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Fundamental Research 2024年第1期4卷 167-177页

作者： xin sun Han Hao yong Geng Zongwei Liu Fuquan Zhao State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Belfer Center for Science and International Affairs Harvard UniversityCambridgeMA 02138United States Tsinghua-Rio Tinto Joint Research Center for Resources Energy and Sustainable Development Tsinghua UniversityBeijing 100084China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200240China

Lithium-ion battery(LIB)is the key technology for climate change *** sustainability of LIB supply chain has caused widespread concern since the material utilization efficiency of LIB supply chain has not been well *** study aims to fill this research gap by conducting a dynamic material flow analysis of lithium in China from 2015 to *** indicate that within the temporal boundary,lithium flow and in-use stock grew significantly in China due to the rapid development of the EV market,with lithium flow in domestic production of basic chemicals increasing by 614%to 100 kt,end-use consumption increasing by 160%to 35 kt,and in-use stock increasing by 62%to 195 *** has been a net importer of lithium,of which cumulative imports and exports were 343 kt and 169 kt,*** addition,103 kt of lithium was converted to inventories or was lost during the processing from 2015 to *** optimizing inventory and processing,developing substitutes for lithium for non-battery applications,and improving lithium recycling,China's net import dependency of lithium could be reduced from 27%-86%to 0%-16%.Our study demonstrates that it is urgent to improve material utilization efficiency so that the lithium resource supply can be secured.

关键词： Lithium Lithium-ion battery Critical material Supply chain Material flow analysis

Bioinformatic approaches of liquid–liquid phase separation in human disease

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中华医学杂志(英文版) 2024年第16期137卷 2024 Jul 19页

作者： sun Jun Chen Yilong Bi Ruiye Yuan yong Yu Haopeng Department of Thoracic Surgery and West China Biomedical Big Data Center West China Hospital Sichuan University Chengdu Sichuan China Med-X Center for Informatics Sichuan University Chengdu Sichuan China Department of Orthognathic and TMJ Surgery State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China

Biomolecular aggregation within cellular environments via liquid–liquid phase separation (LLPS) spontaneously forms droplet-like structures, which play pivotal roles in diverse biological processes. These structures are closely associated with a range of diseases, including neurodegenerative disorders, cancer and infectious diseases, highlighting the significance of understanding LLPS mechanisms for elucidating disease pathogenesis, and exploring potential therapeutic interventions. In this review, we delineate recent advancements in LLPS research, emphasizing its pathological relevance, therapeutic considerations, and the pivotal role of bioinformatic tools and databases in facilitating LLPS investigations. Additionally, we undertook a comprehensive analysis of bioinformatic resources dedicated to LLPS research in order to elucidate their functionality and applicability. By providing comprehensive insights into current LLPS-related bioinformatics resources, this review highlights its implications for human health and disease.

关键词： Phase separation Liquid–liquid phase separation Disease Phase separation databases Bioinformatic tools

Atomistic study on the microscopic mechanism of grain boundary embrittlement induced by small dense helium bubbles in iron

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Nuclear Science and Techniques 2024年第3期35卷 84-95页

作者： Lei Peng yong-Jie sun Jing-Yi Shi Yi-Fei Liu Shang-Ming Chen Liu-Liu Li State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China

The helium bubbles induced by 14 MeV neutron irradiation can cause intergranular fractures in reduced activation ferritic martensitic steel,which is a candidate structural material for fusion *** order to elucidate the susceptibility of different grain boundaries(GBs)to helium-induced embrittlement,the tensile fracture processes of 10 types of GBs with and without helium bubbles in body-centered cubic(bcc)iron at the relevant service temperature of 600 K were investigated via molecular dynamics *** results indicate that in the absence of helium bubbles,the GBs studied here can be classified into two distinct categories:brittle GBs and ductile *** atomic scale analysis shows that the plastic deformation of ductile GB at high temperatures originates from complex plastic deformation mechanisms,including the Bain/Burgers path phase transition and deformation twinning,in which the Bain path phase transition is the most dominant plastic deformation ***,the presence of helium bubbles severely inhibits the plastic deformation channels of the GBs,resulting in a significant decrease in elongation at *** bubble-decorated GBs,the ultimate tensile strength increases with the increase in the misorientation ***,the coherent twin boundary∑3{112}was found to maintain relatively high fracture strength and maximum failure strain under the influence of helium bubbles.

关键词： Helium bubble Grain boundary Embrittlement Reduced activation ferritic martensitic steel Molecular dynamics Bain path

Bioinformatics comprehensive analysis confirmed the potential involvement of SLC22A1 in lower-grade glioma progression and prognosis

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BIOCELL 2024年第5期48卷 803-815页

作者： JING HUI NANA sun yong LIU CHUNBO YU yong KE yong CAO ANxiAO YU QINGHONG KONG YUN LIU Guizhou Provincial College-Based Key Lab for Tumor Prevention and Treatment with DistinctiveMedicines Zunyi Medical UniversityZunyi563000China College of Basic Medicine Zunyi Medical UniversityZunyi563000China Department of Dermatology Guizhou Province Cosmetic Plastic Surgery HospitalAffiliated Hospital of Zunyi Medical UniversityZunyi563000China School of Forensic Medicine Zunyi Medical UniversityZunyi563000China

Background:Although it has been established that the human Solute Carrier Family 22(SLC22)functions as a cationic transporter,influencing cellular biological metabolism by modulating the uptake of various cations,its impact on cancer prognosis remains ***:We conducted a comprehensive analysis utilizing data from The Cancer Genome Atlas(TCGA)and other databases to assess the prognostic value and functional implications across various *** of SLC22A1 RNA in glioma U251 cells was performed to access the impact of SLC22A1 on lowergrade glioma(LGG)***:Our findings demonstrated a significant correlation between SLC22A1 expression and the survival time of patients with various cancers(p0.8).Cell proliferation and clone formation experiment proved that decreased expression of SLC22A1 in glioma U251 cells inhibited glioma cell ***:Our findings suggest SLC22A1 has huge prospects as a promising biomarker and therapeutic target for LGG ***22A1 has only been proved to support cellular function *** findings demonstrated a robust connection between the tumor microenvironment and functional proteins that maintain basal cell metabolism,which gifts unique tumor immune characteristics of ***,we provide a highly practical prediction model for estimating the survival rate of LGG patients.

关键词： SLC22A1 LGG prognosis immune nomogram

Face animation based on multiple sources and perspective alignment

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 252-266页

作者： Yuanzong MEI Wenyi WANG xi LIU Wei yong Weijie WU Yifan ZHU Shuai WANG Jianwen CHEN School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China

Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving *** technology could be beneficial in multiple medical fields,such as diagnosis and privacy *** studies on face animation often relied on a single source image to generate an output *** a significant pose difference between the source image and the driving frame,the quality of the generated video is likely to be suboptimal because the source image may not provide sufficient features for the warped feature *** In this study,we propose a novel face-animation scheme based on multiple sources and perspective alignment to address these *** first introduce a multiple-source sampling and selection module to screen the optimal source image set from the provided driving *** then propose an inter-frame interpolation and alignment module to further eliminate the misalignment between the selected source image and the driving *** The proposed method exhibits superior performance in terms of objective metrics and visual quality in large-angle animation scenes compared to other state-of-the-art face animation *** indicates the effectiveness of the proposed method in addressing the distortion issues in large-angle animation.

关键词： Face animation Multiple-source driving Generative adversarial network Medical diagnostics

A Tabletop Nano-CT Image Noise Reduction Network Based on 3-Dimensional Axial Attention Mechanism

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Computers, Materials & Continua 2024年第7期80卷 1711-1725页

作者： Huijuan Fu Linlin Zhu ChunhuiWang xiaoqi xi Yu Han Lei Li Yanmin sun Bin Yan Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou450000China

Nano-computed tomography(Nano-CT)is an emerging,high-resolution imaging ***,due to their low-light properties,tabletop Nano-CT has to be scanned under long exposure conditions,which the scanning process is *** 3D reconstruction data,this paper proposed a lightweight 3D noise reduction method for desktop-level Nano-CT called AAD-ResNet(Axial Attention DeNoise ResNet).The network is framed by theU-net *** encoder and decoder are incorporated with the proposed 3D axial attention mechanism and residual dense *** layer of the residual dense block can directly access the features of the previous layer,which reduces the redundancy of parameters and improves the efficiency of network *** 3D axial attention mechanism enhances the correlation between 3D information in the training process and captures the long-distance *** can improve the noise reduction effect and avoid the loss of image structure *** results show that the network can effectively improve the image quality of a 0.1-s exposure scan to a level close to a 3-s exposure,significantly shortening the sample scanning time.

关键词： Deep learning tabletop Nano-CT image denoising 3D axial attention mechanism

Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence

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Biomedical and Environmental Sciences 2024年第2期37卷 146-156页

作者： LIAO Zhen Yu YANG Shuo HU Song LIU Jia MAO yong Jun sun Shu Qin Department of Geriatrics the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina Department of Critical Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sectional study,between May and November 2022,peripheral venous blood of151 VS patients(case group)and 233 volunteers(control group)were *** SNPs were identified in five genes encoding the components of the MMP-2 signaling pathway,assessed through carotid-femoral pulse wave velocity(cf PWV),and analyzed using multivariate logistic *** multigene influence on the risk of VS was assessed using multifactor dimensionality reduction(MDR)and generalized multifactor dimensionality regression(GMDR)*** Within the multivariate logistic regression models,four SNPs were screened to have significant associations with VS:chemokine(C-C motif)ligand 2(CCL2)rs4586,MMP2 rs14070,MMP2rs7201,and MMP2 *** of the T/C genotype of MMP2 rs14070 had a 2.17-fold increased risk of developing VS compared with those of the C/C genotype,and those of the T/T genotype had a19.375-fold increased ***2 rs4586 and MMP-2 rs14070 exhibited the most significant *** CCL2 rs4586,MMP-2 rs14070,MMP-2 rs7201,and MMP-2 rs1053605 polymorphisms were significantly associated with the risk of VS.

关键词： Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

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Nano-Micro Letters 2024年第8期16卷 341-361页

作者： xi Zhou Quan Zhou Zhaozhi He Yi xiao Yan Liu Zhuohang Huang Yaoji sun Jiawei Wang Zhengdong Zhao xiaozhou Liu Bin Zhou Lei Ren Yu sun Zhiwei Chen xingcai Zhang The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Otorhinolaryngology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China NO.1 Middle School Affiliated to Central China Normal University Wuhan 430223People’s Republic of China

Reactive oxygen species(ROS)plays important roles in living *** ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound *** Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill ***,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) ***,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au *** two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound *** innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

关键词： Metal-organic framework(MOF) Reactive oxygen species(ROS) Cerium dioxide Au nanoparticles Wound healing

The first mitogenome of Lauraceae(Cinnamomum chekiangense)

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Plant Diversity 2024年第1期46卷 144-148页

作者： Changwei Bi Ning sun Fuchuan Han Kewang Xu yong Yang David K.Ferguson State Key Laboratory of Tree Genetics and Breeding Co-Innovation Center for Sustainable Forestry in Southern ChinaKey Laboratory of Tree Genetics and Biotechnology of Educational Department of ChinaKey Laboratory of Tree Genetics and Silvicultural Sciences of Jiangsu ProvinceNanjing Forestry UniversityNanjing 210037China College of Information Science and Technology Nanjing Forestry UniversityNanjing 210037China Research Institute of Subtropical Forestry Chinese Academy of ForestryHangzhou 311400China Co-Innovation Center for Sustainable Forestry in Southern China College of Life SciencesNanjing Forestry UniversityNanjing 210037China Department of Paleontology University of ViennaViennaAustria

There are three distinct genetic systems in higher plants,the dominant nuclear genome and the semi-autonomous organelle genomes(plastids and mitochondria).In contrast to the conserved plastid genome(plastome),the plant mitochondrial genome(mitogenome)is characterized by an intriguing“evolutionary paradox”distinguished by a remarkably low mutation rate but with a significantly high rearrangement rate(Palmer and Herbon,1988;Lai et al.,2022).

关键词： autonomous distinguished Palmer

Fast-response,high-sensitivity multi-modal tactile sensors based on PPy/Ti_(3)C_(2)T_(x) films for multifunctional applications

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Nano Research 2024年第5期17卷 4410-4419页

作者： Guangshuai xi Dongzhi Zhang Mingcong Tang Hao Zhang Yuehang sun Yubiao Zhang Haolin Cai Hui xia Dandi Zhou College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China

In recent years,multi-modal flexible tactile sensors have become an important direction in the development of electronic skin because of their excellent sensitivity,flexibility and wearable *** this work,a humidity-pressure multi-modal flexible sensor based on polypyrrole(PPy)/Ti_(3)C_(2)T_(x) sensitive film packaged with porous polydimethylsiloxane(PDMS)is investigated by combining the sensitive structure generation mechanism of in situ polymerization to achieve the simultaneous detection of humidity and pressure,which has a sensitivity of 89,113.4Ω/%RH in a large humidity range of 0%-97%RH,and response/recovery time of 2.5/1.9 *** tactile pressure sensing has a high sensitivity,a fast response of 67/52 ms,and a wide detection *** device also has excellent performance in terms of stability and repeatability,making it promising for respiratory pattern and motion *** work provides a new solution to address the construction of multi-modal tactile sensors with potential applications in the fields of medical health,epidemic prevention.

关键词： multi-modal sensors humidity-pressure tactile sensors resistive sensors Ti3C2Tx human respiratory and motion detection