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Effect of Postoperativeω-3 Fatty Acid Immunonutritional Therapy on NK Cell Gene Methylation in Elderly Patients with Gastric Cancer

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Current Medical Science 2022年第2期42卷 373-378页

作者： Li-ning XU ying-ying XU gui-ping LI Bo YANG Department of General Surgery The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou450003China Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan430015China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective This study aims to investigate the effect ofω-3 fatty acid immunonutritional therapy on natural killer(NK)cell gene methylation and function in elderly patients with gastric *** A total of 70 cases of elderly patients with gastric cancer were randomized into theω-3 fatty acid group and placebo group,according to the type of nutritional support *** methylation status of the tumor necrosis factor(TNF)-αgene promoter in peripheral NK cells was detected by methylation specific polymerase chain reaction,and the TNF-αlevel in peripheral NK cells was detected by enzyme-linked immunosorbent *** After 14 days of immunonutritional therapy withω-3 fatty acid or placebo,patients in theω-3 group had significantly higher average NK cell activity(0.27 vs.0.24,P=0.013)and lower percentages of TNF-αgene promoter methylation(25.7%vs.60%,P<0.05)than the placebo ***,there were no significant differences in the concentration of albumin,prealbumin and TNF-αin serum,and the NK cell count between theω-3 group and placebo *** The postoperative application ofω-3 fatty acid may improve the activity of NK cells,which is correlated to the methylation status of the TNF-αgene promoter.

关键词： perioperative gastric carcinoma natural killer cell DNA methylation immune nutrition

A Sufficient Condition for Planar Graphs with Maximum Degree 8 to Be 9-totally Colorable

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Acta Mathematica Sinica,English Series 2014年第6期30卷 993-1006页

作者： Jian Sheng CAI Chang Chun TENG gui ying YAN School of Mathematics and Information Sciences Weifang University Academy of Mathematics and Systems Science Chinese Academy of Sciences

A total k-coloring of a graph G is a coloring of V（G） ∪ E（G） using k colors such that no two adjacent or incident elements receive the same color. The total chromatic number χ＇＇（G） is the smallest integer k such that G has a total k-coloring. It is known that if a planar graph G has maximum degree △≥ 9, then ）χ″（G） =△＋ 1. In this paper, we prove that if O is a planar graph with maximum degree 8 and without a fan of four adjacent 3-cycles, then χ″（G） =- 9.

关键词： Total coloring planar graph a fan of four adjacent 3-cycles

Bregman Iterative Model Using theG-norm

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Acta Mathematicae Applicatae Sinica 2014年第1期30卷 179-186页

作者： Yu-ying SHI xiao-zhong YANG Yong-gui ZHU Department of Mathematics and Physics North China Electric Power University School of Science Communication University of China

In this paper, we analyze the Bregman iterative model using the G-norm. Firstly, we show the convergence of the iterative model. Secondly, using the source condition and the symmetric Bregman distance, we consider the error estimations between the iterates and the exact image both in the case of clean and noisy data. The results show that the Bregman iterative model using the G-norm has the similar good properties as the Bregman iterative model using the L2-norm.

关键词： Bregman distance image restoration total variation error estimation iterative regularization

Multi-state Quantum Teleportation via One Entanglement State

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Communications in Theoretical Physics 2008年第8期50卷 363-367页

作者： GUO ying ZENG gui-Hua Moon Ho Lee School of Information Science ＆ Engineering Central South University Changsha 410083 China State Key Laboratory on Fiber-Optic Local Area Networks and Advanced Optical Communication Systems Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Information ＆ Communication Engineering Chonbuk National University Chonju 561-756 Korea

A multi-sender-controlled quantum teleportation scheme is proposed to teleport several secret quan- tum states from different senders to a distance receiver based on only one Einstein-Podolsky-Rosen (EPR) pair with controlled-NOT (CNOT) *** the present scheme,several secret single-qubit quantum states are encoded into a multi-qubit entangled quantum *** communication modes,i.e.,the detecting mode and the message mode,are employed so that the eavesdropping can be detected easily and the teleported message may be recovered *** has an advantage over teleporting several different quantum states for one scheme run with more efficiency than the previous quantum teleportation schemes.

关键词： quantum teleporlation entanglement state

Improved Bounds on the Generalized Acyclic Chromatic Number

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 67-72页

作者： Yu-wen WU Kan-ran TAN gui-ying YAN Beijing Wuzi University Beijing 101149China Johns Hopkins University BaltimoreMarylandUnited States of America Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100080China

An r-acyclic edge chromatic number of a graph G,denoted by α＇r（G）,is the minimum number of colors used to produce an edge coloring of the graph such that adjacent edges receive different colors and every cycle C has at least min {｜C｜,r} *** prove that α＇r（G） ≤（4r ＋ 1）△（G）,when the girth of the graph G equals to max{50,△A（G）} and 4 ≤ r ≤ *** we relax the restriction of the girth to max {220,A（G）},the upper bound of a＇r（G） is not larger than（2r ＋ 5）△（G） with 4 ≤r≤ 10.

关键词： edge coloring r-acyclic edge coloring grith Lovasz local lemma

Establishment of an Assessment System for the Prediction of Severe Post-operative Complications after Hepatectomy Based on Preoperative Parameters

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Current Medical Science 2022年第5期42卷 1088-1093页

作者： Li-ning XU ying-ying XU gui-ping LI Bo YANG Department of General Surgery The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Internal Medicine Henan Cancer HospitalZhengzhou450003China Department of Radiology Hubei Province Integrated Hospital of Chinese and Western MedicineWuhan430015China Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective At present,there is no appropriate system to evaluate the severe complications of liver surgery through the preoperative *** study aimed to design and verify a risk assessment system for the prediction of severe post-operative complications after a hepatectomy based on the preoperative *** A retrospective analysis was performed on 1732 patients who had undergone liver *** severity of the complications was graded by Accordion Severity Grading of post-operative *** variables were screened by multivariate analysis,and graded scores were assigned to the selected variables.A logistic regression equation was used to form the liver operation risk formula(LORF)for the prediction of severe post-operative *** LORF was verified by the receiver operating characteristic(ROC)*** The multivariate correlation analysis revealed the independent influencing factors of the severe post-operative complications of liver surgery were Child-Pugh grade(OR=4.127;P<0.001),medical diseases requiring drug treatment(OR=3.092;P<0.001),the number of liver segments to be removed(OR=2.209;P=0.006),organ invasion(OR=4.538;P=0.024),and pathological type(OR=4.023;P=0.002).The binomial logistic regression model was established to obtain the calculation formula(LORF)of the severe complication *** area under the ROC curve(AUC)of the LORF was *** cut-off value of the expected probability of severe complications was 0.3225(32.25%).Furthermore,in the validation data set,the corresponding AUC of the LORF was *** As a novel and simplified assessment system,the LORF could effectively predict the severe post-operative complications of liver surgery through the preoperative factors,and therefore it could be used to evaluate the risk of severe liver surgical complications before surgery.

关键词： liver surgery complication prediction

Pharmacokinetics of Two Ingredients of the Compound Chinese Herbal Medicine Transdermal Preparation in Cows

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Agricultural Sciences in China 2009年第9期8卷 1138-1142页

作者： WANG gui-xia LI Rui ZHANG xiu-ying Department of Basic Veterinary Science College of Veterinary Medicine Northeast Agricultural University Harbin 150030 P.R.China

The topical administration of the compound Chinese herbal medicine transdermal preparation has been widely used in treating the mastitis of cows. In order to understand the metabolic process, four cows suffering from clinical mastitis were selected for the pharmacokinetic study. The transdermal preparation was applied to the diseased part of breast. Then the plasma and milk samples were collected respectively at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 36 h, The concentrations of baicalin and phillyrin in plasma and milk were determined by HPLC and the data of time-concentrations were analyzed by the pharmacokinetic software. The results showed that two ingredients in the plasma were not detectable, but they in the milk had linear relationship with the time. The peak concentration of baicalin [（2.84 ±0.15）μg mL^-1] appeared at （4.93 ± 0.35） h, AUC0.1OQ was （27.32 ± 7.91） mg L^-1 h^-1, and the mean retention time was （28.31 ±0.49） h. The peak concentration of phillyrin [（0.49 ± 0.41） μg mL^-1] achieved at （3.68 ± 3.14） h, AUC0-LOQ was （4.10± 0.31） mg L^-1 h^-1, and the mean retention time was （14.52 ± 0.02） h. These suggested that two ingredients had slow absorbing speed and high absorbing degree. They could not be eliminated in a short time, thus exerted the topical curative effect.

关键词： Chinese herbal medicine pharmacokinetics transdermal preparation active ingredients mastitis

Effects of Aging and Self-organized Criticality in a Pulse-Coupled Integrate-and-Fire Neuron Model Based on Small World Networks

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Communications in Theoretical Physics 2007年第5期47卷 869-874页

作者： ZHANG gui-Qing ZHANG ying-Yue CHEN Tian-Lun Department of Physics Nankai University Tianjin 300071 China

Effects of aging and self-organized criticality in a pulse-coupled integrate-and-fire neuron model based on small world networks have been studied. We give the degree distribution of aging network, average shortest path length, the diameter of our network, and the clustering coefficient, and find that our neuron model displays the power-law behavior, and with the number of added links increasing, the effects of aging become smaller and smaller. This shows that if the brain works at the self-organized criticality state, it can relieve some effects caused by aging.

关键词： aging self-organized criticality small world networks

Evaluating genetic insights into ulcerative colitis and anxiety:Limitations and future directions

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World Journal of Gastroenterology 2024年第37期30卷 4156-4159页

作者： ying Peng xi-Dai Long Department of Pathology The First Affiliated HospitalGuangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Shenzhen Qianhai Shekou Free Trade Zone HospitalShenzhen 518000Guangdong ProvinceChina Department of Pathology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Liver Surgery Ren Ji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200000China

We reviewed the study by He et al,which investigates the genetic correlation between ulcerative colitis(UC)and anxiety using bidirectional Mendelian *** study reveals a genetic link between UC and anxiety,diverging from prior research associating higher anxiety with Crohn’s *** the study's use of large-scale genome-wide association studies data is commendable,it faces limitations such as single nucleotide polymorphism selection biases,lack of multiple testing corrections,and a reliance on European *** research should address these limitations,incorporate diverse populations,and explore psychotherapeutic interventions to improve UC management and patient outcomes.

关键词： Ulcerative colitis Anxiety Mendelian randomization Genome-wide association study Gut-brain axis Instrumental variables Genetic epidemiology Pleiotropy