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The Correlation Between Decreased Ornithine Level and Alleviation of Rheumatoid Arthritis Patients Assessed by a Randomized,Placebo-Controlled,Double-Blind Clinical Trial of Sinomenine

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Engineering 2022年第9期16卷 93-99页

作者： Ying Shi Hu-Dan Pan Jian-Lin Wu qing-Hua Zou xin-Yi xie Hong-Gang Li Hua Zhou xi-qing bian Wen-Fei Leng Can-Jian Wang Ya-Feng Wang Yong-Fei Fang Liang Liu Department of Rheumatology The Southwest Hospital of Army Military Medical UniversityChongqing 400038China State Key Laboratory of Dampness Syndrome Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine&Macao Institute for Applied Research in Medicine and Health Macao University of Science and TechnologyMacao 999078China People’s Hospital of Changshou Chongqing Chongqing 401220China Traditional Chinese Medicine Hospital Dianjiang Chongqing Chongqing 408300China Medical Management Center World Federation of Chinese Medicine SocietiesBeijing 100101China

Sinomenine(SIN)is commonly used as part of rheumatoid arthritis(RA)therapy in China,but there is still no published evidence of the efficacy of SIN *** work investigates the efficacy and safety of SIN in treating RA patients and analyzes the correlation between ornithine level and the alleviation of disease activity in RA *** this 24 week,randomized,placebo-controlled,double-blind clinical trial,people with mild to moderate RA were randomly assigned(1:1:1,stratified by hospital)to receive SIN(120 mg,twice daily),methotrexate(MTX)(10 mg per week),or SIN+MTX *** primary outcome was the proportion of patients who achieved a 50%improvement in the American College of Rheumatology(ACR50)criteria at week 24 and who showed improvement according to the clinical disease activity index(CDAI).In this prospective subgroup analysis,we also assessed whether the 24-week alterations of disease activity in the treatment group were significantly correlated to the levels of blood *** the 135 enrolled participants,38,39,and 36 patients were treated with SIN,MTX,and SIN+MTX,*** the SIN-treated group,52.63%of patients achieved ACR50 after 24-weeks of treatment,which was comparable to the results in the MTX-treated and SIN+MTX-treated *** and gastrointestinal disorders were the main adverse events;however,the ratio of patients suffering from hepatic disorder in the SIN group(1/38)was much lower than that in the MTX(10/39)and SIN+MTX(8/36)groups.A total of 221 serum samples were collected at the four follow-up time points in the three treatments,and the levels of ornithine,citrulline,and arginine were obtained through ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF/MS).The serum ornithine level decreased after the 24-week treatment along with a decrease in disease activity,and may reflect therapeutic responses with a sensitivity value of 80%.In conclusion,SIN revealed a comparabl

关键词： Rheumatoid arthritis Sinomenine Efficacy Safety Inflammatory biomarker

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The Middle and Lower Cambrian salt tectonics in the central Tarim Basin,China:A case study based on strike-slip fault characterization

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Energy Geoscience 2024年第2期5卷 53-61页

作者： qing bian Jibiao Zhang Cheng Huang SINOPEC Petroleum Exploration and Production Research Institute BeijingChina SINOPEC Northwest Oilfield Company UrumuqiChina

Due to the considerable depth of the salt layers and the lack of calibration by exploratory drilling,the interpretation of the Middle and Lower Cambrian salt formations in the central Tarim Basin poses a *** this paper,we apply the coupling and decoupling deformation theory in salt tectonics to analyze the No.7 fault mapped in the seismic datasets by the response characteristics of the Middle and Lower Cambrian *** quantifying the stratigraphic framework of the Middle and Lower Cambrian strata,we define the position of the salt layer with the seismic *** decoupling is observed in the Middle and Lower Cambrian sequences in the Shuntuoguole Low Uplift,while deformation coupling is observed in these two sequences in the Shaya Uplift.

关键词： Tarim Basin Salt tectonics Strike-slip fault Structural analysis Seismic interpretation of decoupling zone

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Isogeometric Analysis for the Arbitrary AFG Microbeam with Two-Phase Nonlocal Stress-Driven Model

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Acta Mechanica Solida Sinica 2024年第2期37卷 341-360页

作者： Pei-Liang bian Zhaowei Liu Hai qing Tiantang Yu Department of Engineering Mechanics Hohai UniversityNanjing211100China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Scale effects play critical roles in the mechanical responses of *** isogeometric analysis was developed here to investigate the mechanical responses of an axially functionally graded *** Euler–Bernoulli beam model was utilized,and size effects in the structure were modeled with a stress-driven two-phase local/nonlocal integral *** governing equation of microstructures was given in an equivalent differential form with two additional constitutive boundary *** framework was verified and utilized to analyze the microbeam’s static and dynamic mechanical *** present work showed great potential for modeling various types of functionally graded microstructures.

关键词： Isogeometric analysis Size effect Functionally graded material Nonlocal theory Euler-Bernoulli beam

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Prescribed Performance Tracking Control of Time-Delay Nonlinear Systems With Output Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1557-1565页

作者： Jin-xi Zhang Kai-Di Xu qing-Guo Wang IEEE the State Key Laboratory of Synthetical Automation for Process Industries Northeastern UniversityShenyang 110819China Institute of Artificial Intelligence and Future Networks Beijing Normal UniversityZhuhai 519087 Guangdong Key Laboratory of Artificial Intelligence and Multi-Modal Data Processing Beijing Normal University-Hong Kong Baptist University United International CollegeZhuhai 519087

The problem of prescribed performance tracking control for unknown time-delay nonlinear systems subject to output constraints is dealt with in this paper. In contrast with related works, only the most fundamental requirements, i.e., boundedness and the local Lipschitz condition, are assumed for the allowable time delays. Moreover, we focus on the case where the reference is unknown beforehand, which renders the standard prescribed performance control designs under output constraints infeasible. To conquer these challenges, a novel robust prescribed performance control approach is put forward in this ***, a reverse tuning function is skillfully constructed and automatically generates a performance envelop for the tracking error. In addition, a unified performance analysis framework based on proof by contradiction and the barrier function is established to reveal the inherent robustness of the control system against the time delays. It turns out that the system output tracks the reference with a preassigned settling time and good accuracy,without constraint violations. A comparative simulation on a two-stage chemical reactor is carried out to illustrate the above theoretical findings.

关键词： Nonlinear systems output constraints prescribed performance reference tracking time delays

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Facile synthesis of hierarchical NiO/NiFe_(2)O_(4) microsphere composite as efficient visible photocatalyst for 2,4-DCP degradation

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Rare Metals 2024年第4期43卷 1580-1588页

作者： Shabana Shaheen Shuai Xu Ji bian Amir Zada Zi-qing Zhang Yang Qu Li-Qiang Jing Key Laboratory of Functional Inorganic Materials Chemistry(Ministry of Education) International Joint Research Center and Lab for Catalytic TechnologySchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin150080China Department of Chemistry Abdul Wali Khan UniversityMardan23200Pakistan

It is highly desired to develop efficient photocatalysts with recycling property for practical application to degrade toxic ***,nanosheet-assembled NiFe_(2)O_(4)microspheres with commendable activity are successfully synthesized by a facile solvothermal reaction with NH4F as the modifier,and their photoactivities are further improved by coupling with NiO through an in situ growth *** optimized nickel oxide(NiO)/nickel ferrite(NiFe_(2)O_(4))microsphere composite(5NiO/NFO-4)exhibits a satisfactory photocatalytic activity for 2,4-dichlorophenol(2,4-DCP)degradation under visible-light irradiation,which is attributed to its wide visible-light response,well-designed hierarchical structure and enhanced charge transfer and separation by coupling NiO as a high-level energy platform to accept ***,it is found that the NiO/NiFe_(2)O_(4)microsphere photocatalysts can be easily collected and recycled owing to the distinctive magnetic *** work provides a feasible route to rational design visible-light-driven photocatalysts with high-activity for environmental remediation and purification with good recyclability.

关键词： NiFe_(2)O_(4) microspheres NiO/Fe_(2)O_(4) composite Charge separation Visible-light photocatalysis 2 4-Dichlorophenol degradation

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Reduced Spring Precipitation Bias and Associated Physical Causes over South China in FGOALS-f3 Climate Models:Experiments with the Horizontal Resolutions

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Journal of Meteorological Research 2024年第4期38卷 784-804页

作者： Peng ZI Yimin LIU Jiandong LI Ruowen YANG bian HE qing BAO Department of Atmospheric Science Yunnan UniversityKunming 650504 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029

Considerable spring precipitation occurs over South China(SC),a region that is adjacent to large-scale Asian topography and *** reasonable simulation is crucial for improving regional climate *** study investigates spring precipitation biases over SC and their possible causes in atmosphere-only and coupled Flexible Global Ocean–Atmosphere–Land System finite-volume version 3(FGOALS-f3) models with different horizontal *** performance of spring precipitation simulation over SC varies across different FGOALS-f3 model versions,with the best reproducibility in the high-resolution coupled model(25 km).In the low-resolution atmosphere-only model(100–125 km),the precipitation dry bias over SC is closely linked to overestimated surface sensible forcing over the eastern Tibetan Plateau(TP),which weakens the subtropical anticyclone over the western Pacific(SAWP) through regional circulation *** contrast,the high-resolution atmosphere-only model further amplifies surface thermal forcing in the Asian continents,causing intensified land–sea thermal contrast between the Southeast Asian continents and western Pacific,enhanced southerly winds and SAWP,and increased water vapor transport into ***,the reduced middle–high level cold bias over 10°–30°N in the high-resolution atmosphere-only model intensifies the East Asian westerly jet and ascent over SC,leading to enhanced spring precipitation *** high-resolution coupled model simulation not only reduces sea surface cold bias over the Bay of Bengal,thus intensifying the Indian–Burma trough and strengthening low-level water vapor transport into SC,but also enhances ascent over *** a result,the high-resolution coupled model better reproduces the magnitude and pattern of spring precipitation over SC than its atmosphere-only *** with low-resolution models,the domain-mean spring precipitation dry bias decreases by 11.2% over SC in the high-resolution atmosphere-only mod

关键词： South China spring precipitation high resolution Flexible Global Ocean–Atmosphere–Land System finite-volume version 3(FGOALS-f3)models simulation

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BBX9 forms feedback loops with PIFs and BBX21 to promote photomorphogenic development

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JOURNAL OF INTEGRATIVE PLANT BIOLOGY 2024年第9期66卷 1934-1952页

作者： Song, Zhaoqing Ye, Wanying Jiang, qing Lin, Huan Hu, qing xiao, Yuntao bian, Yeting Zhao, Fengyue Dong, Jie Xu, Dongqing Nanjing Agr Univ Coll Agr Natl Ctr Soybean Improvement State Key Lab Crop Genet & Germplasm Enhancement & Nanjing 210095 Peoples R China Zhejiang Univ Coll Agr & Biotechnol Inst Crop Sci Hangzhou 310058 Peoples R China

Light is one of the most essential environmental factors that tightly and precisely control various physiological and developmental processes in plants. B-box CONTAINING PROTEINs (BBXs) play central roles in the regulation of light-dependent development. In this study, we report that BBX9 is a positive regulator of light signaling. BBX9 interacts with the red light photoreceptor PHYTOCHROME B (phyB) and transcription factors PHYTOCHROME-INTERACTING FACTORs (PIFs). phyB promotes the stabilization of BBX9 in light, while BBX9 inhibits the transcriptional activation activity of PIFs. In turn, PIFs directly bind to the promoter of BBX9 to repress its transcription. On the other hand, BBX9 associates with the positive regulator of light signaling, BBX21, and enhances its biochemical activity. BBX21 associates with the promoter regions of BBX9 and transcriptionally up-regulates its expression. Collectively, this study unveiled that BBX9 forms a negative feedback loop with PIFs and a positive one with BBX21 to ensure that plants adapt to fluctuating light conditions.

关键词： Arabidopsis BBX21 BBX9 light signaling photomorphogenesis phyB PIF B-BOX PROTEIN PHYTOCHROME-B TRANSCRIPTION FACTORS RED-LIGHT HIGH-TEMPERATURE CIRCADIAN CLOCK CRYPTOCHROME 1 TARGET GENES ARABIDOPSIS CONSTANS

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Pyruvate kinase M in germ cells is essential for sperm motility and male fertility but not spermatogenesis

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Asian Journal of Andrology 2024年第2期26卷 212-219页

作者： Gao-qing Qian xiao-Chen Wang xi Zhang Bin Shen Qiang Liu State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medical UniversityNanjing 211166China Shanghai Key Laboratory of Reproductive Medicine Department of HistoembryologyGenetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Male germ cells employ specific metabolic pathways throughout their developmental *** a previous study,we discovered heightened expression of pyruvate kinase M(PKM),a pivotal glycolytic enzyme,in spermatogonia and *** gain deeper insights into PKM's roles in spermatogenesis,sperm function,and male fertility,we engineered a conditional-knockout mouse model(Pkm-vkO mice)to selectively disrupt the Pkm gene within germ *** maintaining regular testicular histology and sperm morphology,the male Pkm-vko mice were infertility,characterized by significant impairments in sperm motility and adenosine triphosphate(ATP)*** addition,Pkm-null spermatozoa exhibited similar deficits in protein tyrosine phosphorylation linked to capacitation,as well as compromised performance in in vitro fertilization *** conclude,PKM's presence is not obligatory for the entirety of spermatogenesis in male germ cells;however,it emerges as a critical factor influencing sperm motility and overall male fertility.

关键词： glycolysis male fertility pyruvate kinase M sperm motility spermatogenesis

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Single thiolate replacement of metal nanoclusters

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Science China Chemistry 2024年第2期67卷 523-528页

作者： Ambreen Ambreen Yue Zhou Wanmiao Gu qing You Liang Fang Guoqing bian Nan Yan Nan xia Zhikun Wu Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHefei Institutes of Physical Science(HFIPS)Chinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230601China Institute of Physical Science and Information Technology Anhui UniversityHefei230601China

Surface thiolates play important roles in evincing the structures and properties of thiolated metal nanoclusters—one type of recently emerging inorganic-organic hybrids,and thus the thiolate substitution,especially single thiolate substitution,is highly desirable for subtly tailoring the structures and properties of metal ***,such a single-thiolate substituting is challenging,and its influence on the metal-metal and metal-sulfur bonds remains mysterious due to the absence of the singlethiolate-substituted ***,we developed a combined method,concurrently synthesized the single-thiolate-substituted nanocluster and its parent nanocluster,and successfully resolved their structures by single crystal X-ray crystallography,which reveals that the single thiolate substitute has an obvious influence on the metal-metal and metal-sulfur bond lengths although it has no effect on the absorption ***,the metal-metal and metal-sulfur bonds show various thermal extensibility and even the negative thermal expansion phenomena of the Au–S bond were observed in the single-thiolate-substituted *** bond length-related stability was also ***,this study highlights a novel synthesis method and offers novel structural insights and an in-depth structure-property correlation of thiolated metal nanoclusters.

关键词： metal nanoclusters single thiolate replacement thermal expansion stability intercluster interaction

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Electrostatically connected nanoarchitected electrocatalytic films for boosted water splitting

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Nano Research 2024年第3期17卷 1114-1122页

作者： Chao-Peng Wang Hao Sun Gang bian Jia-xi Wang xixi Pang Guoqi Wang Jian Zhu xian-He Bu School of Materials Science and Engineering National Institute for Advanced MaterialsNankai UniversityTianjin 300350China Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry Nankai UniversityTianjin 300350China Tianjin Key Laboratory for Rare Earth Materials and Applications Nankai UniversityTianjin 300350China

Active sites of two-dimensional(2D)electrocatalysts are often partially blocked owing to their inevitable stacking and hydrophobic polymeric binders in macroscale electrodes,therefore impeding their applications in efficient ***,using layered double hydroxide(LDH)nanosheets as a model 2D electrocatalyst,we demonstrate that their performance toward water splitting can be boosted when they are electrostatically assembled into an organized structure pillared by hydrophilic polyelectrolytes or nanoparticles in a layer-by-layer(LbL)*** particular,their mass activity on a planar electrode can be as large as 2.267 mA·μg^(-1) toward oxygen evolution reaction(OER),when NiFe-LDH nanosheets are electrostatically connected by poly(sodium 4-styrenesulfonate)(PSS),while drop-casted NiFe-LDH nanosheets only have a mass activity of 0.116 mA·μg^(-1).In addition,these homogeneous NiFe-LDH nanofilms can be easily deposited on three-dimensional(3D)surfaces with high areas,such as carbon cloths,to serve as practical electrodes with overpotentials of 328 mV at a current density of 100 mA·cm^(-2),and stability for 40 ***,Pt nanoparticles can be LbL assembled with NiFe-LDH as bifunctional electrodes for synergistically boosted oxygen and hydrogen evolution reactions(HER),leading to successful overall water splitting powered by a 1.5 V *** study heralds the spatial control of 2D nanomaterials in nanoscale precision as an efficient strategy for the design of advanced electrocatalysts.

关键词： layer-by-layer(LbL)assembly layered double hydroxides(LDH) two-dimensional(2D)electrocatalysts oxygen evolution reaction(OER) water splitting

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