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C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization

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World Journal of Stem Cells 2020年第2期12卷 152-167页

作者： huai-Chun Yang Min Zhang Rui Wu Hai-Qing Zheng Li-Ying Zhang Jing Luo Li-Li Li xi-quan hu Department of Rehabilitation Medicine the Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Andrology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND human-derived mesenchymal stromal cells have been shown to improve cognitive function following experimental *** activity of exosomes has been verified to be comparable to the therapeutic effects of mesenchymal stromal ***,the effects of exosomes derived from human umbilical cord mesenchymal stem cells(huC-MSCs)(ExoCtrl)on post-stroke cognitive impairment(PSCI)have rarely been ***,whether exosomes derived from C-C chemokine receptor type 2(CCR2)-overexpressing huC-MSCs(ExoCCR2)can enhance the therapeutic effects on PSCI and the possible underlying mechanisms have not been *** To investigate the effects of ExoCtrl on PSCI and whether ExoCCR2 can enhance therapeutic effects on *** Transmission electron microscopy,qNano®particles analyzer,and Western blotting were employed to determine the morphology and CCR2 expression of ExoCtrl or *** was used to study the binding capacity of exosomes to CC chemokine ligand 2(CCL2)in *** the intravenous injection of ExoCtrl or ExoCCR2 into experimental rats,the effect of ExoCtrl and ExoCCR2 on PSCI was assessed by Morris water *** and oligodendrogenesis were analyzed by Western blotting and immunofluorescence ***-PCR and immunofluorescence microscopy were conducted to compare the microglia/macrophage *** infiltration and activation of hematogenous macrophages were analyzed by Western blotting and transwell migration *** CCR2-overexpressing huC-MSCs loaded the CCR2 receptor into their *** morphology and diameter distribution between ExoCtrl and ExoCCR2 showed no significant ***2 bound significantly to CCL2 but ExoCtrl showed little CCL2 *** both ExoCCR2 and ExoCtrl showed beneficial effects on PSCI,oligodendrogenesis,remyelination,and microglia/macrophage polarization,ExoCCR2 exhibited a significantly superior beneficial *** also found that ExoCCR2 could suppress the

关键词： Cognitive impairment Stroke Exosomes C-C chemokine receptor type 2 Microglia/macrophage polarization Remyelination

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping quan xiaorui Geng Yujing huang Yonghua Zhao Lei xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Promoting the protonation step on the interface of titanium dioxide for selective photocatalytic reduction of CO_(2)to CH_(4)by using red phosphorus quantum dots

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Nano Research 2022年第4期15卷 3042-3049页

作者： Yinglong Lu Minghao Liu Ningchao Zheng xi He Ruiting hu Ruilin Wang quan Zhou Zhuofeng hu School of Environmental Science and Engineering Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation TechnologySun Yat-sen UniversityGuangzhou 510275China

Enhancing the selectivity of hydrocarbon in CO_(2)is a great ***,taking widely-used and highly-stable TiO_(2)as an example,we found that the protonation step,the key step for CH_(4)production,can change from endoergic to exoergic by using red phosphorus quantum ***,the main product in CO_(2)reduction can be shifted from CO into CH_(4).The preparation method is very simple,which just ultrasonically treating the red P in the presence of TiO_(2).With an initial rate of CH_(4)production of 4.69μmol·g^(-1)·h^(-1),under simulated solar light,it manifests a significant 49.4-fold enhancement of CH_(4)yield over TiO_(2).Density functional calculation indicates that the red P optimizes the surface electronic *** Gibbs free energy for CHO^(*)formation(^(-1).12 eV)becomes lower than the desorption energy of the CO(-0.01 eV)when red P is *** indicates that the CO intermediates on the surface are rapidly protonated to produce CHO^(*).Subsequently,the CHO^(*)will be converted into CH_(4)instead of being desorbed from the surface to produce *** study demonstrates that red P quantum dot is a promising candidate for the development of efficient photocatalyst for CO_(2)photoreduction to CH_(4)under solar light irradiation.

关键词： red phosphorus CO_(2)reduction TiO_(2) CH_(4)

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Acute Complication Prediction and Diagnosis Model CLSTM-BPR:A Fusion Method of Time Series Deep Learning and Bayesian Personalized Ranking

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Tsinghua Science and Technology 2024年第5期29卷 1509-1523页

作者： xi Chen quan Cheng School of Economics and Management Fuzhou UniversityFuzhou 350108China

Acute complication prediction model is of great importance for the overall reduction of premature death in chronic *** CLSTM-BPR proposed in this paper aims to improve the accuracy,interpretability,and generalizability of the existing disease prediction ***,through its complex neural network structure,CLSTM-BPR considers both disease commonality and patient characteristics in the prediction ***,by splicing the time series prediction algorithm and classifier,the judgment basis is given along with the prediction ***,this model introduces the pairwise algorithm Bayesian Personalized Ranking(BPR)into the medical field for the first time,and achieves a good result in the diagnosis of six acute *** on the Medical Information Mart for Intensive Care IV(MIMIC-IV)dataset show that the average Mean Absolute Error(MAE)of biomarker value prediction of the CLSTM-BPR model is 0.26,and the average accuracy(ACC)of the CLSTM-BPR model for acute complication diagnosis is 92.5%.Comparison experiments and ablation experiments further demonstrate the reliability of CLSTM-BPR in the prediction of acute complication,which is an advancement of current disease prediction tools.

关键词： Long Short-Term Memory(LSTM) Bayesian Personalized Ranking(BPR) sudden illnesses disease predictions

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Locking of Tearing Modes by the Error Field

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Chinese Physics Letters 2011年第9期28卷 190-193页

作者： XU Tao hu Qi-Ming hu xi-Wei YU Qing-quan J-TEXT Tokamak Laboratory State Key Laboratory of Advanced Electromagnetic Engineering and TechnologyCollege of Electric and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074 Max-Planck-Institute Für Plasmaphysik EURATOM Association85748 GarchingGermany

The locking of tearing modes by the error field is studied by nonlinear numerical *** threshold of mode locking for J-TEXT tokamak plasmas is found.

关键词： tokamak locking mode

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A Note on Integral Structures in Some Locally Algebraic Representations of GL_(2)

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Acta Mathematica Sinica,English Series 2021年第1期37卷 59-72页

作者： Yong quan hu Morningside Center of Mathematics Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China Chinese Academy of Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China

In the p-adic local Langlands correspondence for GL2(Qp),the following theorem of Berger and Breuil has played an important role:the locally algebraic representations of GL2(Qp)associated to crystabelline Galois representations admit a unique unitary *** this note,we give a new proof of the weaker statement that the locally algebraic representations admit at most one unitary completion and such a completion is automatically *** proof is purely representation theoretic,involving neither(ψ,Γ)-module techniques nor global *** F is a finite extension of Qp,we also get a simpler proof of a theorem of Vignéras for the existence of integral structures for(locally algebraic)special series and for(smooth)tamely ramified principal series.

关键词： Invariant norm diagram

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A spherical parameterization approach based on symmetry analysis of triangular meshes

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第7期10卷 1009-1017页

作者： Jian-ping hu xiu-ping LIU Zhi-xun SU xi-quan SHI Feng-shan LIU School of Mathematical Sciences Dalian University of Technology Dalian 116024 China Department of Applied Mathematics and Theoretical Physics Delaware State University Dover DE 19901 USA

We present an efficient spherical parameterization approach aimed at simultaneously reducing area and angle dis-tortions. We generate the final spherical mapping by independently establishing two hemisphere parameterizations. The essence of the approach is to reduce spherical parameterization to a planar problem using symmetry analysis of 3D meshes. Experiments and comparisons were undertaken with various non-trivial 3D models, which revealed that our approach is efficient and robust. In particular, our method produces almost isometric parameterizations for the objects close to the sphere.

关键词： Triangular mesh Spherical parameterization Symmetry analysis

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Multi-model ensemble deep learning method for intelligent fault diagnosis with high-dimensional samples

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Frontiers of Mechanical Engineering 2021年第2期16卷 340-352页

作者： xin ZHANG Tao huANG Bo WU Youmin hu Shuai huANG quan ZHOU xi ZHANG School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical and Electronic Engineering Wuhan University of TechnologyWuhan 430070China

Deep learning has achieved much success in mechanical intelligent fault diagnosis in recent years. However, many deep learning methods cannot fully extract fault information to recognize mechanical health states when processing high-dimensional samples. Therefore, a multi-model ensemble deep learning method based on deep convolutional neural network (DCNN) is proposed in this study to accomplish fault recognition of high-dimensional samples. First, several 1D DCNN models with different activation functions are trained through dimension reduction learning to obtain different fault features from high-dimensional samples. Second, the obtained features are constructed into 2D images with multiple channels through a conversion method. The integrated 2D feature images can effectively represent the fault characteristic contained in raw high-dimension vibration signals. Lastly, a 2D DCNN model with multi-layer convolution and pooling is used to automatically learn features from the 2D images and identify the fault mode of the mechanical equipment by adopting a softmax classifier. The proposed method, which is validated using the bearing public dataset of Case Western Reserve University, USA and a one-stage reduction gearbox dataset, has high recognition accuracy. Compared with other classical deep learning methods, the proposed fault diagnosis method has considerable improvements.

关键词： fault intelligent diagnosis deep learning deep convolutional neural network high-dimensional samples

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Three Wave Mixing and Four Wave Scattering Processes in Laser-Plasma Interaction

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Chinese Physics Letters 1996年第1期13卷 28-30页

作者： hu xi-wei Department of Modern Physics University of Science and Technology of ChinaHefei 230026

A nonlinear fluid description for the parameter processes has been *** linear instability analyses about three wave mixing process ω_(0)→ω_(s1)→ω_(s2) and four wave scattering process ω_(0)→ω_(s)+ω_(p1)+ω_(p2) have been *** backward or side scattering light waves emitted from mentioned processes may provide valuable information for the diagnostic of plasma parameters.

关键词： wave mentioned backward

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Diffusion tensor imaging of the brain in patients with Alzheimer's disease and cerebrovascular lesions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第4期8卷 242-247页

作者： CHEN Shao-qiong KANG Zhuang hu xi-quan hu Bing ZOU Yan Department of Radiology the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China Department of Rehabilitation the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 5 10630 China

Background:Recent autopsy study showed a high incidence of cerebrovascular lesions in Alzheimer's disease(AD).To assess the impact of cerebrovascular pathology in AD,we used diffusion tensor imaging(DTI) to study AD patients with and without cerebrovascular *** and Methods:Conventional and DTI scans were obtained from 10 patients with probable AD,10 AD/V patients(probable AD with cerebrovascular lesions) and ten normal *** diffusivity(D) and fractional anisotropy(FA) values of some structures involved with AD pathology were ***:D value was higher in AD patients than in controls in hippocampus and the cingulate *** AD/V patients,increased D value was found in the same structures and also in the thalamus and basal ganglia compared to *** was a significant difference of D value between AD and AD/V *** value reduced in the white matter of left inferior temporal gyrus and in the bilateral middle cingulate gyrus in patients with AD/V compared with *** MMSE(mini-mental state examination) score significantly correlated with FA value in the right hippocampus(r=0.639,P<0.019),in the right anterior cingulate gyrus(r=0.587,P<0.035) and in left parahippocampal gyrus(r=0.559,P<0.047).Conclusion:Cerebrovascular pathology had stronger impact on the D value than the AD pathology alone *** D value in thalamic and basal ganglia may contribute to cognitive decline in AD/V *** FA values in AD/V patients may indicate that cerebrovascular pathology induced more severe white matter damage than the AD pathology alone did.

关键词： Diffusion tensor imaging (DTI) Alzheimer's disease (AD) Cerebrovascular Magnetic resonance imaging (MRI)

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