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Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas

World Journal of Gastroenterology 2005年第31期11卷 4794-4799页

作者： You-Ling Gong Da-Wen xie Zong-Lin Deng Roberd M Bostick xi-jiang miao Jin-Hui Zhang Zhi-Hong Gong Tumor Center West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Epidemiology and Biostatistics School of Public Health and South Carolina Cancer CenterUniversity of South Carolina Columbia SC 29203 USA Department of Epidemiology Rollins Schoolof Public Health Emory University Atlanta GA 30322 USA Department of Computer Science and Engineering University of South Carolina Columbia SC 29203 USA

AIM： Recent laboratory and epidemiological studies suggest that vitamin D is a potential agent for colorectal cancer prevention. Its function is partially mediated by the vitamin D receptor （VDR）. The aim of this study was to investigate whether a novel G （allele ‘U’g〉A （allele ‘u’ polymorphism （Tru9I） in the VDR intron 8 region is associated with risk for colorectal adenoma in a colonoscopy-based case-control study. METHODS： Genotyping for a total of 391 subjects was carried out through PCR and restriction fragment length polymorphism. RESULTS： The frequencies of ‘U’ and ‘u’ alleles were 89.3% and 10.7%, respectively. The ‘Uu’ and ‘uu’ genotypes were associated with decreased risk for adenoma （OR, 0.71; 95%CI, 0.40-1.25）. The inverse association was more pronounced for multiple adenomas and adenomas that were larger had moderate or greater dysplasia, or were sessile： the odds ratios （ORs） were, 0.51 （95%CI, 0.21-1.24）, 0.37 （95%CI, 0.11-1.28）, 0.68 （95%CI, 0.33- 1.41）, and 0.36 （95%CI, 0.13-0.97） respectively. In joint/ combined analyses, inverse associations were more obvious among those who had at least one ‘u’ allele and also were younger （OR, 0.60; 95%CI, 0.26-1.37）, women （OR, 0.38; 95%CI, 0.17-0.88）, did not smoke （OR, 0.39; 95%CI, 0.13-1.23）, or took NSAID （OR, 0.38; 95%CI, 0.12-1.25）, but no evidence existed for interactions with calcium or vitamin D ***： Our findings suggest that the VDR TrugI polymorphism may be associated with lower risk for colorectal adenoma, particularly in interaction with various risk factors, but not with calcium or vitamin D.

关键词： Case-control study Colorectal adenoma Colorectal neoplasia Vitamin D receptor Genetic polymorphism

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Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls

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World Journal of Gastroenterology 2005年第33期11卷 5169-5173页

作者： Zong-Lin Deng Da-Wen xie Roberd M Bostick xi-jiang miao You-Ling Gong Jin-Hui Zhang Michael J Wargovich Department of Epidemiology and Biostatistics University of South Carolina School of Public Health and South Carolina Cancer CenterColumbia SC 29203 United States Department of Epidemiology Rollins School of Public Health Emory University Atlanta GA 30322 United States Department of Computer Science and Engineering University of South Carolina Columbia SC 29201 United States Tumor Center West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Pathology University of South Carolina School of Medicine and South Carolina Cancer CenterColumbia SC 29203 United States

AIM: p53-Inducible ribonucleotide reductase small subunit 2 (p53R2) encodes a 351-amino-acid peptide, which catalyzes conversion of ribonucleoside diphosphates to the corresponding deoxyribonucleotides required for DNA replication and repair. A recent study reported that a point mutation (G/T) in the p53 binding sequence in a colon cancer cell line completely impaired p53R2 protein ***: We screened the p53R2 gene coding regions and a regulatory region which contains a p53 binding sequence in 100 patients with colorectal adenoma and 100 control subjects using PCR, cold SSCP, and direct DNA ***: Although we did not identify genetic variation in all nine exons, four regulatory-region variants were found,of which three were single nucleotide polymorphisms (SNPs) (nt 1 789 C/G, nt 1 928 A/G, 1 933 T/C), and one was 20 bp insertion which replaced a ATTTT between nt 1 831 and 1 835. Additionally, we determined the frequency of these p53R2 variants in a recently concluded case-control study of incident sporadic colorectal adenomas (163 cases and 210 controls).CONCLUSION: Although more detailed functional characterizations of these polymorphisms remain to be undertaken, these polymorphic sites may be useful for identifying alleles associated with mis-splicing, additional transcript factors and, more generally, in cancer-susceptibility association studies.

关键词： Genetic polymorphism Colorectal neoplasia p53R2, SSCP PCR-RFLP

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Asymmetric interfacial engineering regulated charge distribution on Ru/Ni-N-C sites for efficient hydrogen evolution reaction in alkaline and seawater electrolytes

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Science China Chemistry 2025年

作者： Rui Yu xi Cao Chengyang Zhu Qingqing Chen Ziyi Yan Binbin jiang Junjie Mao xianwen Wei Key Laboratory of Electrochemical Clean Energy of Anhui Higher Education Institutes College of Chemistry and Materials ScienceAnhui Normal University Anhui Provincial Key Laboratory of Advanced Catalysis and Energy Materials School of Chemistry and Chemical Engineering Anqing Normal University School of Chemistry and Chemical Engineering Anhui University of Technology

Developing highly efficient and cost-effective electrocatalysts for hydrogen evolution reaction（HER） is grandly challenging in alkaline and alkaline seawater electrolytes. Herein, the asymmetric interfacial active sites with Ru nanoparticles and Ni single atoms in Ru/Ni-N-C were designed through a solvothermal-pyrolysis process. Constructing highly asymmetric interfacial active sites with a strong electron delocalization effect significantly improves HER kinetics. As expected, Ru/Ni-N-C requires low overpotentials with around 20 mV at 10 mA cm-2and robust durability over 48 h in alkaline and alkaline seawater *** at 200 mA cm-2, the overpotentials are close to 100 mV in both above electrolytes for Ru/Ni-N-C. Density function theory calculation results suggest that the asymmetric interface between Ru nanoparticle and Ni-N-C could accelerate the dissociation of water molecules and modulate the hydrogen species, consequently improving the HER performances. This work opens a unique approach for constructing advanced materials for energy conversion.

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铁路大站及区间信号自动控制系统模拟模型的研究

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铁道学报 1998年第6期20卷 9-15页

作者：蒋熙苗建瑞于勇杨肇夏张晓霖北方交通大学

提出了铁路大站及区间信号自动控制系统计算机模拟模型结构，在此基础上建立起车站联锁子模型和双线区间自动闭塞子模型。能满足利用计算机模拟手段进行实验教学和人员培训的需要，并为铁路运输科研课题进行列车运行的精确模拟提供支持。

关键词：铁路车站信号自动控制系统计算机模拟

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基于高层体系结构的铁路编组站综合仿真系统研究

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系统仿真学报 2002年第4期14卷 481-484页

作者：蒋熙苗建瑞于勇杨肇夏北方交通大学交通运输学院北京10044

编组站是铁路运输网络上的重要节点,综合性编组站仿真系统的研究与开发对现代编组站的相关科学研究和教学培训有重要意义。本文分析了编组站技术作业特点,探讨了编组站综合仿真系统的设计原则,借鉴HLA的基本思想和相关的技术规范,设计... 详细信息

编组站是铁路运输网络上的重要节点,综合性编组站仿真系统的研究与开发对现代编组站的相关科学研究和教学培训有重要意义。本文分析了编组站技术作业特点,探讨了编组站综合仿真系统的设计原则,借鉴HLA的基本思想和相关的技术规范,设计了铁路编组站综合仿真系统的仿真体系结构,并介绍了基于此结构而构建的一个编组站仿真培训系统的实例。

关键词：高层体系结构铁路编组站综合仿真系统铁路运输网络计算机仿真

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列车运行及其组织模拟试验系统研究

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铁道学报 1998年第6期20卷 1-8页

作者：杨肇夏蒋熙苗建瑞于勇孙全欣北方交通大学

列车运行及其组织模拟试验系统能为有关科学研究与人员培训提供面向普通线路与高速线路，在自动闭塞、调度集中及移动自动闭塞等制式下列车运行及其扰动与控制的模拟试验环境，对各种试验方案或培训人员作出评价。

关键词：计算机模拟列车运行组织试验系统培训

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Anomaly detection of control rod drive mechanism using long short-term memory-based autoencoder and extreme gradient boosting

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Nuclear Science and Techniques 2022年第10期33卷 53-67页

作者： Jing Chen Ze-Shi Liu Hao jiang xi-Ren miao Yong Xu College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China The Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Fujian Fuqing Nuclear Power Co. Ltd.Fujian 350318China

Anomaly detection for the control rod drive mechanism(CRDM) is key to enhancing the security of nuclear power plant equipment. In CRDM real-time condition-based maintenance, most existing methods cannot deal with long sequences and periodic abnormal events and have poor feature extraction from these data. In this paper,a learning-based anomaly detection method employing a long short-term memory-based autoencoder(LSTM-AE)network and an extreme gradient boosting(XGBoost)algorithm is proposed for the CRDM. The nonlinear and sequential features of the CRDM coil currents can be automatically and efficiently extracted by the LSTM neural units and AE network. The normal behavior LSTM-AE model was established to reconstruct the errors when feeding abnormal coil current signals. The XGBoost algorithm was leveraged to monitor the residuals and identify outliers for the coil currents. The results demonstrate that the proposed anomaly detection method can effectively detect different timing sequence anomalies and provide a more accurate forecasting performance for CRDM coil current signals.

关键词： Anomaly detection CRDM LSTM-AE Residuals XGBoost

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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin Jun Xu Delong jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Contrastive Learning

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Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao xiA Jianing LIANG Yuhao jiang Zhiyang PENG Jiaxu LI Chen xiAO Renyou XU Wenwen WANG xiantao SHANG Shiyang LU Dapeng ZHU Hong-xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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Targeting capabilities of engineered extracellular vesicles for the treatment of neurological diseases

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Neural Regeneration Research 2025年第11期20卷 3076-3094页

作者： xinyu Yang xiangyu Gao xiaofan jiang Kangyi Yue Peng Luo Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Recent advances in research on extracellular vesicles have significantly enhanced their potential as therapeutic agents for neurological *** to their therapeutic properties and ability to cross the blood–brain barrier,extracellular vesicles are recognized as promising drug delivery vehicles for various neurological conditions,including ischemic stroke,traumatic brain injury,neurodegenerative diseases,glioma,and ***,the clinical application of natural extracellular vesicles is hindered by their limited targeting ability and short clearance from the *** address these limitations,multiple engineering strategies have been developed to enhance the targeting capabilities of extracellular vesicles,thereby enabling the delivery of therapeutic contents to specific tissues or ***,this review aims to highlight the latest advancements in natural and targeting-engineered extracellular vesicles,exploring their applications in treating traumatic brain injury,ischemic stroke,Parkinson's disease,Alzheimer's disease,amyotrophic lateral sclerosis,glioma,and ***,we summarized recent clinical trials involving extracellular vesicles and discussed the challenges and future prospects of using targeting-engineered extracellular vesicles for drug delivery in treating neurological *** review offers new insights for developing highly targeted therapies in this field.

关键词： Alzheimer's disease amyotrophic lateral sclerosis engineered extracellular vesicles glioma ischemic stroke neurological diseases Parkinson's disease psychosis targeted drug delivery traumatic brain injury

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