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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第8期14卷 535-553页

作者： Jun-yi liang Jian-long ZHANG xi ZHANG Shi-fei YUAN Cheng-liang YIN National Engineering Laboratory for Automotive Electronic Control Technology Shanghai Jiao Tong University

To solve the low power density issue of hybrid electric vehicular batteries, a combination of batteries and ultracapacitors (UCs) could be a solution. The high power density feature of UCs can improve the performance of battery/UC hybrid energy storage systems (HESSs). This paper presents a parallel hybrid electric vehicle (HEV) equipped with an internal combus- tion engine and an HESS. An advanced energy management strategy (EMS), mainly based on fuzzy logic, is proposed to improve the fuel economy of the HEV and the endurance of the HESS. The EMS is capable of determining the ideal distribution of output power among the internal combustion engine, battery, and UC according to the propelling power or regenerative braking power of the vehicle. To validate the effectiveness of the EMS, numerical simulation and experimental validations are carried out. The results indicate that EMS can effectively control the power sources to work within their respective efficient areas. The battery load can be mitigated and prolonged battery life can be expected. The electrical energy consumption in the HESS is reduced by 3.91% compared with that in the battery only system. Fuel consumption of the HEV is reduced by 24.3% compared with that of the same class conventional vehicles under Economic Commission of Europe driving cycle.

关键词： Energy management Fuel economy Parallel hybrid electric vehicle Hybrid energy storage system (HESS) Fuzzy logic

Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis

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World Journal of Gastroenterology 2005年第30期11卷 4667-4673页

作者： Jian-Min Su Li-Ying Wang Yu-long liang xi-liang Zha Department of Chemistry Fudan University Shanghai 200032 China Department of Biochemistry and Molecular Biology Shanghai Medical College of Fudan University Shanghai 200032 China

AIM： Cell adhesion molecules and their signal molecules play a very important role in carcinogenesis. The aim of this study is to elucidate the role of these molecules and the signal molecules of integrins and E-cadherins, such as （focal adhesion kinase） FAK, （integrin linked kinase） ILK, and β-catenin in hepatocellular carcinoma cell apoptosis. METHODS： We first synthesized the small molecular compound, S-（1,2-dichlorovinyl）-L-cysteine （DCVC）, and identified it, by element analysis and ^1H NMR. To establish the apoptosis model of the SMMC-7721 hepatocellular carcinoma cell, we treated cells with DCVC in EBSS for different concentrations or for various length times in the presence of 20 μmol/L N,N-cliphenyl-p-phenylenediamine, which blocks necrotic cell death and identified this model by flow cytometry and DNA ladder. Then we studied the changes of FAK, ILK, β-catenin, and PKB in this apoptotic model by Western blot. RESULTS： We found that the loss or decrease of cell adhesion signal molecules is an important reason in apoptosis of SMMC-7721 hepatocellular carcinoma cell and the apoptosis of SMMC-7721 cell was preceded by the loss or decrease of FAK, ILK, PKB, and β-catenin or the damage of cell-matrix and cell-cell adhesion. CONCLUSION： Our results suggested that the decrease of adhesion signal molecules, FAK, ILK, PKB, and β-catenin, could induce hepatocellular carcinoma cell apoptosis.

关键词： Cell adhesion signal molecule Hepatocellular carcinoma Cell apoptosis

Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

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Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang Yanbo liang Chao Wang Yunhong Zhang Hong Liu Yu Zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

“Zero‑Strain” NiNb_(2)O_(6) Fibers for All‑Climate Lithium Storage

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Nano-Micro Letters 2025年第1期17卷 348-360页

作者： Yan Zhao Qiang Yuan Liting Yang Guisheng liang Yifeng Cheng Limin Wu Chunfu Lin Renchao Che College of Physics Donghua UniversityShanghai 201620People’s Republic of China School of Materials Science and Engineering Institute of Materials for Energy and EnvironmentQingdao UniversityQingdao 266071People’s Republic of China Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Zhejiang Laboratory Hangzhou 311100People’s Republic of China Inner Mongolia University Hohhot 010021People’s Republic of China

Niobates are promising all-climate Li^(+)-storage anode material due to their fast charge transport,large specific capacities,and resistance to electrolyte ***,their moderate unit-cellvolume expansion(generally 5%–10%)during Li^(+)storage causes unsatisfactory long-term ***,“zero-strain”NiNb_(2)O_(6) fibers are explored as a new anode material with comprehensively good electrochemical *** Li^(+)storage,the expansion of electrochemical inactive NiO_(6) octahedra almost fully offsets the shrinkage of active NbO_(6) octahedra through reversible O *** superior volume-accommodation capability of the NiO_(6) layers guarantees the“zero-strain”behavior of NiNb_(2)O_(6) in a broad temperature range(0.53%//0.51%//0.74%at 25//−10//60℃),leading to the excellent cyclability of the NiNb_(2)O_(6) fibers(92.8%//99.2%//91.1%capacity retention after 1000//2000//1000 cycles at 10C and 25//−10//60℃).This NiNb_(2)O_(6) material further exhibits a large reversible capacity(300//184//318 mAh g−1 at 0.1C and 25//−10//60℃)and outstanding rate performance(10 to 0.5C capacity percentage of 64.3%//50.0%//65.4%at 25//−10//60℃).Therefore,the NiNb_(2)O_(6) fibers are especially suitable for large-capacity,fast-charging,long-life,and all-climate lithium-ion batteries.

关键词： NiNb_(2)O_(6)porous fiber “Zero-strain”mechanism Electrochemical property Harsh-temperature operation Operando characterization

Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： Meng Zheng Lei Zhang Wei liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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2017年8月8日九寨沟M7.0地震及余震震源机制解与发震构造分析

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地球物理学报 2017年第10期60卷 4083-4097页

作者：易桂喜龙锋梁明剑张会平赵敏叶有清张致伟祁玉萍王思维宫悦乔惠珍汪智邱桂兰苏金蓉四川省地震局成都610041 四川赛思特科技有限责任公司成都610041 中国地震局地质研究所地震动力学国家重点实验室北京100029

2017年8月8日在青藏高原东缘四川省九寨沟县发生M7.0级强烈地震,极震区烈度达Ⅸ度,但无明显地表破裂,一定程度上限制了发震构造的确定和后续地震危险性判定.本文基于截止至2017年8月14日的地震资料,采用多阶段定位方法,对主震及余震进... 详细信息

2017年8月8日在青藏高原东缘四川省九寨沟县发生M7.0级强烈地震,极震区烈度达Ⅸ度,但无明显地表破裂,一定程度上限制了发震构造的确定和后续地震危险性判定.本文基于截止至2017年8月14日的地震资料,采用多阶段定位方法,对主震及余震进行了重新定位,同时,利用CAP波形反演方法,获得了M7.0主震与13次M_L≥4.0级余震的震源机制解和震源矩心深度,进而初步分析了本次地震的发震构造.结果显示,九寨沟M7.0地震的矩震级M_w6.4,震源矩心深度5 km,表明主震发生在上地壳浅部,与2003年伊朗巴姆(Bam)M_w6.5地震特征极为相似;12次M_L≥4.0级余震的震源矩心深度6~12 km,显示这些余震发生在主震下部,仅1次例外.重新定位后的余震震中呈NW-SE向窄带展布,位于近NS向的岷江断裂与近EW向的东昆仑断裂带东端分支塔藏断裂所夹持的区域,余震带长轴长约38 km,主震位于余震带中部.根据余震震中分布、主震及余震震源机制解等,推测本次九寨沟M7.0地震及其余震的主发震构造为位于岷江断裂与塔藏断裂之间的树正断裂.震源机制解揭示,树正断裂呈左旋走滑,走向约152°,近SE,倾向SW,倾角约70°,该断裂应属于东昆仑断裂东端的分支断裂之一,或与东南侧的虎牙断裂构成统一断裂系.

关键词：九寨沟M7.0地震重新定位震源机制发震构造树正断裂

厦门口岸新常态下出入境特殊物品卫生检疫监管实践

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中国国境卫生检疫杂志 2016年第6期39卷 437-440页

作者：辛锡龙林为亮张锦长黄艺焕海沧出入境检验检疫局福建厦门361000

在生物医药产业快速发展的形势下,出入境特殊物品卫生检疫监管面临着新的挑战。本文结合厦门口岸实际情况,在厦门口岸特殊物品卫生检疫监管工作的新常态下,探讨实践出入境特殊物品"风险可控、便捷高效"的卫生检疫监管模式,提高检验检疫... 详细信息

在生物医药产业快速发展的形势下,出入境特殊物品卫生检疫监管面临着新的挑战。本文结合厦门口岸实际情况,在厦门口岸特殊物品卫生检疫监管工作的新常态下,探讨实践出入境特殊物品"风险可控、便捷高效"的卫生检疫监管模式,提高检验检疫水平,为企业带来更多便利。

关键词：特殊物品卫生检疫风险管理

Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

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Rare Metals 2024年第4期43卷 1815-1827页

作者： Sheng-Feng Zhou Yu long Yan-liang Yi Cheng Deng Lian-xi Hu Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics Engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2,and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(LIHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12 vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72 to 9.36 and 11.19 GPa,*** a result,the microhardness of coating increases from HV536.25 to HV 738.16,the wear rate decreases from32.4×10^(-3)to 6.1×10^(-3)mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance Laser-induction hybrid cladding

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li xiaoge Wang xiaofan Cao Zhiqun He Chunjun liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Energy dispersive spectroscopy

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment