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World Journal of Gastroenterology 2009年第15期15卷 1829-1835页

作者： xia chen chang-kai sun guo-zhu han jin-yong peng ying li yan-xia liu yuan-yuan lv ke-xin liu qin zhou hui-jun sun Department of Pharmacology Daiian Medical University Dalian 116044 Liaoning Province China

AIM： To investigate the hepatoprotective activity of tea polyphenols （TP） and its relation with cytochrome P450 （CYP450） expression in mice. METHODS： Hepatic CYP450 and CYPbs levels were measured by UV-spectrophotometry in mice 2 d after intraperitoneal TP （25, 50 and 100 mg/kg per day）. Then the mice were intragastricly pre-treated with TP （100, 200 and 400 mg/kg per day） for six days before paracetamol （1000 mg/kg） was given. Their acute mortality was compared with that of control mice. The mice were pre-treated with TP （100, 200, and 400 mg/kg per day） for five days before paracetamol （500 mg/kg） was given. Hepatic CYP2E1 and CYPIA2 protein and mRNA expression levels were evaluated by Western blotting, immunohistochemical staining and transcriptase-polymerase chain reaction. RESULTS： The hepatic CYP450 and CYPb5 levels in mice of TP-treated groups （100, 200 and 400 mg/kg per day） were decreased in a dose-dependent manner compared with those in the negative control *** significantly attenuated the paracetamol-induced hepatic injury and dramatically reduced the mortality of paracetamol-treated mice. Furthermore, TP reduced CYP2E1 and CYPIA2 expression at both protein and mRNA levels in a dose-dependent manner. CONCLUSION： TP possess potential hepatoprotective properties and can suppress CYP450 expression.

关键词： Tea polyphenols Cytochrome P450 Paracetamol-induced hepatotoxicity

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang li li‑Jiao Wang jing‑Yu Tang xiang‑Biao Qiu Zhen chen Mao‑yuan Zhao chang‑jun Ning kai Pan Wei Xu Tao li Su‑peng Lu han Yi Rui‑Rui Fan chang‑qing Feng Rong Zhang xiao‑yang sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen yong‑Hao chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu chang‑Cai han Zi‑Jie han guo‑zhu He yong‑cheng He yang Hong Yi‑Wei Hu han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao jin ling Kang Bo li Gong li xiao li yang li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu Guang‑yuan Luan Jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑hui Song Kang sun Zhi‑xin Tan Sheng‑Da Tang jin‑cheng Wang peng‑cheng Wang Zhao‑hui Wang Zhong‑Wei Wen xiao‑Guang Wu Xuan Wu Cong xia yong‑Ji Yu guo‑hui Zhang hang‑chang Zhang lin‑Hao Zhang Qi‑Wei Zhang xian‑peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑yong Zhang Zhi‑Hao zhou ke‑jun zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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In-beam gamma rays of CSNS Back-n characterized by black resonance filter

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-12页

作者： Wang, jin-cheng Ren, Jie Jiang, Wei Ruan, Xi-Chao liu, ying-Yi yang, Hao-Lan Xu, Kuo-Zhi Pan, xin-Yi sun, Qi Bao, Jie Huang, han-Xiong Bai, Hao-Fan Bai, Jiang-Bo Cao, Ping chen, Qi-Ping chen, yong-Hao Duan, Wen-Hao Fan, An-Chuan Fan, Rui-Rui Feng, chang-qing Gu, Min-Hao han, chang-Cai han, Zi-Jie He, guo-zhu He, yong-cheng Hong, yang Hu, Yi-Wei Jiang, Zhi-Jie Kang, ling Lan, chang-lin li, Bo li, Feng li, Qiang li, xiao li, yang liu, Jie liu, Rong liu, Shu-Bin liu, Yi-Na Luan, Guang-yuan Ning, chang-jun Qiu, Yi-Jia Ren, Wen-kai Ren, Zhi-zhou Song, Zhao-hui sun, Kang Tan, Zhi-xin Tang, jing-Yu Tang, Sheng-Da Wang, li-Jiao Wang, peng-cheng Wang, Zhao-hui Wen, Zhong-Wei Wu, xiao-Guang Wu, Xuan Wu, Ze-peng xia, Cong Xie, li-Kun Yi, han Yu, Tao Yu, yong-Ji Zhang, guo-hui Zhang, hang-chang Zhang, Qi-Wei Zhang, xian-peng Zhang, Yu-liang Zhang, Zhi-yong Zhao, Mao-yuan zhou, Zhi-Hao zhu, ke-jun Zou, Chong China Inst Atom Energy Key Lab Nucl Data Beijing 102413 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China Spallat Neutron Source Sci Ctr Dongguan 523803 Peoples R China Chinese Acad Sci Inst High Energy Phys State Key Lab Particle Detect & Elect Beijing 100049 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Peking Univ Sch Phys State Key Lab Nucl Phys & Technol Beijing 100871 Peoples R China Fudan Univ Inst Modern Phys Shanghai 200433 Peoples R China Univ Sci & Technol China State Key Lab Particle Detect & Elect Hefei 230026 Peoples R China Univ Sci & Technol China Sch Nucl Sci & Technol Hefei 230026 Peoples R China Univ Sci & Technol China Dept Modern Phys Hefei 230026 Peoples R China China Acad Engn Phys Inst Nucl Phys & Chem Mianyang 621900 Peoples R China Univ Sci & Technol China USTC Archaeometry Lab Hefei 230026 Peoples R China Northwest Inst Nucl Technol Xian 710024 Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China Univ Sci & Technol China Inst Adv Technol Hefei 230027 Peoples R China

The back-streaming white-neutron beamline (Back-n) of the China Spallation Neutron Source is an essential neutron- research platform built for the study of nuclear data, neutron physics, and neutron applications. Many types of cross-sectional neutron-reaction measurements have been performed at Back-n since early 2018. These measurements have shown that a significant number of gamma rays can be transmitted to the experimental stations of Back-n along with the neutron beam. These gamma rays, commonly referred to as in-beam gamma rays, can induce a non-negligible experimental background in neutron-reaction measurements. Studying the characteristics of in-beam gamma rays is important for understanding the experimental background. However, measuring in-beam gamma rays is challenging because most gamma-ray detectors are sensitive to neutrons; thus, discriminating between neutron-induced signals and those from in-beam gamma rays is difficult. In this study, we propose the use of the black resonance filter method and a CeBr3 scintillation detector to measure the characteristics of the in-beam gamma rays of Back-n. Four types of black resonance filters, Ta-181, Co-59, Ag-nat, and Cd-nat, were used in this measurement. The time-of-flight (TOF) technique was used to select the detector signals remaining in the absorption region of the TOF spectra, which were mainly induced by in-beam gamma rays. The energy distribution and flux of the in-beam gamma rays of Back-n were determined by analyzing the deposited energy spectra of the CeBr3 scintillation detector and using Monte Carlo simulations. Based on the results of this study, the background contributions from in-beam gamma rays in neutron-reaction measurements at Back-n can be reasonably evaluated, which is beneficial for enhancing both the experimental methodology and data analysis.

关键词： In-beam gamma rays Back-n Black filter resonance technique In-beam gamma rays Back-n CeBr3 scintillator Black filter resonance technique C6D6 DETECTOR SYSTEM liNE

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang guofu Cao Jianshe Cao Antoine Chance Xuejun chang Yue chang Zhe chang xinyuan chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin chen Danping chen Fuqing chen Fusan chen Gang chen guoming chen Hua-xing chen huirun chen jinhui chen Ji-yuan chen kai chen Mali chen Mingjun chen Mingshui chen Ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen Tianlu chen Wei chen xiang chen xiaoyu chen xin chen Xun chen Xurong chen Ye chen ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng Huajie cheng Shan cheng Tongguang cheng Yunlong Chi Pietro Chimenti Wen han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu kaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jinR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Genome Sequences Provide Insights into the Reticulate Origin and Unique Traits of Woody Bamboos

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Molecular Plant 2019年第10期12卷 1353-1365页

作者： Zhen-Hua guo peng-Fei Ma guo-Qian yang jin-yong Hu Yun-Long liu En-Hua xia Mi-Cai Zhong Lei Zhao Gui-ling sun Yu-xing Xu You-Jie Zhao Yi-Chi Zhang Yu-xiao Zhang Xue-Mei Zhang Meng-yuan zhou ying guo Cen guo jing-xia liu xia-ying Ye Yun-Mei chen yang yang Bin han Choun-Sea lin ying Lu De-zhu li Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China key Laboratory for Plant Diversity and Biogeography in East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China State key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural UniversityHefeiAnhui 230036China Kunming College of life Science University of Chinese Academy of SciencesKunmingYunnan 650201China lnstitute of Plant Stress Biology State Key Laboratory of Cotton BiologyDepartment of BiologyHenan UniversityKaifengHenan 475001China College of Big Data and Intelligent Engineering Southwest Forestry UniversityKunmingYunnan 650224China Yunnan Academy of Biodiversity Southwest Forestry UniversityKunmingYunnan 650224China National Center for Gene Research Shanghai Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China Agricultural Biotechnology Research Center Academia SinicaTaipei College of Fisheries and life Science Shanghai Ocean UniversityShanghai 201306China

Polyploidization is a major driver of speciation and its importance to plant evolution has been well *** comprise one diploid herbaceous and three polyploid woody lineages,and are members of the only major subfamily in grasses that diversified in forests,with the woody members having a tree-like lignified *** this study,we generated four draft genome assemblies of major bamboo lineages with three different ploidy levels(diploid,tetraploid,and hexaploid).We also constructed a high-density genetic linkage map for a hexaploid species of bamboo,and used a linkage-map-based strategy for genome assembly and identification of subgenomes in *** phylogenomic analyses using a large dataset of syntenic genes with expected copies based on ploidy levels revealed that woody bamboos originated subsequent to the divergence of the herbaceous bamboo lineage,and experienced complex reticulate evolution through three independent allopolyploid events involving four extinct diploid ancestors.A shared but distinct subgenome was identified in all polyploid forms,and the progenitor of this subgenome could have been critical in ancient polyploidizations and the origin of woody *** genetic clues to the unique flowering behavior and woody trait in bamboos were also *** together,our study provides significant insights into ancient reticulate evolution at the subgenome level in the absence of extant donor species,and offers a potential model scenario for broad-scale study of angiosperm origination by allopolyploidization.

关键词： Bambusoideae polyploidization comparative genomics subgenome evolution flowering

Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： xiao-Dong Song Fei yang Hua-yong Wu jing Zhang De-cheng li Feng liu Yu-guo Zhao jin-ling yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long ying Lu Yue-Yu Sui Qiu-Bing Wang ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang zhou Shi Wan-zhu Ma Gang xin Zhi-Ping Qi qing-Rui chang En Ci Da-Gang yuan yang-zhu Zhang jun-Ping Bai Jia-ying chen Jie chen Yin-jun chen Yun-Zhong Dong Chun-Lan han ling li li-Ming liu Jian-jun Pan Fu-peng Song Fu-jun sun Deng-Feng Wang Tian-Wei Wang xiang-Hua Wei Hong-Qi Wu xia Zhao qing zhou Gan-lin Zhang State key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： ling-Long Tang Yu-Pei chen Chuan-Ben chen Ming-yuan chen Nian-yong chen xiao-Zhong chen xiao-jing Du Wen-Feng Fang Mei Feng jin Gao Fei han xia He Chao-Su Hu De-sheng Hu Guang-yuan Hu Hao Jiang Wei Jiang Feng jin jin-Yi Lang jin-Gao li Shao-jun lin Xu liu Qiu-Fang liu lin Ma Hai-Qiang Mai Ji-yong qin liang-Fang Shen ying sun Pei-guo Wang Ren-Sheng Wang Ruo-Zheng Wang xiao-Shen Wang ying Wang hui Wu Yun-Fei xia Shao-Wen xiao Kun-Yu yang jun-lin Yi xiao-Dong zhu jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China Department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China Department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy Surgery Immunotherapy

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun liu Dan-Dan li Wei Dong Yu-Qi liu yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua jing-Yu He jun li Bai Du Ting-Hai Du lin-lin Niu Xue-jun Jiang Bo Cui Jiang-Bin chen yang-Gan Wang Hai-Rong Wang qin Yu jing He Yi-lin Mao xiao-Fang Bin Yue Deng Yu-Dan Tian qing-Hua han Da-jin liu li-qin Duan Ming-jun Zhao Cui-ying Zhang Hai-ying Dai Ze-Hua li ying xiao You-Zhi Hu xiao-Yu Huang Kun xing xin Jiang Chao-Feng liu jing An Feng-Chun li Tao Tao jin-Fa Jiang ying yang Yao-Rong Dong Lei Zhang Guang Fu ying li Shu-Wei Huang li-Ping Dou Lan-jun sun ying-Qiang Zhao Jie li Yun xia jun liu Fan liu Wen-jin He ying li Jian-Cong Tan yang lin Ya-Bin zhou Jian-Fei yang guo-qing Ma hui-jun chen He-Ping liu Zong-Wu liu Jian-Xiong liu xiao-Jia Luo xiao-Hong Bin Ya-Nan Yu Hai-xia Dang Bing li Fei Teng Wang-Min Qiao xiao-Long zhu Bing-Wei chen Qi-Guang chen Chun-Ti Shen yong-yan Wang Yun-Dai chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo yong-Heng Zhao Gang Zhao li-Cai Deng xiao-Wei liu Yi-peng jing Gang Wang Hao-Tong Zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu guo-Ping li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-yuan chen Jian-jun chen Kun-xin chen li chen Xue-Lei chen xiao-yan chen ying chen Norbert Christlieb Jia-Ru Chu chen-zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu peng Gao Xue-Fei Gong Bo-Zhong Gu yan-xin guo Zhan-Wen han Bo-liang He jin-liang Hou yong-hui Hou Wen Hou Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-ying Huo Lei Jia Fang-Hua Jiang xiang Jiang Zhi-Bo Jiang Ge jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li chang-Hua li Guang-Wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li xin-Nan li yan li Yin-Bi li Ye-Ping li yuan liang Chien-cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-jun Ni Zhao-xiang Qi yong-jun Qi Shi-Yin Shen Huo-Ming Shi jing Song Yi-han Song Ding-Qiang Su Hong-jun Su Zheng-Hong Tang qing-Sheng Tao yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-ling Wang Jian-Ping Wang jun-xian Wang Lei Wang Meng-xin Wang Shou-Guan Wang Shu-qing Wang xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang peng Wei Ming-Zhi Wei Hong Wu ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu xiao-Zheng xing ling-Zhe Xu xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang hui-qin yang Ming yang Zheng-Qiu Yao yong Yu hui yuan Hai-Bo yuan Hai-Long yuan Wei-Min yuan Chao Zhai En-peng Zhang Hua-Wei Zhang Jian-Nan Zhang li-Pin Zhang Wei Zhang yong Zhang yan-xia Zhang Zheng-Chao Zhang Ming Zhao Fang zhou Xu zhou Jie zhu yong-Tian zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n

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Nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le yang Zhen‑Dong An Wei Jiang xian‑kai li Wei‑Wei Qiu Zheng‑Fa liao Zi‑Yue zhuang xiao‑Ping Zhang Sheng‑li chen chen‑chen guo Er‑Xi xiao xiao Fang xin‑xiang li xin‑Rong Hu Bing Jiang jin‑cheng Wang Jie Ren Wen Luo Zhi‑Chao zhu Hao‑yang Lan Zong‑Wei Cao Xu Ma ying‑Du liu Pu‑Sen Wang Yi yang Ping Su xian‑Gai Deng Wan‑Bing He Chun‑Wang Ma Yu‑Ting Wang Zhi‑Tao Dai peng‑qin He Ren‑Guang Tang Tao zhou jing Wang han Yi Yue Zhang yong‑Hao chen Rui‑Rui Fan ke‑qing Gao Qiang li Kang sun Zhi‑xin Tan Min‑Hao Gu han‑Tao jing jing‑Yu Tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA Macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411100China key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and Nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value.

关键词： Time-of-flight technique Neutron capture cross sections Maxwell average cross sections

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