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Low molecular weight heparin microcapsule coated occluder for atrial-septal defects

Chinese Medical Journal 2009年第12期122卷 1429-1434页

作者： SUN Yong WU Jian ZHANG Ruo-xi SHI xiu-jie liu Hai-xia ZHAO Yang YU Bo Department of Cardiology Second Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150086 China

Background Whether the low molecular weight heparin microcapsule coated occluder is helpful to endothelialization in atrial-septal defect models is uncertain. This study aimed to investigate the best conditions for low molecular weight heparin coated NiTi alloy occluder and provide the evidence of the efficacy and safety of atrial-septal defect occluders in vivo. Methods Low molecular weight heparin microcapsules were investigated using gelatin as microcapsule material. The prepared low molecular weight heparin gelatin particles were subjected to nickel and titanium alloy occluder coating by sodium hyaluronate. A dog model of atrial septal defects was established after treatment with low molecular weight heparin microcapsule coated occluder （n=4） and uncoated occluder （n=4）. Endotheliocytes and fibroblastic cells in occluders were observed. And the rate of endothelialization was detected. Results When the concentration of gelatin was 1%, the diameters of particles were mostly about 100 μm, and the particle size was uniform. The envelope efficiency of low molecular weight heparin microcapsule was about 80%. The endothelialization of occluder in the model was more obvious in the coated group than in the uncoated group （P 〈0.0001）. Conclusions Low molecular weight heparin can be prepared into microcapsules with their particle size in nanometric grade. The antithrombotic properties are kept in the nickel and titanium alloy occluder successfully coated with sodium hyaluronate. The endothelialization after the interventional occlusion in the coated group is obvious, indicating that low molecular weight heparin is helpful to the growth of endothelial cells in the occlude and the healing after the interventional occlusion.

关键词： low molecular weight heparin sodium hyaluronate microcapsule occluder

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基于组织公平的变革型领导行为与组织公民权行为关系的实证研究

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科研管理 2007年第6期28卷 123-129页

作者：孟太生刘璞井润田电子科技大学管理学院四川成都610054

本文编制了结构化的企业员工组织公民权行为、组织公平和领导行为的问卷,对几家企业的4000多名员工进行了实地调查。用积极主动维度、组织忠诚和帮助维度来衡量组织公民权行为;用分配公平、互动公平来衡量组织公平;用愿景激励、德行垂... 详细信息

本文编制了结构化的企业员工组织公民权行为、组织公平和领导行为的问卷,对几家企业的4000多名员工进行了实地调查。用积极主动维度、组织忠诚和帮助维度来衡量组织公民权行为;用分配公平、互动公平来衡量组织公平;用愿景激励、德行垂范、领导魅力衡量变革型领导行为。分析结果显示,员工个体的差异与组织公民权行为存在相关关系;变革型领导行为的三个维度与组织公民权行为(积极主动、组织忠诚、帮助行为)、组织公平(分配公平、互动公平)都具有显著的关系;还发现组织公平与组织公民权行为之间的积极关系。分析结果证实了组织公平对变革型领导行为与组织公民权行为关系的调节作用。构建了变革型领导行为影响组织公民权行为的理论框架。最后指出了本次研究的一些局限以及就将来研究的一些方向给出一些建议。

关键词：变革型领导行为组织公平组织公民权行为

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Solving Schrodinger Equation with Soft Constrained Monotonic Neural Network

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原子核物理评论 2024年第1期41卷 379-384页

作者： liu Xuan LI Hanlin pu Kaifang PANG Longgang College of Science Wuhan University of Science and TechnologyWuhan 430065China Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China

Artificial Neural Network(ANN)has become a powerful tool in the field of scientific research with its powerful information encapsulation ability and convenient variational optimization *** particular,there have been many recent advances in computational physics to solve variational *** Neural Network(DNN)is used to represent the wave function to solve quantum many-body problems using variational *** this work we used a new Physics-Informed Neural Network(PINN)to represent the Cumulative Distribution Function(CDF)of some classical problems in quantum mechanics and to obtain their ground state wave function and ground state energy through the *** benchmarking against the exact solution,the error of the results can be controlled at a very low *** new network architecture and optimization method can provide a new choice for solving quantum many-body problems.

关键词： deep neural network variational problem Cumulative distribution function ground state wave function

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STAT3和Cyclin D1在人脑胶质瘤中的表达及其意义

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中华实验外科杂志 2010年第10期27卷 1389-1391页

作者：刘细国袁先厚江普查徐成仕武汉大学中南医院神经外科 430071

目的探讨信号转导及转录激活因子3（STAT3）和细胞周期蛋白D1（Cyclin D1）表达与脑胶质瘤生物学行为的关系及意义.方法用逆转录-聚合酶链反应（RT-PCR）和Western blot方法检测并比较68例不同级别胶质瘤和10例正常脑组织中STAT3和Cyc... 详细信息

目的探讨信号转导及转录激活因子3（STAT3）和细胞周期蛋白D1（Cyclin D1）表达与脑胶质瘤生物学行为的关系及意义.方法用逆转录-聚合酶链反应（RT-PCR）和Western blot方法检测并比较68例不同级别胶质瘤和10例正常脑组织中STAT3和Cyclin D1的表达,并对两者表达做相关分析.结果 RT-PCR检测胶质瘤组织STAT3、Cyclin D1的mRNA表达量（2.23±0.32、2.18±0.26）均明显高于正常脑组织（0.53±0.14、0.48±0.11）,Western blot检测胶质瘤组织STAT3、Cyclin D1的蛋白表达量（42.3±2.6）%、（45.4±1.8）%均明显高于正常脑组织（9.8±1.1）%、（10.4±0.9）%,其差异均有统计学意义（P＜0.05）,STAT3和Cyclin D1的表达与胶质瘤级别呈正相关.结论 STAT3可能通过激活其下游靶基因Cyclin D1,引起胶质瘤细胞异常增殖和分化失控.

关键词：信号转导和转录激活因子3 细胞周期蛋白D1 胶质瘤

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Comparative experimental study on inhibiting gas explosion using ABC dry powder and diatomite powder

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Journal of Coal Science & Engineering(China) 2012年第2期18卷 138-142页

作者： DENG Jun pu Guang-mei LUO Zhen-min CHENG Fang-ming School of Energy Engineering Xi'an University of Science and TechnologyXi'an 710054China Key Laboratory of Western Mine Exploitation and Hazard Prevention Ministry of EducationXi'an 710054China

Using a 20 L spherical explosion suppressing test system, the largest gas explosion pressure and maximum pressure rising rate with additives of ultra-fine ABC dry powder and diatomite powder were tested and compared, and the explosion suppression effect of the two kinds of powder was analyzed. Experimental results show that both powders can suppress gas ex- plosion and ABC dry powder is superior to diatomite powder. Adding two powders under the same experimental conditions, when methane concentration is 7.0%, the maximum explosion pressure decreased 39% and 4%, respectively, while the rising rate of the maximum pressure decreased 80% and 53%, respectively. When methane concentration is 9.5%, the maximum ex- plosion pressure decreased 14% and 12%, respectively, the rising rate of maximum pressure decreased 62% and 27%, respec- tively, the maximum explosion pressure decreased 23% and 18%, respectively, while the rising rate of the maximum pressure decreased 77% and 70%, respectively. When methane concentration is 12.0%, the explosion suppression effect of ultra-fine ABC dry powder is not affected by the methane concentration, and the explosion suppression effect of diatomite powder under high methane concentrations is more obvious.

关键词： gas explosion ABC dry powder explosion suppression diatomite

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Research Progress of Perioperative Application of GLP-1 and Its Protective Effects on Organs

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Journal of Clinical and Nursing Research 2023年第4期7卷 19-28页

作者： Hong xi Zhigang Pang Yifan liu Lixiong Xue Jiandong He Wenqu Yang Department of Anesthesiology Shanxi Bethune Hospital(Shanxi Academy of Medical Sciences Tongji Shanxi Hospital)Third Hospital of Shanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Respiratory and Critical Care Medicine Shanxi Bethune HospitalTaiyuan 030032Shanxi ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalTaiyuan 030032Shanxi Province

Glucagon-like peptide-1(GLP-1)is a multifunctional hormone with broad pharmacological potential to control inflammation,protect cardiovascular,kidney,and liver ***,GLP-1 can also cross the blood-brain barrier and bind with GLP-1R distributed in various parts of the brain,thereby reducing apoptosis caused by neuroinflammation and oxygen stress,and promoting learning,memory,cognitive function,neuroprotection,and nerve cell ***,the exact molecular pathway by which GLP-1 receptor agonists(GLP-1RAs)exerts protective effects on many organs is not fully understood,so it is a hot topic of *** this article,the recent research on the multi-organ protection of GLP-1 is reviewed,with emphasis on the research progress in the field of nervous system and perioperative anesthesia.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Protection of organs

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Ginsenoside Rg1 improves anti-tumor efficacy of adoptive cell therapy by enhancing T cell effector functions

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Blood Science 2023年第3期5卷 170-179页

作者： Yue liu Lingna An Chengfei Yang xiaoqi Wang Ruihao Huang xi Zhang Medical Center of Hematology Xinqiao HospitalState Key Laboratory of TraumaBurn and Combined InjuryArmy Medical UniversityChongqing 400037China Department of Urology Xinqiao HospitalArmy Military Medical UniversityChongqing 400037China Jinfeng Laboratory Chongqing 401329 China

Adoptive cell therapy(ACT)has emerged with remarkable efficacies for tumor *** antigen receptor(CAR)T cell therapy,as one of most promising ACTs,has achieved prominent effects in treating malignant hematological ***,the insufficient killing activity and limited persistence of T cells in the immunosuppressive tumor microenvironment limit the further application of ACTs for cancer *** studies have focused on improving cytotoxicity and persistence of T cells to achieve improved therapeutic *** this study,we explored the potential function in ACT of ginsenoside Rg1,the main pharmacologically active component of *** introduced Rg1 during the in vitro activation and expansion phase of T cells,and found that Rg1 treatment upregulated two T cell activation markers,CD69 and CD25,while promoting T cell differentiation towards a mature *** sequencing revealed that Rg1 influenced T cell metabolic reprogramming by strengthening mitochondrial *** co-cultured with tumor cells,Rg1-treated T cells showed stronger cytotoxicity than untreated ***,adding Rg1 to the culture endowed CAR-T cells with enhanced anti-tumor *** study suggests that ginsenoside Rg1 provides a potential approach for improving the anti-tumor efficacy of ACT by enhancing T cell effector functions.

关键词： Anti-tumor efficacy Adoptive cell therapy CAR-T Ginsenoside Rg1 Metabolic regulation

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一种基于空间特征的图像检索法研究

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计算机工程与应用 2006年第27期42卷 73-75页

作者：曾西刘艺电子科技大学物理电子学院成都610054

在基于内容的图像识别技术中,颜色自相关图是一种常用的图像颜色特征提取法。文章在此基础上,考虑图像结构特征,通过对图像进行水平和垂直两次扫描,分别建立图像相似区域的变化图。该算法和颜色自相关图一并应用到SOM网络上,实现了一个... 详细信息

在基于内容的图像识别技术中,颜色自相关图是一种常用的图像颜色特征提取法。文章在此基础上,考虑图像结构特征,通过对图像进行水平和垂直两次扫描,分别建立图像相似区域的变化图。该算法和颜色自相关图一并应用到SOM网络上,实现了一个基于颜色特征和结构特征的图像分类。编程实验结果表明:新算法可以较好地提高基于内容的图像检索的准确性,避免了仅靠图像的颜色特征进行分类和搜索的不能描述图像宏观结构的缺点。

关键词：图像检索图像结构特征颜色自相关图

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融资约束、不确定性与公司投资——理论分析与实证再考察

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复旦学报（社会科学版） 2018年第4期60卷 142-148页

作者：刘康兵申朴上海大学经济学院上海200444 华东理工大学商学院上海200237

文章将投资不可逆和未来需求状态不确定等假设引入一个包含信息不对称的公司投资模型,通过理论分析,证明了公司面临的不确定性水平上升会降低资本预期边际价值,导致其增加额外一单位投资的边际风险溢价上升,进而面临更高程度的外部融资... 详细信息

文章将投资不可逆和未来需求状态不确定等假设引入一个包含信息不对称的公司投资模型,通过理论分析,证明了公司面临的不确定性水平上升会降低资本预期边际价值,导致其增加额外一单位投资的边际风险溢价上升,进而面临更高程度的外部融资约束。文章还利用中国制造业上市公司1998~2015年的面板数据,以公司面临的股票价格波动性作为不确定性代理变量,应用动态面板阈值估计法证实了上述理论预测。文章最后还讨论了上述结论的政策含义和研究的未来扩展。

关键词：融资约束不确定性公司投资

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INFLUENCE OF EXTRUSION ON DAMPING CAPACITIES OF AS-SPRAY DEPOSITED HIGH SILICON ALLOY ZA27 MODIFIED BY CERIUM

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Acta Metallurgica Sinica(English Letters) 1997年第5期10卷 437-444页

作者： YC. liu G.C. Yang YL. Lu and Z.G. Zhu (State Key Lab. of Solidification Processing, Northwestern Polytechnic University, xi’an 710072, China Laboratory of Internal Friction and Defects in Solids, Chinese Academy of Science, Hefei 230031, China ) Northwestern Polytechnical Univ Xi'an China

The effects of cerium modification and extrusion on the resultant damping behavior and mechanical properties of the as-sprayed high silicon alloy ZA27 were investigated in an thort to develop a new functional material possessing high damping capacity and good mechanical properties. The damping capacity, as well as the rslative dynamic modulus, was tneasured at frequencies of 1 and 4 Hertz over the 30 to 200℃runge. At below 80℃ the as-sprayed materials appear to be approximately Asquency independent. Above 80℃, the,naterials becotne temperature sensitive, exhibiting the highest damping for the lowest hequency. The extruded, as-sprayed high silicon alloy ZA27 modified by cerium has the highest damping capacity and elongation values among them. The micro8tructure of the as-sprayed high silicon alloy ZA27 modified by 0. 5 wt% cerium was made up of fine lamellar eutectoid, porositg, a light dot-like phase and a polygonal silicon-rich phase. Finally, the opemtive damping tnechanisms were discussed in light of the data obtained hem characterization of microstructure and damping capacity. The high damping capacity was attributed primarily to phase interface thermoelastic damping between the lamellar phases with various substrvctures,except for the grain refinement.

关键词： spray deposition damping capacity cerium modification extrusion

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