS 25.0 and the ggplot2 pa.kage in R *** In all,530 eligible individuals with RGAVCT were enrolled in this *** median overall survival(OS)of pa.ients with RGAVCT was 24 months,and the survival rates were 80.2%,62.5%,and 42.3%at 12,24,and 59 months,*** complications,tumor size,T stage,and postoperative chemotherapy were identified as independent factors that influenced OS in pa.ients with RGAVCT according to the Cox multivariate analysis model.A Kaplan-Meier analysis revealed that chemotherapy had no effect on OS of pa.ients with stage Ⅰ or Ⅱ RGAVCT;however,chemotherapy did have an effect on OS of stage Ⅲ *** Ⅲ pa.ients who were treated with chemotherapy consisting of dual-or triple-agent regimens had better survival than those treated with single-agent regimens,and no significant difference was observed in the survival of pa.ients treat

关键词： Vascular cancer embolism Postoperative chemotherapy regimen Gastric adenocarcinoma Risk factors Survival

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Mechanism of pa.hymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du Jian-Jun Zhao xia Li Shi-Cong Huang Na Ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROunD pa.hymic acid(pa.is derived from Poria *** has a variety of pharmacological and inhibitory effects on various ***,the mechanism of action of pa.in gastric cancer(GC)remains *** To investigate the mechanism of pa.in treating GC via the combination of network pharmacology and experimental *** The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the pa.*** the STRING database,a protein-protein interaction network was constructed and core targets were *** analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core ***,the network pharmacology findings were validated through in vitro cell assays,encompa.sing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot *** According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pa.hway is likely to be the mechanism by which pa.effectively treats GC,according to KEGG enrichment *** experimental findings showed that pa.could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pa.se the cell *** Network pharmacology demonstrated that pa.could treat GC by controlling a variety of signaling pa.hways and acting on a variety of *** has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： pa.hymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

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中国省域经济韧性与生态效率测度及其协同演化分析

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干旱区地理 2024年第2期47卷 319-331页

作者：周霞王佳北京建筑大学城市经济与管理学院北京100044

统筹经济韧性与生态效率间的动态平衡关系是实现区域可持续发展的重要抓手。以中国30个省份为研究对象,采用组合权重模型、全局非期望超效率SBM模型分别测度国内省级区域适应性循环理论与驱动-压力-状态-响应(DPSR)模型分析框架下的经... 详细信息

统筹经济韧性与生态效率间的动态平衡关系是实现区域可持续发展的重要抓手。以中国30个省份为研究对象,采用组合权重模型、全局非期望超效率SBM模型分别测度国内省级区域适应性循环理论与驱动-压力-状态-响应(DPSR)模型分析框架下的经济韧性、投入产出理论下的生态效率,并通过改进的哈肯模型刻画经济韧性与生态效率间的协同演化特征。结果表明:(1)经济韧性能力在样本观测期内显著上升,区域差异明显扩张,南北区域发展不平衡,存在一定的“东-中-东北-西”阶梯效应。(2)生态效率水平总体呈下降的趋势,区域差异历经“扩张-缩小-再扩张”变化,存在显著性阶梯失衡现象,空间呈“沿海-内陆”递减分布。(3)经济韧性与生态效率的协同演化历经稳定、下降及稳定三阶段,区域间基本不存在阶梯性失衡现象,经济韧性作为协同演化的序参量,主导区域可持续发展。

关键词：经济韧性生态效率协同演化全局非期望超效率SBM模型中国

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Early proactive monitoring of DNA-thioguanine in pa.ients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang Kang Chao xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao pa. Li Shao-Xing Guan Wen Xie xiang Gao Min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Depa.tment of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Depa.tment of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Depa.tment of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROunD Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in pa.ients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte countpa.ients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** pa.ients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

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High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Depa.tment of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Depa.tment of Biomedical Engineering Duke UniversityDurhamNCUSA Depa.tment of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Depa.tment of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Depa.tment of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Depa.tment of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in sepa.ating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(pa.ticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to sepa.ate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize sepa.ating

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基于遥感技术和机器学习的城市街区PM_(2.5)空间分布特征研究——以合肥市滨湖新区为例

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生态环境学报 2024年第9期33卷 1426-1437页

作者：王薇夏宇轩合肥工业大学建筑与艺术学院安徽合肥230601 徽州古村落数字化保护与传承创意安徽省重点实验室安徽合肥230601 合肥城市学院安徽合肥238076

为获取合肥市滨湖新区地面PM_(2.5)浓度,利用地面风速对2022年7月31日-2023年7月31日MODIS传感器MCD19A2数据进行风速订正,并与同期气象数据和合肥市10个国控监测站点的PM_(2.5)数据建立AOD-PM_(2.5)反演模型。结果表明:BP网络训练到第1... 详细信息

为获取合肥市滨湖新区地面PM_(2.5)浓度,利用地面风速对2022年7月31日-2023年7月31日MODIS传感器MCD19A2数据进行风速订正,并与同期气象数据和合肥市10个国控监测站点的PM_(2.5)数据建立AOD-PM_(2.5)反演模型。结果表明:BP网络训练到第10代时训练结果最为理想,均方误差MSE值约为0.027。训练集、验证集、测试集和总体结果回归值r均在0.88以上,总体结果高达0.93。通过BP预测工具箱建立模型,拟合优度达到0.807。选择滨湖新区7个典型测点,测量2023年7月12-16日每日平均PM_(2.5)浓度、地面风速和温湿度,结合气象数据代入反演模型对比发现,估算值和实测值曲线高度吻合,证明该模型可用于反演滨湖新区地面PM_(2.5)浓度。对PM_(2.5)浓度进行估算和分析,结果表明:1)滨湖新区西南侧PM_(2.5)浓度最高,东南侧最低;2)功能区PM_(2.5)浓度呈现为工业区>商业区>居住区>生态园区;3)工业园区废弃物的排放会导致PM_(2.5)浓度升高,对工厂设备的优化使用以及合理处理生产过程中的废弃物可降低PM_(2.5)浓度;4)商业区和居住区中的尾气排放、扬尘、工业排风等均会导致PM_(2.5)浓度升高,优化交通组织,推动新能源汽车的发展可降低PM_(2.5)浓度;5)产业园区的发展模式对城市PM_(2.5)浓度有显著影响,加快产业结构调整,推动产业绿色技术创新可降低PM_(2.5)浓度;6)城市绿地空间对PM_(2.5)有显著调节作用,增加绿地空间连通度、聚集度,加强大型绿地建设可发挥较强的PM_(2.5)消减作用。该研究所建立的AOD-PM_(2.5)反演模型旨在为城市街区PM_(2.5)空间分布特征研究提供可靠方法,具有重要的实践意义。

关键词：遥感技术 PM_(2.5) 气溶胶城市街区风速订正空间分布机器学习

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