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Porta Hepatis Tuberculous Lymphadenopathy: Clinical and Imaging Features of 10 Cases

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Infectious Microbes & Diseases 2024年第1期6卷 29-35页

作者： Wenjuan Hu Ming Hu Jiafeng xia.Shengyue Chen xia.meng Li Chengmin Sheng Wanru Guo Xuewen Feng Yanwan Shangguan Bin Lu Yunzhen shi Junke Qiu Kaijin Xu State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Cardiology the Second Affiliated Hospital of Dalian Medical UniversityDalianChina Department of Infectious Diseases Affiliated Dongyang Hospital of Wenzhou Medical UniversityDongyangChina Department of Tuberculosis Intensive Care Unit Hangzhou Red Cross HospitalHangzhouChina

Porta hepatis tuberculous lymphadenopathy(TL)is rare,and the clinical and imaging manifestations often mimic *** offer a bet-ter understanding of porta hepatis TL and thus improve its diagnosis and treatment,here,we retrospectively reviewed and analyzed 10 porta hepatis TL cases between May 2017 and November *** this study,porta hepatis TL occurred predominantly in women(70%),with a mean age of 43.1 years(range,16-70 years).Among the patients,60%were initially suspected of malignancy(metastatic lymphadenopathy and lymphoma).The clinical manifestations were nonspecific,such as fever and weight loss,without overt abdominal *** patients showed high concentrations of serum C-reactive protein,erythrocyte sedimentation rate,alkaline phosphatase,γ-glutamyl transpeptidase and carbohydrate antigen *** rim-like enhancement was a characteristic finding on contrast-enhanced CT for all the *** examination confirmed the diagnosis in 90%of patients with caseous granulo-matous inflammation and positive results of Xpert MTB/RIF,quantitative real-time PCR and/or metagenomic next-generation sequenc-ing *** patients underwent antituberculosis therapy with a median treatment duration of 13.5 months(range,1-43 months).They all showed satisfactory therapeutic responses with improved symptoms and resolution on imaging after *** examination by biopsy remains the primary diagnostic method.A combination of the characteristic epidemiologic,clinical,imaging fea-tures and lesion biopsy for histopathology are essential for the diagnosis and treatment of TL.

关键词： porta hepatis tuberculous lymphadenopathy misdiagnosis tumor mimicking

Reconstructed parallel sites enhance the reactive oxygen tolerance of non-noble metal catalyst for durable proton exchange membrane fuel cells

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Science China Chemistry 2024年

作者： Wenjie Wang Hui ding Minghao Wang Han Cheng xia.g shi Lin Wang Chun Wang Wangsheng Chu Yi Xie Changzheng Wu National Synchrotron Radiation Laboratory University of Science and Technology of China School of Chemistry and Materials Science CAS Center for Excellence in Nanoscience University of Science & Technology of China Zhejiang Institute of Photoelectronics Institute of Energy Hefei Comprehensive National Science Center

The establishment of reactive oxygen species(ROS) elimination sites in iron-nitrogen-carbon(Fe-N-C) electrocatalysts to achieve durable proton-exchange membrane fuel cells(PEMFCs) performance has attracted broad interest. However, realizing ROS removal efficiency and oxygen reduction reaction(ORR) activity within a single system represents a significant challenge to date. Herein, we demonstrate uniform ROS elimination sites and ORR centers through an electrochemical reconstruction method on the parallel sites of Fe@CeNC electrocatalyst for durable PEMFC. During the reconstruction process, the Fe sites can retain their original configuration. Meanwhile, the pristine Ce clusters will evolve into more efficient, highly dispersed ***, the reconstructed Fe and Ce sites exhibit favorable energy barriers for the ORR and ROS elimination pathways,respectively, thereby maintaining ORR activity and achieving high ROS tolerance. Consequently, the PEMFC assembled with our catalyst shows only a 2% decay in power density after the accelerated durability test. We anticipate that this parallel structure design will provide new insight into the development of more durable electrocatalysts for PEMFCs.

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基于价值函数分解和通信学习机制的异构多智能体强化学习方法

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计算机学报 2024年第6期47卷 1304-1322页

作者：杜威丁世飞郭丽丽张健丁玲中国矿业大学计算机科学与技术学院江苏徐州221116 矿山数字化教育部工程研究中心(中国矿业大学) 江苏徐州221116 天津大学智能与计算学部天津300350

许多现实世界的系统可以被建模为多智能体系统,多智能体强化学习为开发这些系统提供了一种有效的方法,其中基于集中训练与分散执行范式的价值函数分解方法得到了广泛的研究.然而现有的价值分解方法一般缺乏通信机制,在处理需要通信学习... 详细信息

许多现实世界的系统可以被建模为多智能体系统,多智能体强化学习为开发这些系统提供了一种有效的方法,其中基于集中训练与分散执行范式的价值函数分解方法得到了广泛的研究.然而现有的价值分解方法一般缺乏通信机制,在处理需要通信学习的多智能体任务时表现不佳.同时,目前大多数通信机制都是针对同构多智能体环境设计的,没有考虑异构多智能体场景.在异构场景中,由于智能体动作空间或观测空间的异构性,智能体之间的信息共享并不直接.如果不能对智能体的异构性进行有效地建模处理,通信机制将变得无效,甚至会影响多智能体的协作性能.为了应对这些挑战,本文提出一个融合价值函数分解和通信学习机制的异构多智能体强化学习框架.具体地:(1)与采用同构图卷积网络的方法不同,该框架利用异构图卷积网络融合智能体的异构特征信息得到有效的嵌入;(2)利用通信学习模块获得的嵌入信息和局部观测历史计算每个智能体的动作价值,以选择和协调智能体的动作;(3)通过设计的互信息损失函数和价值函数分解模块的损失函数联合训练,能够有效地训练整个方法.本文首先在两个异构多智能体平台上进行实验,实验结果表明该方法能学到比基线方法更有效的策略,在两个平台上相比基线方法分别提高了 13%的平均奖励值和24%的平均胜率.此外,在交通信号控制场景中验证了该方法在现实系统中的可行性.

关键词：价值函数分解异构多智能体强化学习通信机制图神经网络互信息交通信号控制

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian Zhang Guang-Tao Zhang Peng Lv Wen-Jun Zhang Guan-ding Zhao shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-Sheng Zhang Hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

Huangqi Guizhi Wuwu Decoction suppresses inflammation and bone destruction in collagen-induced arthritis mice

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Chinese Herbal Medicines 2024年第2期16卷 274-281页

作者： Jiamin Bao Yongjia Song Minghui Hang Hao Xu Qiang Li Pengyu Wang Tao Chen Mengxiong xia.Qi shi Yongjun Wang xia.yun Wang Qianqian Liang School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai 200032China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of EducationShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: Rheumatoid arthritis(RA) is a chronic inflammatory and destructive arthritis, characterized by inflammatory infiltration and bone destruction. Huangqi Guizhi Wuwu Decoction(HGWD) is traditional Chinese medicine, which has been applied in the treatment of RA in clinical. The aim of this study was to investigate the therapeutic effect of HGWD on collagen-induced arthritis(CIA) mouse ***: DBA/1J female mice were used to establish the collagen-induced arthritis(CIA) model. HGWD was administered intragastrically once a day for four weeks starting on the 22nd day after the first immunization. The body weight, hind paw thickness and clinical score were measured every five days. Gait analysis, histopathological staining, enzyme-linked immunosorbent assay(ELISA), ultrasound imaging and micro-computed tomography imaging were performed to determine the effects of HGWD treatment on inflammation and bone structure in this model. Moreover, Real-time PCR and Western blot analysis were used to detect inflammatory factors m RNA and protein levels after HGWD intervention in RAW264.7 ***: HGWD attenuated symptoms of arthritis, suppressed inflammatory synovium area and the serum levels of inflammatory factors, inhibited joint space enlargement in the knee and ankle joints,reduced numbers of osteoclasts, protected bone destruction, as well as improved motor *** decreased the expression of m RNA for inflammatory factors and the protein expression levels of p-NF-ΚB and ***: These results suggested that HGWD suppresses inflammation, attenuates bone erosion and maintains motor function in collagen-induced arthritis mice.

关键词： bone destruction collagen-induced arthritis Huangqi Guizhi Wuwu Decoction inflammation rheumatoid arthritis

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兰格市场社会主义模式再评价

福建论坛（人文社会科学版） 2024年第1期 68-87页

作者：丁堡骏夏鑫雨浙江大学马克思主义学院

兰格提出了一个市场社会主义模式,试图证明中央计划局可以在没有生产资料市场的条件下通过试错法模拟市场配置资源的过程。兰格模式对苏联、东欧各社会主义国家的经济体制改革产生了深远的影响:一方面,东欧各社会主义国家将市场社会主... 详细信息

兰格提出了一个市场社会主义模式,试图证明中央计划局可以在没有生产资料市场的条件下通过试错法模拟市场配置资源的过程。兰格模式对苏联、东欧各社会主义国家的经济体制改革产生了深远的影响:一方面,东欧各社会主义国家将市场社会主义作为改革蓝图;另一方面,苏联将模拟市场视为制定计划的标准。在改革开放初期,兰格模式曾一度影响了中国经济学理论和经济政策。兰格在运用新古典经济学分析社会主义的经济运行时,并未意识到该理论具有经济自由主义的本质。事实上,兰格对计划(政府)与市场关系的理解没有超越亚当·斯密,对社会主义基本经济规律的认识没有超越欧根·杜林。我们应当吸取兰格模式的经验教训,对中国特色社会主义的经济规律特别是在对市场这个调节手段的认识上要进行更深层次的研究。

关键词：兰格模式社会主义经济核算论战市场社会主义瓦尔拉斯试错过程理论

Tunable off-resonant Rydberg microwave frequency comb spectroscopy based on metawaveguide coupled Rydberg atoms

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CHINESE OPTICS LETTERS 2024年第8期22卷 080201-080201页

作者： Zhang, Lihua Liu, Zongkai Liu, Bang Wang, Qifeng Ma, Yu Han, Tianyu Zhang, Zhengyuan Chen, Hanchao Shao, shiyao Li, Qing Zhang, Jun ding, Dongsheng shi, Baosen Univ Sci & Technol China Key Lab Quantum Informat Hefei 230026 Peoples R China Univ Sci & Technol China Synerget Innovat Ctr Quantum Informat & Quantum Ph Hefei 230026 Peoples R China

Studying Rydberg microwave frequency comb (MFC) spectroscopy helps increase the working bandwidth of the Rydberg receiver. This Letter demonstrates off-resonant Rydberg MFC spectroscopy in a meta-waveguide-coupled Rydberg atomic system. An off-resonant MFC field couples with the Rydberg atoms through a meta-waveguide. The system can receive the microwave field in the working band from 0.5 GHz to 13.5 GHz, and the MFC spectroscopy covers a span of 36 MHz at three different arbitrarily-chosen frequencies of 2 GHz, 3 GHz, and 5.8 GHz. The MFC spectrum that covers a wide range of 125 MHz is also verified. This work is significant for tunable wide-band instant microwave signal detection in the Rydberg atomic system, which is useful in microwave frequency metrology, communication, and radar.

关键词： Rydberg atoms microwave frequency comb spectroscopy metawaveguide tunability

Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu Chuan Yang Ying Zheng xia.peng Li Yu Lu Kenneth Kin Wah To Chenglai xia.Jianye Zhang Zhi shi Zeping Hu Min Huang Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

A Traffic Sign Detection Method for Autonomous Driving Based on Improved YOLOv9

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A Traffic Sign Detection Method for Autonomous Driving Based...