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Asian Pacific Journal of Tropical Medicine 2017年第1期10卷 47-51页

作者： Zhong Han xia-ling lei Hong Zhang Lu Liu Zhi-Sen Chen Wei Yang Zhao-Rong Lun School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationGuangdong Institute of Applied Biological Resources Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangzhou 510990China

Objective: To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety,Methods: Acute toxicity was determined by oral administration of a single dose of 18 100 mg/kg forsythin in NIH mice,Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0,540,1 620,and 6 480 mg/kg in SD ***: In the acute toxicity study,mortality was not observed after 14 days,In addition,clinically relevant adverse effects,or variations in body weight or food consumption were not observed,Similarly,after 30 days in the sub-chronic toxicity study,no mortality or significant toxicological effects such as decreased food consumption,body weight,biochemical parameters and vital organs etc,were noticed,Conclusion: The results revealed that the forsythin from Forsythia suspensa leaves has low or no toxicity via oral administration,and therefore is suitable for further development and applications.

关键词： Forsythin Acute toxicity Sub-chronic toxicity Safety

Controlling the Reactivity of IBA-N_(3)by Switching Halogen Salts:Providing a Universal Strategy for Haloazidation of Alkenes

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Chinese Journal of Chemistry 2024年第16期42卷 1839-1845页

作者： Chen-Xi xia Xin-lei Sun Jinfeng Zhang Yue Ren Yan Yu Kuai Wang ling-Guo Meng Key Laboratory of Green and Precise Synthetic Chemistry and Applications Ministry of Education/School of Chemistry and Materials ScienceHuaibeiNormal UniversityHuaibeiAnhui 235000China

Although various routes have been reported for haloazidation,unavoidable problems exist,such as environmentally unfriendly monomer halogen,the need for in situ generation of unstable halogen azides(XN3),applicability to one type of haloazidation and inability to precisely control ***,we developed a universal strategy for haloazidation of alkenes through controlling the reactivity of IBA-N_(3) by switching halogen salts,allowing for the synthesis of a diversity of halogen azide *** studies have shown that by tuning the reactivity of IBA-N_(3) via switching halogen salts,different intermediates can be controllably produced to achieve regioselectivityand chemoselectivity in thehaloazidationof alkenes.

关键词： Haloazidation Alkene IBA-N_(3) Halogen salts Difunctionalization Selectivity Radicals Synthetic methods

A Denoiser for Correlated Noise Channel Decoding: Gated-Neural Network

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China Communications 2024年第2期21卷 122-128页

作者： xiao Li ling Zhao Zhen Dai Yonggang lei School of Electronic and Information Engineering Beihang UniversityBeijing 100191China Beijing Institute of Tracking and Telecommunications Technology BITTT

This letter proposes a sliced-gated-convolutional neural network with belief propagation(SGCNN-BP) architecture for decoding long codes under correlated noise. The basic idea of SGCNNBP is using Neural Networks(NN) to transform the correlated noise into white noise, setting up the optimal condition for a standard BP decoder that takes the output from the NN. A gate-controlled neuron is used to regulate information flow and an optional operation—slicing is adopted to reduce parameters and lower training complexity. Simulation results show that SGCNN-BP has much better performance(with the largest gap being 5dB improvement) than a single BP decoder and achieves a nearly 1dB improvement compared to Fully Convolutional Networks(FCN).

关键词： belief propagation channel decoding correlated noise neural network

Physical and numerical investigations of target stratum selection for ground hydraulic fracturing of multiple hard roofs

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International Journal of Mining Science and Technology 2024年第5期34卷 699-712页

作者： Binwei xia Yanmin Zhou Xingguo Zhang lei Zhou Zikun Ma State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China

Ground hydraulic fracturing plays a crucial role in controlling the far-field hard roof,making it imperative to identify the most suitable target stratum for effective *** experiments are conducted based on engineering properties to simulate the gradual collapse of the roof during longwall top coal caving(LTCC).A numerical model is established using the material point method(MPM)and the strain-softening damage constitutive model according to the structure of the physical *** simulations are conducted to analyze the LTCC process under different hard roofs for ground hydraulic *** results show that ground hydraulic fracturing releases the energy and stress of the target stratum,resulting in a substantial lag in the fracturing of the overburden before collapse occurs in the hydraulic fracturing *** hydraulic fracturing of a low hard roof reduces the lag effect of hydraulic fractures,dissipates the energy consumed by the fracture of the hard roof,and reduces the abutment ***,it is advisable to prioritize the selection of the lower hard roof as the target stratum.

关键词： Target stratum selection Ground hydraulic fracturing Hard roof control Fracture network Material point method

Research on the MPPT of Photovoltaic Power Generation Based on Improved WOA and P&O under Partial Shading Conditions

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Energy Engineering 2024年第4期121卷 951-971页

作者： Jian Zhong lei Zhang ling Qin School of Electrical Engineering Nantong UniversityNantong226019China

Partial shading conditions(PSCs)caused by uneven illumination become one of the most common problems in photovoltaic(PV)systems,which can make the PV power-voltage(P-V)characteristics curve show *** maximum power point tracking(MPPT)methods have shortcomings in tracking to the global maximum power point(GMPP),resulting in a dramatic decrease in output *** order to solve the above problems,intelligent algorithms are used in ***,the existing intelligent algorithms have some disadvantages,such as slow convergence speed and large search ***,an improved whale algorithm(IWOA)combined with the P&O(IWOA-P&O)is proposed for the MPPT of PV power generation in this ***,IWOA is used to track the range interval of the GMPP,and then P&O is used to accurately find the MPP in that *** with other algorithms,simulation results show that this method has an average tracking efficiency of 99.79%and an average tracking time of 0.16 s when tracking ***,experimental verification is conducted,and the results show that the proposed algorithm has better MPPT performance compared to popular particle swarm optimization(PSO)and PSO-P&O algorithms.

关键词： Photovoltaic power generation maximum power point tracking whale algorithm perturbation and observation

Effects of asymmetric coupling and boundary on the dynamic behaviors of a random nearest neighbor coupled system

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Chinese Physics B 2024年第6期33卷 309-322页

作者：徐玲姜磊 School of Mathematical Sciences Sichuan Normal UniversityChengdu 610066China School of Mathematics and Statistics Linyi UniversityLinyi 276000China

This study investigates the dynamical behaviors of nearest neighbor asymmetric coupled systems in a confined ***, the study derivative analytical stability and synchronization conditions for the asymmetrically coupled system in an unconfined space, which are then validated through numerical simulations. Simulation results show that asymmetric coupling has a significant impact on synchronization conditions. Moreover, it is observed that irrespective of whether the system is confined, an increase in coupling asymmetry leads to a hastened synchronization pace. Additionally, the study examines the effects of boundaries on the system's collective behaviors via numerical experiments. The presence of boundaries ensures the system's stability and synchronization, and reducing these boundaries can expedite the synchronization process and amplify its effects. Finally, the study reveals that the system's output amplitude exhibits stochastic resonance as the confined boundary size increases.

关键词： asymmetric coupled confined space synchronization stochastic resonance stability

Environmental dynamics of nitrogen and phosphorus release from river sediments of arid areas

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Journal of Arid Land 2024年第5期16卷 685-698页

作者： SU Wenhao WU Chengcheng Sun Xuanxuan lei Rongrong lei Li WANG ling ZHU Xinping College of Bioscience and Resources Environment Beijing University of AgricultureBeijing 102206China Xinjiang Tianxi Environmental Protection Technology Co.Ltd. Urumqi 830000China College of Resources and Environment Sciences Xinjiang Agricultural UniversityUrumqi 830052China

Human activities lead to the accumulation of a large amount of nitrogen and phosphorus in sediments in ***,nitrogen and phosphorus can be affected by environment and re-enter the upper water body,causing secondary pollution of the river *** this study,laboratory simulation experiments were conducted initially to investigate the release of nitrogen and phosphorus from river sediments in Urumqi City and the surrounding areas in Xinjiang Uygur Autonomous Region of China and determine the factors that influence their *** results of this study showed significant short-term differences in nitrogen and phosphorus release characteristics from sediments at different sampling *** proposed secondary kinetics model(i.e.,pseudo-second-order kinetics model)better fitted the release process of sediment nitrogen and *** release of nitrogen and phosphorus from sediments is a complex process driven by multiple factors,therefore,we tested the influence of three factors(pH,temperature,and disturbance intensity)on the release of nitrogen and phosphorus from sediments in this *** most amount of nitrate nitrogen(NO_(3)^(–)-N)was released under neutral conditions,while the most significant release of ammonia nitrogen(NH_(4)^(+)-N)occurred under acidic and alkaline *** release of nitrite nitrogen(NO_(2)^(-)-N)was less affected by *** dissolved total phosphorus(DTP)released significantly in the alkaline water environment,while the release of dissolved organic phosphorus(DOP)was more significant in acidic *** release amount of soluble reactive phosphorus(SRP)increased with an increase in *** sediments released nitrogen and phosphorus at higher temperatures,particularly NH_(4)^(+)-N,NO_(3)^(–)-N,and *** highest amount of DOP was released at 15.0℃.An increase in disturbance intensity exacerbated the release of nitrogen and phosphorus from ***_(4)^(+)-N,DTP,and SRP levels increased linearly with the intens

关键词： sediment nitrogen and phosphorus environmental dynamics pseudo-second-order kinetics model dissolved organic phosphorus(DOP) Urumqi City

DNA Damage-driven Inflammatory Cytokines:Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

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Current Medical Science 2024年第2期44卷 261-272页

作者： Meng-jie WANG Yu xia Qing-lei GAO Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor *** intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor *** evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse *** cytokines possess multifaced functions in the anti-tumor immune ***,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor *** manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these *** also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

A feedback control method for phase signal demodulation in fber-optic hydrophones

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 515-528页

作者： Zhiqiang LIU lei xia Qiangfeng LYU Bin WU Ronghua HUAN Zhilong HUANG Department of Mechanics Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310000China Huanjiang Laboratory Zhuji 311899Zhejiang ProvinceChina Advanced Technology Research Institute Zhejiang UniversityHangzhou 310000China

In the realm of acoustic signal detection,the identification of weak signals,particularly in the presence of negative signal-to-noise ratios,poses a significant *** challenge is further heightened when signals are acquired through fiber-optic hydrophones,as these signals often lack physical significance and resist clear systematic *** processing methods,e.g.,low-pass filter(LPF),require a thorough understanding of the effective signal bandwidth for noise reduction,and may introduce undesirable time *** paper introduces an innovative feedback control method with dual Kalman filters for the demodulation of phase signals with noises in fiber-optic hydrophones.A mathematical model of the closed-loop system is established to guide the design of the feedback control,aiming to achieve a balance with the input phase *** dual Kalman filters are instrumental in mitigating the effects of signal noise,observation noise,and control execution noise,thereby enabling precise estimation for the input phase *** effectiveness of this feedback control method is demonstrated through examples,showcasing the restoration of low-noise signals,negative signal-to-noise ratio signals,and multi-frequency *** research contributes to the technical advancement of high-performance devices,including fiber-optic hydrophones and phase-locked amplifiers.

关键词： feedback control method fiber-optic hydrophone acoustic signal detection phase signal

Retrospective and prospective review of the generalized nonlinear strength theory for geomaterials

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1767-1787页

作者： Shunchuan Wu Jiaxin Wang Shihuai Zhang Shigui Huang lei xia Qianping Zhao Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Geohazard Forecast and Geoecological Restoration in Plateau Mountainous Area MNRKunming 650093China Yunnan Key Laboratory of Geohazard Forecast and Geoecological Restoration in Plateau Mountainous Area Kunming 650093China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Strength theory is the basic theory for calculating and designing the strength of engineering materials in civil,hydraulic,mechanical,aerospace,military,and other engineering ***,the comprehensive study of the generalized nonlinear strength theory(GNST)of geomaterials has significance for the construction of engineering rock *** paper reviews the GNST of geomaterials to demonstrate the research status of nonlinear strength characteristics of geomaterials under complex stress ***,it systematically summarizes the research progress of GNST(classical and empirical criteria).Then,the latest research the authors conducted over the past five years on the GNST is introduced,and a generalized three-dimensional(3D)nonlinear Hoek‒Brown(HB)criterion(NGHB criterion)is proposed for practical *** criterion can be degenerated into the existing three modified HB criteria and has a better prediction *** strength prediction errors for six rocks and two in-situ rock masses are 2.0724%-3.5091%and 1.0144%-3.2321%,***,the development and outlook of the GNST are expounded,and a new topic about the building strength index of rock mass and determining the strength of in-situ engineering rock mass is *** summarization of the GNST provides theoretical traceability and optimization for constructing in-situ engineering rock mass strength.

关键词： rock mechanics rock mass strength strength theory failure criterion Hoek-Brown criterion intermediate principal stress deviatoric plane smoothness and convexity

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