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Chinese Journal of Integrative Medicine 2013年第8期19卷 568-572页

作者： xi-yan xin 辛喜艳 (11087) Ying Gao 高颖 (11087) 11087. Department of Neurology Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China

Objective： To explore the effect of phlegm-heat syndrome on the degree of neurological deficit and provide some data support for the correct recognition of the relationship between phlegm-heat syndrome and neurological deficits in stroke patients. Methods： Clinical information were collected on 294 patients with acute ischemic stroke （AIS） whose syndrome and National Institute of Health stroke scale （NIHSS） score were checked at baseline （within the first 3-day admission） and at 7, 14, 28, and 90 days after admission to our clinical research centre. We explored the effect of phlegm-heat syndrome on the degree of neurological deficit following stroke by applying a repeated measures analysis of variance. Results： Stroke patients with phlegm-heat syndrome had higher NIHSS score than patients without the syndrome （P〈0.01）, and there appeared to be a decrease in NIHSS score over time in all patients （P〈0.01）. Conduslons： Phlegm-heat syndrome in patients who have suffered stroke has an effect on the degree of neurological deficiency. Disappearance of phlegm-heat syndrome may improve the degree of neurological deficit observed in stroke patients.

关键词： ischemic stroke phlegm-heat syndrome neurological deficiency repeated measures analysis ofvariance

Mechanism of mesenchymal stem cells in liver regeneration:Insights and future directions

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World Journal of Stem Cells 2024年第9期16卷 842-845页

作者： Yu-xin Jin Hang-Qi Hu Jia-Cheng Zhang xi-yan xin Yu-Tian Zhu yang Ye Dong Li Department of Traditional Chinese Medicine Peking University Third HospitalBeijing 100191China

Mesenchymal stem cells(MSCs)are a prevalent source for stem cell therapy and play a crucial role in modulating both innate and adaptive immune ***-alcoholic fatty liver disease(NAFLD)is characterized by the accumulation of triglycerides in liver cells and involves immune system activation,leading to histological changes,tissue damage,and clinical symptoms.A recent publication by Jiang et al,highlighted the potential of MSCs to mitigate in NAFLD progression by targeting various molecular pathways,including glycolipid metabolism,inflammation,oxidative stress,endoplasmic reticulum stress,and *** this editorial,we comment on their research and discuss the efficacy of MSC therapy in treating NAFLD.

关键词： Mesenchymal stem cells Liver regeneration Non-alcoholic fatty liver disease Immune cells Therapeutic strategy

DIAGNOSIS AND TREATMENT OF CESAREAN SCAR PREGNANCY

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Chinese Medical Sciences Journal 2008年第1期23卷 10-15页

作者： Lan-zhou Jiao Jun Zhao xi-run Wan xin-yan Liu Feng-zhi Feng Tong Ren yang xiang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To investigate the early diagnosis and treatment of cesarean scar pregnancy （CSP）. Methods Clinical data of 28 patients with CSP in Peking Union Medical College Hospital from January 1994 to April 2007, including age, interval from the last cesarean delivery to diagnosis, clinical presentation, location of the lesion, process of diagnosis and treatment, outcome, and follow-up, were retrospectively analyzed. Re, salts CSP constituted 1.05 % of all ectopic pregnancies, and the ratio of CSP to pregnancy was 1 ： 1 221. The mean age of the group was 31.4 years. Twenty-six women had only one prior cesarean delivery. The interval from the last cesarean delivery to diagnosis ranged from 4 months to 15 years. The most common presenting symptoms of CSP were amenorrhoea and vaginal bleeding. Seventeen cases were misdiagnosed as early intrauterine pregnancies and 2 were misdiagnosed as gestational trophoblastic tumor. The other 9 were diagnosed definitely before treatment. The diagnosis was made based on cesarean delivery history, gynecologic examination, ultrasound, and magnetic resonance imaging （MRI）. The treatment of CSP included systemic or local methotrexate administration, conservative surgery, and hysterectomy. The conservative treatment was successful in 24 cases. All of the 28 women were cured through individual therapies. Conclusions CSP is rare and usually misdiagnosed as other diseases. Ultrasound is valuable for diagnosing CSP, and MRI can be used as an adjunct to ultrasound scan. Early diagnosis offers the options of conservative treatment and greatly improves the outcome of patients. Individual therapy is strongly recommended.

关键词： cesarean scar pregnancy misdiagnosis early diagnosis individual therapy

Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Recent advances from mechanisms to therapeutics

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World Journal of Stem Cells 2024年第1期16卷 1-6页

作者： Hang-Qi Hu xi-yan xin Yu-Tian Zhu Rui-Wen Fan Hao-Lin Zhang yang Ye Dong Li Department of Traditional Chinese Medicine Peking University Third HospitalBeijing 100191China

The incidence of premature ovarian insufficiency(POI)is increasing worldwide,particularly among younger women,posing a significant challenge to *** addition to menopausal symptoms,POI leads to several complications that profoundly affect female reproductive function and overall ***,current clinical treatment strategies for this condition are limited and often yield unsatisfactory *** approaches typically involve hormone repla-cement therapy combined with psychological ***,mesenchymal stem cell(MSC)therapies for POI have garnered considerable attention in global *** can restore ovarian reproductive and endocrine functions through diverse mechanisms,including controlling differentiation,promoting angiogenesis,regulating ovarian fibrosis,inhibiting apoptosis,enhancing autocrine and paracrine effects,suppressing inflammation,modulating the immune system,and genetic *** editorial offers a succinct summary of the application of MSC therapy in the context of POI,providing evidence for groundbreaking medical approaches that have potential to enhance reproductive health and overall well-being for women.

关键词： Mesenchymal stem cell therapy Mechanism Premature ovarian insufficiency Therapeutic Women

Fine Particulate Matter-Induced Exacerbation of Allergic Asthma via Activation of T-cell Immunoglobulin and Mucin Domain 1

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Chinese Medical Journal 2018年第20期131卷 2461-2473页

作者： Yun-xia Zhao Hui-Ran Zhang xiu-Na yang Yu-Hao Zhang Shan Feng Feng-Xue Yu xi-xin yan Department of Respiratory and Critical Care Medicine The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Respiratory Medicine The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Department of Respiratory Medicine The Third Hospital of Shijiazhuang Shijiazhuang Hebei 050000 China Department of Emergency Jinzhou General Hospital Hebei 052260 China Department of Internal Medicine The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Department of Central Laboratory The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background： Fine particulate matter （PM2.5） exacerbates airway inflammation and hyperreactivity in patients with asthma, but the mechanism remains unclear. The aim of this study was to observe the effects of prolonged exposure to high concentrations of PM2.5 on the pathology and airway hyperresponsiveness （AHR） of BALB/c mice undergoing sensitization and challenge with ovalbumin （OVA） and to observe the effects of apoptosis and T-cell immunoglobulin and mucin domain 1 （TIM-1） in this process. Methods： Forty female BALB/c mice were divided into four groups： control group, OVA group, OVA/PM group, and PM group （n - 10 in each group）. Mice in the control group were exposed to filtered clean air. Mice in the OVA group were sensitized and challenged with OVA. Mice in the OVA/PM group were sensitized and challenged as in the OVA group and then exposed to PM2.5 for 4 h per day and 5 days per week for a total of 8 weeks using a nose-only ＂PM2.5 online enrichment system＂ in The Second Hospital of Hebei Medical University. Mice in the PM group were exposed to the PM2.5 online enrichment system only. AHR was detected. Bronchoalveolar lavage fluid （BALF） was collected for cell classification. The levels of interleukin-4 （IL-4）, IL-5, and IL-33 in BALF were measured using enzyme-linked immunosorbent assay. Changes in histological structures were examined by light microscopy, and changes in ultramicrostructures were detected by electron microscopy. Apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling （TUNEL） assay in the lung tissues. Western blotting and immunohistochemistry were utilized to analyze the expression of Bcl-2, Bax, and TIM-1 in the lungs. Results： The results showed that AHR in the OVA/PM group was significantly more severe than that in the OVA and PM groups （P 〈 0.05）. AHR in the PM group was also considerably more severe than that in the control group （P 〈 0.05）. The BALF of OVA/PM group （28.00± 6.08 vs. 12.33 ±4.51, t

关键词： Apoptosis Asthma Fine Particulate Matter T-cell Immunoglobulin and Mucin Domain 1

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脑电监测在脑梗死急性期预后判断中的应用

中华神经医学杂志 2012年第7期11卷 752-754页

作者：辛喜艳高颖北京中医药大学东直门医院神经内科北京100700

脑电图***）作为一种特殊而复杂的生物电信号，已被广泛应用到医学研究及临床实践中，对缺血缺氧较高的敏感性决定了其在脑梗死急性期的应用价值，可用于协助诊断、监测病情及判断预后。将脑电特征指标应用于脑梗死急性期近期及远期预... 详细信息

脑电图***）作为一种特殊而复杂的生物电信号，已被广泛应用到医学研究及临床实践中，对缺血缺氧较高的敏感性决定了其在脑梗死急性期的应用价值，可用于协助诊断、监测病情及判断预后。将脑电特征指标应用于脑梗死急性期近期及远期预后的预测中，对准确评估患者功能结局、制定早期康复计划、实施个体化社区服务都具有重要的意义。本文就脑梗死急性期常用脑电特征指标及其在近期与远期预后判断中的应用作一简要概述。

关键词：缺血性中风脑电指标预后

“辨体-辨病-辨证”诊疗模式在多囊卵巢综合征中的应用

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中华中医药杂志 2017年第2期32卷 490-492页

作者：李赛李东辛喜艳北京大学第三医院北京100191

多囊卵巢综合征是集生殖功能障碍和代谢异常于一身的复杂性疾病,严重影响妇女的生殖健康,目前尚无满意的治疗方法。将"辨体-辨病-辨证"诊疗模式诊疗模式应用于多囊卵巢综合征,有助于全面、客观的认识本病的发病规律并判断预后,进行有针... 详细信息

多囊卵巢综合征是集生殖功能障碍和代谢异常于一身的复杂性疾病,严重影响妇女的生殖健康,目前尚无满意的治疗方法。将"辨体-辨病-辨证"诊疗模式诊疗模式应用于多囊卵巢综合征,有助于全面、客观的认识本病的发病规律并判断预后,进行有针对性的个体化治疗以取得更好的临床疗效,并有效预防疾病的发生发展。

关键词：体质辨体辨病辨证多囊卵巢综合征

接受IVF-ET多囊卵巢综合征患者中医证候特征及与妊娠结局关系

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中华中医药杂志 2018年第11期33卷 4909-4912页

作者：辛喜艳郭佳李东北京大学第三医院中医科北京100191

目的:研究接受体外受精与胚胎移植(IVF-ET)的多囊卵巢综合征(PCOS)患者中医证候特征及与妊娠结局的关系。方法:以拟行IVF-ET并诊断为PCOS的195例不孕症患者为研究对象,进行中医证候、妊娠结局相关因素的观察,研究中医证候分布特征及不... 详细信息

目的:研究接受体外受精与胚胎移植(IVF-ET)的多囊卵巢综合征(PCOS)患者中医证候特征及与妊娠结局的关系。方法:以拟行IVF-ET并诊断为PCOS的195例不孕症患者为研究对象,进行中医证候、妊娠结局相关因素的观察,研究中医证候分布特征及不同妊娠结局与中医证候的关系。结果:出现频率较高的证候类型为肾气虚证(66.15%)、肾阳虚证(64.10%)、肝郁气滞证(62.56%)和痰湿证(61.03%);与妊娠成功组比较,妊娠失败组肝郁气滞证、肾阳虚证所占比重较大(P=0.046,P=0.032);发生OHSS的患者以肾阳虚证(79.41%)、痰湿证(75.00%)和肾气虚证(73.53%)为主要证候特征。结论:接受IVF-ET的PCOS患者中肾阳虚证和肝郁气滞证与妊娠结局关系密切,研究结果为PCOS患者IVF-ET前合理、有效的进行中医药辅助治疗,提高临床妊娠率提供一定的临床支持。

关键词：多囊卵巢综合征体外受精与胚胎移植中医证候特征妊娠结局

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运用郑钦安扶阳思想辨治围绝经期汗证体会

中华中医药杂志 2023年第1期38卷 208-210页

作者：辛喜艳王威李东李蓉北京大学第三医院北京100191 国家妇产疾病临床研究中心北京100191 北京大学第三医院中医科北京100191

潮热多汗是围绝经期最突出的临床表现之一,属于中医“汗证”范畴。文章围绕围绝经期汗证治疗中“阴阳辨识”的难点,引入郑钦安先生“阳主阴从”的学术思想和“阴火”理论,提出临证中应仔细辨识“神、色、舌、脉”,多汗若见神疲乏力、困... 详细信息

潮热多汗是围绝经期最突出的临床表现之一,属于中医“汗证”范畴。文章围绕围绝经期汗证治疗中“阴阳辨识”的难点,引入郑钦安先生“阳主阴从”的学术思想和“阴火”理论,提出临证中应仔细辨识“神、色、舌、脉”,多汗若见神疲乏力、困倦思睡、少气懒言、面色暗沉、舌淡胖、苔润滑、脉沉或缓,则属阳虚阴盛所致“阴火”。治疗以扶阳固摄为主,并提出围绝经期汗证属“阴火”者可选用潜阳丹和封髓丹。最后通过临床病案分析,加深对围绝经期汗证扶阳辨治思路的理解。

关键词：围绝经期汗证阴阳辨识阴火扶阳火神派

补肾活血中药对子宫内膜容受性的影响及其调控机制

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中国中药杂志 2018年第10期43卷 2014-2019页

作者：吕博洋李东张浩琳辛喜艳北京大学医学部北京100191 北京大学第三医院北京100191

子宫内膜容受性是指在着床窗期胚胎植入过程中,子宫内膜接受、容纳胚胎植入的能力。它是影响辅助生殖技术胚泡着床率的重要因素,目前辅助生殖技术中大量促性腺激素类药物的使用会降低子宫内膜容受性,抑制胚泡着床,极大影响了辅助生殖的... 详细信息

子宫内膜容受性是指在着床窗期胚胎植入过程中,子宫内膜接受、容纳胚胎植入的能力。它是影响辅助生殖技术胚泡着床率的重要因素,目前辅助生殖技术中大量促性腺激素类药物的使用会降低子宫内膜容受性,抑制胚泡着床,极大影响了辅助生殖的成功率。笔者经中国科学引文数据库检索后发现,自2006—2017年,有121项研究发现补肾活血中药能显著改善植入窗期胞饮突的发育,促进子宫内膜容受性标志物ER,PR,整合素β3,LIF,LPA3等多种分子的表达,从而提高子宫内膜容受性,利于胚胎着床。祖国医学对不孕症的理解源远流长,中医认为＂肾藏精,主生殖＂,肾虚是不孕症的重要病机。补肾活血中药能够补肾填精、养血活血,在不孕症的中西医治疗中发挥了重要作用。研究结果提示补肾活血中药能改善子宫内膜容受性,其作用机制值得进一步研究探讨。该文就补肾活血中药在辅助生殖领域的研究进展进行概括和总结,此外还归纳了当前研究的不足,并初步探讨了补肾活血中药在不孕症治疗中的潜在应用前景。

关键词：补肾活血子宫内膜容受性生殖