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Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-Hua Zhang Zhi-Hua Xu Shuang-Shuang Ni Hong-xia luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

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Reconstruction of biomimetic ionic channels within covalent organic frameworks for ultrafast and selective uranyl capture

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Science China Chemistry 2024年第10期67卷 3423-3431页

作者： Cheng-Rong Zhang xiao-Juan Chen Cheng-Peng Niu Cheng Meng Shun-Mo Yi Xin Liu Jia-Xin Qi Qiu-xia luo Ru-Ping Liang Jian-Ding Qiu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China College of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

The efficient extraction of uranium,as the primary component of nuclear energy,holds significant *** inspiration from the charge interaction observed in biological ion channels,we encapsulated negatively charged polystyrene sulfonate(PSS)or sodium polystyrene carboxylate(PVBA)into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO)in-situ to alter the cavity environment of *** synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium *** negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions,thus creating a highly selective“uranium highway”.Additionally,introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with *** to charge-assisted migration and various interaction mechanisms,both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO *** adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption *** work presents a bionic adsorbent based on covalent organic frameworks(COFs)for the first time,overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture,opening up new avenues for designing multifunctional materials that mimic biological systems.

关键词： covalent organic frameworks Uranium biomimetic ion-channels adsorption

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Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells

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Journal of Pharmaceutical Analysis 2024年第6期14卷 889-901页

作者： Shaowei Huang Xueqian Xie Bo Xu Zengfeng Pan Junjie Liang Meiling Zhang Simin Pan xiaojing Wang Meng Zhao Qing Wang Jinyan Chen Yanyang Li Lian Zhou xia luo School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine510006China School of Basic Medicine Guangzhou University of Chinese Medicine510006China First Clinical Medical College Guangzhou University of Chinese Medicine510000China

Inhibiting the death receptor 3(DR3)signaling pathway in group 3 innate lymphoid cells(ILC3s)presents a promising approach for promoting mucosal repair in individuals with ulcerative colitis(UC).Paeoniflorin,a prominent component of Paeonia lactiflora Pall.,has demonstrated the ability to restore barrier function in UC mice,but the precise mechanism remains *** this study,we aimed to delve into whether paeoniflorin may promote intestinal mucosal repair in chronic colitis by inhibiting DR3 signaling in ILC3s.C57BL/6 mice were subjected to random allocation into 7 distinct groups,namely the control group,the 2%dextran sodium sulfate(DSS)group,the paeoniflorin groups(25,50,and 100 mg/kg),the anti-tumor necrosis factor-like ligand 1A(anti-TL1A)antibody group,and the IgG *** detected the expression of DR3 signaling pathway proteins and the proportion of ILC3s in the mouse colon using Western blot and flow cytometry,***,DR3-overexpressing MNK-3 cells and 2%DSS-induced Rag1^(-/-)mice were used for *** results showed that paeoniflorin alleviated DSS-induced chronic colitis and repaired the intestinal mucosal ***,paeoniflorin inhibited the DR3 signaling pathway in ILC3s and regulated the content of cytokines(interleukin-17A,granulocyte-macrophage colony stimulating factor,and interleukin-22).Alternatively,paeoniflorin directly inhibited the DR3 signaling pathway in ILC3s to repair mucosal damage independently of the adaptive immune *** additionally confirmed that paeoniflorin-conditioned medium(CM)restored the expression of tight junctions in Caco-2 cells via *** conclusion,paeoniflorin ameliorates chronic colitis by enhancing the intestinal barrier in an ILC3-dependent manner,and its mechanism is associated with the inhibition of the DR3 signaling pathway.

关键词： Paeoniflorin Ulcerative colitis Intestinal mucosal barrier DR3 signaling pathway Group 3 innate lymphoid cells

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Cellular metabolism: A key player in cancer ferroptosis

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Cancer Communications 2024年第2期44卷 185-204页

作者： xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng xia Yanyan Tang xia luo Jie Dai Yujuan Zhou Qianjin Liao Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Public Service Platform of Tumor Organoids Technology ChangshaHunanP.R.China Department of Head and Neck Surgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanP.R.China Hengyang Medical School University of South ChinaHengyangHunanP.R.China

Cellular metabolism is the fundamental process by which cells maintain growth and *** produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular *** metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell *** is a recently discovered form of iron-dependent programmed cell *** inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor ***,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well ***,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this ***,we provided a detailed overview of agents used to induce cancer *** explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell *** combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments.

关键词： cancer therapy cellular metabolism ferroptosis inducer ferroptosis

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去泛素化酶在肾细胞癌中的作用

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生物化学与生物物理进展 2024年第2期51卷 276-299页

作者：罗霞金晓锋宁波大学医学部生物化学与分子生物学系浙江省病理生理学技术研究重点实验室宁波315211

肾细胞癌(renal cell carcinoma,RCC)是成人肾脏的原发性恶性肿瘤。泛素-蛋白酶体系统(ubiquitinproteasome system,UPS)对控制蛋白质水平和调节生理病理过程至关重要。去泛素化酶(deubiquitinases,DUBs)是UPS的关键成分,特别是从靶蛋... 详细信息

肾细胞癌(renal cell carcinoma,RCC)是成人肾脏的原发性恶性肿瘤。泛素-蛋白酶体系统(ubiquitinproteasome system,UPS)对控制蛋白质水平和调节生理病理过程至关重要。去泛素化酶(deubiquitinases,DUBs)是UPS的关键成分,特别是从靶蛋白中去除泛素链,通过严格调节正常生理学中泛素化和去泛素化之间的平衡,对蛋白质稳态和质量控制显示出至关重要的作用。越来越多的研究表明,功能异常的DUBs与RCC的进展和转移有关。根据底物的不同,一些DUB可能会抑制RCC,而另一些则促进。本文综述了RCC相关DUB的最新研究进展,描述了其分类、功能作用,总结了DUB在RCC中的作用和作用机制,并讨论了靶向DUBs用于癌症治疗。

关键词：肾细胞癌泛素-蛋白酶体系统去泛素化酶

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外源CO和H_(2)S对NaCl胁迫下加工番茄幼苗光合及叶绿素荧光动力学的影响

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植物营养与肥料学报 2024年第3期30卷 538-549页

作者：骆霞滕元旭崔辉梅石河子大学农学院/特色果蔬栽培生理与种质资源利用兵团重点实验室新疆石河子832003

[目的]研究一氧化碳(CO)和硫化氢(H_(2)S)调控作物幼苗抗盐能力的机理,为缓解盐渍土中NaCl对作物的胁迫提供理论和技术。[方法]以加工番茄品系KT-7为试验材料,采用无土栽培方法进行CO和H_(2)S叶面喷施试验。CO供体为氯化血红素溶液(hemi... 详细信息

[目的]研究一氧化碳(CO)和硫化氢(H_(2)S)调控作物幼苗抗盐能力的机理,为缓解盐渍土中NaCl对作物的胁迫提供理论和技术。[方法]以加工番茄品系KT-7为试验材料,采用无土栽培方法进行CO和H_(2)S叶面喷施试验。CO供体为氯化血红素溶液(hemin 15μmol/L),H_(2)S供体为硫氢化钠溶液(NaHS,50μmol/L),并因处理需要使用了H_(2)S清除剂次牛磺酸溶液(HT,100μmol/L)和血红素加氧酶抑制剂锌原卟啉溶液(ZnPPⅨ,25μmol/L)。试验共设6个处理,除对照根部浇灌营养液,叶面喷施清水外(CK_(0)),其余5个处理均根部浇灌200 mmol/L NaCl溶液,叶面分别喷施清水(CK_(1))、CO、H_(2)S、CO+HT、H_(2)S+ZnPPⅨ。幼苗长至四叶一心时,连续6天进行NaCl浇灌和叶面喷施处理,然后测定幼苗形态学指标,用Li-6800便携式光合测定仪测定光合参数,用Imaging-PAM荧光成像系统测定叶绿素荧光系数,植物效率仪测定叶绿素荧光动力学曲线(OJIP曲线)。[结果]胁迫6天后,加工番茄幼苗的各项形态学参数、净光合速率(P_(n))、实际光化学效率[Y(Ⅱ)]和光系统Ⅱ(PSⅡ)性能指标[PI_(ABS)和PI_((CSM))]显著下降,OJIP曲线产生形变,并出现K点。CO和H_(2)S处理均有效提高了加工番茄幼苗的光合色素含量、光合参数、PSⅡ的综合性能和受体侧的电子传递效率;提升了OJIP曲线中的J点、I点、P点,降低了ΔK,从而缓解了OJIP曲线的形变;CO处理的P_(n)、表观CO^(2)利用率(CUEapp)、Y(Ⅱ)和电子传递速率(ETR)分别较CK_(1)上升了75.63%、100%、60.00%和57.72%,H_(2)S处理分别上升了65.95%、100%、55.00%和52.68%,CO和H_(2)S处理均降低了非光化学淬灭和热耗散的比例,减少了PSⅡ供体侧放氧复合体(OEC)的损伤。CO+HT处理缓解NaCl胁迫的效果和CO处理相似,而H_(2)S+ZnPPⅨ处理则不能缓解NaCl胁迫,其光合色素含量、P_(n)、F_(v)/F_(m)、Y(Ⅱ)、qL、ETR、PI_(ABS)和PI_((CSM))较H_(2)S处理显著下降,热耗散比率则较H_(2)S处理显著升高。[结论]外源施用CO和H_(2)S均可通过提高光合效率,优化PSⅡ能量分配比率,保护光合电子传递链免受盐害损伤,显著提高番茄幼苗的抗盐能力。CO的作用位点可能在H_(2)S下游,具有协同H_(2)S提高加工番茄耐盐性的作用。

关键词：一氧化碳硫化氢加工番茄 NaCl胁迫叶绿素荧光

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Overcoming Spatial Constraints in VR:A Survey of Redirected Walking Techniques

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Journal of Computer Science & Technology 2024年第4期39卷 841-870页

作者： Jia-Hong Liu Yang-Fu Ren Qi Wen Gan Kui Huang Fiona xiao Yu Chen Er-xia luo Khang Yeu Tang Yue-Yao Fu Cheng-Wei Fan Sen-Zhe Xu Song-Hai Zhang Academy of Arts and Design Tsinghua UniversityBeijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China College of Computer Technology and Application Qinghai UniversityXining 810016China Zhili College Tsinghua UniversityBeijing 100084China School of Computer Beijing Information Science and Technology UniversityBeijing 100192China Department of Physics Tsinghua UniversityBeijing 100084China School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China

As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains *** survey comprehensively explores the advancements in redirected walking(RDW)techniques aimed at overcoming spatial constraints in *** addresses this by subtly manipulating users’physical movements to allow for seamless navigation within constrained *** survey delves into gain perception mechanisms,detailing how slight discrepancies between virtual and real-world movements can be utilized without user awareness,thus extending the effective navigable *** RDW control algorithms for gain-based RDW are analyzed,highlighting their implementation and effectiveness in maintaining immersion and minimizing perceptual ***,novel methods extending beyond traditional gain-based techniques are discussed,showcasing innovative approaches that further refine VR *** practical implications of RDW in enhancing safety and reducing physical collisions in VR environments are underscored,alongside its potential to improve user experience by aligning virtual exploration more closely with natural human behavior *** a thorough review of existing literature and recent advancements,this survey provides a systematic understanding for researchers,developers,and industry *** underscores the importance of RDW in the future of VR,emphasizing RDW's role in making VR more accessible and practical across various applications,from education and training to therapy and *** paper concludes with a forward-looking perspective on the continued evolution and potential of RDW in revolutionizing virtual reality experiences.

关键词： virtual reality(VR) redirected walking(RDW) redirection gain perception

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嵌入性理论视角下职业教育教学成果培育的现实审思与路径研究

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高等职业教育探索 2024年第5期23卷 74-80页

作者：罗霞南宁师范大学广西南宁530001

嵌入性理论视角下,对职业教育国家级教学成果奖培育的互嵌境遇进行审思,发现存在完成主体倾斜、建设主体缺位、成果主题同质化、制度保障缺失等方面的多重脱嵌。为了保持教学成果培育的耦合再嵌,一是缩小地区差异,加强团队建设;二是统... 详细信息

嵌入性理论视角下,对职业教育国家级教学成果奖培育的互嵌境遇进行审思,发现存在完成主体倾斜、建设主体缺位、成果主题同质化、制度保障缺失等方面的多重脱嵌。为了保持教学成果培育的耦合再嵌,一是缩小地区差异,加强团队建设;二是统筹权责关系,明确建设宗旨;三是明确区域定位,推进内涵建设;四是规范制度保障,深化成果推广。

关键词：嵌入性理论职业教育教学成果脱嵌再嵌

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职业本科建设的中日比较——以日本专门职大学为例

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宁波职业技术学院学报 2024年第3期28卷 10-16页

作者：罗霞南宁师范大学职业技术师范学院广西南宁530001

专门职大学是日本在面对职业教育身份困境与产业转型发展过程中衍生出的新事物,也是日本高等职业教育的新兴力量。我国职业本科的实施背景与日本相似,发展也有异曲同工之处,因此将日本专门职大学与我国职业本科从各维度进行对比研究,对... 详细信息

专门职大学是日本在面对职业教育身份困境与产业转型发展过程中衍生出的新事物,也是日本高等职业教育的新兴力量。我国职业本科的实施背景与日本相似,发展也有异曲同工之处,因此将日本专门职大学与我国职业本科从各维度进行对比研究,对我国职业本科的建设具有一定的借鉴意义。对比发现,日本专门职大学与我国职业本科在改革背景、课程设置、质量保障、学位授予等方面存在相同之处,但在招考制度、培养定位、专业设置、师资建设、产教融合等层面存在不同之处,同时在这些方面的实践经验可为我国职业本科建设提供参考。

关键词：职业本科专门职大学国际化比较

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单片机技术在电子工程中的应用

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农机使用与维修 2024年第9期 112-115页

作者：罗霞江苏省涟水中等专业学校江苏淮安223400

单片机是现代电子设备中的重要组成部分,是一种集成了处理器核心、存储器、输入/输出端口等多种功能于一体的微型计算机系统,以其小型化、高度集成化和低成本的特点,在各种电子产品中发挥着核心作用。该文系统分析了单片机技术在工业控... 详细信息

单片机是现代电子设备中的重要组成部分,是一种集成了处理器核心、存储器、输入/输出端口等多种功能于一体的微型计算机系统,以其小型化、高度集成化和低成本的特点,在各种电子产品中发挥着核心作用。该文系统分析了单片机技术在工业控制系统、通信设备及安全系统中的应用,阐述了单片机技术对于促进技术创新和进步的推动作用与效果,并提出未来单片机技术发展趋势及研究重点。研究结果旨在为单片机技术及其在电子工程领域中的发展提供理论基础初步探析。

关键词：单片机电子工程集成电路智能系统硬件设计

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