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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu xia.gbing Wu Wei Wu Ying Wang Yan Sun Lingxia. Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying ding Yongzhi xia.George Smith Rui Li Nai-Kui Liu xia.-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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面向工业过程的图像生成及其应用研究综述

自动化学报 2024年第2期50卷 211-240页

作者：汤健郭海涛夏恒王鼎乔俊飞北京工业大学信息学部北京100124 北京工业大学智慧环保北京实验室北京100124 北京工业大学智能感知与自主控制教育部工程研究中心北京100124

在面向工业过程的计算机视觉研究中,智能感知模型能否实际应用取决于其对复杂工业环境的适应能力.由于可利用的工业图像数据集存在分布不均、多样性不足和干扰严重等问题,如何生成符合多工况分布的期望训练集是提高感知模型性能的关键.... 详细信息

在面向工业过程的计算机视觉研究中,智能感知模型能否实际应用取决于其对复杂工业环境的适应能力.由于可利用的工业图像数据集存在分布不均、多样性不足和干扰严重等问题,如何生成符合多工况分布的期望训练集是提高感知模型性能的关键.为解决上述问题,以城市固废焚烧(Municipal solid wastes incineration, MSWI)过程为背景,综述目前面向工业过程的图像生成及其应用研究,为进行面向工业图像的感知建模提供支撑.首先,梳理面向工业过程的图像生成定义和流程以及其应用需求;随后,分析在工业领域中具有潜在应用价值的图像生成算法;接着,从工业过程图像生成、生成图像评估和应用等视角进行现状综述;然后,对下一步研究方向进行讨论与分析;最后,对全文进行总结并指出未来挑战.

关键词：工业过程视觉感知图像生成生成图像评估与应用城市固废焚烧

多样化视域下高校分类发展的现实阻滞与突破进路

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黑龙江高教研究 2024年第3期42卷 33-38页

作者：丁焕霞牛利华东北师范大学吉林长春130024

形成科学合理的高校分类发展格局是建设高等教育强国的关键,多样化作为高校分类发展的理性选择,不断为高校分类发展赋能。当前,我国高校分类发展呈现多样化匮乏的现实样态,“攀高求全”与“尚名逐利”的外部表现形式以及人才培养模式与... 详细信息

形成科学合理的高校分类发展格局是建设高等教育强国的关键,多样化作为高校分类发展的理性选择,不断为高校分类发展赋能。当前,我国高校分类发展呈现多样化匮乏的现实样态,“攀高求全”与“尚名逐利”的外部表现形式以及人才培养模式与专业设置趋同的内部现象表征,共同诱发了社会需求多样性与人才规格均质化的主要矛盾。分类评价标准的“迷离”加之高校对于资源的竞争成为其主要原因。我国应积极通过寻觅多样化的旨归、探索高校分类管理模式以及追寻高校特色自觉,实现高校分类发展理念与实践突破并行。

关键词：多样化同质化高校分类发展

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao Sheng Nie Yu ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu Guisen Li Gang Xu Chunbo Chen Huafeng Liu Yongjun shi Yan Zha Yaozhong Kong Guobin Su Ying Tang Mengchun Gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

基于催速失活的柴油中芳烃加氢失活动力学模型

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石油学报（石油加工） 2024年第2期40卷 472-479页

作者：章晓岩丁石胡志海聂红中石化石油化工科学研究院有限公司北京100083

采用中型固定床加氢实验装置,以混合柴油为原料,对柴油加氢催化剂采用催速失活的方法进行处理,研究比较不同活性的柴油加氢NiMo催化剂的芳烃加氢饱和反应规律。结果表明,通过催速失活方法得到的催化剂相比新鲜剂发生了明显的失活,催化... 详细信息

采用中型固定床加氢实验装置,以混合柴油为原料,对柴油加氢催化剂采用催速失活的方法进行处理,研究比较不同活性的柴油加氢NiMo催化剂的芳烃加氢饱和反应规律。结果表明,通过催速失活方法得到的催化剂相比新鲜剂发生了明显的失活,催化剂的活性损失随着反应时间增加、氢/油体积比减少而增加。在考虑催化剂活性损失的基础上建立三集总多环芳烃加氢饱和失活动力学模型,将计算得到的催速失活实验中活性系数与反应时间和氢/油体积比相关联,得到柴油加氢芳烃饱和活性系数模型,并通过失活动力学模型计算不同活性系数下多环芳烃含量的变化规律。

关键词：芳烃加氢饱和失活动力学柴油活性系数

Crystalline and amorphous metal sulfide composite electrode materials with long cycle life:Preparation and performance of hybrid capacitors

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无机化学学报 2024年第9期40卷 1784-1794页

作者： ding Ning WANG Siyu YU shihua XU Pengcheng HAN Dandan shi Dexin ZHANG Chao College of Chemistry and Pharmaceutical Engineering Jilin Institute of Chemical TechnologyJilinJilin 132022China College of Biology&Food Engineering Jilin Institute of Chemical TechnologyJilinJilin 132022China Connell Chemical Industry Co. Ltd.JilinJilin 132002China Jilin Zhongwang Safety Environment Technology Co. Ltd.JilinJilin 132113China

Crystalline@amorphous NiCo_(2)S_(4)@MoS_(2)(v-NCS@MS)nanostructures were designed and constructed via an ethylene glycol-induced strategy with hydrothermal synthesis and solvothermal method,which simultaneously realized the defect regulation of crystal NiCo_(2)S_(4) in the *** advantage of the flexible protection of an amor-phous shell and the high capacity of a conductive core with defects,the v-NCS@MS electrode exhibited high specif-ic capacity(1034 mAh·g^(-1) at 1 A·g^(-1))and outstanding rate ***,a hybrid supercapacitor was assembled with v-NCS@MS as cathode and activated carbon(AC)as anode,which can achieve remarkably high specific energy of 111 Wh·kg^(-1) at a specific power of 219 W·kg^(-1) and outstanding capacity retention of 80.5%after 15000 cycling at different current densities.

关键词： crystalline@amorphous heterostructure NiCo2S4@MoS2 hybrid supercapacitor defect design long cycle life

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空泡下双向冰级桨水动力性能试验研究

船舶力学 2024年第1期28卷 70-80页

作者：郑思洁周利刁峰丁仕风刘仁伟江苏科技大学船海学院江苏镇江212003 上海交通大学船舶海洋与建筑工程学院上海200240 中国船舶科学研究中心江苏无锡214082

针对空泡效应对双向冰级螺旋桨的正车性能和倒车性能的影响,本文采用螺旋桨模型空泡水筒试验方法,探讨均流环境中空泡数和进速系数对螺旋桨正车和倒车水动力影响,以及在冰阻塞环境中空泡数、进速系数和冰-桨距离对螺旋桨正车和倒车水动... 详细信息

针对空泡效应对双向冰级螺旋桨的正车性能和倒车性能的影响,本文采用螺旋桨模型空泡水筒试验方法,探讨均流环境中空泡数和进速系数对螺旋桨正车和倒车水动力影响,以及在冰阻塞环境中空泡数、进速系数和冰-桨距离对螺旋桨正车和倒车水动力性能影响。研究结果表明:均匀流环境中定水速变转速,严重的空化现象对推力和扭矩的削减大于由螺旋桨转速增加而增加的推力和扭矩;冰阻塞环境中定转速变水速,螺旋桨推力和扭矩受到冰阻塞和空泡共同作用,当空化严重时,推力和扭矩不再随阻塞距离的减小而增加;本双向螺旋桨的倒车性能要比正车性能差,进速系数越大,性能差越大,均匀流中进速系数为0.7时,推力系数的差值在80%左右;冰阻塞中随着冰-桨距离的增加,水动力差值随之增加,但增加幅值较小;空泡不断地在桨叶生成,并在与桨叶分离时快速溃灭,随着冰-桨距离的减小,近冰桨叶表面空化现象越严重,空泡发生面积越大,且空泡形状越不规则。

关键词：空泡效应双向冰级桨均匀流冰阻塞水动力

大容量套扎器套扎与组织胶联合聚桂醇注射治疗GOV型胃底静脉曲张的比较研究

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天津医药 2024年第6期52卷 604-609页

作者：石玉茹石定河南中医药大学第一附属医院消化科 450000 宁波市第二医院消化科

目的比较大容量套扎器与组织胶注射治疗食管胃静脉曲张(GOV)型胃静脉曲张的疗效和安全性,为GOV型胃静脉曲张的治疗提供参考。方法前瞻性纳入150例GOV型胃静脉曲张患者。结合患者病情及意愿将患者分为内镜下曲张静脉套扎术(EBL组,78例)... 详细信息

目的比较大容量套扎器与组织胶注射治疗食管胃静脉曲张(GOV)型胃静脉曲张的疗效和安全性,为GOV型胃静脉曲张的治疗提供参考。方法前瞻性纳入150例GOV型胃静脉曲张患者。结合患者病情及意愿将患者分为内镜下曲张静脉套扎术(EBL组,78例)和内镜下曲张静脉栓塞术(EVO组,72例)。EBL组采用大容量套扎器对GOV型胃静脉曲张进行内镜下套扎治疗;EVO组使用组织胶联合聚桂醇注射治疗。所有患者于首次术后2~3周复查胃镜,观察有无曲张静脉残留及出血(若有,此次随访时需再次治疗)。分别于术后1、3、6个月进行胃镜检查,评估内镜治疗后主要观察指标:曲张静脉止血成功率、技术成功率、根除率、复发率;次要指标(相关并发症):内镜治疗相关出血、发热、败血症和远处栓塞。结果EBL组和EVO组技术成功率、止血成功率、平均治疗次数、胃底静脉曲张根除率差异无统计学意义。EVO组复发率高于EBL组(P<0.05)。EBL组内镜治疗相关出血率低于EVO组,发热率低于EVO组(P<0.05);EVO组中1例患者在注射后发生肺栓塞,3例患者出现败血症。结论大容量套扎器与内镜下注射组织胶根除GOV型胃静脉曲张的短期疗效相似,但前者安全性优于后者。

关键词：食管和胃静脉曲张出血套扎疗法内窥镜检查组织胶

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MXene基罗纹针织物的制备及其应变传感性能

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精细化工 2024年第5期41卷 1014-1021页

作者：郑贤宏唐金好丁斌斌夏文李长龙王炜东华大学化学化工与生物工程学院上海201620 安徽工程大学纺织服装学院安徽芜湖241000 三元控股集团有限公司浙江杭州311200 浙江理工大学纺织科学与工程学院浙江杭州310018

借鉴染色工艺,采用轧烘焙技术制备了高弹性导电过渡金属碳化物/氮化物(MXene)基罗纹针织物,通过SEM、电阻测试、传感性能测试对其进行了结构和性能表征。结果表明,MXene基罗纹针织物具有较好的弹性和弹性回复性,并且织物中MXene负载量... 详细信息

借鉴染色工艺,采用轧烘焙技术制备了高弹性导电过渡金属碳化物/氮化物(MXene)基罗纹针织物,通过SEM、电阻测试、传感性能测试对其进行了结构和性能表征。结果表明,MXene基罗纹针织物具有较好的弹性和弹性回复性,并且织物中MXene负载量随轧烘焙循环次数的增加而增加,织物电阻随轧烘焙循环次数的增加而降低,最低为38.3Ω/□;织物的应变传感性能测试表明,MXene基罗纹针织物传感性能具有明显的各向异性,并且横列方向的传感性能优于纵行方向。MXene基罗纹针织物横列方向的传感系数和传感区间分别为72.80、0~160%,远高于纵行方向(最大传感系数为4.4,传感区间为0~24%)。

关键词： MXene 罗纹针织物应变传感器传感系数功能材料