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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia.LIU xia.ZHAO juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Investigating Sulfur Chemistry in the HD163296 Disk

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Research in Astronomy and Astrophysics 2024年第7期24卷 215-225页

作者： rong Ma Donghui Quan Yan Zhou Jarken Esimbek Dalei Li xia.hu Li xia.Zhang juan Tuo Yanan Feng Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China BinZhou University Binzhou 256600China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China

Sulfur chemistry in the formation process of low-mass stars and planets remains poorly *** protoplanetary disks are the birthplace of planets and its distinctive environment provides an intriguing platform for investigating models of sulfur *** analyzed the Atacama Large Millimeter/submillimeter Array observations of CS 7-6 transitions in the HD 163296 disk and performed astrochemical modeling to explore its sulfur *** simulated the distribution of sulfur-containing molecules and compared it with observationally deduced fractional column *** have found that the simulated column density of CS is consistent with the observationally deduced fractional column densities,while the simulated column density of C_(2)S is lower than the observationally deduced upper limits on column *** results indicate that we have a good understanding of the chemical properties of CS and C_(2)S in the *** also investigated the influence of the C/O ratio on sulfur-containing molecules and found that the column densities of SO,SO_(2),and H_2S near the centra star are dependent on the C/O ***,we found that the N[CS]/N[SO]ratio can serve as a promising indicator of the disk’s C/O ratio in HD ***,the disk of HD 163296 provides a favorable environmen for the detection of sulfur-containing molecules.

关键词： Protoplanetary Disks-Astrochemistry-Molecular Processes

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Creep-Resistant Covalent Adaptable Networks with Excellent SelfHealing and Reprocessing Performance via Phase-Locked Dynamic Covalent Benzopyrazole-Urea Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1545-1556,I0013页

作者： Miao Xie xia.-rong Wang Zhan-Hua Wang He-Sheng xia State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu610065China School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun113001China

Covalent adaptive networks(CANs)are capable of undergoing segment rearrangement after being heated,which endows the materials with excellent self-healing and reprocessing performance,providing an efficient solution to the environment pollution caused by the plastic *** main challenge remains in developing CANs with both excellent reprocessing performance and creep-resistance *** this study,a series of CANs containing dynamic covalent benzopyrazole-urea bonds were developed based on the addition reaction between benzopyrazole and isocyanate *** calculation confirmed that relatively low dissociation energy is obtained through undergoing a five-member ring transition state,confirming excellent dynamic property of the benzopyrazole-urea *** verified by the FTIR results,this nice dynamic property can be well maintained after incorporating the benzopyrazole-urea bonds into polymer *** self-healing and reprocessing performance is observed by the 3-ABP/PDMS elastomers owing to the dynamic benzopyrazole-urea *** separation induced by the aggregation of the hard segments locked the benzopyrazole-urea bonds,which also makes the elastomers display excellent creep-resistance *** hard phase locking strategy provides an efficient approach to design CANs materials with both excellent reprocessing and creep-resistance performance.

关键词： Covalent adaptive networks Self-healing polymer Dynamic covalent bond

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Practical effect of different teaching modes in teaching gastrointestinal surgery nursing

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 166-172页

作者： xia.-juan rong Zhen Ning Department of Nursing Medical College in Jiangxi University of TechnologyNanchang 330098Jiangxi ProvinceChina

BACKGROUND With the continuous development and progress of medical technology,the position of surgical nursing in the field of clinical medicine is becoming in-creasingly *** an important branch of the surgical field,the nursing requirements and difficulty of gastrointestinal surgery are also *** order to improve the teaching quality of nursing care in gastrointestinal surgery,many educators and researchers are actively exploring new teaching *** them,the teaching method case-based learning(CBL),scene-simulated learning(SSL),task-based learning(TBL),combining self-evaluation and training mode is considered as an effective *** method aims to help students to better master knowledge and skills and improve their comprehensive quality by cultivating their self-evaluation *** To explore the practical effect of CBL-SSL-TBL combined with training mode and student self-assessment in nursing teaching of gastrointestinal *** Seventy-one nursing interns in our hospital from December 2020 to December 2021 were *** to different teaching modes,they were divided into observation group CBL-SSL-TBL combined with training mode combined with student self-assessment and control group(conventional teaching mode),of which 36 were in observation group and 35 were in control *** results of operational skills,theoretical knowledge,nursing students'satisfaction,learning effectiveness questionnaire and teaching effect were compared between the two *** Compared between the two groups,the operational skills and theoretical knowledge scores of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).Compared between the two groups,the total satisfaction ratio of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Compared between the two groups,the observation group was lower tha

关键词： Gastrointestinal surgery Nursing teaching Teaching model Practical effect Learning ability

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Surface iodine and pyrenyl-graphdiyne co-modified Bi catalysts for highly efficient CO_(2) electroreduction in acidic electrolyte

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Nano Research 2024年第4期17卷 2381-2387页

作者： Min Zhang juan Wang Xin rong Xiu-Li Lu Tong-Bu Lu MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

CO_(2) electroreduction to formic acid/formate would contribute to alleviating the energy and climate *** work reports a Bi-based catalyst derived from the in-situ electroreduction of Bi_(2)O_(2)CO_(3) modified with iodine and pyrenyl-graphdiyne(PGDY)on the surface for efficient electroreduction of CO_(2) in acidic electrolyte,with a high partial current density of 98.71 mA·cm^(-2) and high Faradaic efficiency(FE)>90%over the potential range from^(-1).2 to-1.5 V *** hydrogen electrode(RHE),as well as the long-term operational stability over 240 h without degradation in H-type *** results and density function theory calculations show that the synergistic effect of surface iodine and PGDY is responsible for this active and extremely stable process of CO_(2) electroreduction via lowering the energy barriers for formation of*OCHO intermediate,suppressing the competitive HER by enhancing the concentration of both K+and CO_(2) at reaction interface,as well as preventing the dissolution and re-deposition of active Bi atoms on surface during catalytic *** work provides new insight into designing highly active and stable electrocatalysts for CO_(2) reduction.

关键词： CO_(2) reduction electrocatalysis Bi-based catalysts acidic electrolyte

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Dynamic analysis of a latent HIV infection model with CTL immune and antibody responses

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International Journal of Biomathematics 2024年第3期17卷 289-316页

作者： Zhiqi Zhang Yuming Chen xia.Wang Libin rong School of Mathematics and Statistics Xinyang Normal University XinyangHenan 464000P.R.China Department of Mathematics Wilfrid Laurier University WaterlooONN2L 3C5Canada Department of Mathematics University of Florida GainesvilleFL 32611USA

This paper develops a mathematical model to investigate the Human Immunodeficiency Virus(HIV)infection *** model includes two transmission modes(cell-to-cell and cell-free),two adaptive immune responses(cytotoxic T-lymphocyte(CTL)and antibody),a saturated CTL immune response,and latent HIV *** existence and local stability of equilibria are fully characterized by four reproduction *** sensitivity analyses,we assess the partial rank correlation coefficients of these reproduction numbers and identify that the infection rate via cell-to-cell transmission,the number of new viruses produced by each infected cell during its life cycle,the clearance rate of free virions,and immune parameters have the greatest impact on the reproduction ***,we compare the effects of immune stimulation and cell-to-cell spread on the model's *** findings highlight the significance of adaptive immune responses in increasing the population of uninfected cells and reducing the numbers of latent cells,infected cells,and ***,cell-to-cell transmission is identified as a facilitator of HIV *** analytical and numerical results presented in this study contribute to a better understanding of HIV dynamics and can potentially aid in improving HIV management strategies.

关键词： HIV infection cell-to-cell transmission adaptive immune response latent infection local stability

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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG rong-rong SHAO Ming-yi FU Yu ZHAO Rui-xia.WANG Jing-wen FANG Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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Reconstruction of biomimetic ionic channels within covalent organic frameworks for ultrafast and selective uranyl capture

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Science China Chemistry 2024年第10期67卷 3423-3431页

作者： Cheng-rong Zhang xia.-juan Chen Cheng-Peng Niu Cheng Meng Shun-Mo Yi Xin Liu Jia-Xin Qi Qiu-xia.Luo Ru-Ping Liang Jian-Ding Qiu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China College of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

The efficient extraction of uranium,as the primary component of nuclear energy,holds significant *** inspiration from the charge interaction observed in biological ion channels,we encapsulated negatively charged polystyrene sulfonate(PSS)or sodium polystyrene carboxylate(PVBA)into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO)in-situ to alter the cavity environment of *** synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium *** negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions,thus creating a highly selective“uranium highway”.Additionally,introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with *** to charge-assisted migration and various interaction mechanisms,both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO *** adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption *** work presents a bionic adsorbent based on covalent organic frameworks(COFs)for the first time,overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture,opening up new avenues for designing multifunctional materials that mimic biological systems.

关键词： covalent organic frameworks Uranium biomimetic ion-channels adsorption

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A multifunctional shear apparatus for rocks subjected to true triaxia. stress and high temperature in real-time

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3524-3543页

作者： Jun Zhao xia.Ting Feng Jia-rong Wang Liang Hu Yue Guo Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

Deep engineering disasters,such as rockbursts and collapses,are more related to the shear slip of rock joints.A novel multifunctional device was developed to study the shear failure mechanism in *** this device,the complete shearedeformation process and long-term shear creep tests could be performed on rocks under constant normal stiffness(CNS)or constant normal loading(CNL)conditions in real-time at high temperature and true-triaxia. *** the research and development process,five key technologies were successfully broken through:(1)the ability to perform true-triaxia. compressioneshear loading tests on rock samples with high stiffness;(2)a shear box with ultra-low friction throughout the entire stress space of the rock sample during loading;(3)a control system capable of maintaining high stress for a long time and responding rapidly to the brittle fracture of a rock sample as well;(4)a refined ability to measure the volumetric deformation of rock samples subjected to true triaxia. shearing;and(5)a heating system capable of maintaining uniform heating of the rock sample over a long *** developing these technologies,loading under high true triaxia. stress conditions was *** apparatus has a maximum normal stiffness of 1000 GPa/m and a maximum operating temperature of 300*** differences in the surface temperature of the sample are constant to within5*** types of true triaxia. shear tests were conducted on homogeneous sandstone to verify that the apparatus has good performance and *** results show that temperature,lateral stress,normal stress and time influence the shear deformation,failure mode and strength of the *** novel apparatus can be reliably used to conduct true-triaxia. shear tests on rocks subjected to high temperatures and stress.

关键词： True-triaxia. shear apparatus Rocks Complete shear stressedeformation process Creep Real-time high-temperature

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Facile preparation of Fe/N-based biomass porous carbon composite towards enhancing the thermal decomposition of DAP-4

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Defence Technology（防务技术） 2024年第1期31卷 288-294页

作者： Er-hai An xia.-xia.Li Cun-juan Yu Ying-xin Tan Zi-jun Fan Qing-xia.Li Peng Deng Xiong Cao School of Environment and Safety Engineering North University of ChinaTaiyuan030051PR China College of Safety and Emergency Management Engineering Taiyuan University of Science and TechnologyTaiyuan030024PR China

Fe/N-based biomass porous carbon composite(Fe/N-p Carbon) was prepared by a facile high-temperature carbonization method from biomass,and the effect of Fe/N-p Carbon on the thermal decomposition of energetic molecular perovskite-based material DAP-4 was *** porous carbonaceous materials was considered as the micro/nano support layers for in situ deposition of Fe/N ***/Np Carbon was prepared simply by the high-temperature carbonization *** was found that it showed the inherent catalysis properties for thermal decomposition of *** heat release of DAP-4/Fe/N-p Carbon by DSC curves tested had increased slightly,compared from DAP-4/Fe/N-p *** decomposition temperature peak of DAP-4 at the presence of Fe/N-p Carbon had reduced by 79°C from384.4°C(pure DAP-4) to 305.4°C(DAP-4/Fe/N-p Carbon-3).The apparent activation energy of DAP-4thermal decomposition also had decreased by 29.1 J/*** possible catalytic decomposition mechanism of DAP-4 with Fe/N-p Carbon was proposed.

关键词： Biomass materials Porous carbon DAP-4 Thermal decomposition Facile method

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