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The action of Pseudomonas aeruginosa biofilms in intrinsic drug resistance

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中华医学杂志(英文版) 2005年第19期 33-40页

作者： xiE Yi, JIA Wen-xiang, ZENG Wei, YANG Wei-qing, CHENG xi, LI Xue-ru, wang Lan-lan, KANG Mei and ZHANG Zai-rongDepartment of Microbiology, College of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu 610041, China

As an important opportunistic pathogen, Pseudomonas aeruginosa (P. aeruginosa, PA) was the most prevalent bacterial pathogens in infectious diseases, such as respiratory tract infections, bacteremia, pneumonia, urinary tract infections, cystic fibrosis, infections of burn, catheter infections and infections of heart valve.~ 1,2 Owing to mass usage of antibiotic agents, P. aeruginosa has shown intrinsic and acquired multi-drug resistance (MDR) that always causes failure in clinical therapy. P. aeruginosa MDR is more commonly due to mutation of antibiotic resistance gene ranging from mutation of type Ⅱ topoisomerase gene (gyrA)~3 to development of active efflux-mediated drug resistance (such as MexAB-OprM).~4 In addition, the formation of P. aeruginosa biofilms markedly enhances bacterial resistance to antibiotics agents.~5 P. aeruginosa biofilms are composed primarily of extracellular polymeric substance (EPS) as well as bacterial cells. This kind of compact substance prevents drugs to produce therapeutic effects.~6 However, in P. aeruginosa, the relationship between intrinsic drug resistance (including mutation of gyrA and active efflux of MexAB-OprM) and biofilms resistance is not clear. This work is to try to illuminate this relationship. We screened mutation of gyrA and active efflux of MexAB-OprM for studying the change of P. aeruginosa intrinsic resistance in process of bacterial biofilms development. Furthermore, we used biofilms strains to co-culture with intrinsic drug resistance strains and to demonstrate survival rate of biofilm strains and intrinsic resistance strains to ciprofloxacin.

关键词： Pseudomonas aeruginosa · drug resistance · bacteria · biofilms

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城区核心竞争力的形成机制及其营造策略

上海交通大学学报（哲学社会科学版） 2004年第5期12卷 49-54页

作者：罗守贵高汝熹王辉上海交通大学安泰管理学院上海200052

在分析城区核心竞争力的特点及内涵的基础上 ,从三个方面论述了城区核心竞争力的形成机制 :一是城区核心竞争力与城市综合竞争力的关系 ;二是城市功能空间定位与城区核心竞争力的关系 ;三是城市产业结构与城区核心竞争力的关系。最后 ,... 详细信息

在分析城区核心竞争力的特点及内涵的基础上 ,从三个方面论述了城区核心竞争力的形成机制 :一是城区核心竞争力与城市综合竞争力的关系 ;二是城市功能空间定位与城区核心竞争力的关系 ;三是城市产业结构与城区核心竞争力的关系。最后 ,有针对性地提出了城区核心竞争力的营造策略 :根据城市性质定位城区核心竞争力 ;通过功能强化提升城区核心竞争力 ;通过产业集聚营造城区核心竞争力 ;借助重大项目营造城区核心竞争力 ;通过制度创新营造城区核心竞争力。

关键词：城区核心竞争力形成机制营造策略城市综合竞争力产业结构制度创新城市功能空间

多波长直线回归法测定番木鳖中的士的宁和马钱子碱

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上海中医药杂志 2004年第8期38卷 58-59页

作者：黄喜茹王伟孙泽东刘振通河北医科大学药学院河北石家庄050017

为建立番木鳖中士的宁和马钱子碱的多波长直线回归测定法 ,选择 2 2 7 2nm～ 2 79 2nm为测定波长区间 ,采用计算机多波长直线回归法程序进行计算 ,不经提取分离直接测定士的宁和马钱子碱的含量。结果显示 :士的宁的线性范围为 8 0～ 30 ... 详细信息

为建立番木鳖中士的宁和马钱子碱的多波长直线回归测定法 ,选择 2 2 7 2nm～ 2 79 2nm为测定波长区间 ,采用计算机多波长直线回归法程序进行计算 ,不经提取分离直接测定士的宁和马钱子碱的含量。结果显示 :士的宁的线性范围为 8 0～ 30 0 μg/ml,r=0 9999;马钱子碱的线性范围为 7 0～ 31 2 μg/ml,r =0 9994 ;士的宁和马钱子碱的平均回收率、相对标准偏差分别为 99 82 %、1 5 4 %和 10 0 5 0 %、0 6 2 %。提示 ,该方法简便、快速、重现性好 ,结果可靠。

关键词：番木鳖士的宁马钱子碱多波长直线回归测定法

Improved multipath routing with WNN for the open networks

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 107-113页

作者： wang Yang wang ru-chuan CHENG xi Depamnent of Computer Science and Technology Nanjing University ofPosts and Telecommunications Nanjing 210003 China College of Mathematics and Computer Science Anhui Normal UniversityWuhu 241000 China College of Computer Science Soochow University Suzhou 215006 China

Multipath routing mechanism is vital for reliable packet delivery, load balance, and flexibility in the open network because its topology is dynamic and the nodes have limited capability. This article proposes a new multipath switch approach based on traffic prediction according to some characteristics of open networks. We use wavelet neural network （WNN） to predict the node traffic because the method has not only good approximation property of wavelet, but also self-learning adaptive quality of neural network. When the traffic prediction indicates that the primary path is a failure, the alternate path will be occupied promptly according to the switch strategy, which can save time for the switch in advance The simulation results show that the presented traffic prediction model has better prediction accuracy; and the approach based on the above model can balance network load, prolong network lifetime, and decrease the overall energy consumption of the network.

关键词： open network multipath routing traffic prediction,WNN

Structured AJAX Data Extraction Based on Agricultural Ontology

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Journal of Integrative Agriculture 2012年第5期11卷 784-791页

作者： LI Chuan-xi SU Ya-ru wang ru-jing WEI Yuan-yuan HUANG He Institute oflntelligent Machines Chinese Academy of Sciences Hefei 230031 P.R.China School of Information Science and Technology University of Science and Technology of China Hefei 230026 P.R.China

More web pages are widely applying AJAX （Asynchronous JavaScript XML） due to the rich interactivity and incremental communication. By observing, it is found that the AJAX contents, which could not be seen by traditional crawler, are well-structured and belong to one specific domain generally. Extracting the structured data from AJAX contents and annotating its semantic are very significant for further applications. In this paper, a structured AJAX data extraction method for agricultural domain based on agricultural ontology was proposed. Firstly, Crawljax, an open AJAX crawling tool, was overridden to explore and retrieve the AJAX contents; secondly, the retrieved contents were partitioned into items and then classified by combining with agricultural ontology. HTML tags and punctuations were used to segment the retrieved contents into entity items. Finally, the entity items were clustered and the semantic annotation was assigned to clustering results according to agricultural ontology. By experimental evaluation, the proposed approach was proved effectively in resource exploring, entity extraction, and semantic annotation.

关键词： information extraction structured data AJAX agricultural ontology semantic annotation

Concentrating partially entangledW-class states on nonlocal atoms using low-Q optical cavity and linear optical elements

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Science China(Physics,Mechanics & Astronomy) 2016年第10期59卷 42-48页

作者： Cong Cao xi Chen YuWen Duan Ling Fan ru Zhang TieJunwang Chuan wang State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications School of Ethnic Minority Education Beijing University of Posts and Telecommunications School of Science Beijing University of Posts and Telecommunications

Entanglement plays an important role in quantum information science, especially in quantum communications. Here we present an efficient entanglement concentration protocol(ECP) for nonlocal atom systems in the partially entangled W-class states, using the single-photon input-output process regarding low-Q cavity and linear optical elements. Compared with previously published ECPs for the concentration of non-maximally entangled atomic states, our protocol is much simpler and more efficient as it employs the Faraday rotation in cavity quantum electrodynamics(QED) and the parameter-splitting method. The Faraday rotation requires the cavity with low-Q factor and weak coupling to the atom, which makes the requirement for entanglement concentration much less stringent than the previous methods, and achievable with current cavity QED techniques. The parameter-splitting method resorts to linear-optical elements only. This ECP has high efficiency and fidelity in realistic experiments, and some imperfections during the experiment can be avoided efficiently with currently available techniques.

关键词： entanglement concentration W-class states cavity QED linear optical elements

The synthesis of B,N-carbon dots by a combustion method and the application of fluorescence detection for Cu^2+

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Chinese Chemical Letters 2017年第5期28卷 1119-1124页

作者： Ming-Cong Rong Ke-xin Zhang Yi-ru wang xi Chen Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis&Instrumentation College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361005China Key Laboratory of Global Change and Marine-Atmospheric Chemistry Third Institute of OceanographyState Oceanic AdministrationXiamen 361005China

Heteroatom doping is an efficient approach to regulate the fluorescence properties of carbon *** aminophenylboronic acid as the raw material,a combustion method was developed for the synthesis of boron,nitrogen-doped carbon dots（B,N-carbon dots）.The B,N-carbon dots emitted green fluorescence and displayed high resistance to both photo bleaching and ionic strength.A facile fluorescence sensing approach for Cu^2＋ was fabricated via static fluorescence *** optimal conditions,a rapid detection of Cu^2＋ could be completed in 2 min with a linearity ranging from 1 μmol/L to 25 μmol/L and a detection limit of 0.3 μmol/L Furthermore,the proposed method showed potential applications for the detection of Cu^2＋ in natural water samples.

关键词： Combustion method B N-carbon dots Fluorescence method Cu^2+ Static fluorescence quenching

基于正交试验设计针刺干预中风患肢肌张力增高的临床研究

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上海针灸杂志 2017年第5期36卷 519-524页

作者：马文崔花顺王波刘希茹王美娟沈卫东上海中医药大学附属曙光医院上海200021

目的筛选针刺干预中风患肢肌张力增高的优选方案。方法 80例符合纳入标准的中风患者,按正交设计方案随机分组,分别采用电针(A),每日针刺次数(B),穴位(C)3个因素2个水平进行治疗。共治疗20次。观察各组治疗前后改良Ashworth量表(modified... 详细信息

目的筛选针刺干预中风患肢肌张力增高的优选方案。方法 80例符合纳入标准的中风患者,按正交设计方案随机分组,分别采用电针(A),每日针刺次数(B),穴位(C)3个因素2个水平进行治疗。共治疗20次。观察各组治疗前后改良Ashworth量表(modified ashworth scale,MAS)评分差值的变化,并进行安全性评价。结果 A因素不同水平MAS评分的差值比较,差异有统计学意义(P0.05)。对腕关节、肘关节、膝关节、踝关节MAS评分改善方面,A_2B_1C_1(即结合电针、每日针刺2次、阴经穴位)为治疗的最佳方案。结论每日2次电针穴位方案为中风患肢肌张力增高针刺干预的优选方案,在临床上可以有效地缓解肌张力和改善肢体功能及临床症状,具有良好的安全性。

关键词：针刺疗法电针正交设计中风后遗症改良Ashworth量表

Estimating energy release performance of oxidizer-activated aluminum fuel particles under ultrafast stimulus

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Defence Technology（防务技术） 2023年第5期23卷 92-99页

作者： Ya-ru Li Hui Ren xin-zhou Wu Hui-xin wang xi-long Yu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China State Key Laboratory of High Temperature Gas Dynamics Institute of MechanicsChinese Academy of SciencesBeijing100190China

Aluminum(Al) particles are good fuel additives to improve the energy output performances of explosives. Under detonation environment, reaction delay of Al particles plays a key role in the energy release efficiency. Up to date, reaction delay of Al particles is still limited by the efficiency of mass and heat transfer from oxidizers to Al particles. To address this issue, a homogeneous fuel-oxidizer assembly has recently become a promising strategy. In this work, oxidizer-activated Al fuel particles(ALG) were prepared with glycidyl azide polymer(GAP) as the oxidizer. The ALG was in uniform spherical shape and core-shell structure with shell layer of around 5 nm which was observed by scanning electron microscope and transmission electron microscope. The localized nanoscale mid-IR measurement detected the uniform distribution of characteristic absorption bond of GAP in the shell layer which confirmed the homogenous fuel-oxidizer structure of ALG. A thermal gravimetric analysis of ALG at ultrafast heating rate of 1000℃/min under argon atmosphere was conducted. The decomposition of GAP finished much earlier than that of GAP at heating rate of 10℃/min. Under ultrafast high laser fluence, the reaction response of ALG was characterized and compared with that of micro-sized Al(μAl). With the increase of laser energy, the propagation distance of the shock wave increased. However, the velocity histories were nearly the same when energies were lower than 299 mJ or higher than 706 mJ. The propagation distance of the shock wave for ALG was 0.5 mm larger than that for μAl at 2.1 μs. The underwater explosion showed the peak pressure and the shock wave energy of the ALG-based explosive were both higher than those of the μAl-based explosive at 2.5 m. This study shows the feasibility to improve the energy release of Al-based explosives via using the oxidizer-activated Al fuel particles with energetic polymer as the oxidizer.

关键词： Aluminum Glycidyl azide polymer Laser Detonation Explosive Ultrafast stimulus