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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANg xia LIU xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(gRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(Pgnificantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, gRP78 and cleaved-caspase-4 expressions(Pgnificantly promoted cell proliferation and reduced apoptosis(Pg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and gRP78 protein expressions(Pggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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A meta-analysis on the clinical efficacy of fire dragon cupping in the treatment of lumbar disc herniation

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Integrative Medicine Discovery 2024年第11期8卷 1-7页

作者： Hai-xia ma Dan ma Bin Lin Juan-xia Zheng Department of Rehabilitation Shenzhen Bao’an Traditional Chinese Medicine HospitalGuangzhou University of Chinese MedicineShenzhen 518000China Department of Rheumatology and Immunology Shenzhen University Affiliated South China HospitalShenzhen 518000China Department of Nutrition Shenzhen Hospital of Southern Medical UniversityShenzhen 518000China.

Background:The incidence of lumbar disc herniation(LDH)is notably *** among experts highlights non-surgical treatments as the primary therapeutic approach for *** medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse *** use can severely impair the liver and kidney functions of ***,the role of safe and effective traditional Chinese medicine techniques becomes *** various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing ***,there is a scarcity of systematic and standardised evidence from evidence-based medicine ***,conducting a meta-analysis is ***:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and *** search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December *** researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising Revman 5.3 software for ***:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),Pgon cupping therapy significantly alleviates LDH,warranting its extensive ***,consid

关键词： fire dragon cupping therapy lumbar disc herniation lumbar spine meta-analysis randomized controlled trial

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Examining the association between delay discounting,delay aversion and physical activity in Chinese adults with type-2 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 675-685页

作者： Yong-Dong An guo-xia ma Xing-Kui Cai Ying Yang Fang Wang Zhan-Lin Zhang Department of Endocrinology People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina Department of gynecology People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina The First Clinical Medical College Lanzhou UniversityLanzhou 730013Gansu ProvinceChina Department of Internal Medicine People's Hospital of HezhengLinxia Hui Autonomous Prefecture 731200Gansu ProvinceChina Department of geratology People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina Department of Medical People's Hospital of Linxia Hui Autonomous PrefectureLinxia Hui Autonomous Prefecture 731100Gansu ProvinceChina

BACKgROUND The role of physical activity in diabetes is critical,influencing this disease's development,man-agement,and overall *** China,22.3%of adults do not meet the minimum level of physical activity recommended by the World Health ***,it is imperative to identify the factors that contributing to lack of physical activity must be *** To investigate the relationship among delay discounting,delay aversion,glycated hemoglobin(HbA1c),and various levels of physical activity in Chinese adults diagnosed with type 2 diabetes mellitus(T2DM).METHODS In 2023,400 adults with T2DM were recruited from the People's Hospital of Linxia Hui Autonomous Prefecture of gansu Province.A face-to-face questionnaire was used to gather demographic data and details on physical activity,delay discounting,and delay *** addition,HbA1c levels were measured in all 400 *** primary independent variables considered were delay discounting and delay *** outcome variables included HbA1c levels and different intensity levels of physical activity,including walking,moderate physical activity,and vigorous physical *** linear regression models were utilized to assess the relationship between delay discounting,delay aversion,and HbA1c levels,along with the intensity of different physical activity measured in met-hours per *** After controlling for the sample characteristics,delay discounting was negatively associated with moderate physical activity(β=-2.386,95%CI:-4.370 to-0.401).Meanwhile,delay aversion was negatively associated with the level of moderate physical activity(β=-3.527,95%CI:-5.578 to-1.476)in the multiple linear regression model,with statistically significant *** Elevated delay discounting and increased delay aversion correlated with reduced levels of moderate physical *** suggests that delay discounting and aversion may influence engagement in moderate physical activity.

关键词： Type 2 diabetes mellitus Delay discounting Delay aversion Physical activity

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Camellia sinensis CsMYB4a participates in regulation of stamen growth by interaction with auxin signaling transduction repressor CsAUX/IAA4

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The Crop Journal 2024年第1期12卷 188-201页

作者： guoliang ma Mingzhuo Li Yingling Wu Changjuan Jiang Yifan Chen Dawei Xing Yue Zhao Yajun Liu xiaolan Jiang Tao xia Liping gao School of Life Science Anhui Agricultural UniversityHefei 230036AnhuiChina Plant for Human Health Institute Department of Plant and Microbial BiologyNorth Carolina State UniversityKannapolisNC 28081USA State Key Laboratory of Tea Plant Biology and Utilization/Key Laboratory of Tea Biology and Tea Processing of Ministry of Agriculture/Anhui Provincial Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefei 230036AnhuiChina

Subgroup 4(Sg4)members of the R2R3-MYB are generally known as negative regulators of the phenylpropanoid pathway in *** previous research showed that a R2R3-MYB Sg4 member from Camellia sinensis(CsMYB4a)inhibits expression of some genes in the phenylpropanoid pathway,but its physiological function in the tea plant remained ***,CsMYB4a was found to be highly expressed in anther and filaments,and participated in regulating filament *** analysis and exogenous auxin treatment showed that the target of CsMYB4a might be the auxin signal ***/indole-3-acetic acid 4(AUX/IAA4),a repressor in auxin signal transduction,was detected from a yeast two-hybrid screen using CsMYB4a as *** silencing assays showed that both CsIAA4 and CsMYB4a regulate filament *** plants overexpressing CsIAA4 were insensitive to exogenous a-NAA,consistent with overexpression of ***-protein interaction experiments revealed that CsMYB4a interacts with N-terminal of CsIAA4 to prevent CsIAA4 *** out of the endogenous NtIAA4 gene,a CsIAA4 homolog,in tobacco alleviated filament growth inhibition and a-NAA insensitivity in plants overexpressing *** results strongly suggest that CsMYB4a works synergistically with CsIAA4 and participates in regulation of the auxin pathway in stamen.

关键词： AUX/IAA4 Auxin signaling CsMYB4a Subgroup 4 R2R3-MYB

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Sequence-Controlled Synthesis of Alternating Poly(ester amide)s using Water as Control Agent in One-Pot

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Chinese Journal of Polymer Science 2024年第8期42卷 1015-1020页

作者： Tao Liu Fang-Fang Niu Kan Cheng Yu-Min xia Bo-Mou ma Xue-Li Wang Jian-Yong Yu Yong He State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Poly(ester amide)s(PEAs)attract much attention as a new kind of biodegradable ***,the synthesis of PEAs with sequence-regulated chain structures is still complicated due to the multistep polymerization,high monomer purity,as well as the usage of organic solvents,which greatly inhibits its development and ***,a one-pot strategy without solvent was developed to synthesize the alternating PEA fromα,ω-amino alcohol and dicarboxylic acid by sequential polycondensation,where water was used as the controlling agent for amidation and ***,the amidation and esterification were controlled to proceed in turn by adding or removing water,realizing the one-pot preparation of alternating *** resultant PEA is characterized by^1H-and^(13)C-NMR,and its chain structure is confirmed to be highly quasi-alternating similar to alternating PEAs prepared by classical methods The evaluations from DSC and Dma demonstrate that the properties of quasi-alternating PEA(T_(m)=102℃,ΔH_(m)=30J·g^(-1))are far superior to those of random PEA(T_(m)=72℃,ΔH_(m)g^(-1)).

关键词： Biodegradable macromolecules Polymer architectures Sequence-controlled synthesis One-pot polymerization

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A Pt/CeO_(2)Hybrid Nanozyme with Stable Peroxidase Activity for the Detection of Acetylcholine

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Chemical Research in Chinese Universities 2024年第2期40卷 268-271页

作者： CUI Xulian ma Baofu PAN Hui xia Yu LIU Li ZHAO Baofeng LIANg Zhen ZHANg Lihua ZHANg Yukui State Key Laboratory of Medical Proteomics Dalian Institute of Chemical PhysicsChinese Academy of ScienceDalian116023P.R.China The Research Center for Medical genomics Key Laboratory of Medical Cell BiologyMinistry of EducationSchool of Life ScienceChina Medical UniversityShenyang110001P.R.China River Fisheries Research Institute Chinese Academy of Fishery SciencesGuangzhou510000P.R.China

Acetylcholine(ACh)is a common neurotransmitterl)that is secreted by cholinergic neurons[2]and is found mainly in the peripheral and central nervous systems.[3]ACh transmits nerve signals from presynaptic to postsynapt... 详细信息

关键词： Acetylcholine/choline Nanozyme Hydrogen peroxide Alzheimer’s disease

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Proactive Caching at the Wireless Edge:A Novel Predictive User Popularity-Aware Approach

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1997-2017页

作者： Yunye Wan Peng Chen Yunni xia Yong ma Dongge Zhu Xu Wang Hui Liu Weiling Li xianhua Niu Lei Xu Yumin Dong College of Computer Science Chongqing UniversityChongqing400044China School of Computer and Software Engineering Xihua UniversityChengdu610039China School of Computer and Information Engineering Jiangxi Normal UniversityNanchang330022China Electric Power Research Institute of State grid Ningxia Electric Power Co. Ltd.Yinchuan750002China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China School of Computer Science and Technology Beijing Institute of TechnologyBeijing100083China School of Computer Science and Technology Dongguan University of TechnologyDongguan523808China School of Emergency management Xihua UniversityChengdu610039China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Mobile Edge Computing(MEC)is a promising technology that provides on-demand computing and efficient storage services as close to end users as *** an MEC environment,servers are deployed closer to mobile terminals to exploit storage infrastructure,improve content delivery efficiency,and enhance user ***,due to the limited capacity of edge servers,it remains a significant challenge to meet the changing,time-varying,and customized needs for highly diversified content of ***,techniques for caching content at the edge are becoming popular for addressing the above *** is capable of filling the communication gap between the users and content providers while relieving pressure on remote cloud ***,existing static caching strategies are still inefficient in handling the dynamics of the time-varying popularity of content and meeting users’demands for highly diversified entity *** address this challenge,we introduce a novel method for content caching over MEC,i.e.,*** synthesizes a content popularity prediction model,which takes users’stay time and their request traces as inputs,and a deep reinforcement learning model for yielding dynamic caching *** results demonstrate that PRIME,when tested upon the MovieLens 1M dataset for user request patterns and the Shanghai Telecom dataset for user mobility,outperforms its peers in terms of cache hit rates,transmission latency,and system cost.

关键词： Mobile edge computing content caching system average cost deep reinforcement learning collaborative mechanism

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An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood

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Microsystems & Nanoengineering 2024年第3期10卷 293-303页

作者： Zhehan ma Jianping xia Neil Upreti Emeraghi David Joseph Rufo Yuyang gu Kaichun Yang Shujie Yang xia.gchen Xu Jean Kwun Eileen Chambers Tony Jun Huang Thomas Lord Department of Mechanical Engineering and materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Pediatrics Duke UniversityDurhamNCUSA Duke Transplant Center Department of SurgeryDuke University School of MedicineDurhamNCUSA

Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research,medical diagnostics,and therapeutic *** protocols for plasma isolation require multiple centrifugation steps or multiunit microfluidic processing to sequentially remove large red blood cells(RBCs)and white blood cells(WBCs),followed by the removal of small ***,we present an acoustofluidic platform capable of efficiently removing RBCs,WBCs,and platelets from whole blood in a single *** leveraging differences in the acoustic impedances of fluids,our device generates significantly greater forces on suspended particles than conventional microfluidic approaches,enabling the removal of both large blood cells and smaller platelets in a single *** a result,undiluted human whole blood can be processed by our device to remove both blood cells and platelets(>90%)at low voltages(25 Vpp).The ability to successfully remove blood cells and platelets from plasma without altering the properties of the proteins and antibodies present creates numerous potential applications for our platform in biomedical research,as well as plasma-based diagnostics and ***,the microfluidic nature of our device offers advantages such as portability,cost efficiency,and the ability to process small-volume samples.

关键词： remove separation removing

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Identification of the lysine and histidine transporter family in Camellia sinensis and the characterizations in nitrogen utilization

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Horticultural Plant Journal 2024年第1期10卷 273-287页

作者： Wei Huang Danni ma Fawad Zaman Xulei Hao Li xia E Zhang Pu Wang Mingle Wang Fei guo Yu Wang Dejiang Ni Hua Zhao National Key Laboratory for germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhanHubei 430070China

In plants,the lysine and histidine transporter(LHT)family represent a class of proteins that mediate the uptake,translocation,and utilization of amino *** tea plant(Camellia sinensis)is a perennial evergreen with a relatively high level of amino ***,systematic identification and molecular characterization of the LHT gene family has rarely been reported in tea *** this study,22 CsLHTs were identified from the‘Shuchazao’genome and classified into two *** modeled three-dimensional structure and the conserved domains presented a high similarity among the LHTs ***,it was predicted that a few genes were conserved through the analysis of the physiochemical characters,structures and cis-elements in *** expression patterns in tea plants revealed that CsLHT7 was mainly expressed in the roots,and CsLHT4 and CsLHT11 exhibited relatively high expression in both the roots and ***,the expression of all three genes could be induced by organic ***,heterogeneous expression of CsLHT4,CsLHT7 and CsLHT11 in Arabidopsis thaliana decreased the aerial parts biomass compared with that in WT plants while significantly increased the rosette biomass only for CsLHT11transgenic plants versus WT ***,our results provide fundamental information about CsLHTs and potential genes in N utilization for further analysis in tea plants.

关键词： Camellia sinensis Nitrogen Lysine and histidine transporter(LHT)family

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A dual-beam piezo-magneto-elastic wake-induced vibration energy harvesting system for high-performance wind energy harvesting

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Science China(Technological Sciences) 2024年第1期67卷 221-239页

作者： ma xiaoQing ZHANg Hang maRgIELEWICZ Jerzy gĄSKA Damian WOLSZCZAK Piotr LITAK grzegorz ZHOU ShengXi School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute in Shenzhen Northwestern Polytechnical UniversityShenzhen 518057China Faculty of Transport and Aviation Engineering Silesian University of TechnologyKrasińskiego 8Katowice 40-019Poland Department of Automation Lublin University of TechnologyNadbystrzycka 36Lublin 20-618Poland

Wind-induced vibration energy harvesting has a great potential for utilizing wind energy to supply power for low-powered *** improve the working performance of energy harvesters effectively,a suitable structural design is *** paper proposes a dual-beam piezo-magneto-elastic wake-induced vibration energy harvesting system to enhance the functional performance of aeroelastic energy harvesters in environments with variable wind *** system contains two piezoelectric beams coupled by magnets(forming upstream and downstream energy harvesters),and each beam is attached with a foam cylinder.A corresponding dynamic model is provided,and output characteristics are obtained at different wind *** and experimental verification indicate that both upstream and downstream energy harvesters can realize efficient energy *** the wind speed exceeds a certain critical value,the amplitudes of the system’s displacement and voltage are *** wind speed threshold value is approximately 1.25 m/*** the wind speed and magnet spacing are 10.2 m/s and 20 mm,respectively,the output power of the system reaches 4.9×10^(−4)***,the wind speed threshold value of the proposed system can be adjusted by an equivalent nonlinear restoring force.

关键词： dual-beam structure piezoelectric energy harvester theoretical model nonlinear dynamics

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