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World Journal of Pediatrics 2022年第4期18卷 271-277页

作者： Yi Cao Wei-Hui Yan Li-Na Lu Yi-Jing Tao Hai-xia Feng qing-qing Wu Yi-Jing Chu Wei Cai ying Wang Division of Pediatric Gastroenterology and Nutrition Xinhua Hospital Affiliated To Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang Rd.ShanghaiChina Shanghai Institute for Pediatric Research ShanghaiChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition No.1665Kongjiang Rd.ShanghaiChina

Background Children with intestinal failure(IF)have frequent catheter-related bloodstream infections(CRBSIs).This study aimed to analyze the clinical presentation and laboratory parameters of CRBSIs in children with *** This 6-year retrospective study was conducted among IF children with CRBSIs at an intestinal rehabilitation center in *** data were collected,including data of temperature and gastrointestinal ***/catheter culture,fecal tests,and calculation of inflammatory index were performed,which were obtained within 1 week since CRBSI *** Fifty children with 87 CRBSIs were identified,of which there were 17 suspected and 70 confirmed ***-two pathogens were cultured from 70 positive blood cultures:63%were Gram-positive organisms,23%were Gram-negative organisms,and 11%were fungal ***,48.6%were enteric organisms;47.2%of bacterial pathogens were consistent between fecal and blood ***,46.3%fecal routines showed abnormalities including increased white blood cells,occult blood positive and the presence of fat *** consistent symptom at onset of CRBSIs was fever and gastrointestinal symptoms including increased stool output,abdominal distension,or both.C-reactive protein(CRP)and procalcitonin(PCT)were elevated,i.e.,16.5 mg/L[interquartile range(IQR)8.7-44.7]and 0.48 ng/mL(IQR 0.2-1.76),*** IF children had a high rate of CRBSIs,of which larger proportions were due to Gram-positive and enteric *** and/or gastrointestinal symptoms,combined with elevated CRP and PCT,is conducive to the early diagnosis of CRBSIs in IF patients.

关键词： Enteric pathogens Fecal examination Gastrointestinal symptoms

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Kinetic Analysis of the Interaction between Nonsteroidal Anti-inflammatory Drugs and Cyclooxygenase-2 Using Wavelength Modulation Surface Plasmon Resonance

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Chinese Journal of Chemistry 2011年第1期29卷 165-170页

作者： Liu, xia Li, ying Lin, Zhao College of Food Science and Technology Hunan Agricultural University Hunan Provincial Key Laboratory of Food Science and Biotechnology Changsha Hunan 410128 China

A surface plasmon resonance （SPR） biosensor based on wavelength modulation technology was developed and validated for the kinetic analysis of the interactions between two nonsteroidal anti-inflammatory drugs （NSAIDs） and cyclooxygenase-2 （COX-2）. After the effect of different concentration COX-2 on the binding capacity of the SPR biosensor surface was studied, the COX-2 was immobilized covalently onto the biosensor surface using a standard amine coupling method. The affinity constants for indomethacin, ketoprofen binding to COX-2 are 7.5× 10^3 L/tool and 9.25 × 10^3 L/mol, respectively. The biosensor surface can be regenerated after being rinsed with 0.01 mol/L NaOH, and the biosensor can be used repeatedly. These indicated that the wavelength modulation SPR biosensor has the potential application in the fields of pharmacokinetics, pharmacodynamics and drug discovery.

关键词： surface plasmon resonance biosensor cyclooxygenase drug affinity

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Interleukins in Epilepsy:Friend or Foe

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Neuroscience Bulletin 2024年第5期40卷 635-657页

作者： Yuan Dong xia Zhang ying Wang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA02115USA

Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million *** in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of ***(ILs),as one of the major contributors to neuroinflammation,are intensively studied for their association and modulatory effects on ictogenesis and *** are commonly divided into pro-and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in ***,both protective and destructive effects have been reported for many *** may be due to the complex nature of ILs,and also possibly due to the different disease courses that those ILs are involved *** this review,we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances,as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

关键词： Epilepsy Interleukins Neuroinflammation

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Liver injury in COVID-19: Known and unknown

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World Journal of Clinical Cases 2021年第19期9卷 4980-4989页

作者： Feng Zhou Jian xia Hai-xia Yuan ying Sun ying Zhang Department of Endocrinology Puren Hospital of Wuhan University of Science and TechnologyWuhan 430080Hubei ProvinceChina Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Since the first report of the coronavirus disease 2019(COVID-19)in December 2019 in Wuhan,China,the outbreak of the disease is currently continuously *** studies have shown varying degrees of liver damage in patients with ***,the exact causes of liver injury and the relationship between COVID-19 and liver injury is *** article describes liver injury induced by COVID-19,analyzes its causes,and discusses the treatment and prognosis of liver damage in patients with COVID-19.

关键词： SARS-CoV-2 COVID-19 Liver injury Prognosis Treatment

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Form Finding and Collapse Analysis of Cable Nets Under Dynamic Loads Based on Finite Particle Method

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Computer Modeling in Engineering & Sciences 2018年第10期117卷 73-89页

作者： ying Yu Ping xia Chunwei Yang Department of Civil Engineering Shantou UniversityShantou515063China

This paper presents form finding and collapse analysis of cable net structure under strong wind using the finite particle method(FPM).As a kind of particle method,the theoretical fundamentals of the FPM are *** to handle geometric and material nonlinearities of cable element are *** fracture criterion and model for cable element are built to simulate the failure of cable *** form-finding and load analysis of two cable nets are then performed in order to initialize the successive of nonlinear *** failure progress of cable nets under dynamic loads is simulated,and the dynamic responses of the typical fracture element are given in *** of the energy variations during the collapse process also show the failure mechanisms of cable nets,which is useful for the structure collapse resistance *** numerical applications highlight the capability of the proposed procedure to solve complicate collapse problems with the FPM.

关键词： Finite Particle Method(FPM) cable net fracture form finding

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Macro-and microfeatures of Early Cambrian dolomitic microbialites from Tarim Basin, China

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Journal of Palaeogeography 2021年第1期10卷 19-38页

作者： ying Li Hong-xia Jiang Ya-Sheng Wu Wen-qing Pan Bao-Shou Zhang Chong-Hao Sun Guo Yang Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Hebei GEO University Shijiazhuang 050031Hebei ProvinceChina Research Institute of Petroleum Exploration and Development Tarim Oilfield CompanyPetroChinaKorla 841000Xinjiang Uygur Autonomous RegionChina

The fabrics of microbialites preserved in limestones are generally better than in dolostones. What are the fabrics of the microbialites preserved in heavily dolomitized dolostones? This paper presents an example of a strongly dolomitized Cambrian microbialite profile. The xiaoerblak Formation(Cambrian Series 2 Stage 3 and lower Stage 4)of the Sugaitblak section in Aksu, Xinjiang Uygur Autonomous Region, China is mainly composed of microbial dolostones. Due to strong alteration by diagenesis, their features, formation and environments have not been fully understood. Here, based on detailed observation on outcrops and thin sections, we show that this formation comprises four kinds of microbialites: laminite, thrombolite, thrombolitic laminite, and Renalcis framestone, in five intervals(Interval I to Interval V). We identified three main types of microbialite fabrics, i.e., clotted fabric, laminated fabric and skeletal fabric, and established a high-resolution vertical evolution sequence of the microbialites. The clotted fabric and the laminated fabric were further divided into subtypes. We found that the original fabrics were mainly affected by dolomitization, recrystallization and dissolution, and the alteration degree of the microbialite fabric is stronger in the lower part of this formation. The laminated fabric has the strongest resistance to diagenesis,followed by the clotted fabric. Based on studies of different rock types and sedimentary structures, we concluded that the sedimentary environment of xiaoerblak Formation consists of three settings: a) Intervals I to III formed in restricted tidal flat environments, b) Interval IV and the lower part of Interval V in restricted deep subtidal environments, and c) upper part of Interval V in shallowing-up open subtidal environments.

关键词： Cambrian Microbialite Thrombolite Fabrics Laminite

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Sorbitol induces flower bud formation via the MADS-box transcription factor EjCAL in loquat

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Journal of Integrative Plant Biology 2023年第5期65卷 1241-1261页

作者： Hong-xia Xu Dong Meng qing Yang Ting Chen Meng Qi xiao-ying Li Hang Ge Jun-Wei Chen Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhou 310021China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100000China College of Forestry Beijing Forestry UniversityBeijing 100083China

Sorbitol is an important signaling molecule in fruit trees. Here, we observed that sorbitol increased during flower bud differentiation(FBD) in loquat(Eriobotrya japonica Lindl.). Transcriptomic analysis suggested that bud formation was associated with the expression of the MADS-box transcription factor(TF) family gene, EjCAL. RNA fluorescence in situ hybridization showed that EjCAL was enriched in flower primordia but hardly detected in the shoot apical meristem. Heterologous expression of EjCAL in Nicotiana benthamiana plants resulted in early FBD. Yeast-one-hybrid analysis identified the ERF12 TF as a binding partner of the EjCAL promoter. Chromatin immunoprecipitation-PCR confirmed that EjERF12 binds to the EjCAL promoter, and β-glucuronidase activity assays indicated that EjERF12 regulates EjCAL *** loquat trees with sorbitol promoted flower bud formation and was associated with increased expression of EjERF12 and EjCAL. Furthermore, we identified EjUF3GaT1 as a target gene of EjCAL and its expression was activated by EjCAL. Function characterization via overexpression and RNAi reveals that EjUF3GaT1 is a biosynthetic gene of flavonoid hyperoside. The concentration of the flavonoid hyperoside mirrored that of sorbitol during FBD and exogenous hyperoside treatment also promoted loquat bud formation. We identified a mechanism whereby EjCAL might regulate hyperoside biosynthesis and confirmed the involvement of EjCAL in flower bud formation in planta. Together,these results provide insight into bud formation in loquat and may be used in efforts to increase yield.

关键词： EjCAL flower bud differentiation hyperoside loquat sorbitol

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A Novel Potassium Nanosensor Powers up the Detection of Extracellular K+ Dynamics in Neuroscience

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Neuroscience Bulletin 2020年第12期36卷 1573-1575页

作者： ying Wang qingyu Wang xia Zhang Institute of Brain Science and Disease Qingdao UniversityQingdao 266071China Department of Anesthesiology Affiliated Hospital of Qingdao UniversityQingdao 266000China

Potassium ions(K+),the pivotal cations for membrane potential,are particularly important for maintaining the physiological function of neurons[1].When the concentration of extracellular K+([K+]o)is pathologically changed,the intrinsic neuronal excitability and synaptic transmission are also altered,which have profound implications for many neurological disorders such as epilepsy,Parkinson's disease,and emotional disorders[2-4].

关键词： Potassium epilepsy emotional

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单层Cs_(2)PbI_(2)Cl_(2)中点缺陷的形成与稳定性

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原子与分子物理学报 2025年第5期42卷 130-136页

作者：何诗颖赵宇清邹代峰许英廖雨洁禹卓良湖南科技大学物理与电子科学学院湘潭411201 智能传感器与新型传感器材料湖南省重点实验室湘潭411201 湖南理工学院物理与电子科学学院岳阳414006

Cs_(2)PbI_(2)Cl_(2)是卤化铅钙钛矿材料的新成员,由于其高的光吸收系数和长的载流子迁移距离等优异的光电物理性能,在太阳能电池、光电探测器、场效应晶体管以及发光二极管等领域受到广泛的关注.其中光电材料及器件的优良特性由电子结... 详细信息

Cs_(2)PbI_(2)Cl_(2)是卤化铅钙钛矿材料的新成员,由于其高的光吸收系数和长的载流子迁移距离等优异的光电物理性能,在太阳能电池、光电探测器、场效应晶体管以及发光二极管等领域受到广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而钙钛矿的点缺陷对电子结构具有重要的调控,且单层Cs_(2)PbI_(2)Cl_(2)中点缺陷的研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对单层Cs_(2)PbI_(2)Cl_(2)的铯空位、碘空位、氯空位、铯替代铅、碘替代铯、碘替代铅、碘替代氯、氯替代铯、氯替代铅和氯替代碘的缺陷形成能和稳定性进行了研究.结果表明:在富铅和缺铅条件下,碘替代氯和氯替代碘的缺陷形成能偏低,且氯替代碘能有效降低体系总能,提高体系稳定性.在缺铅条件下铯空位缺陷形成能低于富铅条件,在缺铅条件下更易形成铯空位;富铅和缺铅条件下对碘替代氯和氯替代碘的缺陷形成能基本无影响.上述研究结果有助于理解点缺陷对钙钛矿材料稳定性的影响,同时也为未来实验上设计基于Cs_(2)PbI_(2)Cl_(2)的高效的光电子器件提供理论依据.

关键词：单层Cs_(2)PbI_(2)Cl_(2) 形成能点缺陷稳定性

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双模态成像仿生纳米粒对甲状腺髓样癌的声动力治疗

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中国组织工程研究 2025年第16期29卷 3410-3419页

作者：朱炜薇凡正超胥莹夏纪筑赵香芝西南医科大学附属医院超声医学科四川省泸州市646000

背景:声动力疗法作为一种新型抗肿瘤治疗手段具有非侵入性和时空可控性的特点,在甲状腺髓样癌无创性治疗中具有广阔的应用前景。目的:制备具有双模态成像能力的仿生癌细胞膜涂层脂质纳米粒,检测纳米粒的理化性质、靶向能力、成像效果、... 详细信息

背景:声动力疗法作为一种新型抗肿瘤治疗手段具有非侵入性和时空可控性的特点,在甲状腺髓样癌无创性治疗中具有广阔的应用前景。目的:制备具有双模态成像能力的仿生癌细胞膜涂层脂质纳米粒,检测纳米粒的理化性质、靶向能力、成像效果、细胞毒性和抗迁移能力。方法:以二棕榈酰磷脂酰胆碱、二棕榈酰磷脂酰甘油、二硬脂酰磷脂酰乙醇胺-聚乙二醇2000、胆固醇、血卟啉单甲醚、全氟己烷为原料,通过薄膜水合-超声振荡法制备脂质纳米粒HP@LNP,其中血卟啉单甲醚装载于脂质纳米结构的疏水层,全氟己烷装载于脂质纳米结构的亲水核心层内;将甲状腺髓样癌细胞膜包覆于脂质纳米粒HP@LNP表面,构建具有主动靶向甲状腺髓样癌细胞能力的仿生脂质纳米粒MHP@LNP。表征纳米粒MHP@LNP的理化性质、靶向能力、免疫逃逸能力、成像效果、细胞毒性和抗迁移能力。结果与结论:①脂质纳米粒MHP@LNP呈现典型的核壳结构,粒径为131.06 nm,平均电位为-30.59 mV,凝胶电泳结果显示脂质纳米粒MHP@LNP与癌细胞膜蛋白图谱相符合,荧光共定位结果显示脂质纳米粒MHP@LNP与癌细胞膜的荧光信号显著重合。脂质纳米粒MHP@LNP纳米粒内血卟啉单甲醚的包封率为87.8%,载药率为14.6%。在低强度聚焦超声刺激下,脂质纳米粒MHP@LNP可发生相变产生微泡,在4 min时超声信号强度达到最大值。在激光照射下,脂质纳米粒MHP@LNP的光声信号强度与其质量浓度呈现线性相关。脂质纳米粒MHP@LNP具有同源细胞靶向能力和免疫逃逸能力。未经低强度聚焦超声照射前的脂质纳米粒MHP@LNP具有良好的生物相容性,而经低强度聚焦超声照射后产生具有细胞毒性的活性氧,有效杀伤甲状腺髓样癌细胞,并抑制甲状腺髓样癌细胞的迁移能力。②结果表明,脂质纳米粒MHP@LNP能够在超声和光声双模态成像引导下实现声动力治疗,用于治疗甲状腺髓样癌。

关键词：脂质纳米粒声动力疗法低强度聚焦超声声敏剂活性氧癌细胞膜同源靶向纳米医学光声成像双模态成像

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