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Supervised topic models with weighted words:multi-label document classification

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Frontiers of Information Technology & Electronic Engineering 2018年第4期19卷 513-523页

作者： Yue-peng ZOU Ji-hong OUYANG xi-ming li College of Computer Science and Technology Jilin University MOE Key Laboratory of Symbolic Computation and Knowledge Engineering Jilin University

Supervised topic modeling algorithms have been successfully applied to multi-label document classification *** models include labeled latent Dirichlet allocation(L-LDA)and ***,these models neglect the class frequency information of words(i.e.,the number of classes where a word has occurred in the training data),which is significant for *** address this,we propose a method,namely the class frequency weight(CF-weight),to weight words by considering the class frequency *** CF-weight is based on the intuition that a word with higher(lower)class frequency will be less(more)*** this study,the CF-weight is used to improve L-LDA and dependency-LDA.A number of experiments have been conducted on real-world multi-label *** results demonstrate that CF-weight based algorithms are competitive with the existing supervised topic models.

关键词： Supervised topic model Multi-label classification Class frequency Labeled latent Dirichlet allocation (L-LDA) Dependency-LDA

Color Image Super-Resolution and Enhancement with Inter-Channel Details at Trivial Cost

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Journal of Computer Science & Technology 2020年第4期35卷 889-899页

作者： Chuang-Ye Zhang Yan Niu Tie-Ru Wu xi-ming li College of Computer Science and Technology Jilin UniversityChangchun 130012China Key Laboratory of Symbolic Computer and Knowledge Engineering of Ministry of Education Jilin University Changchun 130012China School of Mathematics Jilin UniversityChangchun 130012China

Image super-resolution is essential for a variety of applications such as medical imaging,surveillance imaging,and satellite imaging,among ***,the most popular color image super-resolution is performed in each color channel *** this paper,we show that the super-resolution quality can be further enhanced by exploiting the cross-channel *** by the High-Quality linear Interpolation(HQli)demosaicking algorithm by Malvar et al.,we design an image super-resolution scheme that integrates intra-channel interpolation with cross-channel details by isotropic linear *** its simplicity,our super-resolution method achieves the accuracy comparable with the existing fastest state-of-the-art super-resolution algorithm at 20 times faster *** is well applicable to applications that adopt traditional interpolations,for improved visual quality at trivial computation *** comparative study verifies the effectiveness and efficiency of the proposed super-resolution algorithm.

关键词： image super-resolution isotropic linear interpolation inter-channel detail enhancement low cost

Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第9期11卷 690-701页

作者： Ning ZHOU Wei-xing CHEN WeiZHANG Lan li xi JIN You-ming li Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:The aim of our study was to perform a systematic review and meta-analysis of the efficacy of short-term protocols for Helicobacter pylori eradication and to review the safety and adverse profiles of these eradication ***:literatures were located through electronic searches by PubMed,Medline,ISI Web of Knowledge,and Cochrane library using the relevant *** of important meetings were searched manually in some journal *** bibliographies were identified from the reference lists of identified *** independent reviewers systemically identified randomized controlled trials(RCTs) comparing short-duration protocols vs.7-d proton pump inhibitor(PPI)-based triple protocols,as well as studies reporting eradication rates of short-duration protocols for *** effect size was calculated as relative risk(RR) and 95% confidence intervals(CI) using Review Manager 4.2,and Plightly fewer adverse-effects were found in short-term ***:Although more economical,short-duration protocols are inferior to 7-d PPI-based triple protocols with regarding to eradication rate of *** of more than 3 d,however,may be equivalent to 7-d protocols.

关键词： Helicobacter pylori Eradication therapy Short-term Meta-analysis Adverse effects

Topic modeling for large-scale text data

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Frontiers of Information Technology & Electronic Engineering 2015年第6期16卷 457-465页

作者： xi-ming li College of Computer Science and Technology Jilin University Changchun 130012 China MOE Key Laboratory of Symbolic Computation and Knowledge Engineering Jilin University Changchun 130012 China

This paper develops a novel online algorithm, namely moving average stochastic variational inference （MASVI）, which applies the results obtained by previous iterations to smooth out noisy natural gradients. We analyze the convergence property of the proposed algorithm and conduct a set of experiments on two large-scale collections that contain millions of documents. Experimental results indicate that in contrast to algorithms named ＇stochastic variational inference＇ and ＇SGRLD＇, our algorithm achieves a faster convergence rate and better performance.

关键词： Latent Dirichlet allocation (LDA) Topic modeling Online learning Moving average

Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury

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Neural Regeneration Research 2022年第10期17卷 2157-2165页

作者： ming-xi li Jing-Wen Weng Eric S.Ho Shing Fung Chow Chi Kwan Tsang Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong Special Administrative RegionChina Department of Biology and Department of Computer Science Lafayette CollegeEastonPAUSA

Injuries to the central nervous system(CNS)such as stroke,brain,and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon *** brain has a surprising intrinsic capability of recovering itself after ***,the hostile extrinsic microenvironment significantly hinders axon *** advances have indicated that the inactivation of intrinsic regenerative pathways plays a pivotal role in the failure of most adult CNS neuronal ***,substantial evidence has convincingly demonstrated that the mechanistic target of rapamycin(mTOR)signaling is one of the most crucial intrinsic regenerative pathways that drive axonal regeneration and sprouting in various CNS *** this review,we will discuss the recent findings and highlight the critical roles of mTOR pathway in axon regeneration in different types of CNS ***,we will demonstrate that the reactivation of this regenerative pathway can be achieved by blocking the key mTOR signaling components such as phosphatase and tensin homolog(PTEN).Given that multiple mTOR signaling components are endogenous inhibitory factors of this pathway,we will discuss the promising potential of RNA-based therapeutics which are particularly suitable for this purpose,and the fact that they have attracted substantial attention recently after the success of coronavirus disease 2019 *** specifically tackle the blood-brain barrier issue,we will review the current technology to deliver these RNA therapeutics into the brain with a focus on nanoparticle *** will propose the clinical application of these RNA-mediated therapies in combination with the brain-targeted drug delivery approach against mTOR signaling components as an effective and feasible therapeutic strategy aiming to enhance axonal regeneration for functional recovery after CNS injury.

关键词： axon sprouting axon regeneration brain targeted drug delivery CNS injury ischemic stroke mTOR nanoparticle neural circuit reconstruction PTEN RNA-based therapeutics

Investigation of one-lung ventilation postoperative cognitive dysfunction and regional cerebral oxygen saturation relations

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第12期16卷 1042-1048页

作者： xi-ming li Feng li Zhong-kai liU ming-tao SHAO Department of Anesthesiology Linyi City People's Hospital Human Resource Department Linyi City People's Hospital Department of Emergency Surgery Linyi City People's Hospital

Objective： To explore the relationship of postoperative cognitive dysfunction （POCD） in one-lung ventilation （OLV） patients and regional cerebral oxygen saturation （rSO2）. Methods： Twenty-nine male and twenty-one female cases of OLV received thoracic surgery, with American Standards Association （ASA） physical status being at Grades Ⅰ-Ⅲ. Neuropsychological tests were performed on the day before operation and 7 d after operation, and there was an intraoperative continuous monitoring of rSO2. The values of rSO2 before anesthesia induction （t1）, at the beginning of OLV （t2）, and at the time of OLV 30 min （t3）, OLV 60 min （t4）, the end of OLV （t5）, and the end of surgery （t6） were recorded. The intraoperative average of rSO2 （ rSO2 ）, the intraoperative minimum value of rSO2 （rSO2, rn=n）, and the reduced maximum percentage of rSO2 （rSO2, %max） when compared with the baseline value were calculated. The volume of blood loss, urine output, and the amount of fluid infusion was recorded. Results： A total of 14 patients （28%） in the 50 cases suffered from POCD. The values of mini-mental state examination （MMSE）, the digit span and the digit symbol on the 7th day after the operation for POCD in OLV patients were found to be significantly lower than those before the operation （P〈0.05）. The values of MMSE and vocabulary fluency scores were significantly lower than those in the non-POCD group （P〈0.05）. The values of rSO2 in the POCD group of OLV patients at t2 and t3 and the values of rSO2 in the non-POCD group at t2 were found to be significantly higher than those at tl （P〈0.05）. The values of rSO2, %max in the POCD group were significantly higher than those in the non-POCD group （P〈0.05）. When the value of rSO2, %max is more than 10.1%, it may act as an early warning index for cognitive function changes, Conclusions： POCD after OLV may be associated with a decline in rSO2.

关键词： One-lung ventilation Postoperative cognitive dysfunction Regional cerebral oxygen saturation

Clinical efficacy and safety of recruitment maneuver in patients with acute respiratory distress syndrome using low tidal volume ventilation： a multicenter randomized controlled clinical trial

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Chinese Medical Journal 2010年第21期123卷 3100-3105页

作者： xi xiu-ming JIANG li ZHU Bo RM group Intensive Care UniL Fuxing Hospital Capital Medical Umversity Beijing 100038 China

Background The recruitment maneuver （RM） has been shown to improve oxygenation in some patients with acute respiratory distress syndrome. But there is a lack of standardization and lack of clinical studies to prove the improvement on clinical outcome. We conducted this study to evaluate the clinical efficacy and safety of the RM in patients with acute respiratory distress syndrome （ARDS） using Iow tidal volume *** We randomly assigned 110 patients with ARDS from 14 Chinese intensive care units （ICUs） at the tertiary teaching hospitals. Patients with PaO2 ≤200 mmHg at FiO2 1.0 and PEEP ≥10 cmH2O were included in the *** were randomized into two groups： control group and RM group. The tidal volume was set to 6-8 mi per kilogram of predicted body weight （PBW） in both groups. RM was performed by continuous positive airway pressure （CPAP） of 40 cmH2O maintained for 40 seconds. RMs was conducted every eight hours for the first five days, or stopped within five days if the patient reached the weaning *** One hundred and ten patients had completed the requirements for the primary study goals, 55 from the RM group and 55 control patients. Baseline characteristics remained similar in the two groups. In the RM group the PaO2/FiO2 was significantly increased compared to baseline at 120 minutes after RM on day one and day two （P=0.007and P=0.001）. There were no significant differences between the RM and control group in hospital mortality （41.8% vs.56.4%, P=0.13）, 28-day mortality （29.1% vs. 43.6%, P=0.11） and ventilator-free days at day 28 （10.8±10.1 vs. 7.4±10.0,P=0.08）. ICU mortality （32.7% vs. 52.7%, P=0.03）, the rate of survival with unassisted breathing for at least 48 consecutive hours at day 28 （58.2% vs. 36.2%, P=0.02）, and nonpulmonary organ failure-free days at day 28 （17.4±11.1vs. 13.0±12.0, P=0.03） favored the RM group. There was no significant difference in mean blood pressure and heart rate before RM and at 30, 60, 120 minut

关键词： respiratory distress syndrome, adult respiration, artificial recruitment maneuver positive-pressure respiration randomized controlled trial

Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第10期15卷 870-878页

作者： xi-ming li ming-tao SHAO Jian-juan WANG Yue-lan WANG Department of Anesthesiology Affiliated Qianfoshan Hospital of Shandong University Department of Anesthesiology Linyi City People's Hospital Department of Emergency Surgery Linyi City People's Hospital Department of Anesthesiology Shandong Lunan Ophthalmologic Hospital

Objective： To investigate the relationship between post-operative cognitive dysfunction（POCD） and regional cerebral oxygen saturation（rSO2） and β-amyloid protein（Aβ） in patients undergoing laparoscopic pancreaticoduodenectomy. Methods： Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction（t0）, at the beginning of laparoscopy（t1）, and at the time of pneumoperitoneum 120 min（t2）, pneumoperitoneum 240 min（t3）, pneumoperitoneum 480 min（t4）, the end of pneumoperitoneum（t5）, and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay（EliSA）. Results： Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO2（rSO2, %max） was significantly higher in the POCD group than in the non-POCD group. The rSO2, %max value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values（P〈0.01）. After 24 h, levels of plasma Aβ in the POCD group were significantly higher than those in the non-POCD group（P〈0.01）. Conclusions： The development of POCD in patients undergoing laparoscopic pancreaticoduodenectomy is associated with alterations of rSO2 and Aβ. Monitoring of rSO2 might be useful in the prediction of POCD, and Aβ might be used as a sensitive biochemical marker to predict the occurrence of POCD.

关键词： Laparoscopic pancreaticoduodenectomy Regional cerebral oxygen saturation β-Amyloid protein Post-operative cognitive dysfunction

Underlying IgM heavy chain amyloidosis in treatment-refractory IgA nephropathy: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3055-3061页

作者： Hai-Ting Wu Yu-Bing Wen Wei Ye Bing-Yan liu Kai-Ni Shen Rui-Tong Gao ming-xi li Department of Nephrology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Monoclonal immunoglobulin can cause renal damage,with a wide spectrum of pathological changes and clinical manifestations without hematological evidence of *** disorders can be missed,especially when combined with other kidney *** SUMMARY A 61-year-old woman presented with moderate proteinuria with normal renal *** was diagnosed with IgA nephropathy combined with monoclonal gammopathy of undetermined significance after the first renal *** having received immunosuppressive treatment for 3 years,the patient developed nephrotic *** renal biopsy and laser microdissection/mass spectrometry analysis confirmed heavy chain *** nine cycles of bortezomib,cyclophosphamide and dexamethasone,she achieved very good partial hematological and kidney *** Renal injury should be monitored closely in monoclonal gammopathy patients without obvious hematological malignancy,especially in patients with other preexisting renal diseases.

关键词： Monoclonal gammopathy IgA nephropathy Renal biopsy Laser microdissection/mass spectrometry Case report