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Left bundle branch pacing in a ventricular pacing dependent patient with heart failure:A case report

World Journal of Clinical Cases 2022年第20期10卷 7090-7096页

作者： Bing-Xue Song xia-xia Wang Yi An ying-ying Zhang Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Left bundle branch pacing(LBBP)is a physiological pacing method that has emerged in recent *** is an ideal choice for patients with complete left bundle branch block who are in need of cardiac resynchronization therapy(CRT).Moreover,LBBP is superior in maintaining physiological ventricular activation and can effectively improve heart function and quality of life in patients with pacemaker-induced ***,LBBP in pacing-dependent patients who already have cardiac dysfunction has not been well *** SUMMARY A 69-year-old male patient presented with symptoms of chest tightness,palpitation and systolic heart failure with New York Heart Association class III for 1 *** 12-lead electrocardiogram showed atrial fibrillation with third-degree atrioventricular block and ventricular premature *** revealed a right bundle branch block,atrial fibrillation with third-degree atrioventricular block,frequent multifocal ventricular premature beats,Ron-T and ventricular *** echocardiogram documented an enlarged left atrium and left ventricle and a low left ventricular ejection *** angiography indicated a stenosis of 30%in the middle left anterior descending ***,a CRT-D pacemaker was the best choice for this patient according to previous ***,the patient was worried about the financial burden.A single-chamber pacemaker with LBBP was selected,with the plan to take amiodarone and upgrade with dual-chamber implantable cardioverter-defibrillator or CRT-D at an appropriate *** the follow-up at 3 mo after LBBP,the patient showed an improvement in cardiac function with slight improvement in echocardiography parameters,and the New York Heart Association functional class was maintained at ***,the patient no longer suffered from chest tightness and *** showed decreased ventricular arrhythmia of less than 5%.CONCLUSION LBBP might be used in patients with heart failure

关键词： Left bundle branch area pacing Physiological pacing Heart failure Cardiac resynchronization therapy Pacing-dependent Case report

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L log L criterion for a class of multitype superdiffusions with non-local branching mechanisms

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Science China Mathematics 2019年第8期62卷 1439-1462页

作者： Zhen-qing Chen Yan-xia Ren Renming Song Department of Mathematics University of Washington Seattle WA 98195 USA LMAM School of Mathematical Sciences & Center for Statistical SciencePeking University Beijing 100871 China Department of Mathematics University of Illinois Urbana IL 61801 USA

In this paper, we provide a pathwise spine decomposition for multitype superdiffusions with nonlocal branching mechanisms under a martingale change of measure. As an application of this decomposition,we obtain a necessary and sufficient condition(called the L log L criterion) for the limit of the fundamental martingale to be non-degenerate. This result complements the related results obtained in Kyprianou et al.(2012),Kyprianou and Murillo-Salas(2013) and Liu et al.(2009) for superprocesses with purely local branching mechanisms and in Kyprianou and Palau(2018) for super Markov chains.

关键词： multitype superdiffusion non-local branching mechanism switched diffusion spine decomposition martingale

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The unique carrier mobility of Janus MoSSe/GaN heterostructures

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Frontiers of physics 2021年第3期16卷 155-163页

作者： Wen-Jin Yin xiao-Long Zeng Bo Wen qing-xia Ge ying Xu Gilberto Teobaldi Li-Min Liu School of Physics and Electronic Science Hunan University of Science and TechnologyXiangtan411201China School of Physics Beihang UniversityBeijing100083China Scientific Computing Department STFC UKRIRutherford Appleton LaboratoryHarwell CampusOX110QXDidcotUnited Kingdom Stephenson Institute for Renewable Energy Department of ChemistryUniversity of LiverpoolL693BXLiverpoolUnited Kingdom School of Chemistry University of Southampton HighfieldSO171BJSouthamptonUnited Kingdom

Heterostructure is an effective approach in modulating the physical and chemical behavior of materials. Here, the first-principles calculations were carried out to explore the structural, electronic, and carrier mobility properties of Janus MoSSe/GaN heterostructures. This heterostructure exhibits a superior high carrier mobility of 281.28 cm^(2)·V^(−1)·s^(−1) for electron carrier and 3951.2 cm^(2)·V^(−1)·s^(−1) for hole carrier. Particularly, the magnitude of the carrier mobility can be further tuned by Janus structure and stacking modes of the heterostructure. It is revealed that the equivalent mass and elastic moduli strongly affect the carrier mobility of the heterostructure, while the deformation potential contributes to the different carrier mobility for electron and hole of the heterostructure. These results suggest that the Janus MoSSe/GaN heterostructures have many potential applications for the unique carrier mobility.

关键词： Janus heterostructure carrier mobility first-principles calculation

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Development of multidimensional sequence operation theory with applications to risk evaluation in power system generation scheduling

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Science China(Technological Sciences) 2008年第6期51卷 724-734页

作者： Chongqing Kang&Email:cqkang@*** GaoFeng Yang qing xia State Key Lab of Power Systems Department of Electrical Engineering Tsinghua University Beijing 100084 China Yangjiaping Power Supply Bureau Chongqing Electric Power Corporation Chongqing 400050 China

Sequence operation theory (SOT) is a powerful tool for solving complex probabilistic problems in power system. However, the basic single dimension SOT cannot satisfy the requirement of multi-state; multi-attribute analysis, which is often the case in actual power system practice. To address this problem, multidimensional sequence operation theory (MSOT) is developed. On the basis of previous research, this paper first categorizes the situations by the number of state variables; the number of attribute values,; defines the multidimensional sequence for single state variable; multiple attribute values, as well as the multidimensional sequence for multiple state variables; multiple attribute values. Corresponding to those definitions, four types of operations between two discrete multidimensional sequences are derived respectively. Therefore, the sequence is extended from single dimensional to multidimensional, establishing an integrated theory of multidimensional sequence operation. In particular, the basic single dimension SOT can be viewed as a special case of MSOT with only one state variable; one attribute value. Finally, the paper demonstrates the effectiveness of MSOT through an example of risk evaluation in power system generation scheduling.

关键词： power system multidimensional sequence operation theory vector Hadamard products uncertainty

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FINITE ELEMENT NUMERICAL SIMULATION OF THREE-DIMENSIONAL SEEPAGE CONTROL FOR DEEP FOUNDATION PIT DEWATERING

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Journal of Hydrodynamics 2008年第5期20卷 596-602页

作者： LUO Zu-jiang ZHANG ying-ying WU Yong-xia College of Civil Engineering Hohai University Nanjing 210098 China

For deep foundation pit dewatering in the Yangtze River Delta, it is easy to make a dramatic decrease of the underground water level surrounding the dewatering area and cause land subsidence and geologic disasters. In this work, a three-dimensional finite element simulation method was applied in the forth subway of Dongjiadu tunnel repair foundation pit dewatering in Shanghai. In order to control the decrease of the underground water level around the foundation pit, the foundation pit dewatering method was used to design the optimization project of dewatering ,which was simulated under these conditions that the aquifers deposited layer by layer, the bottom of the aquifers went deep to 144.45 m, the retaining wall of foundation pit shield went deep to 65 m, the filters of the extraction wells were located between 44 m to 59 m, the water level in the deep foundation pit was decreased by 34 m, and the maximum decrease of water level outside the foundation pit was 3 m. It is shown that the optimization project and the practical case are consistent with each other. Accordingly, the three-dimensional finite element numerical simulation is the basic theory of optimization design of engineering structures of dewatering in deep foundation pit in such areas.

关键词： Yangtze River Delta land subsidence deep foundation pit dewatering seepage control

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Study on gold concentrate leaching by iodine-iodide

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International Journal of Minerals,Metallurgy and Materials 2013年第4期20卷 323-328页

作者： Hai-xia Wang Chun-bao Sun Shao-ying Li Ping-feng Fu Yu-guo Song Liang Li Wen-qing Xie Key Laboratory of the Ministry of Education of China for High-Efficient Mining and Safety of Metal Mines University of Science and Technology Beijing China Gold Association Shuangqishan Gold Mine

Gold extraction by iodine-iodide solution is an effective and environment-friendly method. In this study, the method using iodine-iodide for gold leaching is proved feasible through thermodynamic calculation. At the same time, experiments on flotation gold concentrates were carried out and encouraging results were obtained. Through optimizing the technological conditions, the attained high gold leaching rate is more than 85%. The optimum process conditions at 25℃ are shown as follows： the initial iodine concentration is 1.0%, the iodine-to-iodide mole ratio is 1：8, the solution pH value is 7, the liquid-to-solid mass ratio is 4：1, the leaching time is 4 h, the stirring intensity is 200 r/mim, and the hydrogen peroxide consumption is 1%.

关键词： gold extraction leaching iodine iodides

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Effect of interface behaviour on damage and instability of PBX under combined tension-shear loading

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Defence Technology（防务技术） 2023年第5期23卷 137-151页

作者： Quan-zhi xia Yan-qing Wu Feng-lei Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China

To study the effect of interface behaviour on the mechanical properties and damage evolution of PBX under combined tension-shear loading, the present work establishes the numerical model of a PBX three-phase hybrid system, which introduces a nonlinear plastic damage cohesion model to study the mechanical response and damage process. The parameters in the model were fitted and *** the crack growth rate as the feature, the damage state in each stage was determined, and the damage instability criterion was given. The effects of interfacial tensile strength and shear strength on the damage process of PBX were studied. On this basis, serrated and hemispherical structures interface of PBX has been developed, which affects the damage process and instability during the loading *** results indicate that damage state response of PBX experiences the process of stable load bearing,unstable propagation, and complete failure. At the critical moment of instability, the overall equivalent effective strain of material reaches 3024 με and instability loading displacement reaches 0.39 mm. The increase of interfacial tensile strength and shear strength significantly inhibits the damage of PBX. The effect of interfacial shear strength on critical instability of PBX is approximately 1.7 times that of the interfacial tensile strength. Further, interface opening along the normal direction is the main damage form at the interface. Serrated and hemispherical rough interfaces can significantly inhibit propagation of cracks, and the load bearing capacity is improved by 22% and 9.7%, respectively. Appropriate improvement of the roughness of the interface structure can effectively improve the mechanical properties. It is significantly important to have a better understanding of deformation, damage and failure mechanisms of PBX and to improve our predictive ability.

关键词： PBX explosives Interface behaviour Damage Instability Crack propagation

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Camrelizumab(SHR-1210) leading to reactive capillary hemangioma in the gingiva: A case report

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World Journal of Clinical Cases 2020年第3期8卷 624-629页

作者： qing Yu Wen-xia Wang Department of Periodontology School and Hospital of StomatologyShandong University Shandong Key Laboratory of Oral Tissue Regeneration Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration

BACKGROUND Oncologic immunotherapy is attracting attention as an effective strategy for cancer treatment. Currently, there are two kinds of inhibitors: Anti-PD-1 antibodies and anti-PD-L1 antibodies. These inhibitors have shown significant implications in improving the outcomes of certain cancer types in recent ***, along with its effectiveness, adverse events cannot be ignored. As an anti-PD-1 antibody, camrelizumab(SHR-1210) has some side effects in tumor immunotherapy. The most common adverse event is reactive capillary hemangioma. While it is widely reported to occur in the skin, gingival reactive capillary hemangioma is rarely *** SUMMARY A 54-year-old man complained of gingival overgrowth on the anterior aspect of the maxilla and mandible for more than 6 mo. He had been placed on SHR-1210 for lung cancer for 7 mo. A gingival mass extending from canine to canine was noted on the lingual surfaces of the mandible. Gingival enlargement was noted in the front teeth. A clinical diagnosis of gingival reactive capillary hemangioma and chronic periodontitis was made. The treatment involved a complex local treatment(repeated local applications of an antibiotic paste, scaling and root planning, and surgery). The excised tissue was sent for histopathological examination, which confirmed the diagnosis of capillary hemangioma. After the operation, most of the gingival enlargement was reduced. At the 2-mo follow-up,it was noted that the gingival overgrowth was immediately reduced after the replacement of the anti-PD-1 agent with an anti-PD-L1 *** As the prescription for SHR-1210 has increased considerably in recent years, the occurrence of its possible side effects, including gingival reactive capillary hemangioma, has increased. It is recommended that regular oral examinations be performed before and during the treatment of tumors with SHR-1210.

关键词： Camrelizumab Adverse effects Reactive capillary hemangioma Gingiva Case report

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IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma

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Cancer Communications 2018年第1期38卷 667-676页

作者： Liang Wang Xi-wen Bi Yu-jia Zhu ying-zhi He Qiu-yu Lai Zhong-jun xia qing-qing Cai Department of Hematology ZhuJiang HospitalSouthern Medical UniversityGuangzhou 510280GuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060Guang-dongP.R.China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hematologic Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:Natural killer/T-cell lymphoma(NKTCL)is a highly aggressive non-Hodgkin lymphoma often resistant to *** level of soluble IL-2 receptorα(IL-2Rα)is elevated in NKTCL patients and correlates signifi-cantly with treatment response and *** the current study we examined the potential role of IL-2Rαby over-expressing IL-2Rαin representative cell ***:Levels of IL-2Rαwere evaluated in the human natural killer cell line NK-92 and the NKTCL cell line *** vectors were used to express latent membrane protein 1(LMP1)in NK-92 cells,and IL-2Rαin both NK-92 and SNK-6 *** biological effects of these genes on proliferation,apoptosis,cell cycle distribution,and chemosensitiv-ity were ***:Expression of IL-2Rαwas significantly higher in SNK-6 cells than in NK-92 *** LMP1 in NK-92 cells remarkably up-regulated IL-2Rαlevels,whereas selective inhibitorss of the proteins in the MAPK/NF-κB pathway significantly down-regulated IL-2Rα.IL-2Rαoverexpression in SNK-6 cells promoted cell proliferation by altering cell cycle distribution,and induced resistance to gemcitabine,doxorubicin,and *** effects were reversed by an anti-IL-2Rα***:Our results suggest that LMP1 activates the MAPK/NF-κB pathway in NKTCL cells,up-regulating IL-2Rα***-2Rαoverexpression promotes growth and chemoresistance in NKTCL,making this interleukin receptor a potential therapeutic target.

关键词： Natural killer/T-cell lymphoma Latent membrane protein 1 Epstein-Barr virus Interleukin-2 receptor alpha

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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

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Frontiers of Medicine 2010年第2期4卷 235-240页

作者： Ge-qing xia Yu HU Ze-Hua WANG Li ZOU Chao-ying WU Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

This study was aimed to detect maternal serum levels of thromboxane B2(TXB2)in different durations of pregnancy and explore the predictive value of TXB2 for *** employing a prospective and double-blind study method,180 pregnant women with previously normal blood pressures during their progestation were included in the *** venous blood samples were obtained during 10+0–14+6(period I),20+0–24+6(period II)and 30+0–34+6(period III)weeks of *** serum levels of TXB2 were measured by enzyme-linked *** pathogenetic condition and pregnancy outcomes of these cases were observed.(1)Among the 180 previously normotensive women,ten developed preeclampsia(case group;four severe and six mild preeclampsia).One hundred and seventy remained normal till the end of pregnancy(control group).(2)With development of pregnancy,the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen through the Wilcoxon Signed Ranks *** was a statistical signiﬁcance in maternal TXB2 levels between two different gestational stages(P0.05);the levels of TXB2 were signiﬁcantly higher in the case group than in the control group during periods II and III of gestation(both P<0.05).(3)The best cutoff points of maternal TXB2 were 3750 and 4400 ng/mL during periods II and III of gestation by receiver operator characteristic(ROC)curve;and the sensitivity,speciﬁcity,positive predictive value,negative predictive value and odds radio of TXB2 in predicting preeclampsia were 80%,69.5%,13.3%,98.33%,9.11 and 90%,68.82%,13.84%,99.13,19.86,*** levels of maternal serum TXB2 were detected a long time before clinical symptoms *** maternal serum TXB2 after 20 weeks of gestation had predictive value,and the index after 30 weeks was superior

关键词： thromboxane B2 preeclampsia

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