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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第5期24卷 432-449页

作者： Shiguo xiao Yuan QI Pan xia Key Laboratory of High-Speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 60031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Department of Geological Engineering Southwest Jiaotong UniversityChengdu 610031China

According to the limit equilibrium state of soils behind rigid walls and the pseudo-static approach,a general closed-form solution to seismic and static active earth pressure on the walls,which considers shear and tension failure of the retained soil,is put forward using a variational calculus method.The application point of the active resultant force specified in the proposed method is explained with a clear physical meaning related to possible movement modes of the walls.In respect of the derived nine dependent equations reflecting the functional characteristics of the earth pressure,the proposed method can be performed easily via an implicit strategy.There are 13 basic factors related to the retained soils,walls,and external loads to be involved in the proposed method.The tension crack segment of the slip surface is obviously influenced by these parameters,apart from vertical seismic coefficient and geometric bounds of the surcharge,but the shear slip segment maintains an approximately planar shape almost uninfluenced by these parameters.Noticeably,the proposed method quantitatively reflects that the resultant of the active earth pressure is always within a limited range under different possible movements of the same wall.

关键词： Active earth pressure Tensile strength cut-off Variational calculus method Pseudo-static method Strip surcharge

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable,safe and efficient vaccine adjuvant

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Frontiers of Chemical Science and Engineering 2022年第6期16卷 973-984页

作者： Lili Yuan xiao-Dong Gao Yufei xia Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China

To increase antibody secretion and dose sparing,squalene-in-water aluminium hydrogel(alun^-stabilised emulsions(ASEs)have been developed,which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses.Nevertheless,the squalene(oil)in previous attempts suffered from limited oxidation resistance,thus,safety and stability were compromised.From a clinical translational perspective,it is imperative to screen the optimal oils for enhanced emulsion adjuvants.Here,because of the varying oleic to linoleic acid ratio,soybean oil,peanut oil,and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions,which were then screened for their stability and immunogenicity.Additionally,the underlying mechanisms of oil phases and emulsion stability were unravelled,which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets.As a result,compared with squalene-in-water ASEs,soybean-in-water ASEs exhibited comparable immune responses and enhanced stability.By optimising the oil phase of the emulsion adjuvants,this work may offer an alternative strategy for safe,stable,and effective emulsion adjuvants.

关键词： pickering emulsion vaccine adjuvant alum-stabilised emulsion oleic to linoleic acid ratio stability

Novel and Efficient Randomized Algorithms for Feature Selection

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Big Data Mining and Analytics 2020年第3期3卷 208-224页

作者： Zigeng Wang Xia Xiao Sanguthevar Rajasekaran Department of Computer Science and Engineering University of ConnecticutStorrsCT 06269USA

Feature selection is a crucial problem in efficient machine learning,and it also greatly contributes to the explainability of machine-driven decisions.Methods,like decision trees and Least Absolute Shrinkage and Selection Operator(LASSO),can select features during training.However,these embedded approaches can only be applied to a small subset of machine learning models.Wrapper based methods can select features independently from machine learning models but they often suffer from a high computational cost.To enhance their efficiency,many randomized algorithms have been designed.In this paper,we propose automatic breadth searching and attention searching adjustment approaches to further speedup randomized wrapper based feature selection.We conduct theoretical computational complexity analysis and further explain our algorithms’generic parallelizability.We conduct experiments on both synthetic and real datasets with different machine learning base models.Results show that,compared with existing approaches,our proposed techniques can locate a more meaningful set of features with a high efficiency.

关键词： feature selection randomized algorithms efficient selection

E26 transformation-specific 1 is implicated in the inhibition of osteogenic differentiation induced by chronic high glucose by directly regulating Runx2 expression

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The Journal of Biomedical Research 2022年第1期36卷 49-57页

作者： Wenqian xia xiao Han Lin Wang Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Nantong Stomatological Hospital of Nantong University NantongJiangsu 226001China

Chronic high glucose(HG) plays a crucial role in the pathogenesis of diabetes-induced osteoporosis by inhibiting the differentiation and proliferation of osteoblasts. This study aims to examine the role of E26 transformation-specific 1(ETS1) in the inhibition of osteoblast differentiation and proliferation caused by chronic HG, as well as the underlying mechanism. Chronic HG treatment downregulated ETS1 expression and inhibited differentiation and proliferation of MC3 T3-E1 cells. Downregulation of ETS1 expression inhibited the differentiation and proliferation of MC3 T3-E1 cells under normal glucose conditions, and ETS1 overexpression attenuated the damage to cells exposed to chronic HG. In addition, ETS1 overexpression reversed the decrease in runt-related transcription factor 2(Runx2) expression in MC3 T3-E1 cells treated with chronic HG. Using chromatin immunoprecipitation(ChIP) and luciferase reporter assays, we confirmed that ETS1 directly bound to and increased the activity of the Runx2 promoter. In summary, our study suggested that ETS1 was involved in the inhibitory effect of chronic HG on osteogenic differentiation and proliferation and may be a potential therapeutic target for diabetes-induced osteoporosis.

关键词： ETS1 Runx2 chronic high glucose osteoblast differentiation proliferation

Pathogenic roles of long noncoding RNAs in melanoma: Implications in diagnosis and therapies

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Genes & Diseases 2023年第1期10卷 113-125页

作者： Yuai xiao Yu xia Yuchong Wang Chunyu Xue Department of Plastic Surgery Changhai HospitalNaval Medical UniversityShanghai 200433China

Melanoma is one of the most dangerous types of cutaneous neoplasms,which are pigment-producing cells of neuroectodermal origin found all over the body.A great deal of research is focused on the mechanisms of melanoma to promote better diagnostic and treatment options for melanoma in its advanced stages.The progression of melanoma involves alteration in different levels of gene expression.With the successful implementation of next-generation sequencing technology,an increasing number of long noncoding RNAs(lncRNAs)sequences have been discovered,and a significant number of them have phenotypic effects in both in vitro and in vivo studies,implying that they play an important role in the occurrence and progression of human cancers,particularly melanoma.A number of evidence indicated that lncRNAs are important regulators in tumor cell proliferation,invasion,apoptosis,immune escape,energy metabolism,drug resistance,epigenetic regulation.To better understand the role of lncRNAs in melanoma tumorigenesis,we categorize melanomaassociated lncRNAs according to their cellular functions and associations with gene expression and signaling pathways in this review.Based on the mechanisms of lncRNA,we discuss the possibility of lncRNA-target treatments,and the application of liquid biopsies to detect lncRNAs in melanomadiagnosisandprognosis.

关键词： Cellular functions Long noncoding RNAs Melanoma

Achievements of the national malaria control and elimination program in the People’s Republic of China:the Atlas of Malaria Transmission in China

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Frontiers of Medicine 2023年第1期17卷 85-92页

作者： Jun Feng Li Zhang Zhigui xia Shuisen Zhou Ning xiao xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai 200025China School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghai 200025China

In 2017,China achieved the target of zero indigenous malaria case for the first time,and has been certified as malaria free by World Health Organization in 2021.To further summarize the historical achievements and technical experiences of the elimination program,a project on the Roadmap Analysis and Verification for Malaria Elimination in China was carried out.Results of the project were compiled and published as the Atlas of Malaria Transmission in China(The Atlas).The Atlas using modern digital information technologies,has been supported by various data from 24 malaria endemic provinces of China since 1950,to assess the changes in malaria epidemic patterns from 1950 to 2019 at national and provincial levels.The Atlas is designed as two volumes,including a total of 1850 thematic maps and more than 130 charts,consisting of introductory maps,thematic maps of malaria epidemic and control at national and provincial levels.It objectively and directly shows the epidemic history,evolution process,and great achievements of the national malaria control and elimination program in China.The Atlas has important reference value for summing up historical experience in the national malaria elimination program of China,and malaria control and elimination in other endemic countries in the world.

关键词： malaria transmission control elimination China atlas

Empirical Likelihood for Partially Linear Errors-in-variables Models with Longitudinal Data

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 664-683页

作者： Li YAN xiao-yan TAN xia CHEN School of Mathematics and Statistics Shaanxi Normal UniversityXi’an 710119China

Empirical likelihood inference for partially linear errors-in-variables models with longitudinal data is investigated.Under regularity conditions,it is shown that the empirical log-likelihood ratio at the true parameters converges to the standard Chi-squared distribution.Furthermore,we consider some estimates of the unknown parameter and the resulting estimators are shown to be asymptotically normal.Some simulations and a real data analysis are given to illustrate the performance of the proposed method.

关键词： empirical likelihood measurement error confidence regions coverage probability longitudinal data

An Adaptive Padding Correlation Filter With Group Feature Fusion for Robust Visual Tracking

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IEEE/CAA Journal of Automatica Sinica 2022年第10期9卷 1845-1860页

作者： Zihang Feng Liping Yan Yuanqing xia Bo xiao Key Laboratory of Intelligent Control and Decision of Complex Systems the School of AutomationBeijing Institute of TechnologyBeijing 100081China IEEE the School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China

In recent visual tracking research,correlation filter(CF)based trackers become popular because of their high speed and considerable accuracy.Previous methods mainly work on the extension of features and the solution of the boundary effect to learn a better correlation filter.However,the related studies are insufficient.By exploring the potential of trackers in these two aspects,a novel adaptive padding correlation filter(APCF)with feature group fusion is proposed for robust visual tracking in this paper based on the popular context-aware tracking framework.In the tracker,three feature groups are fused by use of the weighted sum of the normalized response maps,to alleviate the risk of drift caused by the extreme change of single feature.Moreover,to improve the adaptive ability of padding for the filter training of different object shapes,the best padding is selected from the preset pool according to tracking precision over the whole video,where tracking precision is predicted according to the prediction model trained by use of the sequence features of the first several frames.The sequence features include three traditional features and eight newly constructed features.Extensive experiments demonstrate that the proposed tracker is superior to most state-of-the-art correlation filter based trackers and has a stable improvement compared to the basic trackers.

关键词： Adaptive padding context information correlation filter(CF) feature group fusion robust visual tracking

TRAF proteins as key regulators of plant development and stress responses

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Journal of Integrative Plant Biology 2022年第2期64卷 431-448页

作者： Hua Qi Fan-Nv xia Shi xiao Juan Li State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Plant ProtectionSouth China Agricultural UniversityGuangzhou510642 China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou510642 China State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou510275 China College of Agronomy Hunan Agricultural UniversityChangsha410128 China

Tumor necrosis factor receptor-associated factor(TRAF)proteins are conserved in higher eukaryotes and play key roles in transducing cellular signals across different organelles.They are characterized by their C-terminal region(TRAF-C domain)containing seven to eight antiparallelβ-sheets,also known as the meprin and TRAF-C homology(MATH)domain.Over the past few decades,significant progress has been made toward understanding the diverse roles of TRAF proteins in mammals and plants.Compared to other eukaryotic species,the Arabidopsis thaliana and rice(Oryza sativa)genomes encode many more TRAF/MATH domaincontaining proteins;these plant proteins cluster into five classes:TRAF/MATH-only,MATH-BPM,MATH-UBP(ubiquitin protease),Seven in absentia(SINA),and MATH-Filament and MATHPEARLI-4 proteins,suggesting parallel evolution of TRAF proteins in plants.Increasing evidence now indicates that plant TRAF proteins form central signaling networks essential for multiple biological processes,such as vegetative and reproductive development,autophagosome formation,plant immunity,symbiosis,phytohormone signaling,and abiotic stress responses.Here,we summarize recent advances and highlight future prospects for understanding on the molecular mechanisms by which TRAF proteins act in plant development and stress responses.

关键词： autophagy E3 ubiquitin ligase hormone signaling plant development plant stress responses protein adaptor TRAF family proteins

Serosurvey for SARS-CoV-2 among blood donors in Wuhan,China from September to December 2019

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Protein & Cell 2023年第1期14卷 28-36页

作者： Le Chang Lei Zhao Yan xiao Tingting Xu Lan Chen Yan Cai xiaojing Dong Conghui Wang Xia Xiao Lili Ren Lunan Wang National Center for Clinical Laboratories Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Beijing Engineering Research Center of Laboratory Medicine Beijing HospitalBeijing 100730China Department of Laboratory Wuhan Blood CenterWuhan 430030China Confirmation Laboratory for Transfusion Transmitted Disease Institute of Blood Transfusion of Hubei ProvinceWuhan 430030China National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Quality Control Wuhan Blood CenterWuhan 430030China Graduate School Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

The emerging of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused COVID-19 pandemic.The first case of COVID-19 was reported at early December in 2019 in Wuhan City,China.To examine specific antibodies against SARS-CoV-2 in biological samples before December 2019 would give clues when the epidemic of SARS-CoV-2 might start to circulate in populations.We obtained all 88,517 plasmas from 76,844 blood donors in Wuhan between 1 September and 31 December 2019.We first evaluated the pan-immunoglobin(pan-Ig)against SARS-CoV-2 in 43,850 samples from 32,484 blood donors with suitable sample quality and enough volume.Two hundred and sixty-four samples from 213 donors were pan-Ig reactive,then further tested IgG and IgM,and validated by neutralizing antibodies against SARS-CoV-2.Two hundred and thirteen samples(from 175 donors)were only pan-Ig reactive,8(from 4 donors)were pan-Ig and IgG reactive,and 43(from 34 donors)were pan-Ig and IgM reactive.Microneutralization assay showed all negative results.In addition,213 screened reactive donors were analyzed and did not show obviously temporal or regional tendency,but the distribution of age showed a difference compared with all tested donors.Then we reviewed SARS-CoV-2 antibody results from these donors who donated several times from September 2019 to June 2020,partly tested in a previous published study,no one was found a significant increase in S/CO of antibodies against SARS-CoV-2.Our findings showed no SARS-CoV-2-specific antibodies existing among blood donors in Wuhan,China before 2020,indicating no evidence of transmission of COVID-19 before December 2019 in Wuhan,China.

关键词： severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 seroprevalence neutralizing antibodies blood donors