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Infrared thermography and meridian-effect evidence and explanation in Bell's palsy patients treated by moxibustion at the Hegu (LI4) acupoint Overall regulation or a specific target?

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Neural Regeneration Research 2012年第9期7卷 680-685页

作者： ling guan Gaobo Li Yiling Yang Xiufang Deng Peisi Cai Department of Acupuncture and Moxibustion Chinese PLA General Hospital Beijing 100853 China Beijing Aierci Infrared Medical Science and Technology Limited Company Beijing 100055 China

Subjects with Bell＇s palsy and healthy individuals were treated with moxibustion thermal stimulation on the Hegu （LI4） acupoint; an infrared thermal imaging system was used to observe facial-temperature changes. Bell＇s palsy patients developed low or high temperatures at the affected side, with poor symmetry. Healthy people showed high temperatures on the forehead, medial angle of the eye, nasal ala and around the lips, but low temperatures on bilateral cheeks, thus forming a ＂T-type hot area＂ in the face, with good temperature symmetry. Moxibustion treatment for 11 minutes significantly improved high asymmetry in temperature in the faces of Bell＇s palsy patients. This evidence indicates that moxibustion treatment on Hegu enables increases in facial temperatures in healthy people and Bell＇s palsy patients, especially around the lips. Moxibustion stimulation at the Hegu not only improves the global circulation but also has specific effects on the lips in Bell＇s palsy patients, but the underlying mechanism needs further investigation.

关键词： Bell’s palsy infrared skin temperature face moxibustion neural regeneration

Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding-ovulation dysfunction patients

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World Journal of Clinical Cases 2020年第15期8卷 3259-3266页

作者： Lu Wang Hai-Yun guan He-xia xia Xiu-Ying Chen Wei Zhang Department of Reproductive Endocrinology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China

BACKGROUND Dydrogesterone has shown significant efficacy in treatment of irregular menstrual cycle due to abnormal uterine bleeding-ovulation dysfunction(AUB-O),but there were few relevant *** observational study was designed to evaluate the effectiveness of dydrogesterone for the treatment of Chinese patients with *** To evaluate the effects of dydrogesterone on menstrual-cycle(MC)regularization and metabolism in the patients with *** A prospective,non-interventional,single-arm,post-marketing observational study was *** women aged 16 years or above with AUB-O who had been prescribed dydrogesterone were *** patients were treated with dydrogesterone 10 mg from day 16 to day 25 of each cycle,consecutively for at least 3 *** main outcome was defined as the percentage of patients whose MCs returned to normal(defined as 21 d

关键词： Dydrogesterone Abnormal uterine bleeding-ovulation dysfunction Menstrual cycle Hormone Testosterone Dehydroepiandrosterone sulfate

Grape Seed Procyanidin Extract Reduces Arsenic- Induced Renal Inflammatory Injury in Male Mice

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Biomedical and Environmental Sciences 2017年第7期30卷 535-539页

作者： WANG Cheng LI Jun SONG guan ling NIU Qiang XU Shang Zhi FENG Gang ling WANG Hai xia LI Yu LI Shu Gang LI Feng Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education) Shihezi University School of Medicine Shihezi 832002 Xinjiang China Department of Medical Imageing of the First Affiliated Hospital Shihezi University School of Medicine Shihezi 832002 Xinjiang China Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases {Ministry of Education) Shihezi University School of Medicine Shihezi 832002 Xinjiang China Department of Pathology of Beijing chaoyang hospital the Capital Medical University Beijing 100020 China

The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract （GSPE） relieves arsenic trioxide （As2O3）-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor （NF）-KB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-KB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.

关键词： in were Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice GSPE IKK NF of Figure As

Difference in normal corneal thickness and curvature between Mongolian and Han nationalities

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 399-402页

作者： Hai-xia Zhao Li Zhang Wen-Ying guan Department of Ophthalmology the Affiliated Hospital of Inner Monogolia Medical University

AIM: To investigate the differences in central corneal thickness(CCT) and curvature in myopic patients with different genders between Mongolian and Han nationalities in the Inner Mongolia ***: Patients with myopia, among whom 122cases(244 eyes) were Mongolian and 150 cases(300eyes) were Han, were selected. Pentacam was used to measure the corneal curvature, whereas CCT was determined by Pentacam, Orbscan and ultrasound ***: Comparisons of the curvature of men and women in Mongolia showed a significant difference(P <0.05) by comparing of the CCT values measured by three methods in Han and Mongolian in Inner Mongolia, we can draw a conclusion that the CCT values measured by Pentacam are less than the values by Orbscan and ultrasound pachymetry, and there are statistically significant difference in CCT measurement among the instruments except between the Orbscan and ultrasound pachymetry. The CCT values of Mongolians are more than Han people, and the analysis exhibited statistical significance. The CCT values measured by Orbscan in Mongolia of women are more than men, the difference showed statistical ***: Corneal curvature in Mongolian females was significantly higher than that in males. However, no significant difference was observed among Han males and females. The CCT values of Mongolian females were higher than those of males. The normal CCT values measured by Pentacam in Mongolian myopic patients were smaller than those obtained by Orbscan or ultrasound. The normal CCT values of Mongolian patients with myopia were higher than those reported for domestic people.

关键词： pentacam orbscan mongolian nationality Han nationality gender central corneal thickness

Helicobacter pylori γ-glutamyl transpeptidase:A formidable virulence factor

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World Journal of Gastroenterology 2013年第45期19卷 8203-8210页

作者： Samantha Shi Min ling Khay guan Yeoh Bow Ho Department of Microbiology Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Helicobacter pylori(***)produce an enzyme known asγ-glutamyl transpeptidase(HpGGT)that is highly conserved and common to all *** has been gaining increasing attention as an important virulence factor of the bacterium,having been demonstrated to be an important colonization factor in several animal models and has also recently been strongly associated with the development of peptic ulcer *** the results of various independent researcher groups,it is clear that HpGGT acts through several pathways to damage gastric epithelial cells including the induction of apoptosis and cell cycle arrest,production of reactive oxygen species leading to DNA damage,promotion of inflammation by increasing cyclooxygenase-2 and interleukin-8 expression,and upregulation of heparin-binding epidermal growth factor-like growth factor resulting in cell survival and *** addition,the potential role of HpGGT in promoting gastric carcinogenesis will also be discussed in this *** from affecting the gastric epithelium,HpGGT also has immunomodulatory actions on host immune cells where it displays an antiproliferative effect on T cells by inducing cell cycle arrest and also works with other *** virulence factors to skew dendritic cells towards a tolerogenic phenotype,possibly contributing to the persistence of the pathogen in the gastric mucosa.

关键词： Helicobacter pylori Gamma-glutamyl transpeptidase Pathogenesis Immunomodulation Carcinogenesis

Water migration in subgrade soil under seasonal freeze-thaw cycles in an alpine meadow on the Qinghai-Tibet Plateau

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Journal of Mountain Science 2022年第6期19卷 1767-1781页

作者： WU guan-qing XIE Yong-li WEI Jin YUE xia-bing School of Highway Chang'an UniversityXi'an 710064China

Highway frost heave and thawing settlement caused by water migration towards the freezing front and ice lens development is widespread in the alpine meadow area of the southeast QinghaiTibet Plateau(QTP). A laboratory experiment on a highway reconstruction and expansion project in the QTP was carried out in this work to analyze the effects of fine particle content, initial water content, and the number of freeze-thaw cycles(FTCs) on frost depth, temperature gradient(Grad T), total water intake, and water intake flux. Based on the results of the laboratory experiment, a modified model of migration potential related to fine particle content, freeze-thaw history, and freezing time was established. The results show that, with the increase of fine particle content, the frost depth of soil decreases, the curve of total water intake over time is transformed from an Sshape to an arch, and the curve of water intake flux over time is transformed from a peak shape to descending shape. The variation trend of migration potential with freezing time and the freeze-thaw history is the same as that of water intake flux with freezing time and freeze-thaw history. The variation trend of soil intake flux can be used as a reference to determine the variation trend of soil migration potential. This study provides a reference for the design and construction of highway subgrade in the alpine meadow area of the QTP.

关键词： Water migration Seasonally frozen ground Freeze-thaw cycles Laboratory experiment Migration potential model Qinghai-Tibet Plateau

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高流强RFQ质子加速器研制

原子能科学技术 2009年第B12期43卷 159-164页

作者：傅世年关遐令中国科学院高能物理研究所北京100049 中国原子能科学研究院北京102413

在国家"973"计划洁净核能项目的支持下,中国科学院高能物理研究所与中国原子能科学研究院合作,建成了我国首台强流质子加速器。它是1台四翼型结构的射频四极(radio-frequency qaudrupole,RFQ)加速器,这种先进加速结构可为来自离子源的... 详细信息

在国家"973"计划洁净核能项目的支持下,中国科学院高能物理研究所与中国原子能科学研究院合作,建成了我国首台强流质子加速器。它是1台四翼型结构的射频四极(radio-frequency qaudrupole,RFQ)加速器,这种先进加速结构可为来自离子源的低能强流束提供周期性强聚焦,并同时在纵向对束流进行聚束和加速。我国建成的这台RFQ加速器束流能量为3.5 MeV,脉冲流强达46 mA,束流工作比大于7%。本文将介绍这台RFQ加速器的物理设计、研制、调试和出束实验的结果。

关键词：强流质子束射频四极加速器加速器驱动的次临界系统

Seed priming with chitosan improves maize germination and seedling growth in relation to physiological changes under low temperature stress

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第6期10卷 427-433页

作者： Ya-jing guan Jin HU xian-ju WANG Chen-xia SHAO Seed Science Center College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China Yuan Longping High-Tech Agriculture Co. Ltd. Changsha 410001 China

Low temperature stress during germination and early seedling growth is an important constraint of global production of maize. The effects of seed priming with 0.25%, 0.50%, and 0.75% （w/v） chitosan solutions at 15 ℃ on the growth and physiological changes were investigated using two maize （Zea rnays L.） inbred lines, HuangC （chilling-tolerant） and Mo17 （chilling-sensitive）. While seed priming with chitosan had no significant effect on germination percentage under low temperature stress, it enhanced germination index, reduced the mean germination time （MGT）, and increased shoot height, root length, and shoot and root dry weights in both maize lines. The decline of malondialdehyde （MDA） content and relative permeability of the plasma membrane and the increase of the concentrations of soluble sugars and proline, peroxidase （POD） activity, and catalase （CAT） activity were detected both in the chilling-sensitive and chilling-tolerant maize seedlings after priming with the three concentrations of chitosan. HuangC was less sensitive to responding to different concentrations of chitosan. Priming with 0.50% chitosan for about 60-64 h seemed to have the best effects. Thus, it suggests that seed priming with chitosan may improve the speed of germination of maize seed and benefit for seedling growth under low temperature stress.

关键词： Seed priming Chitosan Low temperature stress Germination Physiological changes Maize

Design,synthesis and neuroprotective effects of Fenazinel derivatives

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Chinese Chemical Letters 2017年第7期28卷 1505-1508页

作者： Qing-Wei Zhang ling Jiang guan Wang Jian-Qi Li Novel Technology Center of Pharmaceutical Chemistry Shanghai Institute of Pharmaceutical IndustryShanghai 201203China Shanghai Engineering Research Center of Pharmaceutical Process Shanghai 201203China School of Engineering China Pharmaceutical UniversityNanjing 211198China

In search of novel neuroprotective agents with higher potency and lower h ERG liability, a series of novel Fenazinel derivatives were designed and synthesized, among which compounds 8m–o containing amide moiety exhibited good neuroprotective effects in vitro and in vivo. Especially, the representative compound 8o showed lower activity in a patch clamp h ERG K^＋ion channel screen and could be considered as a lead compound for further development. These findings provided an alternative approach to the development of drugs more potent than Fenazinel for the intervention of ischemic stroke.

关键词： Fenazinel Synthesis hERG Neuroprotective Ischemic stroke