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Perfluorooctane sulfonate promotes the migration of colorectal cancer cells by inducing epithelial-mesenchymal transition

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Journal of Environmental Sciences 2024年第11期145卷 1-12页

作者： Fangfang Li Lu Chen bi-xia Peng Yuyang Lei Minjie Li Liang-Hong Guo Institute of Environmental and Health Sciences China Jiliang UniversityHangzhou 310018China Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province Hangzhou 310015China College of Quality and Safety Engineering China Jiliang UniversityHangzhou 310018China College of Life Sciences China Jiliang UniversityHangzhou 310018China

The potential association between colorectal cancer(CRC)and environmental pollutants is *** studies have found that some perfluoroalkyl acids,including perfluorooctane sulfonate(PFOS),induced colorectal tumors in experimental animals and promoted the migration of and invasion by CRC cells in vitro,but the underlying mechanism is ***,we investigated the effects of PFOS on the proliferation and migration of CRC cells and the potentialmechanisms involving activating the PI3K/Akt-NF-κB signal pathway and epithelial-mesenchymal transition(EMT).It was found that PFOS promoted the growth andmigration of HCT116 cells at non-cytotoxic concentrations and increased the mRNA expression of the migration-related angiogenic cytokines vascular endothelial growth factor(VEGF)and interleukin-8(IL-8).In a mechanistic investigation,the up-stream signal pathway PI3K/Akt-NF-κB was activated by PFOS,and the process was suppressed by LY294002(PI3K/Akt inhibitor)and BAY11-7082(NF-κB inhibitor)respectively,leading to less proliferation of HCT116 ***,matrix metalloproteinases(MMP)and EMT-related markers were up-regulated after PFOS exposure,and were also suppressed respectively by LY294002 and ***,the up-regulation of EMT markers was suppressed by a MMP inhibitor *** together,our results indicated that PFOS promotes colorectal cancer cell migration and proliferation by activating the PI3K/Akt-NF-κB signal pathway and epithelial-mesenchymal *** could be a potential toxicological mechanism of PFOS-induced malignant development of colorectal cancer.

关键词： Perfluorooctane sulfonate Colorectal cancer Cell migration PI3K/Akt-NF-κB Epithelial-mesenchymal transition

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Pleomorphic rhabdomyosarcoma of the vagina: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2396-2403页

作者： Pan Xu Shan-Shan Ling E Hu bi-xia Yi Department of Gynecology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000Zhejiang ProvinceChina Zhejiang University School of Medicine Hangzhou 310006Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma(RMS)of the vagina in postmenopausal women is an extre-mely rare malignant tumor that was originally described as a unique group of soft tissue sarcomas originating from primitive mesenchymal *** was first re-ported in postmenopausal women in 1970,and fewer than 50 postmenopausal patients have been reported to *** SUMMARY A 68-year-old multiparous female was admitted to the hospital on October 11,2023,with the chief complaint of a mass causing vaginal prolapse with incomplete urination that had persisted for 4 *** vaginal mass was approximately the size of a pigeon egg;after lying down,the vaginal mass *** resection was performed,and vaginal pleomorphic RMS was diagnosed based on pathology and immunohistochemical staining *** patient is currently undergoing *** present study also reviewed the clinical,histolo-gical,and immunohistochemical features and latest treatment recommendations for vaginal *** abnormal vaginal mass should be promptly investigated through pelvic examination and appropriate *** current initial treat-ment for vaginal RMS is biopsy and primary *** When surgery is planned for vaginal RMS,an organ-preserving approach should be considered.

关键词： Rhabdomyosarcoma Vagina Postmenopausal woman Pleomorphic Case report

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Dynamic simulation insights into friction weakening effect on rapid long-runout landslides:A case study of the Yigong landslide in the Tibetan Plateau,China

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China Geology 2024年第2期7卷 222-236页

作者： Zi-zheng Guo Xin-yong Zhou Da Huang Shi-jie Zhai bi-xia Tian Guang-ming Li School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Tianjin Municipal Engineering Design&Research Institute(TMEDI) Tianjin 300392China

This study proposed a novel friction law dependent on velocity,displacement and normal stress for kinematic analysis of runout process of rapid *** well-known Yigong landslide occurring in the Tibetan Plateau of China was employed as the case,and the derived dynamic friction formula was included into the numerical simulation based on Particle Flow *** showed that the friction decreased quickly from 0.64(the peak)to 0.1(the stead value)during the 5s-period after the sliding initiation,which explained the behavior of rapid movement of the *** monitored balls set at different sections of the mass showed similar variation characteritics regarding the velocity,namely evident increase at the initial phase of the movement,followed by a fluctuation phase and then a stopping *** peak velocity was more than 100 m/s and most particles had low velocities at 300s after the landslide *** spreading distance of the landslide was calculated at the two-dimension(profile)and three-dimension scale,*** with the simulation result without considering friction weakening effect,our results indicated a max distance of about 10 km from the initial unstable position,which fit better with the actual situation.

关键词： Rapid long-runout landslide PFC Friction weakening Three-dimension Numerical simulation Tibetan Plateau Hydrogeology Engineering Geological hazards survey engineering

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Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis

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Current Medical Science 2024年第3期44卷 611-622页

作者： Ying CHEN bi-xia LI Ting-ting NIU Shu-jun YANG Li-chao WU Le-huai SHI Duo-bing ZOU Ning-ning WU Li-xia SHENG xiao YAN Gui-fang OUYANG Qi-tian MU Laboratory of Stem Cell Transplantation The First Affiliated Hospital of Ningbo UniversityNingbo315300China Ningbo Clinical Research Center For Hematologic Malignancies Ningbo315300China Department of Hematology The First Affiliated Hospital of Ningbo UniversityNingbo315300China School of Medicine Hangzhou City UniversityZhejiang UniversityHangzhou310000China Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province Ningbo315300China

Objective Acute myeloid leukemia(AML)is an aggressive hematological malignancy characterized by abnormal myeloid blast *** studies have demonstrated that circular RNAs play a role in AML *** this study,we aimed to investigate the clinical significance of circ_0012152 in AML and elucidate its underlying molecular mechanism in the pathogenesis of this *** Circ_0012152 expression was detected by quantitative real-time polymerase chain reaction in samples obtained from 247 patients with AML and 40 healthy controls.A systematic analysis of clinical characteristics and prognostic factors was also *** growth was assessed using the Cell Counting Kit-8(CCK-8)assay,and apoptosis and cell cycle progression were evaluated by flow ***,RNA pull-down was performed to identify target microRNAs,and transcriptome RNA sequencing and bioinformatics analyses were utilized to identify downstream mRNA *** Circ_0012152 was significantly upregulated in samples from patients with AML and served as an independent adverse prognostic factor for overall survival(OS)(hazard ratio:2.357;95%confidence interval 1.258–4.415).The circ_0012152 knockdown reduced cell growth,increased apoptosis,and inhibited cell cycle progression in AML cell *** pull-down and sequencing identified miR-652-3p as a target microRNA of circ_*** growth inhibition by circ_0012152 knockdown was significantly relieved by miR-652-3p *** suggested that miR-652-3p targeted SOX4,as the decrease in SOX4 expression resulting from circ_0012152 knockdown was upregulated by miR-652-3p inhibitors in AML *** Circ_0012152 is an independent poor prognostic factor for OS in AML,and it promotes AML cell growth by upregulating SOX4 through miR-652-3p.

关键词： acute myeloid leukemia circ_0012152 miR-652-3p SOX4 cell growth

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Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019

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biomedical and Environmental Sciences 2024年第3期37卷 278-293页

作者： JIANG Jie Ying LIANG Dan WANG Li xiaO Yun LIANG Yu Feng KE bi xia SU Juan xiaO Hong WANG Tao ZOU Min LI Hong Jian KE Chang Wen School of Public Health Shantou UniversityShantou 515063GuangdongChina Guangdong Provincial Center for Disease Control and Prevention Guangdong Workstation for Emerging Infectious Disease Control and PreventionGuangzhou 511430GuangdongChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan UniversityGuangzhou 510632GuangdongChina School of Public Health Sun Yat-sen UniversityGuangzhou 510275GuangdongChina School of Public Health Southern Medical UniversityGuangzhou 510515GuangdongChina Shantou University Medical College Shantou 515041GuangdongChina

Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,*** This study included individuals aged 28 days–85 years.A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens,including RVA,using a Gastrointestinal Pathogen Panel,followed by genotyping,virus isolation,and complete sequencing to assess the genetic diversity of *** The overall RVA infection rate was 14.59%(103/706),with an irregular epidemiological *** proportion of co-infection with RVA and other pathogens was 39.81%(41/103).Acute gastroenteritis is highly prevalent in young children aged 0–1 year,and RVA is the key pathogen circulating in patients 6–10 months of age with diarrhea.G9P[8](58.25%,60/103)was found to be the predominant genotype in the RVA strains,and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic *** analysis showed that gene reassortment events,selection pressure,codon usage bias,gene polymorphism,and post-translational modifications(PTMs)occurred in the G9P[8]and G3P[8]*** This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China,further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic *** the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.

关键词： Infectious diarrheal disease Rotavirus Phylogenetic analysis Gene rearrangement Codon usage bias Genetic diversity

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第一性原理计算研究γ'-Co3(V,M)(M=Ti,Ta)相的结构稳定性、力学和热力学性质

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物理学报 2024年第8期73卷 261-272页

作者：袁文翎姚碧霞李喜胡顺波任伟上海大学材料基因组工程研究院上海200444 上海大学高品质特殊钢冶金与制备国家实验室上海200444 上海交通大学上海市先进高温材料及精密成形重点实验室上海200240 上海大学文化遗产保护基础科学研究院上海200444 上海大学物理系量子与分子结构国际中心上海200444

本文采用基于密度泛函理论的第一性原理计算方法并结合准谐德拜模型,对Co基高温合金中γ'-Co_(3)(V,M)(M=Ti,Ta)相的结构稳定性、热力学性质以及有限温度下的力学性质进行了系统的研究和讨论.结果表明,γ'-Co_(3)(V,M)相能以L12结构稳... 详细信息

本文采用基于密度泛函理论的第一性原理计算方法并结合准谐德拜模型,对Co基高温合金中γ'-Co_(3)(V,M)(M=Ti,Ta)相的结构稳定性、热力学性质以及有限温度下的力学性质进行了系统的研究和讨论.结果表明,γ'-Co_(3)(V,M)相能以L12结构稳定存在,其具有良好的抵抗变形的能力.γ'-Co_(3)(V,Ti)相的热力学性能对温度的敏感性要大于γ'-Co_(3)(V,Ta)相,且γ'-Co_(3)(V,M)相具有高温稳定性.在有限温度下,随着温度的升高,γ'-Co_(3)(V,M)相由塑性材料向脆性材料过渡转变,而且,除了硬度性能有所提升外,γ'-Co_(3)(V,MM=Ti,Ta)相的力学性能均呈下降趋势.

关键词：高温合金第一性原理结构稳定性热力学性质

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论闽语的创新音变

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华侨大学学报（哲学社会科学版） 2024年第1期 147-160页

作者：袁碧霞华侨大学文学院福建泉州362021

闽语语音的保守性已为学界所共知,但其创新性也不容忽视。从历史音变出发,参照官话语音史和其他方言,闽语在声、韵、调上彰显诸多创新。首先,从声母看,闽语既存在一些普遍的音变(如腭化音变等),也在部分方言片发生较为特殊的音变,如边... 详细信息

闽语语音的保守性已为学界所共知,但其创新性也不容忽视。从历史音变出发,参照官话语音史和其他方言,闽语在声、韵、调上彰显诸多创新。首先,从声母看,闽语既存在一些普遍的音变(如腭化音变等),也在部分方言片发生较为特殊的音变,如边音擦化、擦音唇齿化现象。其次,从韵母角度看,除中古韵类之间的合并创新音变外(如,歌豪不分),我们还指出闽语介音的历史音变(包括介音的转移、消失、产生)以及鼻化韵与韵尾的演变所体现出的创新性。同时近期我们还发现闽东部分方言存在舒声促化现象。最后,在声调方面,闽语除调类上的合并与调值上的变异外,还存在音节类型与声调分合关系的特殊音变。

关键词：闽语音变闽东方言

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85例低血磷性佝偻病患儿诊断、治疗与随访的回顾性研究

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中国当代儿科杂志 2024年第7期26卷 677-682页

作者：李海琦陈秋霞车若琛郑必霞张爱华陈颖南京医科大学附属儿童医院江苏南京210000 南京医科大学附属儿童医院儿科学重点实验室江苏南京210000

目的了解低血磷性佝偻病(hypophosphatemic rickets,HR)患儿的诊断、治疗及并发症情况,探讨疾病疗效评价指标,了解患儿身高增长规律。方法回顾性分析2008年1月—2022年12月于南京医科大学附属儿童医院诊治的85例HR患儿的首诊临床资料及... 详细信息

目的了解低血磷性佝偻病(hypophosphatemic rickets,HR)患儿的诊断、治疗及并发症情况,探讨疾病疗效评价指标,了解患儿身高增长规律。方法回顾性分析2008年1月—2022年12月于南京医科大学附属儿童医院诊治的85例HR患儿的首诊临床资料及5年随访资料。结果85例HR患儿中,男性46例(54%),女性39例(46%);首诊年龄范围为6个月至13岁9个月,中位年龄为2.75岁;平均身高标准差数值为-2.0±1.1。首诊时患儿血磷降低,血碱性磷酸酶(alkaline phosphatase,ALP)升高,99%(84/85)患儿存在下肢畸形,PHEX基因突变阳性率为93%(55/59)。患儿治疗1年后ALP水平及双下肢间距较前明显减低(P<0.05)。患儿身高在治疗后第1年增长最快,为8.23 cm/年;存在青春期身高突增峰速度(peak height velocity,PHV)阶段,持续约2年,男性患儿PHV阶段身高共增长9~20 cm,女性患儿PHV阶段身高共增长10~15 cm。患儿主要并发症为肾钙质沉着及甲状旁腺功能亢进。肾钙质沉着治疗后第1年发生率为55%(22/40),其发生率随病程延长而增加(P<0.001);尿磷/尿肌酐比值升高与肾钙质沉着的风险升高呈正性关联(OR=1.740,P<0.001)。甲状旁腺功能亢进治疗后第1年发生率为64%(27/42)。结论对存在下肢畸形、身材矮小、生长缓慢的儿童,及早进行血磷、血钙、ALP检测及下肢影像学检查有助HR的早期诊断,必要时可结合基因检测确诊。ALP结合骨骼畸形改善及身高年增长情况可作为HR治疗疗效的评价指标。患儿青春期PHV阶段身高总增长小于正常儿童,需密切随访,及时调整治疗方案.

关键词：低血磷性佝偻病诊断治疗随访身高儿童

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基于百度指数的广东省森林旅游网络关注度及时空差异性分析

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台湾农业探索 2024年第1期 53-59页

作者：林碧虾许福志汕头职业技术学院文化旅游学院广东汕头515000 福建理工大学互联网经贸学院福建福州350000

【目的/意义】在国家大力推动生态文明建设和广东省实行绿化大行动的背景下,探索广东省森林旅游的时空演变规律,以期为森林旅游市场需求预测及宣传营销提供借鉴。【方法/过程】借助百度指数,运用数理模型、计量工具分析国内31个省份对... 详细信息

【目的/意义】在国家大力推动生态文明建设和广东省实行绿化大行动的背景下,探索广东省森林旅游的时空演变规律,以期为森林旅游市场需求预测及宣传营销提供借鉴。【方法/过程】借助百度指数,运用数理模型、计量工具分析国内31个省份对广东森林旅游网络关注度的时空特征及影响因素。【结果/结论】研究结果显示:在时间层面,网络关注度总体呈“S”型波动,淡旺季明显,夏季>秋季>春季>冬季,黄金周前兆效应显著但有减小趋势。在空间层面,客源市场呈现“广东省内和江苏省双核心,向周边省份递减”“二级市场居多,趋向均衡化”的发展态势。通过灰色关联度分析发现,经济发展水平、教育水平、交通便捷度、互联网发展水平和节庆活动是影响网络关注度的主要因素。

关键词：百度指数森林旅游网络关注度广东省时空差异

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Community attitudes toward ecotourism development and environmental conservation in nature reserve:a case of Fujian Wuyishan National Nature Reserve,China

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Journal of Mountain Science 2017年第7期14卷 1405-1418页

作者： CHEN bi-xia QIU Zhen-mian Faculty of Agriculture University of the RyukyusNishihara Town School of Economics Fujian Normal University Kanazawa University

Using social exchange theory, this study investigated residents＇ attitudes toward the preliminary stage of tourism development in nature reserves in Wuyishan National Nature Reserve of China, and the socio-economic and negative effects of residents＇ attitude toward the tourist industry. Results of the questionnaire survey indicated that local people perceived they could benefit from the economic activities related to tourism, and were supportive of the conservation of natural resources and local culture, sustainable community development, and community participation in ecotourism planning and management. This study also revealed that the variables of age, gender, education level, household income, family size, non-farm work arrangements, and the distance to tourism attractions, have significant association with respondents＇ attitudes toward ecotourism development, or negative impacts of the tourist industry. Respondents who are male, or have a higher household income, are more supportive of tourism development inside the reserve. Younger and more highly educated community members are more likely to support learning more about natural and cultural resources and landscapes. Respondents who have a hieher household income, or live far fromthe village center, are more concerned about the negative environmental impacts of tourism development.

关键词： Economic benefits Environmentalconservation Nature reserve Residents' attitude Tourism development Wuyishan National NatureReserve

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