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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： Xinyu Yang xiangyu Gao xiaofan Jiang Kangyi yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

Synthesis of the Stereoisomers of the Sex Pheromones of the Southern Corn Rootworm

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Chemical Research in Chinese Universities 2001年第1期17卷 51-55页

作者： HUANG Jin xia li Yan ZHOU Zhong qiang yue xia li Faculty of Chemistry and Material Science Hubei UniversityWuhan 430062P.R.China Faculty of life Science Huazhong University of Science and TechnologyWuhan 430074P.R.China Huazhong Agricultural University Wuhan 430070P.R.China

A simple and efficient asymmetric synthesis of the sex pheromone of the southern corn rootworm is discribed. The key step is the asymmetric Michael addition of enoylsultam with virtually complete asymmetric induction(... 详细信息

关键词： Synthesis Asymmetric Michael addition Sultam Pheromone

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

Influence of roll-pitch seeker DRR and parasitic loop on Lyapunov stability of guidance system

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Journal of Systems Engineering and Electronics 2021年第6期32卷 1509-1526页

作者： li yue WEN xianghua li Wei WEI Lan xia Qunli School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China No.5718 Factory Chinese People’s Liberation ArmyGuilin 541002China

This paper focuses on the influence of the disturbance rejection rate(DRR)and parasitic loop parameters on the stability domain of the roll-pitch seeker's guidance *** DRR models of the roll-pitch seeker caused by different types of disturbance torques and the scale deviation of different sensors are *** optimal DRR model of the roll-pitch seeker,which contains the scale deviation model,is proposed by formula *** model of the roll-pitch seeker's guidance system is established and equivalently simplified by the dimensionless *** Lyapunov stability criterion for stability analysis of the guidance system is given by means of the passivity theorem and related definitions and lemmas.A simplified model of the roll-pitch seeker's guidance system,which is suitable for the Lyapunov stability criterion,is established by formula derivation and equivalent *** conditions that satisfy the Lyapunov stability criterion are *** simulation with Nyquist plots is used to analyze the influence of different DRR parameters on the stability domain of the roll-pitch seeker's guidance *** results of this paper can provide reference for the stability analysis of systems related to the roll-pitch seeker.

关键词： roll-pitch seeker guidance system disturbance rejection rate(DRR) parasitic loop Lyapunov stability Nyquist analysis

Coaxial Fe_(2)O_(3)/TiO_(2)nanotubes for enhanced photo-Fenton degradation of electron-deficient organic contaminant

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Rare Metals 2021年第12期40卷 3543-3553页

作者： yue li Dan-Dan Cheng Yan Luo li-xia Yang Henan International Joint Laboratory of Rare Earth Composite Materials School of Materials and Chemical EngineeringHenan University of EngineeringZhengzhou 451191China High Level Laboratory of Jiangxi Province for Persistent Pollutants Control Recycle and ReuseNanchang Hangkong UniversityNanchang 330063China

Coaxial Fe_(2)O_(3)/TiO_(2)nanotubes(Fe_(2)O_(3)/TiO_(2)NTs)were prepared by two anodic oxidation *** synthesized Fe_(2)O_(3)/TiO_(2)NTs catalysts showed high photocatalytic activity in heterogeneous photo-Fenton *** the help of Fe_(2)O_(3)/TiO_(2)NTs,4-nitrophenol(10 mg·L^(-1),50 ml),a typical electron-deficient organic contaminant,can be completely removed by adding only0.4 mmol·L^(-1)of H_(2)O_(2)under *** results clarify that the calculated position of Fe_(2)O_(3)/TiO_(2)NTs valence band is at 2.944 eV,its potential is higher than the potential of OH~-/·OH(2.800 eV),thereby ensuring the generation of·***,the transformation of photogenerated electrons from the conduction band of TiO_(2)to Fe_(2)O_(3)accelerates the reduction of Fe^(3+)to Fe^(2+).The unstable Fe^(2+)can be oxidized by H_(2)O_(2)to produce high yields of·***,both the coaxial heterojunction and fast Fe^(2+)/Fe^(3+)conversion provide abundant·OH to effective attack the electron-deficient benzene ring passivated by the nitro ***,surface-catalyzed degradation of 4-nitrophenol can be carried out step by *** work contributes a detailed understanding of charge transfer in semiconductor composites and degradation of organic contaminants.

关键词： Fe_(2)O_(3) TiO_(2) Coaxial Electron Deficient organic contaminant Photo-Fenton catalysis

Beauty Restored xiamen presents a successful case of sustainable development of a bay city

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ChinAfrica 2025年第1期17卷 36-39页

作者： xia YUANYUAN xiamen

Riding along xiamen’s Xinglin Bay Marine Bicycle Lane feels like gliding between the sea and *** 2.6-km-long pathway,built above the sea,links two sides of the bay.

关键词： xiamen Marine sustainable

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can li Zi-Jia Hao Xu-Ya Chai Pei-Sai li Yang liu li-xia liu Ying Xu Pan-Pan Yang ling-E li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (lity rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Evaluating Breakthrough Pressure in Gas Diffusion Layers of Proton Exchange Membrane Fuel Cells

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Journal of Thermal Science 2010年第5期19卷 459-464页

作者： Ma yue Jia li Zhang Zhuqian Wang xia School of Mechanical and Electroriic Control Engineering Beijing Jiaotong University Beijing 100044 China Department of Mechanical Engineering Oakland University Rochester MI 48309 USA

This paper studied the breakthrough pressure for liquid water to penetrate the gas diffusion layer(GDL) of a proton exchange membrane fuel cell(PEMFC).An ex-situ testing was conducted on a transparent test cell to visualize the water droplet formation and detachment on the surface of different types of GDLs through a CCD *** breakthrough pressure,at which the liquid water penetrates the GDL and starts to form a droplet,was *** breakthrough pressure was found to be different for the GDLs with different porosities and *** equilibrium pressure,which is defined as the minimum pressure required maintaining a constant flow through the GDL,was also *** equilibrium pressure was found to be much lower than the breakthrough pressure for the same type of GDL.A pore network model was modified to further study the relationship between the breakthrough pressure and the GDL properties and *** breakthrough pressure increases for the thick GDL with smaller micro-pore size.

关键词： PEMFC Gas diffusion layer Visualization Network model

Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid