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Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma

Chinese Neurosurgical Journal 2022年第2期8卷 111-119页

作者： Liyun Zhong Pei Yang Chuanbao Zhang Zheng Wang Tao Jiang Baoshi Chen xia shan xiaoguang Qiu Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijingChina China National Clinical Research Center for Neurological Diseases 119 South 4th Ring Road WestBeijing 100070China Department of Radiotherapy Beijing Tiantan HospitalCapital Medical University119 South 4th Ring Road WestBeijing 100070China

Background:Adjuvant temozolomide(TMZ)chemotherapy with standard regimen remarkably improves survival in patients with high-grade glioma(HGG).However,the influence of long-term TMZ chemotherapy on serum ions concentration is unclear.Methods:One hundred and thirty-eight patients with HGG were included.Their blood samples were collected for blood biochemistry and routine test.The alteration in serum ions concentration,total protein,albumin,globin,and blood cells counts were used to identify the impact of long-term TMZ chemotherapy.Results:Through the comparation of quantitative value of diverse parameters among different chemotherapy cycles,we identified that serum potassium concentration had a downward trend after TMZ administration(1st vs.6th,p<0.001;1st vs.12th,p<0.001).Additionally,the correlation analysis showed that platelets was negatively correlated with chemotherapy cycles(r=−0.649,p=0.023).The hematological adverse events mainly centered on grade 1 to 2.Conclusion:Long-term administration of TMZ may lead to serum ions disturbance.Besides the myelosuppression,we should pay attention to the alteration in serum ions concentration,and give patients proper symptomatic treatment when necessary.

关键词： High-grade glioma(HGG) Temozolomide(TMZ) Chemotherapy Toxicity

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Serum microRNA expression profiling revealing potential diagnostic biomarkers for lung adenocarcinoma

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Chinese Medical Journal 2020年第21期133卷 2532-2542页

作者： xia shan Lan Zhang Dan-xia Zhu Xin Zhou Huo Zhang Qing-Xie Liu Jian-Wei Tang Wei Wen Tong-shan Wang Wei Zhu Ping Liu Department of Oncology First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Respiration The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingJiangsu 210000China Department of Radiation Oncology Suzhou Municipal Hospital Affiliated to Nanjing Medical UniversitySuzhouJiangsu 215001China Department of Oncology The Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003China Department of Oncology Clinical Medical College of Yangzhou UniversitySubei People’s Hospital of Jiangsu ProvinceYangzhouJiangsu 225000China Department of Thoracic Surgery First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Background:Recent studies have demonstrated that microRNAs(miRNAs)in the blood circulation can serve as promising diagnostic markers for cancers.This four-stage study aimed at finding serum miRNAs as potential biomarkers for lung adenocarcinoma(LA)diagnosis.Methods:The study was carried out between 2016 and 2017.The Exiqon miRNA qPCR panel(3 LA vs.1 normal control[NC]pooled serum samples)was used for initial screening to acquire miRNA profiles.Thirty-five dysregulated miRNAs were further evaluated in the training(24 LA vs.24 NCs)and testing stages(110 LA vs.110 NCs)using quantitative real-time polymerase chain reaction assays.Results:Four serum miRNAs(miR-133a-3p,miR-584-5p,miR-10b-5p,and miR-221-3p)were significantly overexpressed in LA patients compared with NCs.The diagnostic value of the four-miRNA panel was validated by an external cohort(36 LA vs.36 NCs).The areas under the receiver operating characteristic curve of the four-miRNA panel in the training,testing,and external validation stages were 0.734,0.803,and 0.894 respectively.Meanwhile,the expression level of miR-221-3p was much higher in LA tumor samples than that in the adjacent normal tissues(19 LA vs.19 NCs).The expression level of miR-10b-5p was also elevated in the serum-derived exosomes samples(18 LA vs.18 NCs).The expression of miR-133a-3p,miR-584-5p,and miR-10b-5p was significantly elevated in LA patients with epidermal growth factor receptor mutation compared with NCs.Conclusion:The study established a four-miRNA signature in serum that could improve the diagnostic capability of LA.

关键词： Serum microRNA Lung adenocarcinoma Diagnostic biomarker Exosomes Epidermal growth factor receptor

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高校强化有组织科技创新的思考和实践

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研究与发展管理 2024年第3期36卷 169-174页

作者：朱才朝夏杉珊肖韶重庆大学科技创新发展战略研究院重庆400044 重庆大学前沿交叉学科研究院重庆400045

提速建设科技强国,推动高水平科技自立自强是党和国家在新征程对创新发展和转型升级提出的新要求。高校作为国家战略科技力量重要组成部分,应切实担负起推动科技创新的使命担当和历史责任,加强有组织科研,持续优化创新体系,加快突破关... 详细信息

提速建设科技强国,推动高水平科技自立自强是党和国家在新征程对创新发展和转型升级提出的新要求。高校作为国家战略科技力量重要组成部分,应切实担负起推动科技创新的使命担当和历史责任,加强有组织科研,持续优化创新体系,加快突破关键核心技术。而高校加强有组织科研的路径和方式还需要进一步研究探索。本文分析总结了美国、欧洲、日本等发达国家高校在科技创新上的主要做法,梳理了国内重点高校在科研管理体制机制改革、加强有组织科研方面的重点举措,并结合重庆大学在强化有组织科技创新方面的实践经验,从加强与国家需求紧密对接、完善创新体系、推进技术科学发展、完善人才流动机制等方面提出强化有组织科技创新的意见和建议,为我国高校推动有组织科研、打造国家战略科技力量提供参考和借鉴。

关键词：有组织科技创新高校学科交叉对策建议创新实践

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miR-338-3p acts as a tumor suppressor in lung squamous cell carcinoma by targeting FGFR2/FRS2

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Cancer Pathogenesis and Therapy 2023年第2期1卷 87-97页

作者： xia shan Cheng Zhang Chunyu Li Xingchen Fan Guoxin Song Jingfeng Zhu Risheng Cao Xiuwei Zhang Wei Zhu Department of Respiration Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210000China Women&Children Central Laboratory Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210036China Women&Children Intensive Care Unit Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210036China Department of Oncology Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210029China Department of Pathology Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210029China Department of Nephrology Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210029China Department of Science and Technology Jiangsu Province HospitalAnd Nanjing Medical University First Affiliated HospitalNanjingJiangsu 210029China

Background:Lung cancer refers to the occurrence of malignant tumors in the lung,and squamous cell carcinoma is one of the most common pathological types of non-small cell lung cancer.Studies have shown that microRNAs(miRNAs)play an important role in the occurrence,development,early diagnosis,and treatment of lung cancer.This study aimed to explore the role and possible mechanism of MicroRNA-338-3p(miR-338-3p)in lung squamous cell carcinoma(LUSC).

关键词： miR-338-3p FGFR2

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Intratumor heterogeneity,microenvironment,and mechanisms of drug resistance in glioma recurrence and evolution

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Frontiers of Medicine 2021年第4期15卷 551-561页

作者： Zhaoshi Bao Yongzhi Wang Qiangwei Wang Shengyu Fang xia shan Jiguang Wang Tao Jiang Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Divison of Life Science Department of Chemical and Biological EngineeringCenter for Systems Biology and Human Healthand State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyHong KongChina China National Clinical Research Center for Neurological Diseases Beijing 100050China Division of Life Science Hong Kong University of Science and TechnologyHong KongChina Center of Brain Tumor Beijing Institute for Brain DisordersBeijing 100069China Department of Radiotherapy Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Glioma is the most common lethal tumor of the human brain.The median survival of patients with primary World Health Organization grade IV glioma is only 14.6 months.The World Health Organization classification of tumors of the central nervous system categorized gliomas into lower-grade gliomas and glioblastomas.Unlike primary glioblastoma that usually develop de novo in the elderly,secondary glioblastoma enriched with an isocitrate dehydrogenase mutant typically progresses from lower-grade glioma within 5-10 years from the time of diagnosis.Based on various evolutional trajectories brought on by clonal and subclonal alterations,the evolution patterns of glioma vary according to different theories.Some important features distinguish the normal brain from other tissues,e.g.,the composition of the microenvironment around the tumor cells,the presence of the blood-brain barrier,and others.The underlying mechanism of glioma recurrence and evolution patterns of glioma are different from those of other types of cancer.Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.However,the detailed reasons for the progression and recurrence of glioma remain controversial.In this review,we introduce the different mechanisms involved in glioma progression,including tumor heterogeneity,the tumor microenvironment and drug resistance,and their pre-clinical implements in clinical trials.This review aimed to provide new insights into further clinical strategies for the treatment of patients with recurrent and secondary glioma.

关键词： glioma evolution mechanism strategies tumor heterogeneity secondary glioma

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Buckling morphology of glassy nematic films with staggered director field

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1841-1852页

作者： shan xia Linghui HE College of Civil Engineering Anhui Jianzhu UniversityHefei 230601China Department of Modern Mechanics and State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

The photo-induced buckling of axially periodic glassy nematic films with alternating stripped director domains is explored by the F¨oppl-von K′arm′an plate theory along with a modified kinetics approach.The effects of domain widths on the critical light intensity as well as the buckling morphology are examined numerically.It is found that in most cases the buckled film forms regularly aligned dimples and protrusions,but shows large scale bending perpendicular to the periodic axis if the widths of the stripes are nearly the same.In addition,change in light intensity is shown to alter the wavenumber of the buckling pattern.These results are expected helpful to the design of shape-shifting structures with glassy nematic films.

关键词： glassy nematic flm buckling morphology staggered director field

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电化学储能产业发展现状及措施建议

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合成材料老化与应用 2024年第3期53卷 59-62页

作者：刘滨夏姗姗田超中国电子产品可靠性与环境试验研究所

随着国际能源紧张，新能源技术普及和应用的需求也大幅增加，电化学储能产业发展迎来机遇。该文从国内电化学储能产业政策、科技发展以及产业布局等角度进行研究分析；探讨市场机制不成熟、标准体系不完善、系统可靠性有待提升、系统安... 详细信息

随着国际能源紧张，新能源技术普及和应用的需求也大幅增加，电化学储能产业发展迎来机遇。该文从国内电化学储能产业政策、科技发展以及产业布局等角度进行研究分析；探讨市场机制不成熟、标准体系不完善、系统可靠性有待提升、系统安全问题复杂等问题。建议在产业政策层面，需根据国内产业发展的实际阶段加大政策创新力度；在科技发展层面，应更多关注电化学储能系统的标准体系完善、可靠性和安全性提升；在产业布局层面，当前国内电化学储能产业发展基础良好，瓶颈在于商业模式不成熟，模式创新有待加强。

关键词：电化学储能产业政策技术发展产业布局

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Preparation and application of graphene-based wearable sensors

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Nano Research 2022年第11期15卷 9850-9865页

作者： shan xia Ming Wang Guanghui Gao Polymeric and Soft Materials Laboratory School of Chemical Engineering and Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012China Beijing Graphene Institute(BGI) Beijing 100871China

With the development of digital healthcare technology,the demand for non-invasive monitoring of human health is rapidly increasing.In recent years,the research and application of timely,economical,and easy-to-operate wearable sensing devices have attracted much attention.Among recent studies,graphene has been widely used to improve the sensing performance of wearable sensors due to its advantages in mechanical,electrical,and thermal properties.This review mainly focuses on summarizing graphene and its derivative-based wearable sensors and their latest developments in personal health monitoring.We will first introduce the novel structure and sensing mechanism of different types of graphene sensors.Then,we summarize the latest applications of the graphene wearable sensors in human health monitoring,including human activity,heart rate,pulse,electrophysiological signal,and electronic skin.Finally,the future challenges and prospects of graphene wearable devices will be discussed.

关键词： graphene sensor health monitoring physiological signal electronic skin

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Expression of HLA-DR genes in gliomas: correlation with clinicopathological features and prognosis

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Chinese Neurosurgical Journal 2017年第3期3卷 154-162页

作者： Xing Fan Jingshan Liang Zhifeng Wu xia shan Hui Qiao Tao Jiang Beijing Neurosurgical Institute Capital Medical University Beijing China Beijing Neurosurgical Institute Capital Medical University Beijing ChinaBeijing Tiantan Hospital Capital Medical University Beijing ChinaDepartment of Clinical Oncology Beijing Academy of Critical Illness in Brain Beijing 100069 China

Human leukocyte antigen (HLA)-DR is a classical major histocompatibility complex (MHC) class II molecule encoded by five genes: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5. The current study aimed to investigate the role of these genes in gliomas by analyzing microarray data. We enrolled 305 patients with histologically confirmed gliomas, and performed microarray data analysis along with studying their clinical characteristics. A new variable, termed HLA-DR score, was defined to explain the expression information of all five HLA-DR genes by factor analysis. HLA-DR scores in each grade of glioma and normal brain tissue were compared using one-way ANOVA. Lastly, correlations of HLA-DR scores with progression-free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier and Cox analysis. Our study indicated that an increased HLA-DR score, i.e. overexpression of HLA-DR genes, was correlated with a more aggressive glioma tumor grade (p < 0.001, One-way ANOVA). Moreover, the HLA-DR score was significantly higher in astrocytic tumors than oligodendroglial tumors (−0.718 ± 3.177 versus −2.975 ± 2.662, t-test) in low-grade gliomas (LGGs). Kaplan-Meier analysis of both PFS (p = 0.046, log-rank test; p = 0.021, Breslow test) and OS (p = 0.029, Breslow test) showed significant differences in the clinical outcomes between LGG patients with high versus low HLA-DR scores. Finally, the HLA-DR score was further identified to be an independent prognostic factor of clinical outcomes by multivariate analysis (p = 0.042 and p = 0.025, for PFS and OS, respectively) in LGG patients. Expression of HLA-DR genes can be used to predict the tumor grade in gliomas, and the histological subtype in LGG. Furthermore, they are also an independent predictor for LGG patient survival.

关键词： Glioma Human leukocyte antigen-DR Prognosis

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云南输电线路的定额参数套取规则的实现方式

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工程建设与设计 2024年第10期 44-46页

作者：夏青山蒲思昌兴艳云南电网有限责任公司昆明650000 云南电网有限责任公司电网规划建设研究中心昆明650011

在输电线路参数的计算方法的理论探讨的基础上,对影响输电线路参数的工程计算结果主要因素进行了分析,解决了输电线沿线各区段土壤电阻率差异大、难以精确测量等问题。项目提出了分段计算,并进行了杆塔参数的简化处理,实现了技术的改进... 详细信息

在输电线路参数的计算方法的理论探讨的基础上,对影响输电线路参数的工程计算结果主要因素进行了分析,解决了输电线沿线各区段土壤电阻率差异大、难以精确测量等问题。项目提出了分段计算,并进行了杆塔参数的简化处理,实现了技术的改进。研究结果表明:新的计算方法不仅可以应用到实际工程中,还能准确地测定输电线路中的参数。

关键词：输电线路定额参数套取规则分段计算电阻率

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