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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia liu xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Numerical simulations for radon migration and exhalation behavior during measuring radon exhalation rate with closed-loop method

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Nuclear Science and Techniques 2024年第1期35卷 81-95页

作者： Ming xia Yong-Jun Ye Shu-Yuan liu School of Resources Environment and Safety Engineering University of South ChinaHengyang 421001China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001China

Accurate measurements of the radon exhalation rate help identify and evaluate radon risk regions in the *** these measurement methods,the closed-loop method is frequently ***,traditional experiments are insufficient or cannot analyze the radon migration and exhalation patterns at the gas–solid interface in the accumulation *** CFD-based technique was applied to predict the radon concentration distribution in a limited space,allowing radon accumulation and exhalation inside the chamber intuitively and *** this study,three radon exhalation rates were defined,and two structural ventilation tubes were designed for the *** consistency of the simulated results with the variation in the radon exhalation rate in a previous experiment or analytical solution was *** effects of the vent tube structure and flow rate on the radon uniformity in the chamber;permeability,insertion depth,and flow rate on the radon exhalation rate and the effective diffusion coefficient on back-diffusion were *** on the results,increasing the inser-tion depth from 1 to 5 cm decreased the effective decay constant by 19.55%,whereas the curve-fitted radon exhalation rate decreased(lower than the initial value)as the deviation from the initial value increased by approximately 7%.Increasing the effective diffusion coefficient from 2.77×10^(-7) to 7.77×10^(-6) m^(2) s^(-1) made the deviation expand from 2.14 to 15.96%.The conclusion is that an increased insertion depth helps reduce leakage in the chamber,subject to notable back-diffusion,and that the closed-loop method is reasonably used for porous media with a low effective diffusion coefficient in view of the back-diffusion *** CFD-based simulation is expected to provide guidance for the optimization of the radon exhalation rate measurement method and,thus,the accurate measurement of the radon exhalation rate.

关键词： Radon exhalation Numerical simulation Accumulation chamber

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BCCLR:A Skeleton-Based Action Recognition with Graph Convolutional Network Combining Behavior Dependence and Context Clues

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Computers, Materials & Continua 2024年第3期78卷 4489-4507页

作者： Yunhe Wang Yuxin xia Shuai liu College of Information Science and Engineering Institute of Interdisciplinary StudiesHunan Normal UniversityChangsha410081China School of Educational Sciences Institute of Interdisciplinary StudiesHunan Normal UniversityChangsha410081China

In recent years,skeleton-based action recognition has made great achievements in Computer Vision.A graph convolutional network(GCN)is effective for action recognition,modelling the human skeleton as a spatio-temporal *** GCNs define the graph topology by physical relations of the human ***,this predefined graph ignores the spatial relationship between non-adjacent joint pairs in special actions and the behavior dependence between joint pairs,resulting in a low recognition rate for specific actions with implicit correlation between joint *** addition,existing methods ignore the trend correlation between adjacent frames within an action and context clues,leading to erroneous action recognition with similar ***,this study proposes a learnable GCN based on behavior dependence,which considers implicit joint correlation by constructing a dynamic learnable graph with extraction of specific behavior dependence of joint *** using the weight relationship between the joint pairs,an adaptive model is *** also designs a self-attention module to obtain their inter-frame topological relationship for exploring the context of *** the shared topology and the multi-head self-attention map,the module obtains the context-based clue topology to update the dynamic graph convolution,achieving accurate recognition of different actions with similar *** experiments on public datasets demonstrate that the proposed method achieves better results and realizes higher quality representation of actions under various evaluation protocols compared to state-of-the-art methods.

关键词： Action recognition deep learning GCN behavior dependence context clue self-attention

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Interface engineering via molecules/ions/groups for electrocatalytic water splitting

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Nano Research 2024年第9期17卷 7864-7879页

作者： Defang Ding Youwen liu Fan xia Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430074China State Key Laboratory of Materials Processing and Die&Mould Technology and School of Materials Science and Engineering Huazhong University of Science and Technology WuhanHubei 430074China

The electrochemical water splitting to produce hydrogen converts electric energy into clean hydrogen energy,which is a groundbreaking concept of energy *** achieve high efficiency,numerous strategies have been developed to enhance the performance of *** these,interface engineering with molecules/ions/groups,serves as a versatile approach for optimizing the performance of electrocatalysts in water *** the basis of numerous achievements in high-performance electrocatalysts engineered through molecules/ions/groups at interface,a comprehensive understanding of these advancements is crucial for guiding future ***,after providing a concise overview of the background,the interface engineering via molecules/ions/groups for electrocatalytic water splitting is demonstrated from three ***,the engineering of electronic state of electrocatalysts by molecules/ions/groups at interface to reduce the Gibbs free energy of the corresponding ***,the modification of local microenvironment surrounding electrocatalysts via molecules/ions/groups at interface to enhance the transfer of reactants and ***,the protection of electrocatalysts with molecule/ion/group fences improves their durability,including protecting active sites from leaching and defending them against harmful *** fundamental principles of these three aspects are outlined for each,along with pertinent ***,several research directions and challenges are proposed.

关键词： electrocatalyst water splitting interface engineering molecules/ions/groups

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A dynamical neural network approach for distributionally robust chance-constrained Markov decision process

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Science China Mathematics 2024年第6期67卷 1395-1418页

作者： Tian xia Jia liu Zhiping Chen School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049China

In this paper,we study the distributionally robust joint chance-constrained Markov decision *** the logarithmic transformation technique,we derive its deterministic reformulation with bi-convex terms under the moment-based uncertainty *** cope with the non-convexity and improve the robustness of the solution,we propose a dynamical neural network approach to solve the reformulated optimization *** results on a machine replacement problem demonstrate the efficiency of the proposed dynamical neural network approach when compared with the sequential convex approximation approach.

关键词： Markov decision process chance constraints distributionally robust optimization moment-based ambiguity set dynamical neural network

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Trotter–Kato Approximations of Impulsive Neutral SPDEs in Hilbert Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1229-1243页

作者： Ming liu xia ZHANG Ling Fei DAI School of Mathematical Sciences Tiangong UniversityTianjin 300387P.R.China

This paper studies a class of impulsive neutral stochastic partial differential equations in real Hilbert *** main goal here is to consider the Trotter-Kato approximations of mild solutions of such equations in the pth-mean(p≥2).As an application,a classical limit theorem on the dependence of such equations on a parameter is *** novelty of this paper is that the combination of this approximating system and such equations has not been considered before.

关键词： Impulsive neutral stochastic partial diferential equation Trotter-Kato approximations classical limit theorem

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Robust boundary-induced bulk propagations in elastic waveguides with nonplanar surfaces

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 88-96页

作者： Baizhan xia Jielong Zhang Zihan Jiang Jianting liu State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Trivial elastic waveguides induced by line defects and nontrivial elastic waveguides protected by topological edge states have been extensively examined in planar waveguide *** these investigations,little is known about topologically protected bulk states and their resulting robust transmission properties,especially in nonplanar elastic waveguides with folded,curved,and twisted *** Dirac waveguides with robust boundary-induced bulk states are *** states arise from the truncated boundaries of bulks with linear Dirac conical dispersions,differing from topologically protected edge states ensured by the bulk-edge *** proof is provided,in which boundary-induced bulk states show robustly high-throughput transmissions along the waveguides,even with folded,curved,and twisted *** results not only open up new avenues for examining novel topological phenomena about bulk but also offer new platforms for developing topological devices with nonplanar surfaces.

关键词： elastic waveguides boundary-induced bulk propagations Dirac conical dispersions nonplanar surfaces

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Joint Optimization of Trajectory and Task Offloading for Cellular-Connected Multi-UAV Mobile Edge Computing

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Chinese Journal of Electronics 2024年第3期33卷 823-832页

作者： Jingming xia Yufeng liu Ling TAN School of Artificial Intelligence Nanjing University of Information Science and Technology Engineering Research Center of Digital Forensics Ministry of Education Nanjing University of Information Science and Technology

Since the computing capacity and battery energy of unmanned aerial vehicle(UAV) are constrained,UAV as aerial user is hard to handle the high computational complexity and time-sensitive *** paper investigates a cellular-connected multi-UAV network supported by mobile edge *** UAVs carrying tasks fly from a given initial position to a termination position within a specified *** handle the large number of tasks carried by UAVs,we propose a energy cost of all UAVs based problem to determine how many tasks should be offloaded to high-altitude balloons(HABs) for computing,where UAV-HAB association,the trajectory of UAV,and calculation task splitting are jointly ***,the formulated problem has nonconvex ***,an efficient iterative algorithm by applying successive convex approximation and the block coordinate descent methods is put ***,in each iteration,the UAV-HAB association,calculation task splitting,and UAV trajectory are alternately ***,for the nonconvex UAV trajectory optimization problem,an approximate convex optimization problem is *** numerical results indicate that the scheme of this paper proposed is guaranteed to converge and also significantly reduces the entire power consumption of all UAVs compared to the benchmark schemes.

关键词： Energy consumption Multi-access edge computing Costs Power demand Autonomous aerial vehicles Iterative algorithms Convex functions

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TaSRO1 interacts with TaVP1 to modulate seed dormancy and pre-harvest sprouting resistance in wheat

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Journal of Integrative Plant Biology 2024年第1期66卷 36-53页

作者： Shupeng liu Li Li Wenlong Wang Guangmin xia Shuwei liu Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life ScienceShandong UniversityQingdao 266237China

Dormancy is an adaptive trait which prevents seeds from germinating under unfavorable environmental *** with weak dormancy undergo pre-harvest sprouting(PHS)which decreases grain yield and *** the genetic mechanisms that regulate seed dormancy and resistance to PHS is crucial for ensuring global food *** this study,we illustrated the function and molecular mechanism of TaSRO1 in the regulation of seed dormancy and PHS resistance by suppressing *** tasro1 mutants exhibited strong seed dormancy and enhanced resistance to PHS,whereas the mutants of tavp1 displayed weak *** evidence has shown that TaVP1 is epistatic to *** evidence has shown that TaSRO1 interacts with TaVP1 and represses the transcriptional activation of the PHS resistance genes TaPHS1 and ***,TaSRO1 undermines the synergistic activation of TaVP1 and TaABI5 in PHS resistance ***,we highlight the great potential of tasro1 alleles for breeding elite wheat cultivars that are resistant to PHS.

关键词： wheat seed dormancy pre-harvest sprouting(PHS) ABA signaling vivipary

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A NEW GLOBAL OPTIMIZATION ALGORITHM FOR MIXED-INTEGER QUADRATICALLY CONSTRAINED QUADRATIC FRACTIONAL PROGRAMMING PROBLEM

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Journal of Computational Mathematics 2024年第3期42卷 784-813页

作者： Bo Zhang Yuelin Gao xia liu xiaoli Huang School of Civil and Hydraulic Engineering School of Mathematics and StatisticsNingxia UniversityYinchuan 750021China School of Mathematics and Information Science North Minzu UniversityYinchuan 750021China Ningxia Province Key Laboratory of Intelligent Information and Data Processing Yinchuan 750021China School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China

The mixed-integer quadratically constrained quadratic fractional programming(MIQCQFP)problem often appears in various fields such as engineering practice,management science and network ***,most of the solutions to such problems are often designed for their unique *** paper puts forward a new global optimization algorithm for solving the problem *** first convert the MIQCQFP into an equivalent generalized bilinear fractional programming(EIGBFP)problem with integer ***,we linearly underestimate and linearly overestimate the quadratic functions in the numerator and the denominator respectively,and then give a linear fractional relaxation technique for EIGBFP on the basis of non-negative *** that,combining rectangular adjustment-segmentation technique and midpointsampling strategy with the branch-and-bound procedure,an efficient algorithm for solving MIQCQFP globally is ***,a series of test problems are given to illustrate the effectiveness,feasibility and other performance of this algorithm.

关键词： Global optimization Branch and bound Quadratic fractional programming Mixed integer programming

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