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Predicting short-term major postoperative complications in intestinal resection for Crohn’s disease:A machine learning-based study

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World Journal of gastrointestinal Surgery 2024年第3期16卷 717-730页

作者： Fang-Tao Wang Yin Lin xiao-Qi Yuan Ren-Yuan gao xiao-Cai Wu Wei-Wei Xu Tian-Qi Wu Kai xia Yi-Ran Jiao Lu Yin Chun-qiu Chen Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKgROUND Due to the complexity and numerous comorbidities associated with Crohn’s disease(CD),the incidence of postoperative complications is high,significantly impacting the recovery and prognosis of ***,additional stu-dies are required to precisely predict short-term major complications following intestinal resection(IR),aiding surgical decision-making and optimizing patient *** To construct novel models based on machine learning(ML)to predict short-term major postoperative complications in patients with CD following *** A retrospective analysis was performed on clinical data derived from a patient cohort that underwent IR for CD from January 2017 to December *** study participants were randomly allocated to either a training cohort or a validation *** logistic regression and random forest(RF)were applied to construct models in the training cohort,with model discrimination evaluated using the area under the curves(AUC).The validation cohort assessed the performance of the constructed *** Out of the 259 patients encompassed in the study,5.0%encountered major postoperative complications(Clavien-Dindo≥III)within 30 d following IR for *** AUC for the logistic model was 0.916,significantly lower than the AUC of 0.965 for the RF *** logistic model incorporated a preoperative CD activity index(CDAI)of≥220,a diminished preoperative serum albumin level,conversion to laparotomy surgery,and an extended operation time.A nomogram for the logistic model was *** for the surgical approach,the other three variables ranked among the top four important variables in the novel ML *** Both the nomogram and RF exhibited good performance in predicting short-term major postoperative complic-ations in patients with CD,with the RF model showing more superiority.A preoperative CDAI of≥220,a di-minished preoperative serum albumin level,and an extended operation time might be the most crucial ***

关键词： Crohn’s disease Postoperative complications Nomogram Random forest Intestinal resection

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Neglected Mendelian causes of stroke in adult Chinese patients who had an ischaemic stroke or transient ischaemic attack

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Stroke & Vascular Neurology 2024年第3期9卷 194-201,I0001-I0103页

作者： Wei Li Hao Li Chaoxia Lu Jialu Zhao Huichun Xu Zhe Xu Braxton Mitchell Yong Jiang Hong-qiu gu Qin Xu Anxin Wang xia Meng Jinxi Lin Jing Jing Zixiao Li Wanlin Zhu Zhigang Liang Mengxing Wang Yongjun Wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Division of Endocrinology Diabetes and NutritionDepartment of MedicineUniversity of Maryland School of MedicineBaltimoreMarylandUSA Department of Neurology Qindao University Medical College Affiliated Yantai Yuhuangding HospitalYantaiShandongChina Clinical Center for Precision Medicine in Stroke Capital Medical UniversityBeijingChina

Background and purpose Multiple factors play important roles in the occurrence and prognosis of ***,the roles of monogenic variants in all-cause ischaemic stroke have not been systematically *** aim to identify underdiagnosed monogenic stroke in an adult ischaemic stroke/transient ischaemic attack(TIA)cohort(the Third China National Stroke Registry,CNSR-III).Methods Targeted next-generation sequencing for 181 genes associated with stroke was conducted on DNA samples from 10428 patients recruited through *** genetic and clinical data from electronic health records(EHRs)were reviewed for completion of the diagnostic *** assessed the percentages of individuals with pathogenic or likely pathogenic(P/LP)variants,and the diagnostic yield of pathogenic variants in known monogenic disease genes with associated *** In total,1953 individuals harboured at least one P/LP variant out of 10428 ***,792(7.6%)individuals(comprising 759 individuals harbouring one P/LP variant in one gene,29 individuals harbouring two or more P/LP variants in different genes and 4 individuals with two P/LP variants in ABCC6)were predicted to be at risk for one or more monogenic diseases based on the inheritance ***,230 of 792 individuals manifested a clinical phenotype in the EHR data to support the diagnosis of stroke with a monogenic *** most diagnosed Mendelian cause of stroke in the cohort was cerebral autosomal dominant arteriopathy with subcortical infarcts and *** were no relationships between age or family history and the incidence of first symptomatic monogenic stroke in *** The rate of monogenic cause of stroke was 2.2%after reviewing the clinical *** reasons that Mendelian causes of stroke may be missed in adult patients who had an ischaemic stroke/TIA include a late onset of stroke symptoms,combination with common vascular risks and the absence of a promine

关键词： patients transient likely

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农户生产性服务约束方式选择逻辑:来自生产风险与交易成本的考量

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农业技术经济 2024年第1期 111-126页

作者：李丹周宏夏秋南京林业大学经济管理学院南京210037 南京农业大学经济管理学院南京210095 南京财经大学国际经贸学院南京210023

服务约束行为是农户在农业生产性服务“委托—代理”问题下的理性反应。本文基于服务风险和交易成本视角,探讨了农户服务约束行为的驱动因素。研究发现:(1)为降低农业生产性服务过程中“委托—代理”问题所引致的生产风险,农户作为风险... 详细信息

服务约束行为是农户在农业生产性服务“委托—代理”问题下的理性反应。本文基于服务风险和交易成本视角,探讨了农户服务约束行为的驱动因素。研究发现:(1)为降低农业生产性服务过程中“委托—代理”问题所引致的生产风险,农户作为风险规避者,会通过一系列服务约束手段规范服务供给主体的作业行为,尤其是在生产风险较高的插秧、施肥和打药环节表现更为突出。(2)交易成本的高低是影响农户不同服务约束方式选择的主要因素,土地细碎化程度越高,服务合约缔造的交易成本越高,越不利于农户服务合约签订;农业劳动力质量越高,服务监督的机会成本就越高,会抑制农户服务监督行为的发生。(3)服务供给者来源与组织化程度对农户服务约束行为具有调节作用,服务供给者来源越熟悉且组织化程度越高,越能降低农户对生产风险的担忧,从而减少服务约束。由此,为抑制服务供给方“委托—代理”行为发生,建议在培养组织化、本土化的服务供给主体同时要探索构建服务供需双方的激励相容机制。

关键词：风险规避交易成本农业生产性服务约束

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The BCL-2 inhibitor APg-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

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Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan Luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen Feiteng Lu Miaozhen qiu Penghui Zhou Zengfei xia Kangmei Zeng Jianhua Zhan Ting Zhou qiuyun Luo Wentao Pan Lin Zhang Chaozhuo Lin Yan Huang Li Zhang Dajun Yang Hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T *** the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer *** found that the selective BCL-2 inhibitor APg-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse *** single-cell RNA sequencing,we found that APg-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy ***,we demonstrated that APg-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine *** a result,APg-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell *** immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on ***,these data provide evidence that further study on APg-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APg-2575 ICIs Macrophages NLRP3

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Experimental investigation of closed-loop active control to modulate coherent structures by mu-level method

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Chinese Physics B 2024年第7期33卷 408-417页

作者：白建侠范子椰姜楠李秋营郑小波 Department of Mathematics Tianjin Renai CollegeTianjin 301636China Institute of Mechanics Department of MechanicsSchool of Mechanical EngineeringTianjin UniversityTianjin 300354China College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Tianjin Key Laboratory of Modern Engineering Mechanics Tianjin 300354China

The experimental research on zero-net-mass-flux jet closed-loop active control was conducted in the wind *** mu-level method successfully detected burst events of the coherent structures. The streamwise velocity signals in the turbulent boundary layer were measured by HWA. The drag reduction rate of 16.7% is obtained comparable to that of the open-loop control and saves 75% of the input energy at the asynchronous 100 V/160 Hz control case, which reflects the advantages of the closed-loop control. The experimental findings indicate that the intensity increases in the near-wall *** perturbation of the PZT vibrators on the skewness factor is concentrated in the region y+generation of highspeed fluids is depressed and the downward effect of high-speed fluids weakens. The alteration of energy distribution and the discernible impact of modulation between structures of varying scales are observed. The correlation coefficient exhibits a strong positive correlation, which indicates that the large-scale structures produce modulation effect on small-scale *** occurrence of burst events is effectively suppressed. The disturbance has the characteristics of stable periodicity,positive and negative symmetry, low intermittency, and high pulsation strength. The conditional phase waveform shows that the fluctuation amplitude increases, indicating amplitude modulation effects on coherent structures.

关键词： turbulent boundary layer(TBL) burst event coherent structures mu-level method

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The activation of adenosine monophosphate–activated protein kinase inhibits the migration of tongue squamous cell carcinoma cells by targeting Claudin-1 via epithelial–mesenchymal transition

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Animal Models and Experimental Medicine 2024年第05期 606-616页

作者： Xin-Yue Zhou qiu-Ming Liu Zhuang Li xia-Yang Liu Qi-Wei Zhao Yu Wang Feng-Hua Wu gang Zhao Rui Sun xiao-Hong guo Department of Basic Medicine Hubei University of Chinese Medicine Hubei Shizhen Laboratory Sino-german Biomedical Center Hubei University of Technology Center of Applied Biotechnology Wuhan Institute of Bioengineering Department of Stomatology Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Tongji Shanxi Hospital Third Hospital of Shanxi Medical University Department of Oral and Maxillofacial Surgery Shanxi Provincial People's Hospital

Background: The role of Claudin-1 in tongue squamous cell carcinoma(TSCC) metastasis needs further clarification, particularly its impact on cell migration. Herein, our study aims to investigate the role of Claudin-1 in TSCC cell migration and its underlying ***: 36 TSCC tissue samples underwent immunohistochemical staining for Claudin-1. Western blotting and immunofluorescence analyses were conducted to evaluate Claudin-1 expression and distribution in TSCC cells. Claudin-1 knockdown cell lines were established using short hairpin RNA transfection. Migration effects were assessed through wound healing assays. Furthermore, the expression of EMTassociated molecules was measured via western ***: Claudin-1 expression decreased as TSCC malignancy increased. Adenosine monophosphate–activated protein kinase(AMPK) activation led to increased Claudin-1 expression and membrane translocation, inhibiting TSCC cell migration and epithelial–mesenchymal transition(EMT). Conversely, Claudin-1 knockdown reversed these inhibitory effects on migration and EMT caused by AMPK ***: Our results indicated that AMPK activation suppresses TSCC cell migration by targeting Claudin-1 and EMT pathways.

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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu qiu-Sha Huang Hai-xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang xiao-Jun Huang xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sgalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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Applications of deep learning for detecting ophthalmic diseases with ultrawide-field fundus

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 188-200页

作者： Qing-Qing Tang xia.g-gang Yang Hong-qiu Wang Da-Wen Wu Mei-xia Zhang Department of Ophthalmology and Research Laboratory of Macular Disease West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Hong Kong University of Science and Technology(guangzhou) Guangzhou 511400Guangdong ProvinceChina

AIM:To summarize the application of deep learning in detecting ophthalmic disease with ultrawide-field fundus images and analyze the advantages,limitations,and possible solutions common to all ***:We searched three academic databases,including PubMed,Web of Science,and Ovid,with the date of August *** matched and screened according to the target keywords and publication year and retrieved a total of 4358 research papers according to the keywords,of which 23 studies were retrieved on applying deep learning in diagnosing ophthalmic disease with ultrawide-field ***:Deep learning in ultrawide-field images can detect various ophthalmic diseases and achieve great performance,including diabetic retinopathy,glaucoma,age-related macular degeneration,retinal vein occlusions,retinal detachment,and other peripheral retinal *** to fundus images,the ultrawide-field fundus scanning laser ophthalmoscopy enables the capture of the ocular fundus up to 200°in a single exposure,which can observe more areas of the ***:The combination of ultrawide-field fundus images and artificial intelligence will achieve great performance in diagnosing multiple ophthalmic diseases in the future.

关键词： ultrawide-field fundus images deep learning disease diagnosis ophthalmic disease

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游戏化视角下博物馆重构观众关系的路径研究

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东南文化 2024年第4期 140-147页

作者：邓又溪柴秋霞复旦大学文物与博物馆学系上海200433

在数字时代,注意力资源走向短缺,博物馆与观众的关系已经超越了“以观众为中心”的指涉,需要重新定位与再组织。当前观众具有主动性更强、情绪需求更高和深度注意下降的特点,博物馆需借助游戏元素与激励机制,激发观众的主动参与意识,从... 详细信息

在数字时代,注意力资源走向短缺,博物馆与观众的关系已经超越了“以观众为中心”的指涉,需要重新定位与再组织。当前观众具有主动性更强、情绪需求更高和深度注意下降的特点,博物馆需借助游戏元素与激励机制,激发观众的主动参与意识,从吸引观众注意迈向引导观众自发求知。博物馆首先应明确以创造观众与观众、观众与空间的情感联结为游戏化目标,向知识守门者的实践角色演进,要加强把关和引导观众主动反馈,以多主体协作来进行游戏化实践。

关键词：博物馆数字时代观众注意力游戏化激励机制

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慢性淋巴细胞白血病中B细胞受体同型模式的生物学特征和临床意义

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中华血液学杂志 2024年第2期45卷 197-202页

作者：邱彤璐李建勇夏奕南京医科大学第一附属医院江苏省人民医院血液科南京医科大学血液研究重点实验室江苏省肿瘤个体化医学协同创新中心南京210029

慢性淋巴细胞白血病(CLL)是西方成人最常见的白血病,尽管CLL在亚洲人种中发病率偏低,但随着人口老龄化,CLL发病率在我国呈上升趋势。CLL细胞与微环境的交互中,B细胞受体免疫球蛋白(B-cell receptor immunoglobulin,BCR Ig)对抗原的识别... 详细信息

慢性淋巴细胞白血病(CLL)是西方成人最常见的白血病,尽管CLL在亚洲人种中发病率偏低,但随着人口老龄化,CLL发病率在我国呈上升趋势。CLL细胞与微环境的交互中,B细胞受体免疫球蛋白(B-cell receptor immunoglobulin,BCR Ig)对抗原的识别起重要作用,免疫球蛋白重链可变区(Ig heavy variable region,IgHV)的突变状态更是判断CLL预后的经典标志物。超过40%的CLL患者间存在IgHV的偏向性使用和高度相似的重链可变区互补决定区3(heavy complementarity-determining region 3,HCDR3)氨基酸片段,此现象称为同型模式BCR。不同亚群的同型模式BCR存在独特的生物学和临床特征。其中IgHV有突变但预后差的#2亚群和发生Richter转化风险高的#8亚群被欧洲CLL研究启动组推荐纳入IgHV突变状态的临床报告之中。本文综述CLL中同型模式BCR的定义、分布、生物学特征和临床意义。

关键词：慢性淋巴细胞白血病 B细胞受体互补决定区3 Richter 免疫球蛋白偏向性重链可变区临床报告

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