检索结果-南通市图书馆

维普期刊数据库

Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen Qin Qian-Nan Ren Hong-xi Zhang Ya-Ru Liu Ke Huang Wei Wu Guan-ping Dong Yan Ni Jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： Biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 392-397页

作者： Yong-Dan Zhao Yidan Wang Rongrong Wang Lina Chen Hengtong Zuo xi Wang Jihong Qiang Geng Wang Qingxia Li Canqi ping Shuqiu Zhang Hao Wang School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China National Center for Nanoscience and Technology Beijing 100190China Artemisinin Research Center Institute of Chinese Materia MedicaBeijing 100700China

Artemisinin(ART)resistance has been an emerging clinical problem,severely compromising antimalarial efficacy and threatening the global malaria elimination *** intensive studies about the molecular mechanism for ART resistance are under way,no effective therapeutic targets for reversing resistance have been ***,we explore glutathione(GSH)as a therapeutic target to develop a thermo-responsive nanoplatform to specifically co-deliver ART and GSH synthesis inhibitor(L-buthionine sulfoximine,BSO)in a sustained manner,effectively reversing ART resistance in *** combining with BSO,ART exerts increased antimalarial activity with reduced half-maximal inhibitory concentration(IC50)by 7.43-fold in ART-resistant *** work reveals that the GSH in ART-resistant parasites can be a promising therapeutic target for reversing ART resistance,paving the way for developing drug candidates and intelligent nanomedicines in malaria therapy.

关键词： Nanomedicines Drug delivery Artemisinins resistance Malaria Glutathione

维普期刊数据库

A gas sensing neural circuit for an olfactory neuron

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第10期 26-40页

作者： xi-Kui Hu Song Zhu Juan Yang Zhao Yao ping Zhou Jun Ma School of Science Chongqing University of Posts and Telecommunications School of Physics and Electronics Central South University Department of Physics Lanzhou University of Technology

A gas sensor can convert external gas concentration or species into electric voltage or current signals by physical adsorption or chemical changes. As a result, a gas sensor in a nonlinear circuit can be used as a sensitive sensor for detecting external gas signals from the olfactory system. In this paper, a gas sensor and a field-effect transistor are incorporated into a simple FithzHugh–Nagumo neural circuit for capturing and encoding external gas signals. An improved functional neural circuit is obtained, and the effect of gas concentration, gas species and neuronal activity can be discerned as the gate voltage, threshold voltage and activation coefficient of the field-effect transistor, respectively. The gas concentration can affect the neural activities from quiescent to normal working and, finally, to saturation state in bursting, spiking, periodic and chaotic firings with different frequencies. The effects of gas species and neuronal activity on the firing state can also be achieved in this functional neural circuit. In addition, variations in the gate voltage, threshold voltage and activation coefficient can cause switching between different firing modes. These results can be helpful in designing artificial olfactory devices for bionic gas recognition and other coupled systems arising in applied sciences.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

多晶材料散射模型及识别实验研究

物理学报 2024年第3期73卷 134-142页

作者：刘昱贺西平贺升平陕西师范大学物理学与信息技术学院陕西省超声重点实验室西安710119 泸州高新技术研究所泸州646000

超声波识别在国防、军事、航空航天、核设施等高科技领域具有重要的应用价值.利用超声波可以实现对个体金属材料的识别,但现有研究侧重于识别材料超声信号差异的算法,缺乏识别机理.本文以2A12铝合金为例,利用6个晶粒在尺寸、形状、排布... 详细信息

超声波识别在国防、军事、航空航天、核设施等高科技领域具有重要的应用价值.利用超声波可以实现对个体金属材料的识别,但现有研究侧重于识别材料超声信号差异的算法,缺乏识别机理.本文以2A12铝合金为例,利用6个晶粒在尺寸、形状、排布方向以及排列顺序不同时,建立了10个2A12铝合金微结构的初级模型,以此类比多晶金属材料的复杂微观结构.利用Comsol有限元软件仿真计算了金属材料不同微观结构中的超声波时域信号,并将回波信号中的的背向散射信号提取为超声指纹.定义了特征差异Q,量化了具有不同微结构的散射模型间的超声指纹的差异.结果表明,微观结构的细微变化也会导致超声信号出现差异,其中晶粒尺寸的变化对信号的影响更为显著.随后提出了超声识别算法,并对4块形状完全一致的2A12铝合金样品进行了识别实验.识别结果表明,利用超声指纹可以准确识别出目标样品,且各样品间的超声指纹有显著区别.最后对样品进行了扫描电子显微镜实验,所得电子显微镜图片显示了各样品真实微观结构的形貌与差异,证实了所建立的超声散射模型的有效性.

关键词：超声散射微观结构多晶材料超声识别有限元方法

维普期刊数据库博看期刊

The evolution and functional divergence of 10 Apolipoprotein D-like genes in Nilaparvata lugens

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第1期31卷 91-105页

作者： Jia-Bao Lu Peng-Peng Ren Qiao Li Fang He Zhong-Tian Xu Sai-Nan Wang Jian-ping Chen Jun-Min Li Chuan-xi Zhang Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina Technology Center of Wuhan Customs District HubeiChina Institute of Insect Science Zhejiang UniversityHangzhouChina

Apolipoprotein D(ApoD),a member of the lipocalin superfamily of proteins,is involved in lipid transport and stress *** only a single copy of the ApoD gene is found in humans and some other vertebrates,there are typically several ApoD-like genes in *** date,there have been relatively few studies that have examined the evolution and functional differentiation of ApoD-like genes in insects,particularly hemi-metabolous *** this study,we identified 10 ApoD-like genes(NlApoD1−10)with distinct spatiotemporal expression patterns in Nilaparvata lugens(BPH),which is an important pest of ***1−10 were found to be distributed on 3 chromosomes in a tandem array of NlApoD1/2,NlApoD3−5,and NlApoD7/8,and show sequence and gene structural divergence in the coding regions,indicating that multiple gene duplication events occurred during *** analysis revealed that NlApoD1−10 can be clustered into 5 clades,with NlApoD3−5 and NlApoD7/8 potentially evolving exclusively in the Delphacidae *** screening using an RNA interference approach revealed that only NlApoD2 was essential for BPH development and survival,whereas NlApoD4/5 are highly expressed in testes,and might play roles in ***,stress response analysis revealed that NlApoD3−5/9,NlApoD3−5,and NlApoD9 were up-regulated after treatment with lipopolysaccharide,H2O2,and ultraviolet-C,respectively,indicating their potential roles in stress resistance.

关键词： Apolipoprotein D BPH evolution functional divergence gene duplication NIApoD

Preparation and properties of ZrO_(2)-strengthened porous mullite insulation materials using Y_(2)O_(3) additive

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第6期31卷 1514-1521页

作者： Wang-zhi Yu Yi-hong Shi ping Liu Yong-wan Wu Cheng-hao Song xian-gong Deng xiang Ding Song-lin Ran Yi Zhang Hai-jun Zhang Hai-liang Deng Advanced Ceramics Research Center School of Materials Science and EngineeringAnhui University of TechnologyMa'anshan 243002AnhuiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

ZrO_(2)-strengthened porous mullite insulation materials were prepared by foaming technology utilizing ZrSiO_(4) and Al_(2)O_(3) as primary materials and Y_(2)O_(3) as an *** effects of Y_(2)O_(3) contents on the phase composition,microstructure,mechanical properties,and heat conductivity of the porous mullite insulation materials were investigated.A suitable Y_(2)O_(3) content could promote phase transition of monoclinic ZrO_(2)(m-ZrO_(2))to tetragonal ZrO_(2)(t-ZrO_(2)),reduce pore size,and improve the strengths of as-prepared *** cold crushing strength and bending strength of as-prepared specimens with a 119µm spherical pore size using 6 wt.%Y_(2)O_(3) were 35.2 and 13.0 MPa,respectively,with a heat conductivity being only 0.248 W/(m K).

关键词： Porous mullite insulation material Zirconium oxide Y_(2)O_(3) Mechanical property Heat conductivity

DEM investigation of strength and critical state behaviours of granular materials under true triaxial loadings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 198-212页

作者： Minyi Zhu Guobin gong Jun xia Stephen Wilkinson Department of Civil Engineering Xi'an Jiaotong-Liverpool UniversityChina Department of Civil Engineering and Industrial Design University of LiverpoolLiverpoolUK Faculty of Engineering and Information Sciences University of Wollongong in DubaiUnited Arab Emirates

This paper investigates the strength and critical state(CS)behaviours of granular materials via DEM simulations of true triaxial drained tests under three different loading modes including constant b(in-termediate stress ratio)tests with constantσ'1(major principal stress),constant p(mean pressure)and constantσ'3(minor principal stress)*** this end,a series of samples are generated with the same particle size distribution,and with the confining stresses ranging from 100 kPa to 900 *** CS is achieved for all *** the macroscopic behaviours and the microscopic behaviours are examined and compared considering different loading modes,confining stresses and intermediate stress ratios(b).The critical state lines(CSLs)are found to be unique and independent of the loading modes,but dependent on the b *** CSLs with b=0 and b=1 form the two boundaries of CSLs respectively beyond which CSLs under all other b tests cannot go *** different strength criteria are examined and compared in terms of both peak and CS *** Mohr-Coulomb strength criterion is found to be only suitable for axisymmetric loading *** Lade-Duncan criterion is only suitable for describing peak strengths,which is dependent on the loading modes and confining *** Satake criterion and Matsuoka-Nakai criterion are the more appropriate strength criteria for describing CS failures,indicating that the CS values of both the Satake parameter and the Matsuoka-Nakai parameter describe an inherent property that characterizes the CS failure for a given type of *** CS mechanical coordination number is fitted by a curved line for a given b value,which is unique regardless of the loading *** peak and CS values of both major and minor principal fabric tensors decrease with increasing b values,while they increase with increasing b values for the intermediate principal fabric tensor.

关键词： Discrete element method Intermediate stress ratio Dilation Critical state Failure criterion

Prediction and Regulation of Delamination at Flexible Film/Finite-Thickness-Substrate Structure Interfaces

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Solida Sinica 2024年第2期37卷 238-251页

作者： Yutang Zhou Yunlong Xu Haoran gong Chenyu Wang Department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an710072China School of Instrumentation Science and Opto-Electronics Engineering Beihang UniversityBeijing100191China

Regulating the surface instability of thin film/substrate structures has been successfully applied to prepare new ductile electronic ***,such electronic devices need to be subjected to external loads during operation,which can easily induce delamination of the thin-film electronic device from the *** study aims to investigate the instability characteristics of hard films on flexible substrate surfaces from theoretical analysis and numerical simulation *** finite-thickness substrates,this paper establishes theoretical models for pure bending,bent wrinkle,partial delamination,and total delamination buckling of film/substrate structures based on the nonlinear Euler–Bernoulli beam theory and the principle of minimum energy;then the effects of material and geometric parameters of the structure,interfacial adhesion strength,and pre-strain on the evolutionary path of the four patterns are *** study results show that:the greater Young’s modulus of the substrate is,the larger the parameter region where partial delamination of the film/substrate structure occurs,and the smaller the parameter region where bent wrinkle *** varying Young’s modulus,thickness of the film and substrate,interfacial adhesion coefficient,and pre-strain,the buckling pattern of the structure can be predicted and *** parametric design intervals for each pattern are summarized in the phase *** results of this paper provide theoretical support for the design and reliability evaluation of flexible electronic devices.

关键词： Thin film/finite-thickness-substrate structure Delamination Surface instability Pattern evolution

Temporal-spatial Generation of Astrocytes in the Developing Diencephalon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第1期40卷 1-16页

作者： Wentong Hong Pifang gong xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-ping Ge Chun-Li Zhang Shumin Duan Song Qin Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTexas 75390-9148USA Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineHangzhou 310058China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200032China

tAstrocytes are the largest glial population in the mammalian ***,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the *** lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V ***,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the *** genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the *** occurs at an early time point in the dorsal region relative to that in the ventral region of the developing *** transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal ***,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon.

关键词： Radial glia Astrocyte specification Lineage tracing Diencephalon Third ventricle