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Effect of fertilizer and water content on N_2O emission from three plantation soils in south China

Journal of Environmental Sciences 2005年第6期17卷 970-976页

作者： LI Zhi-an ZOU bi xia Han-ping DING Yong-zhen TAN Wan-neng MA Zhen-rong South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China

The effects of fertilizers and water content on N2O emission were studied using the three most typical plantation soils. Soil incubations were performed and fertilization and water content treatments were designed. At 25% of saturated water content（SWC）, N2O emissions from the soil treated with urea, KNO3, （NH4）2 SO, and KH2 PO, were compared at application rates of 0, 100, 200, 300 and 500 kg/hm2. At 80% of SWC, similar experiments were carried out but at only one application rate（500 kg/hm^2）. N2O emissions at various water contents（20%, 35%, 50%, 65%, 80% and 100% of SWC） were studied. At low water content（25% of SWC）, neither nitrogen nor phosphorus（or potassium） fertilizers led to a high level of N2O emission, which generally ranged from 2.03 to 29.02 μg/（m^2·h）. However, at high water content（80% SWC）, the fertilizers resulted in much greater N2O emission irregardless of soil tested. The highest N2O emission rates after 24 h of water addition were 1233 lag/（ m^2 ·h） for S. superba soil, 1507 lag/（m^2 · h） for P. elliottii soil and 1869 lag/ （m^2 h） for A. mangium soil respectively. N2O emission from soils treated with urea, （NH4）2SO, and KH2PO, immediately dropped to a low level but steadily increased to a very high level for the soil treated with KNO3. High NO3^- content was a basis of high level of N2O emission. N2O emission rates from soils peaked shortly after flooding, rapidly dropping to a very low level in soil from non-legume plantations, but lasting for a relatively long period in soil from legume plantations. When soil water content increased equaling to or higher than 65%, the accumulated N2O emission over a period of 13 d ranged from 20.21-29.78 mg/m^2 for S. superba, 30.57-70.12 mg/m^2 for P. elliottii and 300.89-430.51 mg/m^2 for A. mangium. The critical water content was 50% of SWC, above which a high level of N2O emission could be expected, and below which very little N2O emissions were detected. The results suggest that, at low water content（

关键词： N2O plantation south China Acacia mangium Pinus elliottii Schima superba

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Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-α from M1 macrophages and promotes proliferation of prostate stromal cells

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Asian Journal of Andrology 2022年第5期24卷 513-520页

作者： Yu Tong Yi-Jun Guo Qin Zhang Hai-xia bi Kai Kai Ren-Yuan Zhou Department of Urology Jing’an District Central HospitalFudan UniversityShanghai 200040China Department of Pathology Jing’an District Central HospitalFudan UniversityShanghai 200040China

Androgens and chronic inflammation,which play essential roles in the development of benign prostatic hyperplasia(BPH),are considered to be important factors in disorders of prostate *** two factors may lead to pathological hyperplasia in the prostate transition zone of patients with ***,few studies have examined the mechanism of how dihydrotestosterone(DHT)affects chronic inflammation in prostate tissue during the progression of *** study examined the performance of DHT in lipopolysaccharide-treated M1 macrophages and the subsequent effects on the proliferation of prostate stromal and epithelial *** found that DHT increased secretion of the pro-inflammatory factor tumor necrosis factor(TNF)-αfrom M1 macrophages differentiated from THP-1 *** supernatant of M1 macrophages promoted the proliferation of WPMY-1 prostate stromal cells by upregulating B-cell lymphoma-extra large(Bcl-xL)and cellular Myc(c-Myc)levels by activating TNF-α-mediated nuclear factor-kappa B(NF-κB)and mitogen-activated protein kinase(MAPK)***,this supernatant increased the expression of androgen receptor in WPMY-1 cells,which was TNF-α-***,TNF-αprotein expression was significantly higher in patients with BPH and a large prostate volume than that in those with a small prostate *** analysis showed that higher serum testosterone combined with prostate-specific androgen concentrations was related to TNF-α*** study suggests that DHT modulates the inflammatory environment of BPH by increasing TNF-αexpression from lipopolysaccharide-treated M1 macrophages and promotes the proliferation of prostate stromal *** TNF-α,but not DHT,may be a promising strategy for patients with BPH.

关键词： benign prostatic hyperplasia dihydrotestosterone inflammation macrophage tumor necrosis factor-alpha

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基于脑卒中居家康复APP的远程指导对患者出院后的疗效研究

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老年医学与保健 2024年第3期30卷 698-705页

作者：李瑛申斌李倩颜凯方应祥毕霞上海健康医学院附属周浦医院康复医学科上海201318 上海市浦东新区周浦社区卫生服务中心康复科上海201318

目的观察脑卒中居家康复APP的远程指导对患者出院后肢体功能、日常生活能力、心理状况、社会支持的疗效。方法选取2022年8月—2023年9月从上海市浦东新区周浦医院康复医学科出院后的脑卒中患者100例,随机分成对照组50例、观察组50例。... 详细信息

目的观察脑卒中居家康复APP的远程指导对患者出院后肢体功能、日常生活能力、心理状况、社会支持的疗效。方法选取2022年8月—2023年9月从上海市浦东新区周浦医院康复医学科出院后的脑卒中患者100例,随机分成对照组50例、观察组50例。对照组进行常规居家康复治疗,观察组在居家康复APP远程指导下进行康复治疗,共3个月。干预前后,采用简化Fugl-Meyer运动功能量表(FMA)、Tinetti平衡与步态量表、改良Barthel指数(Mbi)、汉密尔顿抑郁量表(HAMD17)、照顾者压力指数(CSI)进行评估。结果干预前FMA、Tinetti、Mbi、HAMD17、CSI 2组患者评分比较,均无显著性差异(P>0.05);干预第1、第3个月后,2组FMA、Tinetti、Mbi、HAMD17、CSI评分与干预前相比均有显著性差异(Pbi、CSI无显著差异(P>0.05),但2组间FMA-下肢、Tinetti-平衡、HAMD17差异显著(Pbi、HAMD17、CSI差异显著(P<0.05),有统计学意义。结论脑卒中居家康复APP远程指导可有效改善出院后脑卒中患者肢体功能状况和日常生活能力,并降低心理抑郁状况和缓解社会压力。

关键词：老年脑卒中居家康复互联网+ 远程康复指导

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Targeting RAF dimers in RAS mutant tumors:From biology to clinic

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1895-1923页

作者： Huanhuan Yin Qiulin Tang Hongwei xia Feng bi Division of Abdominal Cancer Department of Medical OncologyCancer Center and Laboratory of Molecular Targeted Therapy in OncologyWest China HospitalSichuan UniversityChengdu 610041China

RAS mutations occur in approximately 30%of tumors worldwide and have a poor prognosis due to limited *** targeting of KRAS G12C has achieved significant success in recent years,but there is still a lack of efficient therapeutic approaches for tumors with non-G12C KRAS mutations.A highly promising approach is to target the MAPK pathway downstream of RAS,with a particular focus on RAF ***-generation RAF inhibitors have been authorized to treat BRAF mutant tumors for over a ***,their use in RAS-mutated tumors is not recommended due to the paradoxical ERK activation mainly caused by RAF *** address the issue of RAF dimerization,type II RAF inhibitors have emerged as leading *** clinical studies have shown the initial effectiveness of these agents against RAS mutant ***,type II RAF inhibitors in combination with MEK or ERK inhibitors have demonstrated impressive efficacy in RAS mutant *** review aims to clarify the importance of RAF dimerization in cellular signaling and resistance to treatment in tumors with RAS mutations,as well as recent progress in therapeutic approaches to address the problem of RAF dimerization in RAS mutant tumors.

关键词： RAS mutations RAF dimerization RAF inhibitors Cancer therapy Drug resistance

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基于多元回归的延安市PM2.5浓度预测

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信息技术 2024年第5期48卷 15-21页

作者：王思源任瑛夏必胜王文发延安大学数学与计算机科学学院陕西延安716000

工业化进程的加快带来的不只是经济的飞速发展,还有以PM2.5为主的污染物浓度的增加,给人类的健康以及环境的治理带来不利影响,合理有效的PM2.5浓度预测对于人类健康和环境治理有着重要意义。文中设计了基于多元回归模型的PM2.5浓度预测... 详细信息

工业化进程的加快带来的不只是经济的飞速发展,还有以PM2.5为主的污染物浓度的增加,给人类的健康以及环境的治理带来不利影响,合理有效的PM2.5浓度预测对于人类健康和环境治理有着重要意义。文中设计了基于多元回归模型的PM2.5浓度预测模型,分别预测了延安市春季、夏季、秋季和冬季的PM2.5浓度,与极限树回归、Catboost回归和K邻近回归等回归模型的预测结果进行对比。结果表明多元回归模型的误差较小,拟合精度较高,为延安市大气污染的治理提供了可靠的科学依据。

关键词：多元回归 PM2.5预测极限树回归随机森林

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Cathodoluminescence of ZnO Films

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Chinese Physics Letters 1998年第6期15卷 457-459页

作者： FU Zhu-xi GUO Chang-xin LIN bi-xia LIAO Gui-hong Department of Physics University of Science and Technology of ChinaHefei 230026

The cathodoluminescence of ZnO films deposited on Si substrates by reactive dc sputtering is *** from the characteristic green emission band(522nm)of ZnO,an ultraviolet(392nm)band and a blue(430-460 nm)band have been *** x-ray diffraction and cathodoluminescent spectra reveal the dependences of the luminescence on the preparation conditions and crystallinity of the ZnO films.

关键词： ultraviolet preparation luminescence

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基于PI3K/AKT通路探讨何氏补肾厚膜方改善大鼠薄型子宫内膜的作用机制

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浙江中西医结合杂志 2024年第3期34卷 214-218页

作者：徐新亚陈碧霞吴晓婷浙江中医药大学附属杭州市中医院中医妇科杭州310007

目的基于磷脂酰肌醇激酶(PI3K)/蛋白激酶B(AKT)通路探讨何氏补肾厚膜方(HBHP)改善大鼠薄型子宫内膜(TE)的作用机制。方法 48只SD雌性大鼠,按体质量随机分为对照组、模型组、阳性组和HBHP组,每组12只。除对照组外,其余各组在发情期对大... 详细信息

目的基于磷脂酰肌醇激酶(PI3K)/蛋白激酶B(AKT)通路探讨何氏补肾厚膜方(HBHP)改善大鼠薄型子宫内膜(TE)的作用机制。方法 48只SD雌性大鼠,按体质量随机分为对照组、模型组、阳性组和HBHP组,每组12只。除对照组外,其余各组在发情期对大鼠右侧子宫注入95%乙醇建立TE模型。HBHP组在模型建立后灌胃给药HBHP 10 g/(kg·d),按1 mL/100 g灌胃。阳性组给予小剂量阿司匹林肠溶片0.5 mg/(kg·d),按1 mL/100 g灌胃;对照组及模型组每日灌服生理盐水1 mL/100 g。各组大鼠连续灌胃15 d后,剖腹取子宫。苏木精-伊红(HE)染色观察子宫内膜厚度的变化。免疫组织化学染色和逆转录-定量实时聚合酶链反应(RT-qPCR)检测子宫内膜组织中PI3K、AKT蛋白和mRNA的表达。结果与对照组比较,模型组大鼠的子宫内膜厚度[(357.34±14.35)μm比(526.08±23.21)μm]、腺体数量[(8.09±1.57)比(19.08±1.31)]、子宫湿重[(0.42±0.05)g比(0.80±0.06)g]和子宫脏器指数[(0.16±0.02)%比(0.30±0.03)%]显著降低(P<0.05)。与模型组比较,HBHP组、阳性组子宫内膜厚度[(476.74±21.42)μm、(438.18±22.39)μm比(357.34±14.35)μm]、腺体数量[(16.09±1.34)、(13.91±1.45)比(8.09±1.57)]、子宫湿重[(0.75±0.06)g、(0.68±0.08)g比(0.42±0.05)g]和子宫脏器指数[(0.26±0.02)%、(0.24±0.03)%比(0.16±0.02)%]显著增加(P<0.05)。与对照组比较,模型组子宫内膜组织中PI3K、AKT及p-AKT蛋白表达[PI3K:(0.15±0.01)比(0.42±0.02);AKT:(0.21±0.01)比(0.71±0.11);p-AKT:(0.37±0.02)比(0.88±0.06)]和AKT、PI3K mRNA相对表达量[AKT:(0.42±0.20)比(1.02±0.23);PI3K:(0.58±0.22)比(1.06±0.35)]显著下调(P<0.05)。与模型组比较,HBHP组、阳性组子宫内膜组织中PI3K、AKT及p-AKT蛋白表达[PI3K:(0.33±0.03)、(0.28±0.02)比(0.15±0.01);AKT:(0.57±0.03)、(0.43±0.05)比(0.21±0.01);p-AKT:(0.71±0.04)、(0.54±0.03)比(0.37±0.02)]和AKT、PI3K mRNA相对表达量[AKT:(0.97±0.33)、(0.86±0.30)比(0.42±0.20);PI3K:(0.98±0.55)、(0.87±0.33)比(0.58±0.22)]显著上调(P<0.05)。结论 HBHP可通过增强PI3K/AKT通路来改善TE模型大鼠的子宫内膜厚度。

关键词：薄型子宫内膜大鼠磷脂酰肌醇激酶蛋白激酶B 何氏补肾厚膜方

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Preparation and Characterization of New Type Ionic Liquids

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Chinese Chemical Letters 2003年第5期14卷 523-524页

作者： Qing Hai CAI Yong Kui SHAN Li Yi DAI bi xia SU Ming Yuan HE Center for chemistry of ionic liquid East China Normal UniversityShanghai 200062

A new type of ionic liquids containing cation of diacetone acrylamide [or N-(1,1- bismethyl-3-oxo-butyl)acrylamide] and anions such as CH3COO- (Ac), CF3COO- (TF), BF4-(BF), PF6-(PF), HSO4-(SO) and Cl-(Cl) were prepared by normal neutralization. The obtained ionic liquids were identified by FT-IR and 1H NMR spectroscopy. However, their properties such as melting point, conductivity, viscosity etc. were determined.

关键词： Ionic liquid diacetone acrylamide preparation characterization.

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Application of artificial intelligence in preoperative imaging of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2021年第32期27卷 5341-5350页

作者： bing Feng xiao-Hong Ma Shuang Wang Wei Cai xia-bi Liu Xin-Ming Zhao Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Laboratory of Intelligent Information Technology School of Computer Science and TechnologyBeijing Institute of TechnologyBeijing 100081China

Hepatocellular carcinoma(HCC)is the most common primary malignant liver tumor in *** diagnosis of HCC is challenging because of atypical imaging manifestations and the diversity of focal liver *** intelligence(AI),such as machine learning(ML)and deep learning,has recently gained attention for its capability to reveal quantitative information on ***,AI is used throughout the entire radiomics process and plays a critical role in multiple fields of *** review summarizes the applications of AI in various aspects of preoperative imaging of HCC,including segmentation,differential diagnosis,prediction of histo-pathology,early detection of recurrence after curative treatment,and evaluation of treatment *** also review the limitations of previous studies and discuss future directions for diagnostic imaging of HCC.

关键词： Hepatocellular carcinoma Radiomics Artificial intelligence Diagnosis Treatment Recurrence

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Epithelial to mesenchymal transition in the progression of tubulointerstitial fibrosis

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Chinese Medical Journal 2007年第21期120卷 1925-1930页

作者： LI Min-xia LIU bi-cheng Institute of Nephrology Zhong Da Hospital Southeast University Nanjing 210009 China

Objective To review the mechanisms of epithelial to mesenchymal transition （EMT） and its role in the progression of tubulointerstitial fibrosis. Data sources The data used in this review were obtained mainly from the studies of EMT reported from 2000-2006. Study selection Relevant articles on studies of EMT in tubulointerstitial fibrosis were selected. Data were mainly extracted from the 45 articles listed in the reference section of this review. Results The process of EMT has gained wide recognition as candidate mechanism in progression of chronic fibrotic disorders. New markers were identified and facilitate the observation of EMT. EMT is regulated by many factors through activation of kinase-dependent signaling cascades. Recent findings suggest that EMT is a reversible process, which can be controlled by factors for their epithelial inducing activities. Conclusion Remarkable progresses of EMT research have been made recently. Preventing or reversing EMT is a promising strategy against renal fibrosis.

关键词： epithelial to mesenchymal transition connective tissue growth factor transforming growth factor integrin-linked kinase tubulointerstitial fibrosis

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