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Identification of genetic alterations associated with primary resistance to EGFR-TKIs in advanced non-small-cell lung cancer patients with EGFR sensitive mutations

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Cancer Communications 2019年第1期39卷 52-66页

作者： Fang Wang xia-yao diao xiao Zhang Qiong Shao Yan-Fen Feng Xin An Hai-Yun Wang State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Molecular Diagnostics Sun Yat-sen University Cancer CenterNo.651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Urology Sun Yat-sen Memorial HospitalGuangzhou 510120GuangdongP.R.China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:Identification of activated epidermal growth factor receptor(EGFR)mutations and application of EGFR-tyrosine kinase inhibitors(EGFR-TKIs)have greatly changed the therapeutic strategies of non-small-cell lung cancer(NSCLC).However,the long-term efficacy of EGFR-TKI therapy is limited due to the development of drug *** aim of this study was to investigate the correlation between the aberrant alterations of 8 driver genes and the primary resistance to EGFR-TKIs in advanced NSCLC patients with activated EGFR ***:We retrospectively reviewed the clinical data from 416 patients with stage III/IV or recurrent NSCLC who received an initial EGFR-TKI treatment,from April 2004 and March 2011,at the Sun Yat-sen University Cancer *** genetic alterations associated with the efficacy of EGFR-TKIs,including the alterations in BIM,ALK,KRAS,PIK3CA,PTEN,MET,IGF1R,and ROS1,were detected by the routine clinical *** progression-free survival(PFS)and overall survival(OS)were compared between different groups using Kaplan-Meier survival analysis with the log-rank test.A Cox regression model was used to estimate multivariable-adjusted hazard ratios(HRs)and their 95%confi-dence intervals(95%CIs)associated with the PFS and ***:Among the investigated patients,169 NSCLC patients harbored EGFR-sensitive ***-mutant patients having PTEN deletion had a shorter PFS and OS than those with intact PTEN(P=0.003 for PFS,and P=0.034 for OS).In the combined molecular analysis of EGFR signaling pathway and resistance genes,we found that EGFR-mutant patients coexisted with aberrant alterations in EGFR signaling pathway and those having resistant genes had a statistically poorer PFS than those without such alterations(P<0.001).A Cox proportional regression model determined that PTEN deletion(HR=4.29,95%CI=1.72-10.70)and low PTEN expression(HR=1.96,95%CI=1.22-3.13),MET FISH+(HR=2.83,95%CI=1.37-5.86)were independent predictors for PFS

关键词： Epidermal growth factor receptor Tyrosine kinase inhibitors Resistance Non-small-cell lung cancer

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Microstructure and Wear/corrosion Resistance of Stainless Steel Laser-alloyed with Mn+W_(2)C, Mn+NiWC and Mn+SiC

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 283-294页

作者： ZHOU Rui diao xiaogang SUN Yixin School of Metallurgical Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China CITIC Heavy Cast Iron Industry Co. Ltd.Luoyang 417039China

In-situ formed high Mn steel coating reinforced by carbides was formed by laser surface alloying(LSA).Laser alloyed layers on 1Cr18Ni9Ti steel with Mn+W_(2)C(specimen A),Mn+NiWC(specimen B)and Mn+SiC(specimen C)powders were fabricated to improve the wear and corrosion behavior of 1Cr18Ni9Ti steel blades in high speed *** evolution,phases,element distribution,microhardness,wear and corrosion behavior of the laser alloyed layers were *** indicated that high Mn steel matrix composites with undissolved W_(2)C,WC and other in-situ formed carbides were formed by LSA with Mn+W_(2)C and Mn+NiWC while SiC totally dissolved into the high Mn matrix when adding Mn+*** as the binding phase in Ni-WC powder decreased the crack sensitivity of the alloyed layer as compared with the addition of W_(2)C *** improvement in average microhardness was achieved in the matrix in specimen A,B and C,with the value of 615,602 and 277 HV_(0.5),while that of the substrate was 212 HV_(0.5).The increase of microhardness,wear and corrosion resistance is highly corelated to microstructure,formed phases,type and content of carbides,micro-hardness and toughness of the alloyed layers.

关键词： laser surface alloying stainless steel carbide type microstructure wear and corrosion resistance

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Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： Feng He Sitong Chen Ruili Zhou Hanyu diao Yangyang Han xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

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Distance two Heegaard splittings, JSJ decompositions and ranks of 3-manifolds

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Science China Mathematics 2025年

作者： Wenjie diao Yanqing Zou School of Mathematical Sciences East China Normal University Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice East China Normal University

For any pair of integers g and n with g ≥ 3 and 1 ≤ n ≤ g, we build a 3-manifold with a distance-2,genus-g Heegaard splitting so that(1) it contains n pairwise disjoint and nonisotopic essential tori;(2) after it is cut open along these tori, one resulting piece is hyperbolic while the others are small Seifert fibered spaces;(3) it provides a substantial result to the rank versus genus problem. These generalize a result in Qiu and Zou(2019).

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从1.0到2.0:特朗普政府对华安全战略的延续与政策变化

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国际安全研究 2025年第1期43卷 96-114,158页

作者：刁大明中国人民大学国际关系学院北京100872 中国人民大学外交学系北京100872

2024年美国总统大选以第45任总统唐纳德·特朗普的回归落幕。从“特朗普1.0”到“特朗普2.0”的八年间,国际安全环境、中美关系、美国政经态势以及特朗普个人状态等都发生了重大变化。国际安全环境日益严峻并进入历史转折点;中美关系因... 详细信息

2024年美国总统大选以第45任总统唐纳德·特朗普的回归落幕。从“特朗普1.0”到“特朗普2.0”的八年间,国际安全环境、中美关系、美国政经态势以及特朗普个人状态等都发生了重大变化。国际安全环境日益严峻并进入历史转折点;中美关系因美方对华战略竞争而陷入历史低谷;美国自身政治与社会持续撕裂且经济状况存在隐忧;美国国内期待“特朗普2.0”明确回应国内诉求;特朗普个人则在偏好商人思维的同时也凸显强势与遗产导向。比较而言,“特朗普2.0”的对华安全战略将突出延续性,将延续拜登政府的相关政策,体现为延续对华战略竞争、推进“拜登+特朗普”复合议程并继续将经贸议题置于对华战略竞争的核心地位。在延续战略之下,“特朗普2.0”的对华政策也有可能呈现出一些变化,表现为对外事务聚焦于俄乌冲突和巴以冲突而非中国、经贸作为个人偏好成为主线后的不可控性、国际与国内两个维度对其经贸政策制造的更大压力以及陷入历史低谷的中美关系面对新“特朗普冲击”的自限性。

关键词：特朗普2.0 战略竞争对华安全战略对华政策中美关系

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海外工程二次经营风险及对策——以蒙古某物流园项目为例

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交通企业管理 2025年第1期40卷 89-91页

作者：陈波刁丽霞中铁二十一局集团国际工程有限公司中交铁道设计研究总院有限公司

伴随着全球经济一体化的逐步形成,我国审时度势提出了建设“一带一路”和构建人类命运共同体的倡议。在这样的背景下,抢占海外市场已经成为我国众多企业生存和发展的重要组成部分。伴随海外工程的二次经营管理也成为走出国门的中国企业... 详细信息

伴随着全球经济一体化的逐步形成,我国审时度势提出了建设“一带一路”和构建人类命运共同体的倡议。在这样的背景下,抢占海外市场已经成为我国众多企业生存和发展的重要组成部分。伴随海外工程的二次经营管理也成为走出国门的中国企业必然面临的严峻课题。笔者结合蒙古物流园项目分析海外工程二次经营管理的一些风险,提出了海外工程二次经营管理的一些应对措施。

关键词：海外工程二次经营风险管控市场竞争合同风险蒙古物流园项目

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Improved electron capture capability of field-assisted exponential-doping GaN nanowire array photocathode

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Journal of Materials Science & Technology 2020年第7期42卷 54-62页

作者： Lei Liu Feifei Lu Sihao xia Yu diao Jian Tian Department of Optoelectronic Technology School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China

The exponential-doping GaN nanowire arrays(GaN NWAs)photocathode has a"light-trapping effect",and the built-in electric field can promote the concentration of the photogene rated carrier center to the top surface of the ***,in the preparation ofactual NWAs photocathodes,the problem that photons emitted from the sides of the nanowires cannot be effectively collected has been *** proposed field-assisted exponential-doping GaN NWAs can bend the motion trajectory of the emitted electrons toward the collecting *** this study,the quantum efficiency(QE)and collection efficiency(CE)of the external field-assisted exponential-doping GaN NWAs photocathode are derived based on the two-dimensional carrier diffusion equation and the initial energy and angular distribution,*** a field-assisted exponential-doping GaN NWAs with a width d=200 nm and a height H=400 nm,the optimal structural parameters are obtained:the incident angleθ=50°and the nanowire spacing is L=335.6 *** this basis,the field intensity of 0.5 V/μm can maximize the CE of the *** the results show that the field-assisted approach does contribute to the collection of emitted electrons,which can provide theoretical guidance for high-performance electron sources based on exponential-doping GaN NWAs *** field-assisted exponential-doping GaN NWAs cathode is expected to be verified by the experimental results in the future.

关键词： Exponential-doping GaN nanowire array Photocathode Field-assisted Quantum efficiency Electrons collection

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Melatonin promotes the development of the secondary hair follicles by regulating circMPP5

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1696-1712页

作者： xiaogao diao Lingyun yao Tao Duan Jiaxin Qin Liwen He Wei Zhang Department of Animal Nutrition and Feed Science State Key Laboratory of Animal NutritionCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background The quality and yield of cashmere fibre are closely related to the differentiation and development of secondary hair follicles in the skin of cashmere *** higher the density of secondary hair follicles,the higher the quality and yield of cashmere from the *** of secondary hair follicles commences in the embryonic stage of life and is completed 6 months after *** experimental results from our laboratory showed that melatonin(MT)treatment of goat kids after their birth could increase the density of secondary hair follicles and,thus,improve the subsequent yield and quality of *** changes in the secondary hair follicles resulted from increases in levels of antioxidant and expression of anti-apoptotic protein,and from a reduction in *** present study was conducted to explore the molecular mechanism of MT-induced secondary hair follicle differentiation and development by using whole-genome *** MT had no adverse effect on the growth performance of cashmere kids but significantly improved the character of the secondary hair follicles and the quality of cashmere,and this dominant effect continued to the second *** promotes the proliferation of secondary hair follicle cells at an early *** formation of secondary hair follicles in the MT group was earlier than that in the control group in the second *** genome-wide data results involved KEGG analysis of 1044 DEmRNAs,91 DElncRNAs,1054 DEcircRNAs,and 61 DEmiRNAs which revealed that the mitogen-activated protein kinase(MAPK)signaling pathway is involved in the development of secondary hair follicles,with key genes(FGF2,FGF21,FGFR3,MAPK3(ERK1))being up-regulated and *** also found that the circMPP5 could sponged miR-211 and regulate the expression of *** We conclude that MT achieves its effects by regulating the MAPK pathway through the circMPP5 sponged the miR-211,regulating the expression of MAPK3,to induce

关键词： Cashmere MAPK Melatonin miR-211 Secondary hair follicle

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Analysis of the CDR3 Length Repertoire and the Diversity of TCRα Chain in Human Peripheral Blood T Lymphocytes

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Cellular & Molecular Immunology 2007年第3期4卷 215-220页

作者： Xinsheng yao Ying diao Wanbang Sun Junmin Luo Ming Qin xianying Tang Department of Immunology Zunyi Medical College Zunyi 563003 China Xinsheng yao and Ying diao contributed equally to this work. Center of Reproductive Medicine Zunyi Medical College Zunyi 563003 China

Analysis of complementarity determining region 3 （CDR3） length of T lymphocyte receptors （TCRs） by immunoscope spectratyping technique has been used successfully to investigate the diversity of TCR in autoimmune diseases and infection diseases. In this study, we investigated the patterns of CDR3 length distribution for all 32 TCR AV gene families in human peripheral blood lymphocytes of four normal volunteers by the immunoscope spectratyping technique. It was found that PCR products exhibited an obscure band on 1.5% agarose gel electrophoresis. Each TCR AV family exhibited more than 8 bands on 6% sequencing gel electrophoresis. The CDR3 spectratyping of all TCR AV families showed a standard Gaussian distribution with different CDR3 length, and the expression frequency of CDR3 was similar among the gene families. Most of CDR3 in TCR AV family recombine in frame. However, some of the CDR3 showed out-of frame gene rearrangement. Additionally, we found that in some of TCR AV families there were 18 amino acid discrepancies between the longest CDR3 and shortest CDR3. These results may be helpful to further study the recombination mechanism of human TCR genes, the TCR CDR3 gene repertoire, and the repertoire drift in health people and disease state. Cellular ＆ Molecular Immunology.

关键词： TCR genescan CDR3 spectratyping immunoscope

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MiRNA-429 suppresses the growth of gastric cancer cells in vitro

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The Journal of Biomedical Research 2012年第5期26卷 389-393页

作者： Di Liu Peng xia Dongmei diao yao Cheng Hao Zhang Dawei Yuan Chen Huang Chengxue Dang Department of Surgical Oneology the First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of Genetics and Molecular Biology Medical School of Xi'an Jiaotong University~Key Laboratory of Environment and Genes Related Diseases of Ministry of Education Xi'an Shaanxi 710061 China

Micro-RNAs（miRNAs） have been found to be implicated in a very wide range of physiological *** study was aimed to investigate the regulation of miRNA-429（miR-429） in gastric cancer cells on cell proliferation and *** PCR was employed to detect the expressions of miR-429 after eukaryotic expression plasmid of miR-429 and its inhibitor were transiently transfected into poorly differentiated human gastric can-cer cell line *** 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） reduction as-says were used to examine proliferation *** was analyzed by flow cytometry after *** results showed that 48 h after transfection,overexpression of miR-429 reached maximum *** with mock transfection,miR-429 inhibited tumor cell proliferation significantly（P 〈 0.05） at 48 h and 72 *** Overexpression of miR-429 promoted tumor cell apoptosis when compared with mock transfected cells（P 〈 0.05）.On the contrary,miR-429 inhibitor promoted tumor cell proliferation and inhibited apoptosis when compared with controls（P 〈 0.05）.Our results suggested that miRNA-429 may serve as a tumor suppressor during tumorigenesis of gastric cancer and may be a potential gastric cancer therapeutic target.

关键词： microRNA gastric cancer cell cycle apoptosis

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