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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-Jie Quan Hao liang Yong-Hong Tang Li Jiang xiong-Ying Ji Feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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Penetration Depth of Torpedo Anchor in Two-Layered Cohesive Soil Bed by Free Fall

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China Ocean Engineering 2018年第6期32卷 706-717页

作者： WANG Cheng zhang Min-xi YU Guo-liang SKLOE CISSE School of Naval Architecture Ocean & Civil Engineering Shanghai Jiao Tong University

The penetration depth of torpedo anchor in two-layered soil bed was experimentally investigated. A total of 177 experimental data were obtained in laboratory by varying the undrained shear strength of the two-layered soil and the thickness of the top soil layer. The geometric parameters of the anchor and the soil properties(the liquid limit, plastic limit, specific gravity, undrained shear strength, density, and water content) were measured. Based on the energy analysis and present test data, an empirical formula to predict the penetration depth of torpedo anchor in two-layered soil bed was proposed. The proposed formula was extensively validated by laboratory and field data of previous researchers. The results were in good agreement with those obtained for two-layered and single-layered soil ***, a sensitivity analysis on the parameters in the formula was performed.

关键词： torpedo anchor penetration depth two-layered soil bed

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Study of the structure and the mechanical properties of dynamically cured PP/MAH-g-SEBS/epoxy blends

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Chinese Chemical Letters 2009年第7期20卷 877-880页

作者： Xue liang Jiang Yin xi zhang School of Materials Science and Engineering Wuhan Institute of Technology Wuhan 430073 China Research Institute of Polymer Materials S-hanghai Jiaotong University Shanghai 200030 China

A new method concerning with the simultaneous reinforcing and toughening of polypropylene （PP） was reported. Dynamical cure of the epoxy resin was successfully applied in the PP/maleic anhydride-grafted styrene-ethylene-butylene-styrene （SEBS） triblock copolymer, and the obtained blends named as dynamically cured PP/MAH-g-SEBS/epoxy blends. The stiffness and toughness of the blends are in a good balance, and MAH-g-SEBS was acted as not only an impact modifier but also a compatibilizer. The structure of the dynamically cured PP/MAH-g-SEBS/epoxy blends is the embedding of the epoxy particles by the MAH-g- SEBS.C2009 Xue liang Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Dynamical cure Epoxy resin PP MAH-g-SEBS

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Energy management strategy for a parallel hybrid electric vehicle equipped with a battery/ultra-capacitor hybrid energy storage system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第8期14卷 535-553页

作者： Jun-yi liang Jian-long zhang xi zhang Shi-fei YUAN Cheng-liang YIN National Engineering Laboratory for Automotive Electronic Control Technology Shanghai Jiao Tong University

To solve the low power density issue of hybrid electric vehicular batteries, a combination of batteries and ultracapacitors (UCs) could be a solution. The high power density feature of UCs can improve the performance of battery/UC hybrid energy storage systems (HESSs). This paper presents a parallel hybrid electric vehicle (HEV) equipped with an internal combus- tion engine and an HESS. An advanced energy management strategy (EMS), mainly based on fuzzy logic, is proposed to improve the fuel economy of the HEV and the endurance of the HESS. The EMS is capable of determining the ideal distribution of output power among the internal combustion engine, battery, and UC according to the propelling power or regenerative braking power of the vehicle. To validate the effectiveness of the EMS, numerical simulation and experimental validations are carried out. The results indicate that EMS can effectively control the power sources to work within their respective efficient areas. The battery load can be mitigated and prolonged battery life can be expected. The electrical energy consumption in the HESS is reduced by 3.91% compared with that in the battery only system. Fuel consumption of the HEV is reduced by 24.3% compared with that of the same class conventional vehicles under Economic Commission of Europe driving cycle.

关键词： Energy management Fuel economy Parallel hybrid electric vehicle Hybrid energy storage system (HESS) Fuzzy logic

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Mechanism of Embrittlement and De-Embrittlement for 2.25Cr-1Mo Steel

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Journal of Iron and Steel Research International 2011年第3期18卷 47-51页

作者： zhang xi-liang ZHOU Chang-yu School of Mechanical and Power Engineering Nanjing University of TechnologyNanjing 210009JiangsuChina

The constant embrittlement curve for constant segregation concentration on grain boundary of impurity element P and relationship between equilibrium grain boundary segregation concentration and operation time for 2.25Cr-1Mo steel were derived based on the theory of equilibrium grain boundary *** mechanism of step-cooling test and mechanism of de-embrittlement for 2.25Cr-1Mo steel were *** segregation rate will increase but equilibrium grain boundary segregation concentration of impurity element P will decrease as temperature increases in the range of temper embrittlement *** is one critical temperature of embrittlement corresponding to each embrittlement *** the further heat treating temperature is higher than critical temperature,the heat treating will become a de-embrittlement process;otherwise,it will be an embrittlement *** critical temperature of embrittlement will shift to the direction of low temperature as further *** a result,some stages of step-cooling test would change into a de-embrittlement *** grain boundary desegregation function of impurity element P was deduced based on the theory of element diffusion,and the theoretical calculation and experimental results show that the further embrittlement or de-embrittlement mechanism can be interpreted qualitatively and quantitatively by combining the theory of equilibrium grain boundary segregation with constant embrittlement curve.

关键词： step-cooling test critical embrittlement temperature embrittlement mechanism grain boundary desegregation

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Generation and modulation of multiple 2D bulk photovoltaic effects in space-time reversal asymmetric 2H-FeCl_(2)

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Frontiers of physics 2023年第6期18卷 221-230页

作者： liang Liu xiaolin Li Luping Du xi zhang Institute of Nanosurface Science and Engineering Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics EngineeringShenzhen UniversityShenzhen 518060China School of Physics State Key Laboratory for Crystal MaterialsShandong UniversityJinan 250100China Nanophotonics Research Centre Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China Research Center of Plasma Medical Technology Shenzhen UniversityShenzhen 518060China

The two-dimensional(2D)bulk photovoltaic effect(BPVE)is a cornerstone for future highly efficient 2D solar cells and *** ferromagnetic semiconductor 2H-FeCl_(2) is shown to realize a new type of BPVE in which spatial inversion(P),time reversal(T),and space−time reversal(PT)symmetries are broken(PT-broken).Using density functional theory and perturbation theory,we show that 2H-FeCl_(2) exhibits giant photocurrents,photo-spin-currents,and photo-orbital-currents under illumination by linearly polarized *** injection-like and shift-like photocurrents coexist and propagate in different *** material also demonstrates substantial photoconductance,photo-spin-conductance,and photo-orbital-conductance,with magnitudes up to 4650(nm·μA/V^(2)),4620[nm·μA/V^(2)/(2e)],and 6450(nm·μA/V^(2)/e),***,the injection-currents,shift-spin-currents,and shift-orbital-currents can be readily switched via rotating the magnetizations of 2H-FeCl_(2).These results demonstrate the superior performance and intriguing control of a new type of BPVE in 2H-FeCl_(2).

关键词： 2D ferromagnetism bulk photovoltaic effects photo-spin-currents photo-orbital-currents nonlinear optoelectronics

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基于数据挖掘学习探讨“司气海,调血压”针刺技术研究

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中国中医基础医学杂志 2017年第6期23卷 840-844,882页

作者：徐希法余亮张晓纬邝丽侠武春慧刘健樊小农天津中医药大学研究生院天津300193 天津中医药大学第一附属医院针灸研究所天津300193 天津市针灸学重点实验室天津300193 国家中医药管理局脑病针刺疗法重点研究室天津300193 国家中医药管理局量效关系三级实验室天津300193

目的:了解针灸治疗原发性高血压的选经取穴规律并基于此学习、探讨、领会石学敏院士"司气海,调血压"技术。方法:检索中国知网、万方数据库和重庆维普医药信息资源系统全文数据库中登载的针灸治疗原发性高血压的临床对照研究文献,筛选合... 详细信息

目的:了解针灸治疗原发性高血压的选经取穴规律并基于此学习、探讨、领会石学敏院士"司气海,调血压"技术。方法:检索中国知网、万方数据库和重庆维普医药信息资源系统全文数据库中登载的针灸治疗原发性高血压的临床对照研究文献,筛选合格文献提取文献中腧穴并录入Excel表格进行统计分析。结果:纳入文献166篇,腧穴84个,其中奇穴11个,腧穴总使用频次872次,主穴634次,配穴238次;针灸治疗原发性高血压十四经均有涉及但其重要程度不一,其中以手阳明大肠经、足厥阴肝经、足阳明胃经所用腧穴频次最多,其次为足太阳膀胱经和足少阳胆经等;使用频次前五的腧穴依次为太冲(104次)、曲池(86次)、足三里(64次)、风池(60次)和合谷(45次);身体各部位腧穴选用频次最多的是下肢部(389次),其次为上肢部(175次)和头面颈项部(175次);选用特定穴的频次(735次)远高于非特定穴频次(137次),其中特定穴中五输穴(385次)、原穴(202次)和交会穴(199次)的使用频次明显高于其他特定穴。石学敏院士创立的"司气海,调血压"针刺技术选用的5对腧穴,4对与研究结果一致(足厥阴肝经及手足阳明经肘膝以下的五腧穴和原穴,如太冲、曲池、足三里、合谷等穴),其所属的3条经脉亦与研究结果完全一致,惟一不属于高频率的经穴人迎穴,不仅有中西医理论支持而成为处方中的主穴,而且从所属经脉(足阳明胃经)、所在部位(头面颈项部)、特定穴(交会穴)方面都符合研究结果。结论:石学敏院士"司气海,调血压"(人迎、曲池、合谷、足三里、太冲穴)治疗原发性高血压针刺技术,是大继承基础上的大创新,故对名老中医的学术传承,必须重视对中医经典、疾病中西医知识和前人成果的深入掌握、融会贯通和锲而不舍。

关键词：高血压针灸规律气海理论石学敏

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Experimental Study on the Viscosity of Soft Cohesive Sediments Around A Vibrating Pillar

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China Ocean Engineering 2022年第2期36卷 289-298页

作者： DONG Chuan-ming YU Guo-liang zhang Huai-xin zhang Min-xi SKLOE CISSESchool of Naval ArchitectureOcean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Navigation College Dalian Maritime UniversityDalian 116026China

Offshore structures are subject to environmental loads such as waves,currents,or wind,which may induce cyclic lateral vibration at the *** cyclic vibration loadings may affect the rheological property of the sediments adjacent to the foundation and the stability of the *** is especially true when the structures are founded on cohesive sedimentary *** this study,the viscosity of soft cohesive sediments adjacent to a vibrating pillar was considered,and as a primary index of the rheological characteristics of the *** investigation was performed using the sinking ball *** experimental findings indicated that the viscosity of cohesive sediments decrease with increase of the liquidity index and vibration intensity.A simple semi-empirical formula was *** structures of the cohesive sediments were destroyed due to the mechanical vibration,and the sediments were fluidized during vibration *** shear strength of the cohesive sediments decreased with increased vibration intensity,not only because of the increased pore water pressure but also the decreased viscosity of cohesive sediments following sediment fluidization.

关键词： cohesive sediment vibration intensity viscosity coefficient fluidization liquidity index

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