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World Journal of Psychiatry 2024年第6期14卷 829-837页

作者： Xuan Zhang Zhe wang Gui-Ling Lin Fang-Zhi Wei Yan-Ping Zhuang Wen-Lu Xu Qi Zhang Hui-tao Wu Zi-Man He xi-Yu Yin Ying Liu Long Mi Ai-Min Gong School of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571101Hainan ProvinceChina Department of Rheumatology and Immunology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 570100Hainan ProvinceChina

BACKGROUND Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disorder with varied clinical courses and prognoses,not only did the patients suffer from physical impairment,but also various physical and psychiatric *** evidence have suggested that mental disorders in SLE patients,can lead to various adverse *** To explored the features and influencing factors of mental health in patients with SLE and clarifying the correlations between mental health and personality characteristics and perceived social *** results would provide a basis for psychological intervention in patients with *** The clinical data of 168 patients with SLE admitted at the First Affiliated Hospital of Hainan Medical University between June 2020 and June 2022 were *** assessment and correlation analysis were conducted using the Symptom Checklist-90(SCL-90)and Perceived Social Support Scale,and the collected data were compared with the national norms in *** relevant factors influencing mental health were identified by statistical analysis.A general information questionnaire,the Revised Life Orientation Test,and Short-Form 36-Item Health Survey were employed to assess optimism level and quality of life(QoL),*** Patients with SLE obtained higher scores for the somatization,depression,anxiety,and phobic anxiety subscales than national norms(P<0.05).A correlation was identified between total social support and total SCL-90 score or each subscale(P<0.05).The factors significantly affecting patients’mental health were hormone dosage and disease activity index(DAI)(P<0.05).The average optimism score of patients with SLE was 14.36±4.42,and 30 cases were in the middle and lower levels.A positive correlation was found between optimism level and QoL *** Patients with SLE develop psychological disorders at varying degrees,which are significantly influenced by hormone dosage and ***’menta

关键词： Systemic lupus erythematosus Mental health Quality of life Influencing factors

基于计算机视觉的混凝土表观裂缝识别和宽度测量

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地震工程与工程振动 2024年第3期44卷 41-51页

作者：王文斌王啸霆王涛陈曦中国地震局工程力学研究所地震工程与工程振动重点实验室黑龙江哈尔滨150080 地震灾害防治应急管理部重点实验室黑龙江哈尔滨150080 北京市建筑设计研究院有限公司北京100045

对钢筋混凝土(reinforcement concrete, RC)结构表观裂缝的高效识别可以为结构震损快速评估提供佐证。无论在地震现场还是实验室环境,此类工作均表现出量大、重复的特征,适合利用计算机视觉技术完成,以弥补人工方式低效、不确定性强的... 详细信息

对钢筋混凝土(reinforcement concrete, RC)结构表观裂缝的高效识别可以为结构震损快速评估提供佐证。无论在地震现场还是实验室环境,此类工作均表现出量大、重复的特征,适合利用计算机视觉技术完成,以弥补人工方式低效、不确定性强的劣势。以消费级相机输出图像作为数据源,融合U-Net和VGG-16构造适用于混凝土表观裂缝识别的卷积神经网络(convolutional neuralnetwork, CNN)模型,依托多类型RC构件裂缝图像数据库完成模型训练和测试。利用形态学运算、Otsu阈值分割等技术进一步优化裂缝识别结果作为宽度测量的输入数据。为降低相机光轴与裂缝平面不垂直带来的裂缝宽度测量误差,通过特定靶标对原始图像进行透视误差校正,经检验,透视误差校正后的裂缝宽度测量的平均偏差最大可降低约25%。

关键词：表观裂缝计算机视觉裂缝识别裂缝宽度测量透视误差校正

基于深度学习的复杂地层钻孔图像岩体结构面识别方法

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清华大学学报（自然科学版） 2024年第7期64卷 1136-1146页

作者：吴金吴顺川王焘席雅允北京科技大学土木与资源工程学院北京100083 昆明理工大学国土资源工程学院昆明650093 自然资源部高原山地地质灾害预报预警与生态保护修复重点实验室昆明650093 云南省高原山地地质灾害预报预警与生态保护修复重点实验室昆明650093

基于钻孔电视图像的结构面调查是一种应用广泛的勘测方法,可为岩体质量评价和工程设计提供基础数据支撑。然而,复杂地层中结构面形态各异,宽度差异大且对比度低,传统算法难以准确完整地识别。为此,该文提出一种基于改进的U-Net网络模型... 详细信息

基于钻孔电视图像的结构面调查是一种应用广泛的勘测方法,可为岩体质量评价和工程设计提供基础数据支撑。然而,复杂地层中结构面形态各异,宽度差异大且对比度低,传统算法难以准确完整地识别。为此,该文提出一种基于改进的U-Net网络模型的钻孔电视图像结构面识别方法。首先,采用更深层次的编码解码网络结构,处理对比度低导致的结构面局部断裂问题,并结合通道注意力机制和残差模块提高编码阶段各层级对结构面特征的提取能力。其次,在较低层级跳跃连接中引入多尺度空间注意力模块,提高对复杂形态结构面处理能力,丰富编码层结构面语义特征;同时,通道注意力也被用于充分融合来自编码层和解码层的多通道结构面信息。然后,通过利用与地质作用下地层变形类似的透视变形等方式扩增钻孔图像数据,并结合焦点损失和Dice损失进行联合训练,以减轻图像数据不平衡问题,增强网络泛化能力。最后,将同一钻孔图像作为训练集,邻近钻孔图像作为测试集进行消融和对比实验。结果表明,相比于已有相关网络模型,该文所提方法能更有效地针对复杂地层钻孔图像,较准确、完整地识别各类岩体结构面,精确率和召回率均超过77.00%,比改进前的U-Net网络分割效果分别提高了7.96%和14.99%。该文方法可为现场结构面钻孔调查以及岩体质量评价提供技术支撑。

关键词：钻孔图像结构面识别深度学习 U-Net神经网络注意力机制

Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients

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Journal of Geriatric Cardiology 2024年第5期21卷 542-549页

作者： Qian LI Yue YU Ya-Qiong ZHOU Yi ZHAO Jin WU Yuan-Jing WU Bin DU Pei-Jian wang tao ZHENG Department of Cardiovascular Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Cardiology First Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Neurology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular *** study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)*** A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up *** were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(MI),or ischemia-driven revascularization,were compared among the three *** Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(P<0.001).Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE,ischemia-driven coronary revascularization,non-fatal MI,and mortality in patients within the high tertile than those in the low and intermediate groups(all P<0.001).Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE(hazard ratio[HR]=2.21;95%confidence interval[CI]:1.21-4.03;P=0.009),ischemia-driven coronary revascularization(HR=3.19;95%CI:1.56-6.52;P=0.001),MI(HR=2.61;95%CI:1.35-5.03;P=0.043)and mortality(HR=3.78;95%CI:1.65-8.77;P=0.001).CONCLUSION Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently pre-dict cardiovascular risk in patients with CTO.

关键词： patients coronary occlusion

Boosted photocatalytic removal of NO using direct Z-scheme UiO-66-NH_(2)/Bi_(2)MoO_(6) nanoflowers heterojunction:mechanism insight and humidity effect

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Rare Metals 2024年第8期43卷 3758-3770页

作者： Jiang-Yu-Shan Liang Hai-tao Ren Abdelkader Labidi Qiu-Hui Zhu Qi-Bing Dong Ahmed A.Allam Ahmed Rady Chuan-Yi wang School of Environmental Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China Zoology Department Faculty of ScienceBeni-Suef UniversityBeni-Suef 6251lEgypt Department of Zoology College of ScienceKing Saud University11451 RiyadhSaudi Arabia

In practical applications,relative humidity in the air is a key factor affecting the photocatalytic removal of NO,which is often overlooked in previous ***,we developed a direct Z-scheme UiO-66-NH_(2)/Bi_(2)MoO_(6)heterojunction with a nanoflower-like structure to systematically investigate the effect of relative humidity on photocatalytic removal of *** optimized heterojunction for the removal efficiency of NO was 71.6%at1.07 mg·m^(-3)NO concentration(relative humidity=10%),and the generation of NO_(2) was only 1.1%.Interestingly,with the increase in relative humidity,it showed a higher inhibition effect on NO_(2),while the removal of NO decreased slightly(8%),which might be attributed to the affinity effect of NO_(2) with water molecules and the competitive adsorption of H_(2)O and NO on the surface of the heterojunction ***,the reaction pathways of NO removal at the developed heterojunctions were revealed by in situ DRIFTS *** work provides a novel vision for the development of direct Z-scheme heterojunction photocatalysts to effectively remove NO and inhibit the formation of toxic intermediate NO_(2) under different humidities.

关键词： NO removal Relative humidity Direct Z-scheme Bismuth molybdate Visible-light photocatalysis

Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua tao xiying Chen Feng Yin Yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai Yonghao Lin Jiaxiang Wu Yu Zhang Lu Liang Ao Shen xi-Yong Yu The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

Design of AI-Enhanced and Hardware-Supported Multimodal E-Skin for Environmental Object Recognition and Wireless Toxic Gas Alarm

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Nano-Micro Letters 2024年第12期16卷 1-22页

作者： Jianye Li Hao wang Yibing Luo Zijing Zhou He Zhang Huizhi Chen Kai tao Chuan Liu Lingxing Zeng Fengwei Huo Jin Wu State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063People’s Republic of China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005People’s Republic of China Key Laboratory of Flexible Electronics(KLOFE) School of Flexible Electronics(Future Technologies)Nanjing Tech University30 South Puzhu RoadNanjing 211816People’s Republic of China State Key Laboratory of Transducer Technology Shanghai 200050People’s Republic of China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing Guangzhou 510641People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs and School of Pharmacy Guangdong Medical UniversityDongguan 523808People’s Republic of China The First Dongguan Affiliated Hospital Guangdong Medical UniversityDongguan 523808People’s Republic of China Engineering Research Center of Polymer Green Recycling of Ministry of Education College of Environment and ResourcesFujian Normal UniversityFuzhou 350007People’s Republic of China

Post-earthquake rescue missions are full of challenges due to the unstable structure of ruins and successive *** of the current rescue robots lack the ability to interact with environments,leading to low rescue *** multimodal electronic skin(e-skin)proposed not only reproduces the pressure,temperature,and humidity sensing capabilities of natural skin but also develops sensing functions beyond it—perceiving object proximity and NO2 *** multilayer stacked structure based on Ecoflex and organohydrogel endows the e-skin with mechanical properties similar to natural *** robots integrated with multimodal e-skin and artificial intelligence(AI)algorithms show strong environmental perception capabilities and can accurately distinguish objects and identify human limbs through grasping,laying the foundation for automated post-earthquake ***,the combination of e-skin and NO2 wireless alarm circuits allows robots to sense toxic gases in the environment in real time,thereby adopting appropriate measures to protect trapped people from the toxic *** e-skin powered by AI algorithms and hardware circuits exhibits powerful environmental perception and information processing capabilities,which,as an interface for interaction with the physical world,dramatically expands intelligent robots’application scenarios.

关键词： Stretchable hydrogel sensors Multimodal e-skin Artificial intelligence Post-earthquake rescue Wireless toxic gas alarm

SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA Yun-ding ZOU Zhi-long LIU Gui-xian WU Yuan-ze ZHOU Cheng-xin LUO xiang-tao HUANG Ming-ling xiE Shuang-nian XU xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

Heterostructural NiFeW disulfide and hydroxide dual‐trimetallic core‐shell nanosheets for synergistically effective water oxidatio

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Carbon Energy 2024年第8期6卷 192-204页

作者： Peng‐Fei Guo Yang Yang Bing Zhu Qian‐Nan Yang Yan Jia Wei‐tao wang Zhao‐Tie Liu Shi‐Qiang Zhao Xun Cui Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'anChina School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'anChina Key Laboratory of Carbon Materials of Zhejiang Province Wenzhou Key Lab of Advanced Energy Storage and ConversionZhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina

A stable and highly active core‐shell heterostructure electrocatalyst is essential for catalyzing oxygen evolution reaction(OER).Here,a dual‐trimetallic core‐shell heterostructure OER electrocatalyst that consists of a NiFeWS_(2)inner core and an amorphous NiFeW(OH)_(z)outer shell is designed and synthesized using in situ electrochemical *** electrochemical measurements of different as‐synthesized catalysts with a similar mass loading suggest that the core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)nanosheets exhibit the highest overall performance compared with that of other bimetallic reference catalysts for the ***,the nanosheet arrays were in situ grown on hydrophilic‐treated carbon paper to fabricate an integrated three‐dimensional electrode that affords a current density of 10 mA cm^(−2)at a small overpotential of 182 mV and a low Tafel slope of 35 mV decade^(−1)in basic *** Faradaic efficiency of core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)is as high as 99.5%for *** scanning electron microscope,transmission electron microscope,and X‐ray photoelectron spectroscopy analyses confirm that this electrode has excellent stability in morphology and elementary composition after long‐term electrochemical ***,density functional theory calculations further indicate that the core‐shell heterojunction increased the conductivity of the catalyst,optimized the adsorption energy of the OER intermediates,and improved the OER *** study provides a universal strategy for designing more active core‐shell structure electrocatalysts based on the rule of coordinated regulation between electronic transport and active sites.

关键词： amorphous NiFeW hydroxide core‐shell heterojunction in situ electrochemical tuning NiFeW disulfide oxygen evolution reaction