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Single-cell analyses of circulating tumor cells

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Cancer Biology & Medicine 2015年第3期12卷 184-192页

作者： xi-xi chen Fan Bai Biodynamic Optical Imaging Center School of Life Science Peking University

Circulating tumor cells(CTCs) are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths. The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has already been used as a prognosis marker predicting the survival rate of cancer patients. Yet CTCs should be more potential. Studies on CTCs at single cell level may help revealing the underlying mechanism of tumorigenesis and metastasis. Though far from developed, this area of study holds much promise in providing new clinical application and deep understanding towards metastasis and cancer development.

关键词： Circulating tumor cells (CTCs) single cell sequencing metastasis

Removal of polycyclic aromatic hydrocarbons from aqueous solution by raw and modified plant residue materials as biosorbents

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Journal of Environmental Sciences 2014年第4期26卷 737-748页

作者： Zemin xi Baoliang chen Department of Environmental Science Zhejiang University Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Zhejiang University

Removal of polycyclic aromatic hydrocarbons （PAHs）, e.g., naphthalene, acenaphthene, phenanthrene and pyrene, from aqueous solution by raw and modified plant residues was investigated to develop low cost biosorbents for organic pollutant abatement. Bamboo wood, pine wood, pine needles and pine bark were selected as plant residues, and acid hydrolysis was used as an easily modification method. The raw and modified biosorbents were characterized by elemental analysis, Fourier transform infrared spectroscopy and scanning electron microscopy. The sorption isotherms of PAHs to raw biosorbents were apparently linear, and were dominated by a partitioning process. In comparison, the isotherms of the hydrolyzed biosorbents displayed nonlinearity, which was controlled by partitioning and the specific interaction mechanism. The sorpfion kinetic curves of PAHs to the raw and modified plant residues fit well with the pseudo second-order kinetics model. The sorption rates were faster for the raw biosorbents than the corresponding hydrolyzed biosorbents, which was attributed to the latter having more condensed domains （i.e., exposed aromatic core）. By the consumption of the amorphous cellulose component under acid hydrolysis, the sorption capability of the hydrolyzed biosorbents was notably enhanced, i.e., 6-18 fold for phenanthrene, 6-8 fold for naphthalene and pyrene and 5-8 fold for acenaphthene. The sorpfion coefficients （Kd） were negatively correlated with the polarity index [（O＋N）/C], and positively correlated with the aromaticity of the biosorbents. For a given biosorbent, a positive linear correlation between logKoc and logKow for different PAHs was observed. Interestingly, the linear plots of logKoc-logKow were parallel for different biosorbents. These observations suggest that the raw and modified plant residues have great potential as biosorbents to remove PAHs from wastewater.

关键词： plant residue biosorbent modification sorption polycyclic aromatic hydrocarbons wastewater treatment

Noninvasive Diagnostic Technique for Nonalcoholic Fatty Liver Disease Based on Features of Tongue Images

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Chinese Journal of Integrative Medicine 2024年第3期30卷 203-212页

作者： WANG Rong-rui chen Jia-liang DUAN Shao-jie LU Ying-xi chen Ping ZHOU Yuan-chen YAO Shu-kun Graduate School of Beijing University of Chinese Medicine Beijing100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing100029China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Nanjing Linkwah Micro-electronics Institute Beijing100191China Institute of Microelectronics Tsinghua UniversityBeijing100084China Peking University China-Japan Friendship School of Clinical Medicine Beijing100029China

Objective:To investigate a new noninvasive diagnostic model for nonalcoholic fatty liver disease(NAFLD) based on features of tongue ***:Healthy controls and volunteers confirmed to have NAFLD by liver ultrasound were recruited from China-Japan Friendship Hospital between September 2018 and May 2019,then the anthropometric indexes and sampled tongue images were *** tongue images were labeled by features,based on a brief protocol,without knowing any other clinical data,after a series of corrections and data *** algorithm was trained on images using labels and several anthropometric indexes for inputs,utilizing machine learning ***,a logistic regression algorithm and a decision tree model were constructed as 2 diagnostic models for ***:A total of 720 subjects were enrolled in this study,including 432 patients with NAFLD and 288 healthy *** them,482 were randomly allocated into the training set and 238 into the validation *** diagnostic model based on logistic regression exhibited excellent performance:in validation set,it achieved an accuracy of 86.98%,sensitivity of 91.43%,and specificity of 80.61%;with an area under the curve(AUC) of 0.93 [95% confidence interval(CI) 0.68–0.98].The decision tree model achieved an accuracy of 81.09%,sensitivity of 91.43%,and specificity of 66.33%;with an AUC of 0.89(95% CI 0.66–0.92) in validation ***:The features of tongue images were associated with *** the 2 diagnostic models,which would be convenient,noninvasive,lightweight,rapid,and inexpensive technical references for early screening,can accurately distinguish NAFLD and are worth further study.

关键词： nonalcoholic fatty liver disease noninvasive diagnosis tongue image tongue diagnosis Chinese medicine machine learning

Reconstructing piecewise planar scenes with multi-view regularization

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Computational Visual Media 2019年第4期5卷 337-345页

作者： Weijie xi Xuejin chen University of Science and Technology of China Hefei230026China

Reconstruction of man-made scenes from multi-view images is an important problem in computer vision and computer *** that manmade scenes are usually composed of planar surfaces,we encode plane shape prior in reconstructing man-made *** approaches for single-view reconstruction employ multi-branch neural networks to simultaneously segment planes and recover 3D plane ***,the scale of available annotated data heavily limits the generalizability and accuracy of these supervised *** this paper,we propose multiview regularization to enhance the capability of piecewise planar reconstruction during the training phase,without demanding extra annotated *** multi-view regularization enables the consistency among multiple views by making the feature embedding more robust against view change and lighting ***,the neural network trained by multi-view regularization performs better on a wide range of views and lightings in the test *** on more consistent prediction results,we merge the recovered models from multiple views to reconstruct *** approach achieves state-of-the-art reconstruction performance compared to previous approaches on the public Scan Net dataset.

关键词： scene modeling multi-view regularization neural network

Differential transform method for solving Richards' equation

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Applied Mathematics and Mechanics(English Edition) 2016年第2期37卷 169-180页

作者： xi chen Ying DAI School of Aerospace Engineering and Applied Mechanics Tongji University

An approximate solution to Richards＇ equation is presented, mathematically describing a sort of unsaturated single phase fluid flow in porous media. The approach is a differential transform method （DTM） with interm... 详细信息

关键词： approximate analytical solution Richavds' equation differential transform method (DTM) intermediate variable

Construction and Application of Interfacial Inorganic Nanostructures

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Chinese Journal of Chemistry 2020年第7期38卷 772-786,I0002页

作者： rui Wang Yicheng Wei Li An rui Yang Linchuan Guo Zheng Weng Pengfei Da Wenqing chen Jing Jin Jianyi Li Pinxian xi State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu 730000China

Interfacial nanostructured materials have stimulated extensive interests in the research areas of green energy production and conversion due to their unique structures and *** interfacial crystalline structures with rich intrinsic defects,such as oxygen vacancies,adatoms,grain bounda-ries,and substitutional impurities,have led to unique activities in a variety of catalytic *** rational design and engineering development of the interfaces provide an attractive way to optimize the catalytic performance and finally improve the efficiency of energy conversion and ***,a comprehensive overview of interfacial inorganic nanostructures and their electrocatalytic applications are summarized,and some future challenge and opportunity have also been proposed.

关键词： interfacial attractive summarized

Cramer-Rao bounds for the joint delay-Doppler estimation of compressive sampling pulse-Doppler radar

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Journal of Systems Engineering and Electronics 2018年第1期29卷 58-66页

作者： chen Shengyao xi Feng School of Electronic and Optical Engineering Nanjing University of Science and Technology

Time-delay and Doppler shift estimation is a basic task for pulse-Doppler radar processing. For low-rate sampling of echo signals, several kinds of compressive sampling(CS) pulse-Doppler(CSPD) radar are developed with different analog-to-information conversion(AIC) systems. However, a unified metric is absent to evaluate their parameter estimation performance. Towards this end, this paper derives the deterministic Cramer-Rao bound(CRB)for the joint delay-Doppler estimation of CSPD radar to quantitatively analyze the estimate performance. Theoretical results reveal that the CRBs of both time-delays and Doppler shifts are inversely proportional to the received target signal-to-noise ratio(SNR), the number of transmitted pulses and the sampling rate of AIC systems. The main difference is that the CRB of Doppler shifts also lies on the coherent processing interval. Numerical experiments validate these theoretical results. They also show that the structure of the AIC systems has weak influence on the CRBs, which implies that the AIC structures can be flexibly selected for the implementation of CSPD radar.

关键词： compressive sampling(CS) delay-Doppler estimation Cramer-Rao bound(CRB)

Acute Complication Prediction and Diagnosis Model CLSTM-BPR:A Fusion Method of Time Series Deep Learning and Bayesian Personalized Ranking

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Tsinghua Science and Technology 2024年第5期29卷 1509-1523页

作者： xi chen Quan cheng School of Economics and Management Fuzhou UniversityFuzhou 350108China

Acute complication prediction model is of great importance for the overall reduction of premature death in chronic *** CLSTM-BPR proposed in this paper aims to improve the accuracy,interpretability,and generalizability of the existing disease prediction ***,through its complex neural network structure,CLSTM-BPR considers both disease commonality and patient characteristics in the prediction ***,by splicing the time series prediction algorithm and classifier,the judgment basis is given along with the prediction ***,this model introduces the pairwise algorithm Bayesian Personalized Ranking(BPR)into the medical field for the first time,and achieves a good result in the diagnosis of six acute *** on the Medical Information Mart for Intensive Care IV(MIMIC-IV)dataset show that the average Mean Absolute Error(MAE)of biomarker value prediction of the CLSTM-BPR model is 0.26,and the average accuracy(ACC)of the CLSTM-BPR model for acute complication diagnosis is 92.5%.Comparison experiments and ablation experiments further demonstrate the reliability of CLSTM-BPR in the prediction of acute complication,which is an advancement of current disease prediction tools.

关键词： Long Short-Term Memory(LSTM) Bayesian Personalized Ranking(BPR) sudden illnesses disease predictions

Optimizing guest swapping using elastic and transparent memory provisioning on virtualization platform

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Frontiers of Computer Science 2016年第5期10卷 908-924页

作者： xi LI Pengfei ZHANG rui CHU Huaimin WANG School of Information Science and Engineering Central South University Changsha 410083 China National Laboratory for Parallel and Distributed Processing National University of Defense Technology Changsha 410008 China

On virtualization platforms, peak memory de- mand caused by hotspot applications often triggers page swapping in guest OS, causing performance degradation in- side and outside of this virtual machine （VM）. Even though host holds sufficient memory pages, guest OS is unable to utilize free pages in host directly due to the semantic gap between virtual machine monitor （MM） and guest operat- ing system （OS）. Our work aims at utilizing the free memory scattered in multiple hosts in a virtualization environment to improve the performance of guest swapping in a transparent and implicit way. Based on the insightful analysis of behav- ioral characteristics of guest swapping, we design and im- plement a distributed and scalable framework HybridSwap. It dynamically constructs virtual swap pools using various policies, and builds up a synthetic swapping mechanism in a peer-to-peer way, which can adaptively choose different vir- tual swap pools. We implement the prototype of HybridSwap and evaluate it with some benchmarks in different scenar- ios. The evaluation results demonstrate that our solution has the ability to promote the guest swapping efficiency indeed and shows a double performance promotion in some cases. Even in the worst case, the system overhead brought by Hy- bridSwap is acceptable.

关键词： virtualization memory management guestswapping performance degradation