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Effect of resilience on quality of life and anxiety in patients with breast cancer

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World Journal of Psychiatry 2024年第10期14卷 1458-1466页

作者： Ling-xia kong Yong-xia Yang Qian Zhao Zhi-Lin Feng Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of Psychiatry Zhangjiakou Shalingzi Hospital(Zhangjiakou Mental Health Center)Zhangjiakou 075200Hebei ProvinceChina

BACKGROUND The incidence of breast cancer is high,with serious implications in terms of lives and *** data show that there are approximately 1 million new cases of breast cancer reported annually,with a rising *** patients have poor treatment effects and are prone to anxiety and other negative emotions,which affect their quality of life(QoL).AIM To explore the correlation between mental resilience,QoL,and anxiety in patients with breast *** Using convenience sampling,200 patients with breast cancer were selected from the First Affiliated Hospital of Hebei North *** patients were investigated using the Conner-Davidson Resilience Scale,Self-Rating Anxiety Scale,and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire to analyze the impact of resilience in patients with breast cancer on their QoL and *** The mean(SD)mental resilience score of the patients with breast cancer was 59.68(±9.84)points,the anxiety score was 49.87(±8.26)points,and the QoL score was 59.73(±8.29)***,they showed low mental resilience,mild anxiety,and medium *** was negatively correlated with mental resilience and QoL(r=-0.275,r=-0.289,P<0.05).QoL was positively correlated with mental resilience(r=0.513,P<0.05).Anxiety was a mediating variable between mental resilience and QoL,accounting for 8.58%of the mediating *** Regarding psychological elasticity,anxiety plays an intermediary role in QoL among patients with breast *** staff can improve patients'mental resilience by reducing their anxiety and improving their QoL.

关键词： Breast cancer Mental resilience Quality of life Anxiety Psycho-oncology Mediation effect

High Sensitive Ambipolar Response towards Oxidizing NO2 and Reducing NH3 Based on Bis（phthalocyaninato） Europium Semiconductors

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Chinese Journal of Chemistry 2016年第10期34卷 975-982页

作者： xia kong Zhen Dong Yanling Wu Xiyou Li Yanli Chen Jianzhuang Jiang School of Science China University of Petroleum (East China) Qingdao Shandong 266580 China Beymg Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials Department of Chemistry University of Science and Technology Beijing Beijing 100083 China

High sensitive chemical sensors towards NO2 and NH3 based on the self-assembled nanostructures of the heteroleptic and homoleptic bis（phthalocyaninato） europium complexes with octanaphthoxy phthalocyaninato ligands named Eu（Pc）[Pc（ONh）8] （1） and Eu[Pc（ONh）8]2 （2） [Pc = unsubstituted phthalocyaninate; Pc（ONh）8 = 2,3,9,10,16,17,23,24-octanaphthoxy phthalocyaninate] have been developed. The good conductivity, high crystal- linity and large specific surface area for the self-assemblies of 1 render it excellent sensing property for either electron-accepting gas NO2 in 50--250 ppb range or electron-donating gas NH3 in 2.5--12.5 ppm range due to the optimized molecular packing in the uniform-sized nanopartieles depending on the effective intermolecular interaction between double-decker molecules, among the best results of phthalocyanine-based chemical sensors for detection of NO2 and NH3 at room temperature. Interestingly, self-assemblies of I exhibited n-type response to NO2 and p-type response to NH3, which is the first example of ambipolar charge-transporting gas sensors fabricated from single- component organic semiconductors. However, the self-assemblies of 2 with sixteen bulky naphtboxy groups at the periphery of two Pc rings only present an n-type response to strong oxidant gas NO2 in a relatively high concentration of 0.5 - 1.5 ppm, while are insensitive to weak reducing gas NH3 due to the existence of great steric hindrance from bulky naphthoxy groups and more traps and/or defects in self-assemblies.

关键词： phthalocyanine double-decker gas sensor self-assemblies ambipolar semiconductor

Electroencephalogram findings in 10 patients with post-stroke epilepsy:A retrospective study

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World Journal of Clinical Cases 2024年第2期12卷 249-255页

作者： Li-Min Wen Ran Li Yan-Ling Wang Qing-xia kong Min xia Clinical Medicine College Jining Medical UniversityJining 272067Shandong ProvinceChina School of Basic Medical Sciences Shandong UniversityJinan 250012Shandong ProvinceChina Department of Neurology The Affiliated Hospital of Jining Medical UniversityJining 272007Shandong ProvinceChina

BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular ***-term seizures can seriously affect the prognosis and quality of life of ***(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding *** To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform *** From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were *** clinical,imaging,and EEG characteristics were *** stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively *** In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the *** In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.

关键词： Post-stroke epilepsy Electroencephalogram Seizure Stroke Slow wave

CNKSR2 mutation causes the X-linked epilepsy-aphasia syndrome:A case report and review of literature

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World Journal of Clinical Cases 2018年第12期6卷 570-576页

作者： Ying Sun Yi-Dan Liu Zhi-Feng Xu Qing-xia kong Yan-Ling Wang Cheeloo College of Medicine Shandong University First Hospital of Handan Department of Neurology Affiliated Hospital of Jining Medical University

The mutation in CNKSR2 leads to a broad spectrum of phenotypic variability and manifests as an X-linked intellectual disability. However, we reported that the male patient in this study not only had intellectual disability but also epileptic seizures. In addition, there were progressive language impairment, attention deficit hype-ractivity disorder and autism. Electroencephalograms showed continuous spike-and-wave during sleep. Genetic testing revealed a de novo mutation of the CNKSR2 gene(c.2185C >T, ***729Ter) in the child that was not detected in the parents. Therefore, the child was diagnosed with X-linked epilepsy aphasia syndrome. Deletion of the CNKSR2 gene has been rarely reported in epilepsy aphasia syndrome, but no de novo mutation has been found in this gene. This report not only adds to the spectrum of epilepsy aphasia syndrome but also helps clinicians in diagnosis and genetic counseling.

关键词： Epilepsy Language impairment Mental retardation De novo mutation of CNKSR2 X-linked epilepsy-aphasia syndrome

Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： Ling-xia kong Yan-Hong Zhao Zhi-Lin Feng Ting-Ting Liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

CODING STANDARD FACILITATES TIBETAN LANGUAGE APPLIES ON APP OF CHINA-MADE MOBILE PHONE

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China's Tibet 2021年第3期32卷 26-30页

作者： kong xia 不详

Thanks to the information highway and the successful rolling out of modern science and technology,the long-enduring Tibetan language has been able to keep up with China's widespread localization movement,especially when it comes to China-made electronic devices,allowing for the tongue’s silent yet irrepressible travel across the snowy plateau so that the Tibetan people may enjoy the same convenience of diversified digital services as anyone *** in all corners of the Tibet Autonomous Region can almost never be found without a smartphone in hand;these accessories have become local fashion statements in addition to general can’t-do-withouts to those living upon the *** the scenes,however,few know of just how arduous everything was to make the Tibetan language available on the devices themselves,with coding standards no walk in the park.

关键词： Tibetan corners travel

Regulation of the expression of proinflammatory cytokines induced by SARS-CoV-2

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World Journal of Clinical Cases 2021年第7期9卷 1513-1523页

作者： xiang-Ning Zhang Long-Ji Wu xia kong Bi-Ying Zheng Zhe Zhang Zhi-Wei He Department of Pathophysiology Guangdong Medical UniversityDongguan 523808Guangdong ProvinceChina Department of Clinical Microbiology Institute of Laboratory MedicineGuangdong Medical UniversityDongguan 523808Guangdong ProvinceChina Department of ENT and Head and Neck Surgery First Affiliated Hospital of Guangxi Medical UniversityNanning 531000Guangxi Zhuang Autonomous RegionChina

An outbreak of a novel coronavirus was reported in Wuhan,China,in late *** has spread rapidly through China and many other countries,causing a global *** February 2020,over 28 countries/regions have reported confirmed *** with the infection known as coronavirus disease-19(COVID-19)have similar clinical features as severe acute respiratory syndrome first encountered 17 years ago,with fever,cough,and upper airway congestion,along with high production of proinflammatory cytokines(PICs),which form a cytokine *** induced by COVID-19 include interleukin(IL)-6,IL-17,and monocyte chemoattractant *** production of cytokines is regulated by activated nuclear factor-kB and involves downstream pathways such as Janus kinase/signal transducers and activators *** expression is also regulated by post-translational modification of chromosomal *** residues in the peptide tails stretching out from the core of histones bind the sequence upstream of the coding portion of genomic *** modification,particularly methylation,activates or represses gene *** have been reported to be induced by histone modification and stimulate exudation of hyaluronic acid,which is implicated in the occurrence of *** findings indicate the impact of the expression of PICs on the pathogenesis and therapeutic targeting of COVID-19.

关键词： SARS-CoV-2 COVID-19 Proinflammatory cytokines Transcription factor Histone Post-translational modification

Amyloid fibril-supported Pd nanoparticles as electrocatalyst for hydrogen peroxide reduction

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Nuclear Science and Techniques 2016年第4期27卷 152-157页

作者： Li-xia kong Lan-Jie Wang Lan-Lan Su Zhi-Jie Zhao Zhong-Dan Yan Gong-Jun Zhang Xing-Fei Zhou Faculty of Science Ningbo University Ningbo Institute of Material Technology and Engineering Chinese Academy of Sciences

Palladium nanoparticles(Pd NPs) were fabricated by using insulin amyloid fibrils(INSAFs) as *** force microscopy measurements showed that ultrasmall Pd NPs were well adsorbed and dispersed on surfaces of INSAFs. X-ray photoelectron spectroscopy confirmed the partial reduction of Pd ion into metallic Pd(0) probably due to the presence of Cys groups on surface of the insulin fibrils. The electrochemical performance of Pd/INSAFs to reduction of H_2O_2 was further evaluated by cyclic voltammetry. The remarkably high electrocatalytic activity, low detection limitation and excellent stability make the Pd/INSAFs a promising bio-nanoelectrocatalyst.

关键词： Pd纳米粒子纤维表面过氧化氢还原催化剂粉样钯纳米粒子 X射线光电子能谱负载

Compound heterozygous mutations in tripeptidyl peptidase 1 cause rare autosomal recessive spinocerebellar ataxia type 7:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6618-6623页

作者： Rui-Han Liu Xin-Yu Wang Yuan-Yuan Jia Xing-Chen Wang Min xia Qiong Nie Jia Guo Qing-xia kong Department of Pediatrics Affiliated Hospital of Jining Medical UniversityJining 272000Shandong ProvinceChina College of TCM Shandong University of Traditional Chinese MedicineJinan 250012Shandong ProvinceChina Clinical Medical College Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Neurology Affiliated Hospital of Jining Medical UniversityJining 272000Shandong ProvinceChina Cheeloo College of Medicine Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Spinocerebellar ataxia recessive type 7(SCAR7)is a rare clinical manifestation beginning in childhood or ***7 is caused by tripeptidyl peptidase 1(TPP1)gene mutations,and presents with cerebellar ataxia,pyramidal signs,neurocognitive impairment,deep paresthesia,and cerebellar *** SUMMARY Here,we describe a 25-year-old female patient in China who presented with increasing difficulty walking,falling easily,shaking limbs,instability holding items,slurred speech,coughing when drinking,palpitations,and frequent hunger and *** resonance imaging showed cerebellar *** exome sequencing detected two compound heterozygous mutations in the TPP1 gene:c.1468G>A ***490Lys and c.1417G>A *** the patient’s clinical presentation and genetic test results,we hypothesized that complex heterozygous mutations cause TPP1 enzyme deficiency,which may lead to *** We report the first case of SCAR7 from *** also identify novel compound heterozygous mutations in the TPP1 gene associated with SCAR7,expanding the range of known disease-causing mutations for SCAR7.

关键词： Spinocerebellar ataxia recessive type 7 Tripeptidyl peptidase 1 Compound heterozygous variant Case report